Product Overview

Innovation with Integrity

Analytical Solutions

Bruker the performance leader in life science and analytical systems.

Right from the beginning, which is now more than fifty years ago, Bruker has been driven by a single idea: to provide the best technological solution for each analytical task. Today, worldwide, more than 5,400 employees in over 70 locations on all continents are focusing their efforts on this permanent challenge. Bruker systems cover a broad spectrum of applications in all fields of research and development and are used in all industrial production processes for the purpose of ensuring quality and rocess reliability. Bruker continues to build upon its extensive range of products and solutions, expand its broad base of installed systems and maintain a strong reputation amongst its customers. As one of the world's leading analytical instrumentation companies, Bruker remains focused on developing state-of-the-art technologies and innovative solutions for todays ever complex analytical questions.

Bruker Innovation with Integrity

Life Science

Quality & Process Control

Materials Research

Food & Environment

Pharma & Biotech

Clinical Research

ISBN-13 978-3-929431-25-4

X-Ray and Elemental Analysis X-Ray Fluorescence (XRF) X-Ray Diffraction (XRD) Crystallography Energy Dispersive X-Ray Spectroscopy (EDS) Optical Emission Spectroscopy (OES) CS/ONH Analysis Magnetic Resonance Nuclear Magnetic Resonance (NMR) Magnetic Resonance Imaging (MRI) Electron Paramagnetic Resonance (EPR) Mass Spectrometry and Chemical Analysis FT-Mass Spectrometry (FTMS) MALDI Liquid Chromatography Mass-Spectrometry (LC-MS) Inductively Coupled Plasma Mass-Spectrometry (ICP-MS) Gas Chromatography Mass Spectrometry (GC-MS) CBRNE Detection Optical Vibrational Spectroscopy FT-Infrared Spectroscopy (FT-IR) Raman Spectroscopy Near Infrared Spectroscopy (NIR) Microanalysis Atomic Force Microscopy (AFM) Scanning Probe Microscopy (SPM) Stylus and Optical Metrology Tribology

Bruker offices
www.bruker.com/map 3

Bruker Corporation
The Bruker name has become synonymous with the excellence, innovation and quality that characterizes our comprehensive range of scientific instrumentation. Our trusted solutions encompass a wide number of analytical techniques ranging from Magnetic Resonance to Mass Spectrometry and Gas Chromatography, to Microanalysis, Optical, and X-Ray Spectroscopy. These market- and technology -leading products are driving and facilitating many key application areas such as life science research, pharmaceutical analysis, applied analytical chemistry applications, materials research and nanotechnology, clinical research, molecular diagnostics and homeland defense. Visit our website to discover more about our technologies and solutions. www.bruker.com

Karlsruhe, Germany

Fllanden, Switzerland

Bremen, Germany

Rheinstetten, Germany

Bruker analytical excellence, acknowledged expertise and global presence.

Application lab in Singapore

MR Imaging labs in Ettlingen, Germany

Magnet Production in Wissembourg, France

Santa Barbara, USA

Shanghai, China

Wissembourg, France

Singapore

Yokohama, Japan

Fremont, USA

Content:
Nuclear Magnetic Resonance 8 Fourier / Avance III NanoBay 10 Avance III / Avance 1000 12 DNP NMR Spectrometer / Metabolic Profiler 14 Magnets / Probes 16 CryoProbes & Prodigy / Solid Probes 18 TopSpin / Automation 20 Complete Molecular Confidence (CMC-se) 22 Assure / FoodScreener 24 Hyphenation / Latest Technologies 26 Power Supplies / RF Transmitters Time Domain NMR 30 the minispec TD-NMR Analyzers 33 HyperQuant Magnetic Resonance Imaging 36 BioSpec 38 ClinScan 40 PharmaScan 41 Icon 42 BGA-S Gradient Series 43 USR Magnets 44 MRI CryoProbe 45 Micro-Imaging 46 ParaVision / Beyond Standard BioSpecs Electron Paramagnetic Resonance 50 ELEXSYS 54 ELEXSYS Accessories 55 EMXplus 56 EMXmicro 57 e-scan Mass Spectrometry 60 MALDI-TOF 62 LC-MS and Ion Trap 64 LC-MS and o-TOF 66 UHR-TOF and FTMS 68 Ion Sources, Software & Applications 70 ICP-MS and GC-MS 72 GC Systems and GC Accessories 74 GC Accessories and Consumables 75 Maldi Biotyper Consumables CBRN Detection 78 Prepared for a changing world of threats 79 Chemical Hazardous Agent Detection 80 Chemical & Radiation Detection 81 Biological Detection 82 First Responders & Environmental Protection 83 Software Solutions Optical Vibrational Spectroscopy 86 FT-IR Spectrometers 88 Remote Sensing Systems 89 Raman Spectrometers 90 FT-IR & Raman Microscopy 91 FT-NIR Spectrometers 92 Process Analytical Technologies 93 Opus-Spectroscopy Software Analytical X-ray, AFM, OES 96 X-ray Diffraction 99 X-ray Fluorescence Analysis 102 Optical Emission Spectrometry 104 CS / ONH Analysis 106 Microanalysis 107 Chemical and Biological Crystallography Atomic Force Microscopy 110 Atomic Force and Scanning Probe Microscopy 111 Stylus and Optical Metrology

Tables
T 2 38 NMR Tables T 39 48 X-Ray

Diffractometry Tables and Raman Tables Tables

T 49 53 EPR / ENDOR Tables T 54 61 IR Spectroscopy T 62 76 Mass Spectrometry T 77 85 Chemical Tables T 86 94 Physical Tables T 95 96 International

Dailing Codes / World Time Zones

2012 Monthly Calendar Participation at Exhibitions and Conferences Bruker Users Meetings worldwide Training Courses
Represents public holidays.

Nuclear Magnetic Resonance

Solutions for Life Sciences and Analytical Research

Innovation with Integrity

NMR
7

Fourier
Dedicated high-resolution NMR spectrometer delivers affordable NMR for all your common applications in education and routine chemistry research
Fourier brings NMR within everyones reach. It delivers powerful performance at extremely compact size, low weight and most importantly, minimal cost. With its new Fourier probe technology and a unique push-button, power on/off concept, ease of siting and handling is guaranteed. Designed and built by the worlds NMR market leader, Fourier unique qualities include the industry standard operating software, TopSpin. TopSpins various tools for exploring the world of NMR make Fourier the ideal solution for chemistry education and routine analysis. Researchers have access to numerous pre-defined 1D and 2D experiments and interactive, automated processing tools help to transfer spectroscopic data into a corresponding report.

Benefits
n Affordable

NMR spectrometer for Chemistry Education and Small Molecule Analysis n Industry Standard TopSpin software n Providing higher throughput with the SampleXpress Lite 16 position sample changer n Proven IconNMR software for automation control n New robust Fourier NMR probe for easiest handling n 1D/2D Proton and Carbon NMR for every Chemist
Easy sample loading on the SampleXpress Lite

Sample setup with the intuitive IconNMR interface

Avance III NanoBay

The Most Fully Integrated State- of-the-Art NMR Spectrometer Ever
The Avance III NanoBay is the most comprehensively integrated, state-ofthe-art NMR spectrometer ever produced. The NanoBays innovative design sees Brukers high-performance Avance III NMR spectrometer technology boldly held within an exceptionally compact enclosure. It delivers high-productivity with highest quality NMR information for pharmaceutical and industrial chemists, as well as food analysis, diagnostics research and other small molecule applications.

Amix provides a collection of powerful tools that enable statistical and spectroscopic analyses of your NMR data. For a wide variety of applications, such as metabolomics, small molecules research and mixture analysis an increase in productivity can be achieved.

IconNMRTM is the graphical user interface for fully automated acquisition and processing. This productivity tool excels whenever large numbers of samples accrue, or where multiple users access your spectrometer.

Benefits
Ultra compact, innovative design high-end NMR spectrometer Available at 300 and 400 MHz Featuring UltraShield TM Plus magnet technology Easy siting in small analytical laboratories TopSpinTM - Intuitive routine user interface Based on well-proven Avance III spectrometer technology High-fidelity NMR information for a wide range of chemical applications
Avance III NanoBay 400 MHz spectrometer

Avance III
The Avance III is the ultimate NMR platform for life-sciences and materials research. Robust, automated and easy-to-use it is the ideal NMR analysis system for the pharmaceutical, biotech, and chemical industries, for metabonomics, materials science, molecular diagnostics, and much more. The Avance III is the newest generation in the very successful Avance series, which has established Bruker as the clear technological and market leader in NMR and pre-clinical MRI worldwide. The Avance III spectrometer architecture is designed around an advanced digital concept which provides an optimized pathway for high-speed RF generation and data acquisition with highly modular and scalable transmitters and multiple receiver channels. The Avance III platform provides 25 ns event timing (12.5 ns clock), and simultaneous phase, frequency and amplitude switching with capabilities that exceed the requirements of even the most demanding solid-state NMR experiments. The second-generation digital receiver technology delivers high dynamic range, high digital resolution and large-bandwidth digital filtering. The unique digital lock system provides the utmost in field/frequency stability.

Benefits

Patented Direct Digital Synthesis One-chip RF generation Timing Resolution: 12.5 ns Minimum event time: 25 ns High-speed RF generation and data acquisition Scalable transmitters and multiple receiver channels High-dynamic range and digital resolution Large-bandwidth digital filtering

Ultra-High Field Avance III 850 MHz NMR system

10

Avance 1000
Bruker is proud to provide the worlds highest field NMR system of highest sensitivity and dispersion to the scientific research community. With this instrument, research in biochemistry, structural biology and other molecular research will be pushed to new frontiers. The first Avance 1000 NMR system equipped with a CryoProbe has been installed at the new Centre de RMN Trs Haut Champs in Lyon, France. n 1 GHz NMR system with 23.5 T persistent superconducting magnet n Standard bore, 54 mm diameter n UltraStabilized sub-cooling technology, achieving the highest field and most compact magnet coil at this field strength n Proprietary jointing technology enabling high current and high-field joints with minimum resistance for maximum field stability n 5-mm triple-resonance CryoProbe, enabling unique 1 GHz NMR applications n 1.3-mm, 2.5-mm & 3.2-mm double and triple resonance MAS probes, enabling unique 1 GHz NMR solids applications

Worlds First 1 NMR System Installed

1GHz (23.5 T) UltraStabilized magnet installed at Centre de RMN Trs Haut Champs, Lyon, Fr. Courtesy: Prof. L. Emsley.

RNA, 3D NOESY-(13C)-HSQC at 1 GHz with CryoProbe

NMR structure determination of the conserved secondary structural motif of 23S rRNAs by John King, Christos Shammas and Vasudevan Ramesh, (University of Manchester).

RNA, 1 GHz vs 800 MHz

Solid State NMR 15N-13C correlations at 1 GHz

(15N)
ppm
T49 G14 G41 G38

35 Hz

110

G9

T53

115
E27 T25 N35 K28 F30 A24 Q32 V29 K31 D36 A48 V21 N37

T51 T16 T18 Y45 T17

Comparison of 13C planes of the 1 GHz and 800 MHz 3D NOESY-(13C)-HSQC spectra. (A) (139.29ppm) (A27) (B) (138.96 ppm) arising from G20 H8 proton and the NOEs observed thereof to G19.

27 Hz

E42 V54

120

K50 V39 Y33 D47 A26 W43 A20 L7 N8 A23 I6 K13 T55 L5 D46 L12 E19 Q2 K4 Y3 K10 E15

125

A34

130
F52 D40 E56

Acknowledgements:
168

135 180 178 176

(13C) / ppm

174

172

170

168

180

178

176

174 172 (13C) / ppm

170

NCO correlation recorded on U[ N, C]-microcrystalline GB1 without (left) and with (right) a S3E J-decoupling block; 60 kHz MAS, T1max=40 ms, T2max=50 ms, NS=48, exp. time=17 hrs.
15 13

Dr. Moreno Lelli, Dr. Jzef Lewandowski, Dr. Guido Pintacuda, Dr. Anne Lesage, Dr. Benedicte Elena, and Prof. Lyndon Emsley with CRMN, Lyon, France.

11

DNP-NMR Spectrometer
Sensitivity Boost for Biomolecular NMR
Dynamic Nuclear Polarization (DNP) experiments transfer polarization from electron to nuclear spins enhancing sensitivity and dramatically reducing signal averaging time. Bruker Avance DNP-NMR Spectrometers are designed specifically for solid-state NMR, delivering unsurpassed sensitivity for exciting new applications.

Benefits
263 GHz DNP - NMR Spectrometer DNP CPMAS of 13C-Proline
13 DNP = 45 C CPMAS spectra with and without microwaves irradiation of a micro-crystalline yeast Triose Phos13 C Chemical Shift (ppm) phate IsoCourtesy of Prof. Ann McDermott, merase (TIM) Columbia University frozen solution with 20 mM TOTAPOL. 32 scans, 2 s recycle delay, 9 kHz MAS, 100 K sample temperature, 400 MHz 1H frequency.

