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Syllabus BCHM 101a, Fall 2015: Module 1: Kinetics: Sept 7 No Brandeis Classes, Labor Day

This document is a syllabus for the BCHM 101a biochemistry course offered in the fall of 2015. The course covers enzyme kinetics and catalysis over 6 modules from August to December. Module 1 introduces kinetics and enzyme catalysis concepts like reaction rates, activation energy, and the Michaelis-Menten model. Module 2 covers isomerization reactions like proline racemization. Module 3 focuses on thiamine pyrophosphate dependent reactions such as decarboxylation. Module 4 examines group transfer reactions including proteases like chymotrypsin. Module 5 reviews pyridoxal phosphate dependent reactions. The final module covers redox reactions involving NAD and flavins. The syllabus outlines topics,

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42 views2 pages

Syllabus BCHM 101a, Fall 2015: Module 1: Kinetics: Sept 7 No Brandeis Classes, Labor Day

This document is a syllabus for the BCHM 101a biochemistry course offered in the fall of 2015. The course covers enzyme kinetics and catalysis over 6 modules from August to December. Module 1 introduces kinetics and enzyme catalysis concepts like reaction rates, activation energy, and the Michaelis-Menten model. Module 2 covers isomerization reactions like proline racemization. Module 3 focuses on thiamine pyrophosphate dependent reactions such as decarboxylation. Module 4 examines group transfer reactions including proteases like chymotrypsin. Module 5 reviews pyridoxal phosphate dependent reactions. The final module covers redox reactions involving NAD and flavins. The syllabus outlines topics,

Uploaded by

william1230
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Syllabus BCHM 101a, Fall 2015:

Module 1: Kinetics
August 27
August 31
Sept. 2
Sept. 3
Sept 7
Sept. 9
Sept. 10
Sept 14
Sept. 16
Sept. 17
Sept. 21
Sept 23
Sept. 24
Sept 28

Introduction in the World of Enzymes


Review chemical kinetics, first order, second order, reversible reactions,
chemical kinetics, parallel reactions, steady state, molecularity versus order
Transition state theory, temperature dependence of reactions,
no Brandeis classes, Labor Day
Eyring Equation
Energy diagrams for uncatalyzed versus catalyzed reactions, intermediates
versus transition states
no class
Enzyme kinetics, steady state, Michaelis Menten,
Vmax, kcat, rate equations for different enzymatic reactions, Haldane
Relation
General mechanisms of enzyme catalysis
no class
General mechanisms of enzyme catalysis
no class

Module 2: Isomerizations
Sept. 29
Sept 30
Oct. 1
Oct. 5
Oct. 7
Oct. 8
Oct. 12

Isomerizations: [1,1] hydrogen shifts, Proline Racemase


Isotope Effects
Prolyl cis/trans isomerases
no class
[1,2] hydrogen shifts, Triose phosphate isomerase
Triose phosphate isomerase
Exam

Module 3: ThDP reactions


Oct. 14
Oct. 15
Oct. 19
Oct. 21
Oct. 22

Decarboxylation: a-ketoacids versus b-ketoacids


no class, Biochem retreat
ThDP reactions, oxidative versus nonoxydative decarboxylation
PDC
other ThDP enzymes

Module 4: Group transfer reactions


Oct. 26
Oct 28
Oct 29
Nov. 2
Nov. 4
Nov. 5
Nov. 9
Nov. 11
Nov. 11
Nov. 12

Group transfer reactions: Proteases


Chymotrypsin
Chymotrypsin
Inhibitors
Economics of enzyme catalysis
Phosphoryl transfer reactions
Phosphoryl transfer reactions
Kinetics of 2 substrate reactions makeup for Nov. 23
6.20-8.20 Exam 2
Acyl Activation

Module 5: PLP reactions


Nov. 16
Nov. 18
Nov. 19

PLP reactions
PLP reactions
PLP reactions

Nov. 23
Nov. 30

no class (makeup)
no class (makeup

Module 6: Redox reactions


Dec 2
Dec. 2
Dec. 3
Dec. 7
Dec. 9

Redox reactions: NAD


6.20-7.10 pm makeup for Nov. 30 DHFR
Flavin reactions
Summary of the course
6.20-9.20 pm Final Exam

Four-Credit Course (with three hours of class-time per week)


Success in this 4 credit hour course is based on the expectation
that students will spend a minimum of 9 hours of study time per
week in preparation for class (readings, papers, discussion
sections, preparation for exams, etc.).

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