TAS2R16

Taste 2 receptor member 16
Identifiers
Symbols	TAS2R16 ; T2R16
External IDs	OMIM: 604867 MGI: 2681247 HomoloGene: 9660 IUPHAR: 669 GeneCards: TAS2R16 Gene
Gene ontology Molecular function • protein binding • bitter taste receptor activity Cellular component • endoplasmic reticulum • trans-Golgi network • plasma membrane • external side of plasma membrane • integral component of membrane Biological process • detection of chemical stimulus involved in sensory perception of bitter taste • G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50833	387347
Ensembl	ENSG00000128519	ENSMUSG00000043865
UniProt	Q9NYV7	P59529
RefSeq (mRNA)	NM_016945	NM_207022
RefSeq (protein)	NP_058641	NP_996905
Location (UCSC)	Chr 7: 122.99 – 123 Mb	Chr 6: 23.97 – 23.97 Mb
PubMed search	[1]	[2]

TAS2R16 (taste receptor, type 2, member 16) is a human gene that encodes for a receptor that may play a role in the perception of bitterness.

The TAS2R16 gene is located on the long (q) arm of chromosome 7 at position 31.1 - 31.3, from base pair 122,228,764 to base pair 122,229,639.

Clinical significance

Variants of this gene have been linked to an increased risk for alcohol dependence.

There is an East African origin for high salicin sensitivity, and thus sensitivity to bitterness in people from this region, with this phenotype matched to TAS2R16 variants.

See also

• Taste receptor

External links

• GeneCard for TAS2R16
• TAS2R16 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)