DNP on membrane proteins

DNP-enhanced solid-state NMR experiments at high field Polarization enhancement yields up to a factor of 80 gain in sensitivity, to date Unique high power 263 GHz micro-wave source with easyto-use software-controlled high-power gyrotron (9.7 T) Microwave transmission line designed for optimum beam propagation to the sample Low-temperature MAS probe technology with cold spinning gas supply and built-in wave guide 395 GHz (600 MHz 1H) and 528 GHz (800 MHz 1H) spectrometers in development

13

C Chemical Shift (ppm)

13

C Chemical Shift (ppm)

Courtesy of Prof. David Weliky, Michigan State University

DNP experiments on membrane-associated HIV gp41protein with uniform 13C,15N labeling at Ala-6 and Gly-10. (a) 13C CPMAS spectra with and without waves showing a factor of 22 DNP signal enhancement at 100 K, 8 kHz MAS, 32 scans, 5 s recycle delay. (b) DNP-enhanced DARR 13C-13C correlation experiment with 15 ms mixing time, 32 scans, 8 kHz MAS, and 200 points in f1.

12

Metabolic Profiler
Metabolic profiling and finger printing is a key process in the pharmaceutical industry for studying drug efficacy or toxicology. In clinical research, metabolic profiling helps to identify biomarker compounds for early disease detection and monitoring, and enables researchers to study the effects of drugs in biological systems in a rapid and robust method.

Integrated Analysis
The Metabolic Profiler is a dedicated, integrated LC-NMR/MS solution for metabolic analysis featuring an Avance NMR spectrometer and a micrOTOF-Q II. This system provides a simple, easy to use and inexpensive base for acquiring the spectroscopic data needed for basic metabolic profiling. The system delivers the integration of automated sample handling, acquisition, collection and archiving of your data, and enables the comparative and statistical analysis needed for your research.

Reference Compound Spectral Database

The most complete metabolite NMR spectral database available which contains over 17,000 spectra of the most common endogenous metabolites. By taking into account the effects of pH, field strength and by using one as well as two dimensional NMR data, the database enables the assignment of metabolites in biofluids, cell extracts and tissues in a unique and unambiguous way. Linking the database to AMIX enables automatic investi-gations, such as matching to mixture spectra. Direct integration into statistical data evaluation is also possible.
Analysis with AMIX

Data Management
SampleTrack is an Oracle -based information system that utilizes SQL tools for organizing, searching and archiving sample information, which can simplify experimental control of large sample sets.

Statistical Analysis
The AMIX program provides a comprehensive range of powerful tools that enable statistical and spectroscopic analyses of both your NMR and MS data. AMIX features Pattern Match - which can define spectral patterns in multiple ways and project these to spectra. In addition, the Multi-Integration features can be used to identify and quantify metabolites in complex mixtures.

AMIX analyzes data and is linked to the Spectral Database for further comparative analysis.

13

Magnets
Bruker has specialized in the design and production of magnets and cryogenic systems for a wide range of applications, becoming the worlds largest manufacturer of superconducting magnets for NMR. Bruker is engaged in every aspect of the magnet business including research and development, production and testing, individual site planning, as well as service and support.

US2
The US represents the efficient combination of Brukers renowned magnet technologies (UltraStabilized and UltraShield) for enhanced system performance and siting flexibility at UltraHigh Field strength.

Ascend
This new magnet line at 400 to 850 MHz incorporates the key technologies of the well-established UltraShield Plus magnets, with new innovations for superior performance. The AscendTM magnet design features advanced superconductor technology, enabling the design of smaller magnet coils, resulting in a significant reduction in the size of the cryostat. Ascend magnets are therefore easier to site, safer to run and have lower operational costs. These high-performance systems are ideal for structural biology research and materials research applications.

UltraStabilized
UltraStabilized is our innovative magnet technology for Ultra-High Field NMR up to 1000 MHz. This proprietary technology provides reliable, stable operation at reduced helium bath temperature and ambient pressure.

Ascend 500, 600, and 700 MHz systems

14

Probes
X Observe Probes
These probes are optimized for observation of X-nuclei. They are available in selective or broadbanded versions for double, triple and quadruple resonance experiments, including automated tuning and matching.
1

H Inverse Probes

The inner coil of these versatile probes, in multinuclear or selective configuration, is fully optimized for 1H observation at highest sensitivity with optimal lineshape. The available configurations and choices of X-nuclei are identical to those for X Observe Probes.

Inverse MicroProbes
For highest H sensitivity per mole of substance, e.g. in natural products applications, Bruker offers 1- and 1.7-mm 1H/13C/15N fixed-frequency probes.
1

SmartProbe

SmartProbe
The SmartProbeTM delivers highest sensitivity on both the multinuclear and proton channel. The SmartProbe design exclusively features a broadband frequency channel enabling fully automated applications on protons and the widest range of X-nuclei. This unique probe technology enables fluorine applications including 19F observe with 1H decoupling and vice versa.

SmartProbe Applications with X-nuclei

Decaborane 11B COSY

Comparison of the 19F, 1H HOESY and HMBC experiment. While the HOESY spectrum has a correlation to the proton of the heterocycle, the HMBC shows a correlation to the NH protons.

15

CryoProbes & Prodigy

CryoProbe technology has delivered the single largest increase in detection sensitivity ever achieved in the evolution of NMR equipment. The factor 3-4 jump in sensitivity enables the use of correspondingly smaller sample quantities that are impractical with conventional probes, or enables the user to increase sample throughput up to 16-fold. a conventional 5-mm probe. For optimal X-nucleus detection we offer the 5-mm Quad CryoProbe in 13 C/ 31P/19F/1H and 15N/13C/ 31P/1H versions. All high-resolution CryoProbes are equipped with a 2H lock and a Z-gradient. A 1H micro-imaging CryoProbe is also offered to enhance the study of sample structure and properties in the micrometer range.

CryoProbe Prodigy

Product Lines
Bruker offers the largest range of CryoProbe configurations from 400 MHz to 1000 MHz, including proton optimized probes such as our 1.7- and 5-mm inverse triple-resonance probes, as well as 10-mm dual 13C observe probes. The 1.7-mm Micro-CryoProbe offers an increase in sensitivity per mole of more than an order of magnitude compared to
CryoProbe Prodigy with pump and control unit

SNR Comparison with Conventional RT Probe

Prodigy
CryoProbe Prodigy
CryoProbe Prodigy, a new, revolutionary CryoProbe that delivers tremendous boosts in sensitivity at an affordable price. Costing significantly less than a conventional CryoProbe, the broadband CryoProbe Prodigy uses nitrogen-cooled RF coils and preamplifiers to deliver a sensitivity enhancement over room temperature (RT) probes of a factor of 2 to 3 for X-nuclei from 15N to 31P. The sensitivity gain on the proton channel exceeds standard probe performance by a factor of 2 or more.

BBO RT Probe

Comparison of the 13C-sensitivity of a standard BBO probe with the CryoProbe Prodigy at 400 MHz. Sample: 50 mM quinine, 32 scans each.

16

Solid Probes
Our comprehensive range of the most advanced solids probes are ideal for inorganic and biological samples using experiments such as CP, d.CP, MQMAS, or REDOR. Maximal spinning rates are 70 kHz for the ultra-high speed 1.3-mm MAS probe for materials science, 30 kHz for the 3.2-mm triple-resonance Efree MAS probe for protein research, and 15 kHz for the 4-mm HR-MAS probe with Z gradient for metabolomics studies. The BioSolids probe product line is based on one of two technologies, TL 2 or Efree. For optimum performance these probes are configured as fixed frequency triple resonance probes, most often requested for proton, carbon and nitrogen. TL 2 probes yield the best overall sensitivity with high 1H sensitivity for inverse detection experiments.

Efree probe

TL2
TL 2 technology is the choice when high-decoupling fields are needed for optimum decoupling in J-coupling based experiments and when sample heating is not an issue. TL 2 probes are best used for dry and non-salty samples, or samples that are kept in a frozen state.

1.9-mm MAS
The new 1.9-mm MAS probe now enables fast spinning of nuclei less sensitive than 19F and 1H, offering 42 kHz spinning frequency at 10 L active sample volume. NMR using fast magic angle spinning

Efree
Efree probes are specifically designed to minimize RF heating. The two coil configuration provides enhanced sensitivity for 13C and 15N and the highest tuning and matching stability for safe, long term experiments. Minimized RF heating ensures the integrity of your protein, even while operating at room temperature.

1.3-mm MAS
The 1.3-mm probe product line provides the highest spinning speeds coupled with high-sensitivity and RF fields. Where sample heating might become an issue, convenient low power decoupling can be employed.
700 MHz 2D FSLG-HETCOR of L-tyrosine-HCl. Spinning frequency was 42 kHz, RF field for FSLG was 140 kHz. Projections are 1D 13C CP/ MAS and 1H wPMLG-5 spectra, respectively. Note that only directly bonded 1 H 13C correlations are visible. NCO PAIN CP with ultrafast sample rotation. Spectra with 3 ms (red) and 6ms (blue) mixing time for long distance contacts in GB1 at 60 kHz rotation, 5C with 7580 kHz, 13C, 15N and 15 kHz on 1H. (Lewandowski et al. JACS 129, 728 (2007))

17

TopSpin
Ideal for first-time spectrometer users as well as routine users, TopSpins different acquisition tools make it easy for both beginner and expert to find their way to an NMR spectrum. TopSpin provides a wealth of data processing visualization and administration features, including:

Features

Comprehensive set of functionalities for dealing with 1D to 5D data including automatic forward/backward or delayed linear prediction Inverse Fourier transform processing of rows, columns, planes and subcubes of nD datasets Interactive and automatic multi-dimensional peak picking and integration..

PC-standard user interface offers easy accessibility for Windows and Linux users Comprehensive functionalities for processing, displaying and analyzing single and multidimensional spectra Intuitive acquisition Non-uniform sampling Small molecule characterization BioTools - Biomolecular NMR made easy Method development environment Result publishing, predefined and user-defined layouts Lineshape analysis for solidstate NMR, including dynamic NMR Regulatory compliance support tools (audit trailing, electronic signature, autoarchiving) Special licenses for students and universities

TopSpin User Interface

TopSpin for Mac OS X

Entirely programmed in the native Apple Mac OS X environment, the new TopSpin software caters to MAC users familiarity with the unique and intuitive characteristics of that operating system, while maintaining the proven capabilities, look and feel of TopSpin. Incorporating a comprehensive range of NMR data analysis, processing and simulation features, TopSpin includes modules for efficient small molecule characterization and structural biology research.
TopSpin 3.1 on Mac

18

Automation
Avance NMR systems meet the most demanding of automation needs by streamlining every aspect of NMR analysis, including sample submission, sample preparation, automatic probe tuning, data acquisition, processing, data distribution and archiving. Depending upon the laboratorys needs or goals, automation may involve highthroughput screening, overnight automation or multi-user open access.

IconNMR
This productivity tool excels whenever large numbers of samples are submitted for standardized experiments, or when many users access the spectrometer. IconNMRTM supports sample changers and sample preparation robots. The user can set up or supervise measurements remotely via a Web browser from a desktop or pocket PC.

SampleXpress
Brukers easy-to-use, cost effective solution for medium-throughput automation in NMR routine and research applications. Its compact, exceptionally integrated design drastically reduces sample exchange times to just a few seconds, making SampleXpressTM ideal for optimizing throughput in standard NMR service laboratories running 30-100 samples per day. In addition, efficiency is maximised thanks to interchangeable, easy-fill cassette modules that can be loaded off-system and in parallel with current experiments. The system is also equipped with integrated bar code reader for automatic sample identification.

SampleXpress

SampleJet
SampleJet changer for 300-700 MHz NMR systems offers both high-throughput as well as individual sample capabilities in a single NMR sample changer. Its versatile design can accept samples from five 96-position racks, allowing batch analysis of up to 480 tubes. In addition, the SampleJet easily accepts single tube samples via a separate carousel that can hold up to forty-seven 1-, 1.7-, 3- and 5-mm tubes.

