Template:PBB/7097

Toll-like receptor 2
PDB rendering based on 1fyw.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Identifiers
Symbols	TLR2 ; CD282; TIL4
External IDs	OMIM: 603028 MGI: 1346060 HomoloGene: 20695 ChEMBL: 4163 GeneCards: TLR2 Gene
Gene ontology Molecular function • lipopolysaccharide binding • lipopolysaccharide receptor activity • receptor activity • transmembrane signaling receptor activity • protein binding • signaling pattern recognition receptor activity • triacyl lipopeptide binding • diacyl lipopeptide binding • peptidoglycan binding • protein heterodimerization activity • lipoteichoic acid binding Cellular component • cytoplasm • plasma membrane • integral component of plasma membrane • external side of plasma membrane • cell surface • intrinsic component of plasma membrane • Toll-like receptor 1-Toll-like receptor 2 protein complex • Toll-like receptor 2-Toll-like receptor 6 protein complex Biological process • toll-like receptor signaling pathway • response to molecule of fungal origin • cytokine secretion involved in immune response • positive regulation of leukocyte migration • regulation of dendritic cell cytokine production • cell surface pattern recognition receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • apoptotic process • inflammatory response • immune response • signal transduction • I-kappaB phosphorylation • positive regulation of gene expression • positive regulation of Wnt signaling pathway • lipopolysaccharide-mediated signaling pathway • interleukin-10 production • negative regulation of interleukin-12 production • negative regulation of interleukin-17 production • positive regulation of chemokine production • positive regulation of interferon-beta production • positive regulation of interleukin-12 production • positive regulation of interleukin-18 production • positive regulation of interleukin-6 production • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • positive regulation of toll-like receptor signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • positive regulation of NF-kappaB import into nucleus • detection of triacyl bacterial lipopeptide • detection of diacyl bacterial lipopeptide • positive regulation of tumor necrosis factor biosynthetic process • chloramphenicol transport • negative regulation of growth of symbiont in host • innate immune response • positive regulation of nitric oxide biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cytokine secretion • positive regulation of inflammatory response • defense response to Gram-positive bacterium • positive regulation of NF-kappaB transcription factor activity • positive regulation of nitric-oxide synthase biosynthetic process • induction by symbiont of defense-related host nitric oxide production • positive regulation of macrophage cytokine production • cellular response to bacterial lipopeptide • cellular response to lipoteichoic acid • cellular response to peptidoglycan • cellular response to diacyl bacterial lipopeptide • cellular response to triacyl bacterial lipopeptide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7097	24088
Ensembl	ENSG00000137462	ENSMUSG00000027995
UniProt	O60603	Q9QUN7
RefSeq (mRNA)	NM_003264	NM_011905
RefSeq (protein)	NP_003255	NP_036035
Location (UCSC)	Chr 4: 153.7 – 153.71 Mb	Chr 3: 83.84 – 83.84 Mb
PubMed search	[1]	[2]