Syncoilin

syncoilin
Identifiers
Symbol	SYNC1
Entrez	81493
HUGO	28897
OMIM	611750
RefSeq	NM_030786
UniProt	Q9H7C4
Other data
Locus	Chr. 1 p35.1-p33

Syncoilin is a muscle-specific intermediate filament, first isolated as a binding partner to α-dystrobrevin, as determined by a yeast two-hybrid assay.

Later, a yeast two-hybrid method was used to demonstrate that syncoilin is a binding partner of desmin. These binding partners suggest that syncoilin acts as a mechanical "linker" between the sarcomere Z-disk (where desmin is localized) and the dystrophin-associated protein complex (where α-dystrobrevin is localized). However, the specific in vivo functions of syncoilin have not yet been determined.

Abnormally high levels of syncoilin have been shown to be a characteristic of neuromuscular wasting diseases, such as desminopathy and muscular dystrophy. Therefore, syncoilin is being explored as a promising marker of neuromuscular disease.

External links

• Syncoilin at the US National Library of Medicine Medical Subject Headings (MeSH)