SampleCase
SampleCaseTM is the first NMR automation solution that provides easy, safe and convenient access to fully-fledged NMR automation at user height. Ensuring simple random access automation without the need for steps or ladders, it also enables manual insertion and ejection of samples with the simple push of a button. The user-friendly system can be fitted to almost any Bruker NMR magnet.
SampleCase

19

Complete Molecular Confidence (CMCTM)

CMC-i: Structure Consistency Analysis
Only complete computational NMR spectral analysis provides a safe assessment of the consistency between a given structure and its 1H NMR spectrum. Finally overcoming tedious manual procedures, optimizing predicted spectral parameters to match experimental data using iterative spectral analysis is now possible in full automation.
n Complete n Benefits

from PERCHs highly sophisticated algorithms for predicting chemical shifts and couplings and optimizing them to match the experimental data using iterative quantum mechanical spectral analysis safe assessment of the consistency between a given structure and its 1H NMR spectrum data based upon the quality of the fit and the similarity between predicted and actual spectral parameters, with optional use of HSQC information estimation of sample purity

n Extremely

NMR spectral analysis yielding fully assigned spectra and highly accurate spectral parameters extracted from data, even for overlapping signals and strongly coupled spin systems

n Accurate

CMC-q

CMC-q: Absolute Quantification

Complete Molecular Confidence for quantification (CMC-q) is a complete workflow solution that facilitates automatic NMR-based quality assurance in batches.
n CMC-q

provides quick access to automated NMR quality assurance and quantification of larger batches of samples. Delivering accurate, precise information on sample concentration and water content in typical screening samples, CMC-q also marks questionable structures and provides a suggestion for spectral assignment. This is ideally complemented with LC-MS information such as that derived from Brukers SmartFormula program. on a file-in, file-out basis, the user supplies an input file describing the samples to be measured, and receives an output file of results. spectra interpretation function can also analyze individual datasets and prepare spectra for publication or for further analysis.

n Operating

n The

Single and multiple result view

20

Increasing Speed

CMC-assist: Data Interpretation and Workflow Steamlining

The most powerful software tool for interactive, assisted NMR data analysis is now available. Designed for NMR end-users, CMC-assist efficiently extracts information from complex NMR data, conducts assessments and generates detailed reports for direct transfer to publications, patents and lab journals. CMC-assist not only excels as an off-line analysis interface but its automatied NMR interpretation power can also be used to generate results directly at any Bruker NMR instrument equipped with the latest control software, making it the most efficient and streamlined NMR workflow on the market.

Automatic data analysis includes: - Integration and 1H number determination - Multiplet analysis - Structural assignment - Consistency statement - Concentration Reports include detailed PDF and multiplet string in different journal formats Windows, Linux or Mac operation systems are fully supported
CMC-assist & CMC-se

Seamless integration with Bruker spectrometers State-of-the-art analysis engine, powered by modern human logic emulation algorithms Automatic results may be refined manually

CMC-assist User Interface

CMC-se: Structure Elucidation

CMC-se is an NMR software package for simple and efficient structure elucidation of small molecules. With its innovative approach, CMC-se accelerates the spectroscopists workflow during the elucidation process by automating many of the key analysis and interpretation steps. In combination with Brukers Avance NMR spectrometer product line, CMC-se is the only elucidation tool that integrates high-quality NMR data acquisition with sophisticated software analysis. CMC-se is available for the major operating systems: Windows, Linux and Mac OS X.

Simple and efficient structure elucidation of small molecules in drug discovery and natural products research Automates many of the necessary analysis and interpretation steps Seamless integration of NMR acquisition and sophisticated software analysis Enables both accomplished researchers and beginners to expedite the elucidation of unknown substances in diverse pharmaceutical and chemical applications Organizes the data for a molecule into a single project, and provides unique graphical tools for data visualization and interpretation

21

Assure
Assure RMS-Raw Material Screening
Impurities and adulterants in starting materials pose potential health threats when present in the manufacturing of pharmaceutical APIs and drug products. These same impurities and adulterants may also result in lower production yields and increased product purificaQuantification

tion. Screening starting materials by NMR using Assure - Raw Material Screening identifies problem samples prior to use and prevents costly manufacturing mistakes. Designed for GMP and GLP environments, Assure - Raw Material Screening provides a traceable record of sample analysis and results. Applications include pharmaceutical and chemical production and analytical reference standards.

Features
System Suitability Test for GMP/GLP Labs n Automated Data Acquisition n Automated Quantitative and Qualitative Analysis n Automated Report Generation n QC Report - a pass or fail report n Detailed Expert Report - total analysis n Lock-out mode for access-limited users n Convenience Features n Sample SBASE/KBASE n Customizable
n

Quantification results of main components and impurities are reported in a simple to read format with a user defined pass/fail threshold.

Assure SST - System Suitability

Assure-System Suitability Test (SST) is the ideal tool for any NMR spectroscopy laboratory. In full automation, the NMR spectrometer is validated regularly for instrument performance and optimized before you run your samples. Choose from a list of available individual tests to perform lineshape and sensitivity measurements on your liquid-state NMR spectrometer that will run at a time convenient for your facility. Probe-specific parameter settings enable use on practically any liquid-state NMR probe. Assure-SSTs Temperature Calibration feature calibrates AND adjusts the temperature of the sample to the actual desired value. Accuracy in temperature provides optimal results for spectral reproducibility from instrument to instrument.
n

n n

n n

Fully Automated Performance Validation Instrument Optimization Monitors performance of walk-up instruments Enables NMR specialist to produce more results Improves data quality Meets GLP requirements

22

FoodScreener
The JuiceScreener, combined with its SGF Profiling technique, can deliver huge amounts of information derived from one single experiment, instead of multiple individual analysis steps. This provides higher throughput and reliability than conventional techniques, leading to a significant reduction in cost per sample. This enables up to 5 times more sample investigations with no change in budget, resulting in an improved and more comprehensive quality control screening program.

Features

Push-Button Routine
SGF Profiling is a fully automated pushbutton routine that needs no interaction from the operator. From sample bar code registration, preparation and handling, to data acquisition and statistical evaluation, all steps are under the control of SampleTrack, Brukers laboratory information system.

Spectroscopic Database
Screening is based on a constantly updated, extensive spectroscopic database that includes thousands of NMR spectra from mainly authentic juices. Currently the data base includes about 40 different fruit types from more than 50 production sites worldwide. In addition, the database also provides access to hundreds of small molecule compounds for further analysis of unknown ingredients.
Origin Authentification of Orange Juice

Fully automated push-button NMR solution including evaluation and reporting Simultaneous absolute quantification of all relevant organic ingredients for juice assessment High-throughput with minimal sample preparation Reduced cost per sample Reliable screening method providing targeted and non-targeted multimarker analyses Enables the detection of unexpected fraud Screening is based on an extensive NMR spectroscopic database of more than 8000 reference juices, obtained from production sites all over the world Complex statistical models enable the analysis of: origin authenticity, species purity, fruit content, false labeling, production process control and sample similarity

23

Hyphenation
Major tools for small molecule research and mixture analysis include HPLC, SPE, NMR and MS. Bruker offers hyphenated systems to meet various research needs. While NMR can be used to investigate the complete mixture, LC-NMR can analyse the individual compounds separated by the chromatography. An LC-NMR interface can easily be added to any NMR system from Bruker thereby also enabling hyphenated LC-(SPE)-NMR(/MS) applications. By combining the structural resolving power of NMR for the separated compounds with the mass accuracy of the micrOTOF, we can offer the most complete system for structural analysis available today.

LC-(SPE)-NMR
Two different methods for coupling are possible: either by coupling the chromatography system directly to the NMR spectrometer, or by the intermediate
LC-SPE-NMR-MS Results

Hyphenated system including sample preparation, NMR, LC and MS

collection of the samples. Direct coupling can be performed as stopflow or on-flow analysis. For intermediate collection loop-storage or collection on solid phase extraction (SPE)-cartridges is possible. The use of SPE provides an efficient interface between chromatography and NMR even enabling the analysis of low level metabolites.

LC-(SPE)-NMR-MS of Apple Juice high resolution mass spectra from m/z 355.1034 (upper part) of chlorogenic acid and the comparison with ion trap library (lower part) 1 H NMR spectrum of chlorogenic acid and the comparison with reference compound commercially available.

24

Immediate Access to Latest Technologies

Contract Bruker Analytical Services
Everyone can now benefit from Brukers latest technologies, instrumentation, and unmatched experience in analytical applications. We offer supporting services that include advanced high-resolution NMR and mass spectrometry applications. Our customers can benefit from access to the latest developments in the field through Brukers cooperations with academic and industrial research labs. Our experts can also assist you with special customized projects.

Benefits
n

Short and long term support increases project handling capacity Latest, most advanced Bruker technologies Unique analytical expertise and knowledge Method development and feasibility studies

Customized Projects
When additional measures are needed, our technical experts will discuss the range of special capabilities available to you. Whether it is a short term project where specialized equipment is a necessity, method development is required or feasibility studies are needed, we can help you with our extensive resources.

Advanced NMR Services

n n n n n

n n n n

Structure verification and elucidation Reaction and purity control Quantitative analysis Variable temperature experiments Screening methods for pharmaceutical and clinical research Food quality control Juice analysis using SGF-profiling Metabonomics studies Natural product analysis

Additional Analytical Services

n n n n

n n n

Mass Spectrometry & Imaging EPR (ESR) Spectroscopy TD (Time Domain) NMR Spectroscopy X-ray Diffraction, Crystallography & Fluorescence FT-IR Spectroscopy & Microscopy Raman Spectroscopy & Microscopy LC-(SPE)-NMR/MS

25

High-Performance Power Supplies

High-Voltage Power Supplies
Bruker high-voltage power supplies find their main applications in IOT- and Klystron-based RF transmitters in Particle Physics. Our power supplies provide high-voltages of up to 50 kV at broad range, from 1 kW up to several Megawatts. The compact solid-state design is based either on the latest switch mode technique or, in the case of highest power applications, based on SCR (Thyristor) control.

High-Current Power Supplies

Bruker high-current power supplies are employed in industry and particle physics research worldwide. Our high-current power supplies, available for pulsed or DC, monopolar, bipolar or four-quadrant operation, deliver high-currents of up to 30.000 A. Based on the latest switch mode technology they ensure optimum efficiency and enable standalone, fail-safe operation. The option of linear mode regulation provides maximum stability and minimum noise and fluctuations from 1% to better than 1 ppm (part per million). For high-power applications our high-current power supplies benefit from SCR (Thyristor) control. We offer single- and multi-channel supplies starting in the 100 Watt range going up to several Megawatts.

Klystron power supply for the MAMI C race track microtron, Mainz University, Germany.

26

RF Transmitters
Bruker Radio Frequency Transmitters are established in nuclear physics applications all over the world. Our high-voltage power supplies, capable of emitting power from 100 Watt up to 300 kW and more, benefit from modern switch mode design for optimum efficiency and feature SCR (Thyristor) control to handle the highest power applications. Choose from single or stacked solidstate amplifiers, whilst IOT amplifiers deliver optimum peak power conversion efficiency. For arc protection our emitter tubes operate with defined stored energy, with optional solid-state crowbar circuits to protect the sensitive elements. Start-up and operating procedures are handled automatically ensuring standalone, fail-safe operation, while a solidstate safety system ensures maximum protection for the transmitter elements and the user applications.

RF IOT high-power transmitter at ELBE FZD Rossendorf, Dresden, Germany.

27

Content:

TD-NMR Products
30 31 32 33 minispec mq Series minispec one Series minispec LF Series minispec ProFiler HyperQuant

28

Time Domain NMR

Time Domain Benchtop NMR Analyzers

Innovation with Integrity

TD-NMR
29

the minispec TD-NMR Analyzers

The minispec benchtop product lines utilize Time-Domain (TD-)NMR spectroscopy, a method related to High-Resolution NMR and Magnetic Resonance Imaging MRI. Unique permanent magnet and radio frequency (RF) technologies are applied to investigate the sample as a whole, nondestructive and non-invasive. Turnkey solutions for Quality Control (QC) are offered with straight-forward calibrations comprising well-known international recognized standard methods according to ISO, ASTM and AOCS. the minispec series provide also a sound of basis for R&D applications like MRI contrast agent research, determination of droplet size distribution in emulsions and obesity research.

