Torasemide

Torasemide

File:Torasemide.svg
File:Torasemide bas.png
Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601212
Pregnancy category	US: C (Risk not ruled out)
Legal status	US: ℞-only
Routes of administration	Oral, IV
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Biological half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS Number	56211-40-6 Y
ATC code	C03CA04 (WHO)
PubChem	CID: 41781
IUPHAR/BPS	7312
DrugBank	DB00214 Y
ChemSpider	38123 Y
UNII	W31X2H97FB Y
KEGG	D00382 Y
ChEBI	CHEBI:9637 N
ChEMBL	CHEMBL1148 Y
Chemical data
Formula	C16H20N4O3S
Molecular mass	348.421 g/mol
SMILES O=S(=O)(c2c(Nc1cc(ccc1)C)ccnc2)NC(=O)NC(C)C
InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) Y Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand names Demadex, Diuver, and Examide.

Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss. No evidence of torasemide-induced ototoxicity has been demonstrated in humans.

External links

• Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient