TGF beta receptor 1

Transforming growth factor, beta receptor 1
Transforming growth factor, beta receptor 1
	PDB rendering based on 1b6c.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1B6C, 1IAS, 1PY5, 1RW8, 1TBI, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J, 4X2K, 4X2N
Identifiers
Symbols	TGFBR1 ; AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TGFR-1; tbetaR-I
External IDs	OMIM: 190181 MGI: 98728 HomoloGene: 3177 ChEMBL: 4439 GeneCards: TGFBR1 Gene
EC number	2.7.11.30
Gene ontology
Molecular function	• protein kinase activity; • protein serine/threonine kinase activity; • receptor signaling protein serine/threonine kinase activity; • transforming growth factor beta-activated receptor activity; • transforming growth factor beta receptor activity, type I; • receptor signaling protein activity; • type II transforming growth factor beta receptor binding; • protein binding; • ATP binding; • growth factor binding; • SMAD binding; • metal ion binding; • transforming growth factor beta binding; • I-SMAD binding;
Cellular component	• intracellular; • cell; • endosome; • plasma membrane; • bicellular tight junction; • membrane; • receptor complex; • transforming growth factor beta receptor homodimeric complex;
Biological process	• activation of MAPKK activity; • skeletal system development; • angiogenesis; • in utero embryonic development; • kidney development; • blastocyst development; • epithelial to mesenchymal transition; • negative regulation of endothelial cell proliferation; • positive regulation of endothelial cell proliferation; • lens development in camera-type eye; • regulation of transcription, DNA-templated; • protein phosphorylation; • apoptotic process; • cell cycle arrest; • signal transduction; • transforming growth factor beta receptor signaling pathway; • heart development; • positive regulation of cell proliferation; • germ cell migration; • male gonad development; • post-embryonic development; • anterior/posterior pattern specification; • regulation of gene expression; • positive regulation of gene expression; • regulation of epithelial to mesenchymal transition; • positive regulation of pathway-restricted SMAD protein phosphorylation; • peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • signal transduction by protein phosphorylation; • collagen fibril organization; • positive regulation of cell growth; • negative regulation of transforming growth factor beta receptor signaling pathway; • regulation of protein ubiquitination; • negative regulation of chondrocyte differentiation; • activin receptor signaling pathway; • intracellular signal transduction; • wound healing; • endothelial cell activation; • extracellular structure organization; • regulation of protein binding; • endothelial cell migration; • positive regulation of transcription, DNA-templated; • thymus development; • neuron fate commitment; • embryonic cranial skeleton morphogenesis; • skeletal system morphogenesis; • mesenchymal cell differentiation; • artery morphogenesis; • cell motility; • positive regulation of cellular component movement; • positive regulation of filopodium assembly; • positive regulation of protein kinase B signaling; • parathyroid gland development; • palate development; • pharyngeal system development; • cardiac epithelial to mesenchymal transition; • pathway-restricted SMAD protein phosphorylation; • positive regulation of SMAD protein import into nucleus; • response to cholesterol; • cellular response to transforming growth factor beta stimulus; • positive regulation of apoptotic signaling pathway; • negative regulation of extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
Orthologs
Species	Human
Entrez	7046
Ensembl	ENSG00000106799
UniProt	P36897
RefSeq (mRNA)	NM_001130916
RefSeq (protein)	NP_001124388
Location (UCSC)	Chr 9:; 99.1 – 99.15 Mb
PubMed search	[1]
	v; t; e;

Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) is a TGF beta receptor. TGFBR1 is its human gene.

Function

The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transducing the TGF-β signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys–Dietz aortic aneurysm syndrome (LDS, LDAS).^[1]

Interactions

TGF beta receptor 1 has been shown to interact with:

Inhibitors

References

↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^2.0 ^2.1 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^14.0 ^14.1 Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ Lua error in package.lua at line 80: module 'strict' not found.

External links

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[1] Lua error in package.lua at line 80: module 'strict' not found.

[pmid11102446-2] 2.0 ^2.1 Lua error in package.lua at line 80: module 'strict' not found.

[pmid12015308-3] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9872992-4] Lua error in package.lua at line 80: module 'strict' not found.

[pmid7518616-5] Lua error in package.lua at line 80: module 'strict' not found.

[pmid7791754-6] Lua error in package.lua at line 80: module 'strict' not found.

[pmid8530343-7] Lua error in package.lua at line 80: module 'strict' not found.

[pmid18591668-8] Lua error in package.lua at line 80: module 'strict' not found.

[pmid15148321-9] Lua error in package.lua at line 80: module 'strict' not found.

[pmid14722617-10] Lua error in package.lua at line 80: module 'strict' not found.

[pmid14657019-11] Lua error in package.lua at line 80: module 'strict' not found.

[pmid11163210-12] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9215638-13] Lua error in package.lua at line 80: module 'strict' not found.

[pmid10757800-14] 14.0 ^14.1 Lua error in package.lua at line 80: module 'strict' not found.

[pmid9774674-15] Lua error in package.lua at line 80: module 'strict' not found.

[pmid9856985-16] Lua error in package.lua at line 80: module 'strict' not found.

[pmid8235612-17] Lua error in package.lua at line 80: module 'strict' not found.

[pmid10716993-18] Lua error in package.lua at line 80: module 'strict' not found.

[pmid7890683-19] Lua error in package.lua at line 80: module 'strict' not found.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

TGF beta receptor 1

Contents

Function

Interactions

Inhibitors

See also

References

Further reading

External links

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Tools