Textile Industry Spin Finish on Fibres (OPU) Coatings on Polymers Polymer Industry Xylene soluble content in polypropylene Density and crystallinity in polyethylene Rubber content in polymers like ABS or polystyrene Cross-link density of elastomers Petrochemical Industry Hydrogen content in hydrocarbons (ASTM D 7171 method) Oil content in paraffin and wax Pharmaceutical Industry Fat and lean in live mice and rats Contactless weight determination Moisture and solvents in powders and tablets Contrast agent investigations near MRI fields: 0.25 T, 0.5 T, 0.75 T, 1.0 T and 1.5 T Healthcare Industry Fluorine content in toothpaste Melting properties of cosmetics R&D and Academics All types of temperature dependent relaxation time studies Diffusion experiments Single-Sided NMR

the minispec mq Series

the minispec mq Series

The award winning mq series covers a wide range of applications for both R&D and routine quality control and offers multiple expansion capabilities. With the addition of innovative accessories and readily exchangeable probe assemblies, the mq Series is suited for a full range of time domain NMR measurements. Typical applications are: Food Industry Solid Fat Content in fat compositions (AOCS Cd 16b-93, ISO 8292 & IUPAC 2.150 methods) Oil and moisture in seeds and oil seed residues (AOCS Ak4-95, ISO 10565 & 10632 methods, USDA GIPSA approved) Solid Fat Content as well as total fat content in chocolate and chocolate related products Droplet size analysis in O/W and W/O emulsions Oil, water and protein in dry and wet food and feed

30

Dedicated Solutions for Industrial Quality Control

the minispec turnkey analysis workflow

the minispec Plus multi-lingual software including 3 user levels

Readily available calibration standards, such as Bruker's certified SFC samples

No sample preparation, just insert sample into the minispec mqone

the minispec mqone Series

The mqone Analyzer is not just an analytical device. It offers a dedicated solution for the analytical task of daily quality control (QC) in the industry. The simple calibration, the intuitive workflow and the multilingual software allow the operation of the mqone Analyzer by everybody. The three user levels and compliance to 21CFR part 11 lead to safe and fully traceable data. The high performance of the mqone Analyzer guarantees high result quality and the well known Bruker quality ensures a long lifetime of your mqone Analyzer.

the minispec mqone Analyzers

mqone SFC Analyzer Solid-Fat Content (ISO, AOCS) mqone Seed Analyzer and mqone Seed Analyzer XL Oil and Moisture in Seeds, press cake, residues (ISO, IUPAC, AOCS) mqone Hydrogen Analyzer Hydrogen in Fuels (ASTM) mqone Spin Finish Analyzer Finish on Fibre, Oil-Pick-Up (OPU) mqone Polymer Analyzer Xylene-soluble content in PP mqone Total Fat Analyzer Total Fat Content determitation in Food and Feed

the minispec mqone

31

the minispec LF Series

the minispec LF series
Brukers minispec LF Series of whole Body Composition Analyzers provides a precise method for measurement of Lean Tissue, Fat, Free Fluid and Total Body Fluid in live mice and rats. Longitudinal studies are possible as the animal is carefully handled without the need of anaesthesia. Measurements with the LF Series are done in minutes without the need for any sample preparation. With the new minispec LF110 also rats with mass >= 1kg can be analysed.
the minispec LF90 II

the minispec LF50 H

the mq-ProFiler
The mq-ProFiler is a compact NMR analyzer equipped with a single-sided magnet and RF probes capable of performing 1H-NMR experiments on the surface or surface near volume elements. This device is a portable TD-NMR analyzer without any sample size restriction for industrial process/ quality control and research. Typical applications of the mq-ProFiler are: Cross link density, filler materials, aging in tires (even with steel bars) and other polymers In-package food analysis: Fat content extent of gel formation, etc. Moisture content, porosity, and effect of hydrophobic treatments in building materials Fast monitoring of Fat content in high moisture foods like fresh salmon fish Porosity, separation of oil from water signal and drainage/absorption/drying study in rocks and other porous materials Contamination (oil) in moisture-free soil Skin hydration study

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HyperQuant
HyperQuantTM is a benchtop time-domain NMR reader that precisely and quantitatively delivers both the magnetic hyperpolarization and thermal polarization status of a sample. This proprietary solution applies a unique permanent 0.94 Tesla magnet system combined with an innovative MR probe design and novel NMR pulse sequence capabilities. This unique combination enables quantification of the thermal polarization level of 13C-labeled samples using volumes as low as 1 ml. The hyperpolarization enhancement factors can be obtained directly on the sample of interest, without the need for a separate calibration reference.

Features

Effect of Hyperpolarization

Direct quantification of magnetic hyperpolarization and thermal polarization levels Calibration-free technology based on direct comparison of hyperpolarized and thermally polarized state Turn-key 13C application Proven bench-top TD-NMR design Unique 0.94 T permanent magnet system Only 1 ml of sample volume required Tracing of the 13 C hyperpolarization decay Thermal signal determination with 99% accuracy Quantifying concentrations of fully labeled 13C samples External trigger interface to HyperSenseTM Applicable to all hyperpolarization methods including DNP and Para-Hydrogen

33

Content:

MRI Products
36 38 40 41 42 43 44 45 46 47 BioSpec ClinScan PharmaScan Icon BGA-S Gradient Series USR Magnets MRI CryoProbe Micro-imaging ParaVision Beyond Standard BioSpecs

34

Magnetic Resonance Imaging

Solutions for Molecular Imaging and Preclinical Research

Innovation with Integrity

MRI
35

BioSpec
The BioSpec series is designed for the emerging market of preclinical and molecular MRI. State-of-the-art MRI CryoProbe technology together with ultra-high field USR magnets deliver high spatial resolution in vivo enabling customers to come closer to the molecular and cellular level. Thanks to its innovative modular concept, virtually any small animal MR imaging application in life science, biomedical and preclinical research can be conducted. Whatever your application is, the BioSpec series will deliver the optimum solution, will perfectly equip you for the most demanding tasks and challenges.

Standard and optional Product Features

microflex

High-end UltraShield Refrigerated (USR) magnets from 4.7 up to 15,2 Tesla A wide range of bore sizes (11 to 40 cm) for investigations on any kind of animals Helium zero-boil-off and nitrogen free magnets for reduced service costs Scalable Avance III architecture with up to 16 receiver and 6 transmitter channels Parallel imaging (GRAPPA) for almost all applications including EPI Multiple transmit imaging applications BGA-S gradients with highest amplitudes, slew rates, shim strengths, and duty cycles Motorized animal positioning for increased throughput IntraGate - Self gated steady-state cardiac imaging (no external triggering devices) Phased-array RF coil technology for maximum sensitivity and minimum scan times MRI CryoProbe delivers an exceptional increase in sensitivity to 250 % ParaVision - Intuitive software package, for multi-dimensional MRI/MRS data acquisition,reconstruction, analysis and visualization

36

Innovative Animal MRI Solutions for Molecular and Preclinical Imaging

BioSpec benefits from the excellence of Bruker BioSpin, the global market and technology leader in analytical magnetic resonance instruments including NMR, preclinical MRI and EPR. With an install base of over 500 MRI systems worldwide and more than 40 local Bruker offices on all continents, you can rely on our long term expertise and dedicated after sales support.

DTI of the Song Control System (SCS) of Starlings

DTI is used to quantify seasonal changes in the SCS. The density of axonal connections changes under hormonal influences.
Courtesy: De Groof, A. Van der Linden, RUCA, Antwerp, Belgium.

Cardiac Angiography
Visualization of coronary arteries in vivo (mice) using IntraGate.

Mouse Abdomen
T2 RARE abdominal mouse imaging with excellent contrast.
Courtesy: D. Elverfeldt, B. Kreher, J. Hennig et al., University Hospital Freiburg, Germany.

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ClinScan
With the ClinScan you enter the field of translational research and molecular imaging. The ClinScan, a 7 T animal MRI and MRS scanner is designed to further facilitate translational research from mice to men in the field of preclinical and molecular imaging. ClinScan is Bruker BioSpins solution for an emerging market of research MRI systems that allows a direct and fast transfer of preclinical studies on animal models to clinical studies on humans. By virtue of the strategic alliance with Siemens Medical Solutions on human high-field MR systems, ClinScan uses the clinical user interface syngo MR. Its operation is identical to that of Siemens Magnetom TIM systems.

Product Description

7 T Bruker USR magnet (Ultra Shielded Refrigerated, bore size 20 cm or 30 cm) Bruker gradient and shim coil (gradient strength of 290 mT/m or 630 mT/m, slew rate of 1160 T/m/s or 6300 T/m/s) Bruker RF array coil technology in combination with numerous animal handling accessories Siemens Magnetom Avanto technology with up to 32 receive channels Clinical routine user interface syngo MR to enable efficient workflow and highly automated state-of-theart MRI and MRS applications on small animals

Multi Modality Imaging - MRI/PET

Simultaneous in vivo imaging of a F-18-FDG labeled mouse heart at 7 T. PET and MRI acquisition was done in parallel without interference between the two modalities.

Diffusion imaging (DTI)

Courtesy: B. Pichler, H. Wehrl, M. Judenhofer et al., Laboratory for Preclinical Imaging University Tbingen, Germany.

ClinScan systems are designed for translational molecular MRI and provide the clinical routine user interface syngo MR that facilitates straightforward transfer of protocols from benchtop to bedside and vice-versa.

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Application Packages
Application packages for animal MRI resemble the application packages you already know from clinical MRI. Sequences and protocols are optimized for the specific needs in animal MRI.

Standard Imaging
The application suite is a full set of programs and protocols optimized for a wide range of high-field applications.
Rat brain, BOLD fMRI

Parallel Imaging

iPAT (integrated parallel Imaging) techniques including GRAPPA & mSENSE Higher speed and temporal resolution

Diffusion and Perfusion Imaging Echo Planar Imaging (EPI)

Multi directional diffusion weighting Tensor calculation including tractography Perfusion applications including processing

Cardiac imaging

Cardiac Imaging

True FISP & 2D/3D FLASH segmented Prospective triggering & retrospective gating Retrospectively gated cine imaging BOLD Imaging Single Shot EPI with PACE for BOLD-Imaging Automatic image reconstruction as well as on-the-fly t-test calculation in real-time for variable paradigms

Chemical shift imaging with outer volume suppression

Spectroscopic Imaging & Spectroscopy

Spin Echo & STEAM, PRESS and CSI Hybrid CSI technique including volume selection and FoV encoding Multi-nuclei option
Cartilage of rat knee (DESS) and rat brain, inner ear (CISS 3D)

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PharmaScan
Dedicated MR Scanner for Pharmaceutical, Biomedical and Molecular Imaging Research
The PharmaScan is a high-field, easy-touse and at the same time easy-to-install and very cost-effective MR-system. It is designed for MRI applications on small animals such as mice and rats in the field of routine pharmaceutical, biomedical and molecular imaging research. With the integrated automatic image acquisition and analysis, fast and reliable results can be obtained by simple operation of the system by non-academic personnel, without compromising full flexibility for the MR expert.

HighResolution DTI
Coronal map of the major principle diffusion direction of a rat brain. The diffusion tensor imaging, with 30 diffusion directions, is acquired by the segmented echo planar imaging technique.

Mouse Lung Imaging using Ultra Short TE (UTE) Imaging

Radial scan with ultra short TE enables the visualization of detailed lung structures without using expensive hyperpolarized helium techniques.

Standard and optional Product Features

H MRI and MRS routine system, optimized for small rodents (such as rats, mice, gerbils) Actively shielded magnets at 4.7 T and 7 T allows easy and cost-efficient siting 16 cm clear bore size with 72 mm free access for the animal Parallel imaging (GRAPPA) High-performance BGA-9 or BGA-9S (as an option) gradients with highest amplitude, slew rates, shim strengths, and duty cycles optimized for small animal imaging No Faraday cage required 2 25 m floor space required Scalable Avance III architecture incorporates up to 4 receivers AutoPac - Motorized, positioning system for routine animal handling and increased animal throughput IntraGate - Self gated steady-state cardiac imaging requiring no external trigger devices Phased-array RF coil technology for increased sensitivity and reduced scan times MRI CryoProbe - Sensitivity increase up to a factor of 2.5 ParaVision - Fully intuitive software package for multi-dimensional MRI/ MRS data acquisition, reconstruction, analysis and visualization

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Icon
IconTM is a compact and easy-to-use 1 T permanent magnet high-performance MRI desktop system for preclinical and molecular imaging in biomedical and pharmaceutical research
Designed and built by the worlds preclinical MRI market leader, Icons unique qualities include the industry standard MRI software ParaVision. ParaVision offers a workflow-oriented routine user interface, enabling a wide range of small rodent and material science MRI applications. Operators and researchers have access to numerous optimized measurement protocols and powerful interactive processing and analysis tools to deliver immediate results. Optional software packages enable Icon to perform the latest MRI applications, such as pulsed arterial spin tagging, fast echo-planar

image read-out, or ultra-short echo time techniques. The optional DataManager facilitates efficient data management and archiving. As an education tool, students will find the ParaVision software intuitive, whether it is used to perform research imaging protocols, or to learn programming of new MRI methods.

Image Processing Tools Ultra-fast relaxometry in mouse brain (in vivo) using a Look-Locker type EPI. The color-coded parametric T1 map was laid over the anatomical image. This method enables fast contrast agent tracing in the brain with a temporal resolution of of 1:20 min.

Mouse brain images

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BGA-S Gradient Series

Maximum Gradient and Shim Performance in Animal MRI
The Bruker gradient series BGA-STM delivers unsurpassed performance for the whole range of animal MRI applications. The unique design provides highest gradient strengths and slew rates required for high-field animal imaging. The high cooling efficency results in unmatched duty cycles and as a consequence of it, modern imaging sequences with minimum field of view and a high number of slices for long experiment times can easily be performed. The integrated shim coils add up to ultra-strong shim capabilities. The BGA-S gradients can be operated as inserts and are easily exchangeable for maximum flexibility.

Specifications
BGA-6S Outer diameter [mm] Inner diameter [mm] Strength* [mT/m] at Imax Slew rate* [T/m/s] at Umax Gradient linearity/DSV [% / mm] Number of RT Shims Max. cont. gradient all axis [mT/m each axis] Max. continous gradient one axis [mT/m] Umax [V]/Imax [A] 113 60 1000 11250 5 / 35 9 500 350 300/100 BGA-9S 150 90 760 6840 5 / 60 11 190 130 300/200 BGA-12S 198 114 660 4570 4 / 80 11 330 220 500/300 BGA-20S 303 200 300 1100 3 / 130 9 87 60 500/300

* Output values have been measured on MRI system

Product Description

Highest gradient strengths up to 1000 mT/m Highest slew rates Excellent duty cycle specifications Very high gradient linearity Optimal gradient shielding Maximum shim performance

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USR Magnets
Combining High-Field Magnet Performance with Easy Handling and Siting
The UltraShielded Refrigerated (USR) horizontal bore magnet product line features ultra-high magnetic fields and variable bore sizes in combination with easy handling and siting. Field strengths offered from 4.7 up to 11.7 T deliver optimum sensitivity for high-resolution MRI and MRS. The various bore diameters from 11 to 40 cm ensure optimal experimental performance on a wide range of animal MRI applications. Active shielding based on our well-proven UltraShield technology provides minimum stray fields. For ease of operation all USRTM magnets are nitrogen-free and include helium refrigeration for zero boil-off and minimum service intervals.

Features

Ultra-high magnetic fields Variable bore sizes Highest field homogeneity Compact magnet design Excellent field stability Optimum external disturbance suppression Minimum stray fields Easy and cost efficient siting Nitrogen free Helium refrigeration (zero boil-off1) Longer service intervals (two years) Cold delivery and fast installation Over 180 USR installations worldwide

High-resolution BOLD activation measured at 11.7 T USR magnet.

Courtesy: J.Seehafer, M.Hoehn, MPI for Neurological Research, Cologne, Germany

USR Magnet Product Line for a wide range of applications

47/40 USR
1

70/20 USR 300 7 .0 20 1.31 1.12 2.60 <0.05 2.500 1.5 x 1.5 2 Yes1

70/30 USR 300 7 .0 30 1.49 1.65 2.85 <0.05 5.000 2x3 2 Yes1

94/20 USR 400 9.4 20 1.49 1.65 2.85 <0.05 5.500 2.0 x 3.0 2 Yes1

94/30 USR 400 9.4 30 2.01 1.71 2.90 <0.05 11.500 2.3 x 3.3 2 Yes1

117/16 USR 500 11.7 16 1.46 1.65 2.85 <0.05 7 .000 1.7 x 2.8 2 Yes1

H Frequency (MHz)

200 4.7 40 1.49 1.65 2.85 <0.05 4.700 2x3 2 Yes1

Field Strength (T) Bore Diameter (cm) Length (m) Width (m) Ceiling height (m) Field Drift (ppm/h) Weight (kg) Stray Field (radial x axial) (m x m) Service Interval (year) Zero Boil-off

USR systems are available with field strengths ranging from 4.7 to 11.7 T and bore sizes of 16, 20, 30 or 40 cm as shown in the table.
1

With a valid service contract

43

MRI CryoProbe
New Signal-to-Noise Horizons in Small Animal MRI
Bruker now offers a new series of MRI CryoProbes for MRI systems. They feature very low temperature, closed cycle cooled RF-coils and preamplifiers offering an increase in signal-to-noise ratio (SNR) to a factor of 2.5 over standard room temperature RF-coils in routine MRI applications. The use of the MRI CryoProbeTM in routine imaging of the mouse brain in vivo at 9.4 T delivers outstanding image quality. The increased signal-to-noise ratio enables one to acquire high-resolution images of the microscopic structures in the mouse brain down to the cellular level.

Product Features

Comparison with Nissle staining

Increase in sensitivity to more than 250 % Flexible design for easy siting Standardized interface allowing different MRI CryoProbes to be used with one cooling system Efficient design allows minimal distances between RF-coil and object Carefully controlled thermal environment with no cold surfaces in contact with animal Cooling down outside the magnet possible

Comparison of micro-structures in the mouse cerebellum with histological Nissle staining (left). Identification of anatomical structures like white matter, granular layers, molecular layers and Purkinje cell layers are possible. Courtesy: Rudin M., Baltes C. et al., ETH Zurich, Switzerland

MRI CryoProbeTM at 11.7 T

Ultra-high resolution (35 35 200) m mouse brain imaging in vivo acquired in 20 minutes. Courtesy: V. Rasche University of Ulm, Germany

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Micro-imaging
CryoProbe for Micro-imaging
The extension of Brukers cryogenic NMR probe expertise into the field of MRI microscopy leads to new and exciting opportunities. Micro-imaging techniques for small samples with diameters up to 5 mm benefit from CryoProbeTM technology and a factor 4 improvement in sensitivity. The result is improved image quality, increased spatial resolution and/or reduced scan times. The MIC CryoProbes for 1H at 400-600 MHz offer variable temperature operation over the range from 0 to 80 C and are used with a Bruker BioSpin Micro2.5 gradient system in vertical wide-bore magnets with bore sizes of 89 mm or larger. The newly developed dual 1H/13C microimaging CryoProbe is also available.
13

C Chemical Shift Imaging

Detection of sugar transport. An Angiocanthos plant was fed with 13 C labelled glucose. The C1-13C bound protons (coloured) overlayed to a proton image of the system cross-section C1 a-Glucose (93 ppm (13C), 5.42 ppm (1H)), system field strength 9.4 T, cyclic J cross polarization method in-plane resolution of 13 C image: 156 x 156 m2, slice thickness: 5 mm total scan time 4:00 h.
Courtesy of M. Wenzler, Max Planck Institut fr chemische kologie, Jena, Germany

Research Possibilities

Investigations on plants, insects and other small animals, embryos, or histological tissue samples. Studies of porous and inhomogeneous objects at intermediate field strengths with minimum susceptibility distortions and highest sensitivity. Studies of fast dynamic processes. Microliter spectroscopy.

Diffusion Tensor Imaging on excised human nerve cord

Excised human nerve cord

Multi Gradient Echo Imaging, TR 600 ms, TE 5 ms, 10 m x 10 m x 120 m

Sample provided by Dr. Joerg Raczkowsky, Karlsruhe Institute of Technology, Institute for Process Control and Robotics, Karlsruhe, Germany Dr. med. Ralph Knig, Neurochirurgische Klinik University Ulm, BKH Gnzburg, Germany

Diffusion Tensor Imaging, TR 2.7 s, TE 14.34 ms, 2.5 ms, D 7.0 ms, 31 m x 31 m x 1 mm, effectiv B values 1310 s/mm2 - 1704 s/mm2, Diffusion Tensor Visualization by AVIZO FIRE

45

ParaVision 5.1
Ultimate MR-Acquisition and Processing in Preclinical Research and Life Science
ParaVision is Brukers software package for multi-dimensional MRI/MRS data acquisition, reconstruction, analysis and visualization for its BioSpec, PharmaScan and Micro-imaging product lines. It offers an intuitive routine user interface and cutting-edge techniques for animal MR imaging and spectroscopy - including a rich palette of powerful image evaluation and visualization tools.

Product Description

New Reconstruction and Processing Features

Push-button GRAPPA reconstruction Sum of squares and phase-sensitive phased-array reconstruction Phased-array spectroscopy reconstruction Partial Fourier reconstruction EPI reconstruction with efficient ghost suppression Navigator techniques to reduce motion artifacts in EPI and SPIRAL 2D and 3D region growing Display and analysis of time-course data with the fitting tool ISA Frame-selective loading of image sequences for display, e.g. either timecourse frames or slices for a multi-slice movie dataset 3D visualization with surface rendering Image mask inversion
Designed for research use only.

Intuitive routine workflow Application-oriented, ready-to-use protocols Self-acting, method-specific scanner adjustments Automatic instrumentation recognition Parallel imaging option for all suitable acquisition techniques with automatic generation of composed images/ spectra Half-Fourier (Partial-Fourier) encoding Real-time display of acquired and reconstructed data Data archiving including DICOM export Development environment with powerful tools for rapid prototyping of user-defined experiments and professional method implementation

46

Beyond Standard BioSpecs

Vertical BioSpec
The vertical BioSpec has been engineered for MR research investigations of non-human primates. It enables specifically fMRI studies on monkeys as they are particularly receptive to behavioral conditioning while sitting in upright position. The vertical BioSpecs are offered with two different magnet types operating at 4.7 T and 7 T which both have a high-magnetic field stability and excellent homogeneity. The actively shielded gradient coil with integrated shims is especially designed for a vertically oriented magnet.

Ultra-High Field MRI

Bruker is offering up to 17 T horizontal MRI BioSpec, enabling high-resolution in vivo preclinical MRI on small animals at a microscopic scale. The magnet with a bore size of 25 cm is based on Brukers UltraStabilized subcooling technology offering excellent field homogeneity and stability. A new BGA-STM gradient coil with unsurpassed specifications regarding gradient field strength, gradient slew rate, and gradient duty cycle provides best MRI performance. These innovations will push the current limits of animal MR imaging towards higher spatial and spectral resolution, enabling new applications in the field of molecular imaging and preclinical research.

FLASH imaging on BioSpec 170/25, in-plane resolution: (80 80) m2

Courtesy: D. Le Bihan , NeuroSpin, Paris, France

8 mm

47

Content:

EPR Products
50 51 52 53 54 55 56 57 ELEXSYS-II E780 ELEXSYS-II E500 CW-EPR ELEXSYS-II E580 FT/CW ELEXSYS-II Imaging Unit ELEXSYS-II Multi-Frequency and Multi-Resonance Accessories EMXplus EMXmicro e-scan

48

Electron Paramagnetic Resonance

Solutions for Life Science and Analytical Research

Innovation with Integrity

EPR
49

ELEXSYS-II E780
The World's First Commercial mm-wave 263 GHz EPR Spectrometer
Bruker has pioneered the worlds first commercial mm-wave 263 GHzEPR spectrometer, ELEXSYS-II E780, representing a first step for Brukers EPR division into quasi-optical microwave technology. It incorporates a unique cryo-free superconducting magnet that can be ramped up to 12 T and is combined with new probe technology for optimum sensitivity, even on large samples up to 5 mm. Based on the well-proven Bruker ELEXSYS concept it provides multiple turn-key operation modes including, CW-, Pulse-EPR, ENDOR and ELDOR, thus enabling research groups for the first time, to routinely use very high-frequency EPR technology.

Features
Enables mm-wave very high-field EPR at 263 GHz Quasi optical front-end featuring reflection and induction detection Cryogen free superconducting EPR magnet incorporating 12 T main coil and 0.2 T high-resolution sweep coil Multiple turn-key operation modes including CW-, Pulse-EPR, ENDOR and ELDOR High-sensitivity single mode resonator Non-resonant probe for samples up to 5 mm Variable sample temperature from 4 to 300 K Safe and robust operation Runs routine software package Xepr

High-Field ENDOR

Multinuclear pulsed ENDOR High-Field EPR

TEMPOL Echo Detected Field Swept at 50K

Non-Resonant Probe

Single Mode Resonator TE011

50

ELEXSYS-II E500 CW-EPR

Redefining research level EPR
Introduced in 1997 the ELEXSYS has become the renowned research platform for modern EPR. Over the years a constant technical evolution has assured to keep track with new emerging demands of the EPR society. The second generation of the pulse devices SpecJet-II and PatternJet-II have been launched in 2006 and just recently DICE-II has become available. Yet another major development step has now created ELEXSYS-II. The OS9 acquisition server has been replaced and the SuperX microwave bridge has been redesigned with improved specifications. The new multi-purpose signal processing unit (SPU) plays a central role in the expanded capabilities of the ELEXSYS-II, replacing the signal channel, fast digitizer, and rapid scan with a single integrated unit offering unprecedented performance and specifications.
Standard super-high-Q cavity for ELEXSYS Systems

ELEXSYS-II: The only commercial spectrometer series which covers all EPR techniques
d K-Ban d Q -Ban d d L-Band W-Ban S -Ban mm -w X-Ban av e d

E500 Accessories

E500 Highlights
SuperX microwave units of world record sensitivity weak-pitch signal-to-noise of 3000:1 rapid scan module stationary and time resolved experiments multi purpose signal processing unit reference free spin counting

Teslameter Field-Frequency lock N2 and Helium VT systems automated goniometer DICE-II ENDOR system microwave frequencies from L- to W-Band numerous dedicated probeheads large selection of magnet systems

CW-ENDOR Pulse-ENDOR Pulse-ELDOR Imaging Saturation recovery Rapid scan Transient EPR ODMR
CW-EPR FT-EPR

ER4102 ST

Super X

Cu2+ histidine at 20 K and 20 dB power

51

ELEXSYS-II E580 FT/CW

PatternJet-II
Virtually no experimental limits are imposed by the PatternJet Series of pulse programmers. Designed for the needs of EPR this pulse programmer features a dynamic range of 109, i.e. ns resolution over a time scale of up to one second. The well established concept of our first generation PatternJet has been technically enhanced and carried on to the second generation PatternJet-II with a 1 GHz clock.

SpecJet II
With the first generation of SpecJet a dramatic improvement in pulse-EPR sensitivity could be achieved by highspeed signal averaging. The SpecJet-II with 1 GHz sampling rate now further enhances the abilities to capture fast and short lived transient signals. The real time display of the averaged echo/FID can now be toggled between time and FT mode and greatly facilitate spectrometer handling and signal optimization. The extended memory of PatternJet-II and SpecJet-II allow now overhead free direct phase cycling even for 2D data acquisition. A considerable measuring time saving is achieved with this new feature.

With the recent introduction of the second generation pulse programmer and transient recorder, PatternJet-II and SpecJet-II, improvements in digital resolution and averaging capabilities have again pushed up the performance level of the E580.

zero overhead for 1D phase cycling zero overhead for 2D blocks zero overhead for time evolution averaging (e.g. ESEEM)
PatternJet-II and SpecJet-II

Direct On-Board Phase Cycling

52

ELEXSYS-II Imaging Unit

Biomedical research and material science applications by EPR imaging is a rapidly growing field. Brukers response to this development is the E540 imaging accessory. Based on the proven ELEXSYS architecture, this instrument operates at L- or X-Band and provides the seamless integration of imaging techniques into EPR spectroscopy. The imaging accessory comprises 2D or 3D water cooled gradient coils, power supplies, gradient controller, acquisition and processing software for up to 4D imaging.

High-power gradient accessory for X-Band imaging E540GCX2

2D gradients with 200 G/cm Compatible with ER 073 magnet 25 mm air gap ER4108TMHS resonator Compatible with ER 4112HV Helium system

Imaging accessory for biomedical application E540GCL

3D gradients with 40 G/cm for imaging in L- and X-Band

E540R36 and E540R23

the 36-mm and 23-mm access L-Band probes for animal research
ER4108TMHS

E540SC
the surface coil L-Band probe for animal research

Image of two DPPH crystals with 25 m pixel resolution E540R36

Sensitivity profile of L-Band surface coil

53

ELEXSYS-II Multi-Frequency and Multi-Resonance Accessories

Multi-frequency EPR is commonly understood in terms of its relation to CW-EPR spectroscopy. Brukers commercial Multi-frequency/Multiresonance EPR covers both, CW-EPR and FT-EPR as well as PulseENDOR and Pulse-ELDOR at a multitude of microwave frequencies. Thanks to the ELEXSYS platform design and the advantageous intermediate frequency (IF) concept, every ELEXSYS spectrometer can be expanded for stateof-the-art multi-frequency experiments; now and in the future. All features of the X-Band CW/FT microwave bridge are transferred to the new operating frequency. For each frequency band a dedicated probe provides a maximum of sensitivity and ease of use.
ESEEM Application

High-Frequency/High-Field EPR and ENDOR at 94 GHz

The ELEXSYS family of EPR spectrometers includes two W-band systems, the E600 and E680. The former is optimized for CW-EPR experiments at 94 GHz, while the E680 operates in both CW and FT-mode. The instrument is equipped with a 6 T super conduction magnet featuring an additional high-resolution sweep coil with 2 kG range.

Multi Frequency Options

The Bruker IF Concept allows to add a second or third microwave frequency to the X-band E 580 instrument. These upgrades are available for Q-Band (34 GHz), S-Band (3.4 3.8 GHz) and L-Band (0.8 1.4 GHz). The upgrade comprises the microwave unit and a dedicated probe for variable temperature operation.

Multi Resonance Options

Electron-Nuclear Double Resonance (ENDOR) accessories are available for the EMX-series in CW mode and for the ELEXSYS series in CW and pulse mode. The frequency range is 1 100 MHz for the EMX and 1 650 MHz for ELEXSYS. Dedicated ENDOR resonators for CW and pulse operation at variable temperature complete the ENDOR accessory. Electron-Electron Double Resonance (ELDOR) is a pulse technique and can be added to all pulse spectrometers of the ELEXSYS Q-Band HYSCORE line. The most popular distance measurement technique is supported by specialized probes of the Flexline series.
2

S-Band HYSCORE of BDPA Flexline Pulse-ENDOR Resonator EN4118X-MD4 Distance Measurements

Q-Band 4 Pulse - DEER

H Q-Band single crystal HYSCORE

54

EMXplus
The foundation of EPR
The EMXplus is the next generation of Brukers successful EMX spectrometer line, well-known for its premium performance in CW-EPR research. The design of the EMXplus reflects its dedication to the heart of the matter: rapid and high-quality data. Simply power-on the EMXplus and start your EPR journey. Following self-validation procedures, the EMXplus is ready to use via Brukers WIN-ACQ software.

The Perfect Duo I

The Signal Channel and Field Controller work together seamlessly to provide practically unlimited resolution on both axes: field and signal intensity.

The Perfect Duo II

The EMXplus Signal Channel now offers two detection channels in one. Simultaneous quadrature and 1st & 2nd harmonic detection schemes are just a mouse click away.

Ultra-high-resolution over large sweep

Oxygen in air

Accessories & Options

The PremiumX microwave package for enhanced sensitivity The Variable Temperature Controller can be incorporated into the EMXplus console The ER036TM Teslameter ensures precise g-factor determination in combination with the integrated microwave counter The EMX-ENDOR package allows CW-ENDOR experiments to be performed on EMXplus Systems The full range of microwave frequencies from L- to Q-Band

The spectra show oxygen in air at ambient pressure (top) and reduced pressure (middle) measured at Q-Band. A sweep range of 14 kG was recorded with 180000 points, resulting in a resolution of 80 mG, sufficient for the line width of 300 mG at reduced pressure.

55

EMXmicro
The EMXmicro completes the EMX family and features an electronics cabinet with the footprint of a PC tower. The instruments micro cabinet can be combined with all electromagnets and microwave bridges from L- to Q-Band.

The standard software of the EMX series for data acquisition and processing is provided by WinACQ and WinEPR.

Dual-mode simultaneous detection of 1st and 2nd harmonic EPR spectrum of a vanadyl sample

Xenon
This new software package is an option for the EMXmicro/plus series. It features a Linux front end PC with a new graphical user interface integrating acquisition and processing in an user friendly environment. Xenon features numerous novel tools for data acquisition and processing, e.g. the direct spin counting method without reference sample.

Xenon user interface

56

e-scan
Brukers e-scan product line of table-top EPR (ESR) readers offer dedicated and tailored turn-key systems for specific Quality Control applications as well as systems for medical and pharmaceutical R&D applications of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). All e-scan systems have been designed for and have proven rock-solid in 24/7 operation with the best possible price-performance ratio available today. A few example application fields for e-scan:

Irradiation Dosimetry with Alanine Dosimeters (ISO/ASTM method) Food Irradiation Control (EU standard methods) Beer Shelf Life: flavour stability and antioxidant stability (patented application) Biomedical EPR research: ROS and RNS detection and quantification

e-scan food control inserts (left) and the cavity template. (right).

EPR spectrum of an irradiated chicken bone recorded with the e-scan Food Analyzer.

57

Content:

GC/LC/MS-Products
60 62 64 66 68 70 72 74 75 MALDI-TOF LC-MS and Ion Trap LC-MS and o-TOF UHR-TOF and FTMS Ion sources, Software & Applications ICP-MS and GC-MS GC Systems and GC Accessories GC Accessories and Consumables MALDI Biotyper Consumables

For research use only. Not for use in diagnostic procedures.

58

GC/LC and MS-Systems

Research and Analytical System Solutions

Innovation with Integrity

GC/LC/MS-Systems

59

MALDI-TOF Mass Spectrometers

Brukers FLEX Series of MALDI based mass spectrometers are industry leaders whose performance level can be easily matched to almost any application need. Composed of three increasingly powerful systems; microflex, autoflex speed and ultrafleXtreme, these flexible, powerful, and reliable systems can deliver answers for a wide range of applications such as the MALDI Biotyper solution used in clinical biology to identify microorganisms through characteristic peak patterns; their unique molecular fingerprints. Capable of utilizing a number of intuitive software packages, the FLEX Series brings the power of MALDI mass spectrometry to any level of user.

ultrafleXtreme
The pinnacle of the FLEX series, the ultrafleXtreme is built to deliver the highest levels of performance in sensitivity, resolution, and mass accuracy for a MALDI instrument. Highly flexible, the ultrafleXtreme is especially effective in proteomics, molecular imaging and protein analysis settings as it can utilize the full power of patented 1 kHz smartbeam laser technology. Other cutting edge MALDI technology enhancements such as PAN resolution for broad mass range measurements and LIFT technology to enhance sensitivity, allow the use of the ultrafleXtreme in top-down or bottom-up protein analysis utilizing gel or LC-based workflows. Outstanding in both quanitiative and qualitative applications, the ultrafleXtreme represents the ultimate in MALDI instrument design and performance capabilities.

ultrafleXtreme

60

microflex LT/microflex
The entry level member of the FLEX product family is the microflex series. However, theres nothing minimal about the performance of these instruments. Designed to be compact, affordable, and easy-to-use, the microflex series packs a lot of power into its excellent design. Fully capable of providing answers to a wide range of analytical challenges with its 15k resolution, the microflex series can be scaled to fit many needs with either linear or reflectron based options. The innovative microflex series can bring the value and performance of MALDI mass spectrometry to any laboratory, including those who may have thought mass spectrometry was out of reach.

microflex LT

autoflex speed
The workhorse of the FLEX Series, the autoflex speed has a number of exciting hardware options to deliver a very powerful, yet easy to master, platform for many MALDI based applications. Incorporating proprietary smartbeam 1kHz laser technology, the autoflex speed delivers unrivalled speed, sensitivity, and resolution for an instrument in its class. Hardware options include either MALDITOF or MALDI TOF/TOF configurations. The autoflex speed can also be equipped with a number of specially designed software packages to create a customized instrument for key applications like molecular imaging or protein sequencing and analysis.

autoflex speed

61

LC-MS
Brukers novel amaZon ion trap family of mass spectrometers utilize a unique spherical ion trap architecture that delivers exceptional performance for many analytical tasks. This design, in combination with an ingenious detector and dual ion funnel transfer technology, offers: dramatically improved sensitivity (by a factor of 10x), speed up to 52,000 /sec dynamic range over 4 orders of magnitude mass resolution up to 30,000 high-mass range of 50-3,000 m/z

ProteinScape 3.0 bioinformatics database system

amaZon ion trap for analytical power and utility

Fully automated screening for toxins/drugs based on MS/MS library search. Push button solution in open access environment.

Support of all widely used HPLC, CapLC, nanoLC, and UHPLC systems

62

Ion Trap Mass Spectrometers

The amaZon series of ion traps are equipped with instantaneous polarity switching capabilities for dealing with a variety of analytes. Capable of MSn analysis, ion traps provide the analytical power necessary for very complex samples. Some members of the amaZon ion trap instrument family can utilize ancillary chemistries and techniques ETD (Electron Transfer Dissociation) and PTR (Proton Transfer Reaction) to aid in the analysis of proteins and their posttranslational modifications. Brukers family of ion trap instruments is represented by the amaZon speed, amaZon speed ETD, and amaZon SL instruments.

the analysis of complex samples when more in depth and detailed analysis of molecular structure is needed. Supported by spectral MSn libraries, the amaZon speed is the ultimate mass spectrometer for MS/MS based multi-compound screening.

amaZon speed ETD

Designed especially for the analysis of proteins and their post-translational modifications (phosphorylation, glycosylation, etc.), the amaZon speed ETD is the latest generation instrument for the analysis of post translational modifications (PTMs) and proteomics. Incorporating ETD and PTR molecular fragmentation technologies, the amaZon speed ETD system provides extremely valuable information about the location and nature of various PTMs, as well as very useful de novo sequencing power leading e.g. to full coverage of the protein N- and C-terminal sequence.

amaZon SL
A solid, robust, high value platform for fast LC/MSn applications, the amaZon SL is designed to increase productivity for routine analyses such as chemistry support, quality and process control, and other small molecule analysis applications. The amaZon SL comes equipped with the SmartLine software suite which provides particularly quick and easy access to analytical workflows to help generate reliable results. The amaZon SL is designed for reliable 24/7 operation, even in an open access environment.

amaZon speed
Representing the latest developments in ion trap technology, the amaZon speed provides most of the capabilities of the amaZon family. With greatly enhanced sensitivity, MS/MS speed and ZeroDelay Alternating polarity switching, the amaZon speed is an excellent choice for

amaZon speed ETD

63

LC-MS
Automated detection of multiple compounds and ID of unknowns

High-mass accuracy with high-dynamic range

Intens. x10 4 8

64

128

6
6 109 77 69

141

139

177 180189 227 214

51 59 93 103 22 2 57 3 7 26 34 2831 32 23 15 18 17 27 14 25 73 44 48 61 120 116 100 124 125

145 168 155 143 147 138 146 166 153 156 159 201 199

113

247 130 140 137 158 172 174 167 207 218 215

2
4

Detect multiple targets within one LC-run

0 5

249 117 248 234 60 191200 43 40 70 747988 162 183 127 41 36 112 193 121 210 119 55 72 231 132 81 80 209221 244 171 37 38424647 235 97105 83 5 8 20 250 21 205 101 54 240 19 243 252 190197 212 255 10 13 161 175 98 123 131 33 213 181 16 45 222 150 108 242 179 195 106 58 39 245 228 142 188 198 136 152 115 178 114 9 86 91 251 253 254 56 122 133 151160173184 196 7889 12 239 118 126 11 24 29 35 206 229 135144 82 95102 246 203 216 236 154 176 186 67 50 62 71 75 92 99

10

High-resolution Extracted Ion Chromatogram (hrEIC)

256

11

12 Time [min]

Brukers TOF and quadrupole TOF mass spectrometers feature some of the very latest developments in o-TOF technology to provide maximum confidence for accurate mass molecular formula determination. Capable of delivering hyper-accurate results, Brukers o-TOF platforms combine numerous hardware innovations with unique software packages that deliver industry leading sensitivity, 5 orders of magnitude dynamic range, ppm or better mass accuracy and up to 60,000 resolution for the analysis of small molecules and many types of biomolecules.

micrOTOF focus ll
An outstanding high-performance system, the micrOTOF II benefits from years of experience in LCMS design, and features an excellent combination of resolution and mass accuracy to deliver outstanding results. The perfect choice for straight forward molecular formula determination of small molecules, proteins, or small molecule metabolites, the micrOTOF II can help solve some very tough analytical challenges.

64

o-TOF Mass Spectrometers

# possible formulae

Mass Accuracy several ppm accuracy plus Chemical Expertise additional confidence plus SmartFormula (Mass Accuracy+TIP) sub-ppm confidence

numerous

medium

few
plus SmartFormula3D (fragments-based TIP) unambiguous formula ID

Confident determination of the elemental composition of a LC-MS peak. Isotopic pattern information - SmartFormula3D - reduces the number of molecular formula candidates dramatically.

single

micrOTOF-Q ll
A high-performance hybrid mass spectrometry system, the micrOTOF-Q II combines the very latest in ESI-qTOF technology in MS and MS/MS modes to enable very high levels of confidence in many applications. Whether used with direct infusion or with UHPLC, Fast Chromatography, or other separation techniques, the micrOTOF-Q II delivers some of the best results in molecular formula determination available on the market today. When exact molecular formula determination is the goal, the micrOTOF-Q II is the answer.

micrOTOF-Q ll

65

UHR-TOF Mass Spectrometers

maXis impact
There is no need to make compromises in mass spectrometry anymore. The maXis impact sets a new technology standard where industry leading performance values are all simultaneously available in a single acquisition at full sensitivity. Powered by a series of patented technology innovations, the maXis impact simply provides the very best results without compromise in a cost effective, benchtop format.

maXis 4G
The maXis 4G, with Full Sensitivity Resolution, continues to advance the performance level and capabilities of this revolutionary series of instruments. With significant enhancements in mass accuracy and resolution, and unparalleled sensitivity and speed, the maXis 4G offers the confidence to measure and identify small molecules, proteins and intact large molecules, such as antibodies, with unprecedented levels of certainty in both MS and MS/MS modes.
maXis impact Compound identification and structure confirmation
Intens. x10 5 1.25 +MS2(949.4275)

1.00 1+ 271.2422 0.75

O
O O HO O

O HO HO OH O O

0.50

1+ 395.1181
O

1+ 683.3635

O HO OH

OH

O OH HO OH

1+ 949.4278

0.25

1+ 537.3057

0.00 200 300 400 500 600 700 800 900 m/z

66

FTMS Mass Spectrometers

solariX
solariX, the next-generation hybrid Qq-FTMS, is an easy to use, highperforming system that is equipped to address the most challenging proteomics and complex mixture applications. The broad-band, ultrahigh-resolving power (> 1,000,000 @ m/z 400, 7 T) is essential for tackling complex mixtures, especially those that are not amenable to on-line separation techniques such as; hydrocarbon related analysis (petroleomics), environmental analysis, and metabolomics. For applications that require highperformance LC-MS or LC-MS/MS, the solariX is ideally suited. New functionality provides more resolution when it is needed most and with optional, faster acquisitions for MS/MS data. Added top-down versatility is provided with fully enabled Electron Transfer Dissociation (ETD). This exciting new technique, combined with FTMS performance, is superb for the comprehensive analysis of proteins and peptides and their subtle, posttranslational modifications. The solariX can be configured with Dual ESI/MALDI (based on advanced ion funnel technology) and a range of API source options (APCI, GC-APCI, APPI). Low maintenance, refrigerated magnets are standard with solariX and can be configured with one of several magnetic field options (7T, 9.4T, 12T and 15T).
Crude oil, APPI positve ion
325.19510

C25H25+
-0.1 ppm

325.19845

C22H29S+
0.0 ppm

325.19399 13C C H S+ 1 21 28 0.0 ppm

325.19064 13C C H + 1 24 24 325.18253 C24H23N+ 0.1 ppm 0.1 ppm

325.17805 13C C H N+ 1 23 22 0.1 ppm

325.20178

C19H33S2+
0.1 ppm

325.21617

C22H29O2+
0.1 ppm

325.180

325.190

325.200

325.210

m/z

solariX

67

Ion Sources
CaptiveSpray
Nanoflow LC-MS in daily laboratory work is still one of the bigger challenges in proteomics. The Bruker CaptiveSpray source is a revolutionary ion source with a patented design that provides easier operation than even standard electro spray. CaptiveSpray delivers nanospray sensitivity, resists plugging, and provides reproducible uninterrupted flow for even the most complex proteomics samples. The CaptiveSpray can be used also at low L flow rates to allow the use of larger ID columns. It fits all current Bruker ESI-MS systems.

DirectProbe DIP: Instant answers from solid samples with APCI or APPI
The DirectProbe (DIP) add-on for the Bruker APCI II and APPI II ion source allows direct analysis of liquid and solid samples without tedious sample preparation. In routine organic synthesis analyses, it simplifies identification and characterization of chemical reaction products without compromising sensitivity.

Vortex around spray concentrates and focuses spray into the MS source

DirectProbe

CaptiveSpray LC-MS source

68

Software & Application Directed Solutions

Compass & Bioinformatics
Bruker software solutions are designed to provide maximum information with minimal effort. Highly intuitive and extremely user friendly, our software solutions are all designed and delivered with the user and their application in mind: Compass: Brukers unified software environment for intuitive mass spectrometric instrument control and data processing. Compass OpenAccess: Automated walk-up LC/MS chemical formula generation Compass Security Pack ProteinScape the bioinformatics platform for ID and quantitation BioTools:Interactive protein analysis flexImaging: Comprehensive and powerful MALDI Imaging MALDI Biotyper: The easy software for microbial ID GenoTools: Software solution for the analysis of genomics data MetaboliteTools: Identification and confirmation of metabolites ProfileAnalysis: Comprehensive statistical evaluation of LC-MS data TargetAnalysis: Unambigous molecular formula identification PolyTools: Interpretation of MALDI polymer spectra HPLC Vendors supported by Bruker Compass with full software plug-ins are: Dionex, Waters, Agilent, Hitachi, Thermo/Proxeon, CTC/PAL Autosamplers, Shimadzu and Eksigent.

Applications-Software
Bruker offers dedicated software packages and solutions for various application areas:

Life Science Research and Clinical Application Solutions

PRIME: Proteomics through Integrated MALDI and ESI MALDI Molecular Imaging Identification of Microorganisms Lipidomics Nucleic Acid Analysis LC-MS based Metabolomics Metabolite Profiling with LC-MS and NMR

Pharmaceutical and Applied Analytical Application Solutions Identification of Unknowns

Pesticide, Toxin, and Pollutant Screening Drug Metabolite Identification Open Access Chemistry Support Petroleomics Polymer Analysis

Your choice of HPLC

Bruker supports all major vendor HPLC systems for LC-MS applications. Our flexible software plug-in architecture allows for fully integrated HPLC support and method development. Other HPLC systems can be integrated with a simple contact closure.

69

ICP-MS
Bruker innovation, making ICP-MS easier
If youve ever wished that ICP-MS could be simpler, wish no more. The aurora M90 makes light work of it. No matter what your requirements, with a Bruker ICP-MS, you can tackle any application with ease. The aurora M90 delivers industry leading detection limit performance. Collision/reaction interface (CRI) technology makes setup of complex cell systems a thing of the past. Simply turn on the gas flow to remove interferences. Its that simple.
Gas

New clean plasma expansion

Reaction zone

Original plasma jet

Gas

Let Bruker Quantum work for you

If your goal is to spend less time creating methods and optimizing conditions, and more time running samples, Brukers Quantum software delivers. Enjoy accurate results in less time with an intuitive yet flexible user interface that takes the hard work out of ICP-MS.
The CRI injects helium (He) and hydrogen (H2) collision and reaction gasses directly into the plasma as it passes through the orifice of the skimmer cone. This innovative approach suppresses interferences before the analytes are extracted into the ion optics.

aurora M90

70

Gas Chromatograph Mass Spectrometers

Scion SQ
Brukers long traditions of innovation and product reliability have combined to create a new industry standard for gas chromatography single quadrupole mass detection the SCION SQ. By understanding, and then designing to exceed the most critical performance and reliability needs of GC users, Bruker has delivered a system that is especially for, and all about, the ultimate success of the GC user. The SCION SQ detector is designed to meet many important user specified requirements reliable performance, ease of use and simple maintenance-all in a small instrument footprint that saves valuable bench space.

Scion TQ
The SCION triple quadrupole (TQ) detector is a comprehensive solution for your most demanding gas chromatography applications. It delivers unrivalled benchspace savings, the result of an innovative lens-free, elliptical ion-path design that delivers ultra-high sensitivity and chemical noise reduction performance you would expect when innovation merges with a legacy of reliability.

scion TQ

71

Gas Chromatographs
Laboratory gas chromatography systems (GC)
The 400 Series consists of two gas chromatographs and an associated range of analyzers and solutions designed for leading applications. These systems allow chemists and engineers to employ standard methods and/or high-quality trace sample analysis, in the petrochemical, agrochemical and environmental industries. The 450-GC is a highly affordable and powerful analytical instrument that offers robust operation in an easy-to-use package. The system gives users a broad choice of injectors, detectors, switching and sampling valves up to three channels. The high-resolution color touch screen is intuitive and supports local languages. The Bruker 430-GC offers the same outstanding performance as the 450-GC but in a compact, single channel package that occupies about half the bench space of conventional multichannel GC.

450-GC + CP-8400 Designed for research use only.

72

Gas Chromatograph Accessories

Injector, Autosampler
and Detector Options Bruker 400-GC Series GC Accessories represent significant value and upgrade instrument performance and efficiency. The 400-GC Series has been designed to allow the incorporation of a wide range of options to expand the performance and enhance the capabilities of the system. These options include:

Combi PAL/CTC
For Laboratories requiring even greater sample throughput or more extensive sample preparation automation options, Bruker offers the Combi PAL/CTC.

Autosamplers
The CP-8400 range of AutoSamplers combines unattended system operation features with high-throughput and sample capacity, virtually without sample carry over. These systems can be configured for: High-sample throughput with dual and duplicate modes of injection Automatic access to two injectors with a single tower to double analysis output Liquid, ambient headspace, and SPME sampling Pre-programmed injection modes to minimize method development time and guesswork The SHS-40 Automated Headspace Sampler is designed to take maximum advantage of the productivity and cost benefits of Headspace Gas Chromatography (HS-GC). Powerful and robust, the SHS-40 enhances the capabilities of any analytical laboratory to comprehensively and efficiently measure volatile organic compounds (VOCs) from a variety of sources. Fully Automated: Minimal Operator Intervention Highly Productive: Simplified Method Development Easily Integrated: Ready to Use with Bruker GC and GC-MS Systems Flexible: Use for Direct Analysis or React and Analyze Chemistries Robust: Very Low Maintenance Requirements and guesswork

73

Gas Chromatograph Consumables

Brukers commitment to providing the very best in analytical systems extends beyond providing great instrumentation. In most cases, a good analytical system encompasses instrument, software and high-quality consumables. Bruker applies the same demanding standards of quality to its wide range of GC consumables. From septa, ferrules and injector liners to vials and tools, we have the parts and consumables to complete the analytical solution. Our latest and newly launched comprehensive range of GC columns and Super CleanTM Gas filters shows our commitment to providing the latest and best in technology.

Super Clean Gas Filters

Innovative design with product reliability has produced an extensive range of gas filters configured for the most demanding applications. Bruker Gas Purification Systems have the range to satisfy your needs from individual to combination filters, from Ultra purity combined with Ultra capacity, to all in one solution kits. Innovative features designed into the product yield extensive benefits to the user. Ultra-high capacity for long life, less change and improved productivity High-purity output ensures 99.9999% Pure Gas Quick connect fittings for easy, leak-tight filter changes Glass internals prevent diffusion; plastic externally for safety Easy-to-read indicators for planned maintenance and improved up-time

A Selection of GC Columns to Meet Your Needs

Bruker GC columns span a broad range of column diameters, stationary phases, and capillary column materials: Fused Silica (FS) and Inert Steel (IS). Ideal for either routine or research type analyses. Bruker GC column offerings bridge across many important applications and include a number of offerings such as: Standard WCOT (Wall Coated Open Tubular) Small internal diameter Solid stationary phase PLOT (Porous Layer Open Tubular) Inert steel micro-packed an packed colums

74

MALDI Biotyper Consumables

Added Convenience Enhances Assay Productivity
To make it easier and cost effective to routinely use the MALDI Biotyper, Bruker offers a number of kits and accessories designed and tested to maximize the performance and productivity of the MALDI Biotyper system.

Disposable Biotargets 48 Positions

The disposable Biotargets are supplied individually bar-coded in boxes of 25 each. Each target contains 48 positions and 5 additional calibration positions. The silicon-based Biotarget can be re-analyzed as often as necessary until all 48 spots have been used.

Bacterial Test Standard

The Bacterial Test Standard is a typical E.coli extract, containing some additional proteins which can be used for instrument mass calibration as well as a performance verification standard.

BigAnchorChip Targets
The Bruker patented BigAnchorChip targets are especially designed for handling liquid samples. They are specially prepared with a hydrophobic coating which surrounds hydrophilic sample positions.

HCCA (alpha-Cyano-4-hydroxycinnamic acid) Matrix

The matrix is supplied as solid and should be rehydrated using organic solvent OS solution. Typically 1 ul of matrix is added to each sample prior to analysis.

MALDI Sepsityper Kit 50

The MALDI Sepsityper Kit is for the analysis of microorganisms from positive blood cultures. The process typically takes no longer than 20 minutes.

MALDI Biotyper Targets

Bruker offers the widest range of MALDI targets available, including reusable and disposable targets with and without barcodes.

Reusable Polished Steel Targets 96 Positions

This most common and widely used Assay target provides excellent performance for all sample types. These targets can be cleaned and re-used literally thousands of times.

75

Content:

CBRN Products
78 79 80 81 82 83 Prepared for a changing world of threats Chemical Hazardous Agent Detection Chemical & Radiation Detection Biological Detection First Responders & Environmental Protection Software Solutions

76

CBRNE
Chemical, Biological, Radiological, Nuclear and Explosives Detection

Innovation with Integrity

cbrne detection

77

Prepared for a changing World of Threats

Bruker Daltonics since 30 years a trusted manufacturer of CBRNE detection equipment offers and constantly improves their sophisticated CBRNE product line and this way tries to help counter chemical, biological, radiological, nuclear and explosive threats. State-ofthe-art technology, ruggedized design and modular accessories allow flexible and extensive applications.

The complete product line for CBRNE detection

CBRNE technology has always been the core competence of Bruker Daltonics. We were the first supplier who covered the complete range of chemical, biological and nuclear detection. Bruker is specialized in development, engineering and manufacturing of military hardened and easy-to-use analytical systems and is ISO9001 certified. The product line supports all possible use cases for the detection of various threats. systems for these critical infrastructures using combinations of both static and mobile detection systems.

Bruker offers a wide product range including

Mobile Mass Spectrometers Ion Mobility Spectrometers Stand-off detectors based on passiv FTIR FTIR ATR ruggedized Spectrometers Radiation Meters Neutron Induced Gamma Spectrometry Generic Biological Aerosol detectors PCR and ELISA based biological identifiers Bruker CBRNE equipment is in service with armed and naval forces, civil defence and first responders worldwide. Our instruments are part of major reconnaissance vehicles in the world like the CBRNRS Fox or the Korean K-216 and part of the chemical and/or radiological detection system of ships like the German frigate F123/124 and the MEKO 100. The systems are also an integrated part of the protection system within German and Swedish Coast Guard ships.

Systems for CBRNE Defence

Bruker solutions includes personal and handheld point detectors as well as detection systems for reconnaissance vehicles, battle tanks, shipboardor stationary use. Bruker provides sophisticated CBRNE software solutions for instrument control and systems integration.

Safety & Security

Bruker equipment supports not only the response teams from Fire Departments, Police, Customs and Civil Defence in addition, major events such as summits, concerts, parades and sporting events can be targets for terrorist attacks. Harbours, ports, airports and public buildings are also sensitive to the release of hazardous agents. Bruker detection equipment can be integrated into monitoring

78

Chemical Hazardous Agent Detection

RAID series
A series of chemical monitors, covering multiple tasks including monitoring of collective protection facilities and CBRN filter stations, as well as handheld or personal point detection for protection purposes. Based on the well-established Ion Mobility Spectrometry, all important CWA and Toxic Industrial Chemicals (TIC) can be monitored in realtime. The RAID; the first personal chemical agent detector based on Brukers field proven IMS technology; provides unmatched overall sensitivity in this class of instruments. The expandable TIC capability is organised into five libraries that can be tailored with the relevant instrument dataset to meet your specific requirement. The innovative RAID-XP combines chemical and radiological detection into one system. The RAID-M 100 is distinguished by its flexible and easy use for portable and hand-held deployment. It is designed for fast and sensitiv detection and identification of CWA and TICs. The RAID-S2 is specially designed for long term operations. The instrument can either be operated separately, or several instruments can be connected in networks. RAID-AFM can be deployed for stationary chemical detection in vulnerable areas such as air and sea ports and public facilities such as sports arenas. The innovations of a non-radioactive ionisation source or a gamma radiation detector option makes it the most flexible stationary solution in the world.

RAID-AFM (NC version)

Integrated RAID-S2 sensors

RAID-XP

RAID

RAID-M 100

79

Chemical & Radiation Detection

Stand-off detector for atmospheric pollutants
A compact, mobile infrared detector for real-time remote sensing of chemical agent clouds. All known CWA and important Toxic Industrial Chemicals (TICs) can be automatically identified and monitored over a distance of several kilometres either stationary or on the move. Latest developments have resulted in linking two ore more RAPIDs to setup a triangulation system and allowing tomographic reconstruction of chemical clouds.
RAPID

Monitoring of public events with stand off detection of chemical clouds.

MM2
The MM2 sets a milestone in GC/MS technology with a volume of 43 litres and a weight of 35 kg. Equipped with improved Gas Chromatography/ Mass Spectrometry technique it represents the new generation of quadrupole mass spectrometers. The MM2 is optimized for long-term chemical reconnaissance in various armoured vehicles, as well as for mobile chemical agent inspection and detection missions.

MM2

SVG 2
Hand-held, hardened radiation detector, based on state-of-the-art semiconductor technology. Equipped with integrated sensors for gamma and neutron radiation detection, and an external //-probe.
SVG2

80

Biological Detection
VeroTect a generic detector for biological aerosol uses the combination of fluorescence and aerosol shape and size sensors for the detection of biological aerosol clouds. pTD is a fully automated ELISA based on-site identifier for toxins using the unique electrical biochip technology in a disposable consumable. M-BL, the mobile biological lab, offers PCR based detection of pathogens with integrated sample preparation in a ruggedized, easy to use format.

VeroTect

pTD

M-BL

Sample Preparation

Data Acquisition

MALDI Biotyper
The MALDI Biotyper allows fast and reliable identification and classification of microorganisms, such as bacteria, archaea, yeasts or fungi. There is neither a need for any prior PCR amplification, nor for the usage of selective growth media nor for any other pre-assumptions, which may influence the outcome of the analysis. The MALDI Biotyper software identifies microorganisms by the species-specific signal patterns contained in their respective molecular profiles.
For research use only. Not for use in diagnostic procedures.

Analysis

Reference Library

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First Responders & Environmental Protection

E2M
The enhanced environmental mass spectrometer E2M is a mobile, compact and lightweight GC/MS system for fast, reliable onsite identification of organic chemicals from any medium (soil, water, air) within 20 minutes via complementary sampling techniques. Typical fields of application are environmental protection, mobile on-site analysis and event monitoring. The E2M fully supports First Responders and Homeland Security detection and identification activities. The instrument has been developed in close co-operation with German Fire Brigades and Disaster Management Authorities.

Mobile-IR in use

Mobile-IR
Most chemical substances have their own infrared signature; just like a fingerprint. With the new Mobile-IR, it is easy to identify unknown chemicals in just a few seconds, by comparing the fingerprint of the substance with included data bases. Unlike other portable instruments, the Bruker Mobile-IR is designed to be used under adverse conditions. It is waterproof to IP67 standards, and offers a high degree of shock protection.

E 2M

DE-tector RAID-M 100

RAID-M 100
The RAID-M 100 is outside the military used by civil defense forces, first responders and fire fighters to challenge the threat of toxic industrial compounds.

NIGAS

DE-tector
The third generation of IMS based trace detectors is formed with the Drugs Explosive detector of Bruker. The twintube IMS design means no split of the sample before it will be ionised with a non radioactive source. CHIRP and IMSProfiler gives unmatched sensitivity and false alarm suppression.

NIGAS
System for automated, non-invasive detection of chemical warfare agents in ammunition, using Neutron Activation Analysis with a non-radioactive source. The instrument is transportable and can be used even under field conditions.

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Software Solutions
System Integration
Our CBRNE detectors can be easily integrated into any kind of CBRN detection platform. The systems are deployed under various environmental conditions. Ruggedised design and sophisticated accessories allow flexible and extensive applications for the detection of hazardous compounds by mounting the systems on vehicles, ships, helicopters, shelters or by hand-held use under field conditions. Sophisticated software supports the integration of our CBRNE detectors. Bruker has over thirty years of experience in systems integration.

RAPID Control software with alarm window, on-line video picture and function keys for fast access to all system operation parameters.

Analytical support tool XIMS NT

Bruker offers analytical software packages to support the use of their handheld and personal detection equipment in order to get deeper insight into the threat situation and to tailor the instruments to customer specific needs.

CPS Cloud positioning system

CPS collects data from two ore more RAPID systems. It offers triangulation and tomographic reconstruction of detected chemical clouds.

Bruker XIMS software family are control and data systems for the Bruker Ion Mobility Spectrometers (IMS). They are assigned for instrument control of the detector, for data acquisition and analysis of two- and threedimensional IMS spectra on a PC.

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Content:

Optical Vibrational Spectroscopy

86 88 89 90 91 92 93 FT-IR Spectrometers Remote Sensing System FT-Raman Spectrometers FT-IR and Raman Microscopy FT-NIR Spectrometers Process Analytical Technologies OPUS Spectroscopy Software

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Optical Vibrational Spectroscopy

Advanced Research and QA/QC Solutions Based on Infrared and Raman Spectroscopy

Innovation with Integrity

IR/NIR/FT-RAMAN
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FT-IR
Bruker Optics has the industrys most comprehensive FT-IR product-line; from the very compact FT-IR spectrometer to the worlds highest resolution.

ALPHA
About the size of a lab book, the very compact FT-IR spectrometer Alpha will play a big part in your daily routine. Plug & play set-up, easy-to-use software, combined with QuickSnapTM sampling modules assure powerful and reliable FT-IR analysis you expect from Bruker. Alpha is ideal for academic teaching and routine industrial applications.

ALPHA with ATR Sampling Module

Mobile-IR Portable FT-IR

Material Identification Anywhere! Brukers Mobile-IR is a self-contained, rugged portable FT-IR spectrometer that provides benchtop performance, wider spectral coverage and higher spectral resolution. Its ideal for crime scene investigation, environmental monitoring and hazardous material identification applications.
Mobile-IR

TENSOR Series
If you need a FT-IR spectrometer that can rapidly identify, quantify and verify your routine samples, Tensor is the right tool for your laboratory. It combines the highest performance and outstanding flexibility with ease of use. A full line of sample compartment and external FT-IR accessories enable it to be used for various challenging applications.
TENSOR 27 FT-IR Spectrometer

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Most Comprehensive FT-IR Product Line; from the Smallest in Size to the Highest in Resolution

VERTEX Series
The VERTEX Series is built on a fully upgradeable optics platform that is designed with the utmost flexibility in mind. Multiple input and exit ports allows users to connect various external and internal accessories and components to customize the instrument based on applications. Vertex spectrometers share a wide range of features and utilize patented RockSolidTM and Ultra-ScanTM interferometer designs.
VERTEX 70 FT-IR Spectrometer

Vacuum Optics
With the vacuum models, peak sensitivity in the mid-, near- and far IR regions is obtained without the fear of masking very weak spectral features by air water vapor absorptions.For the VERTEX 80v vacuum spectrometer a unique option is available: The new automatic beamsplitter exchange unit BMS-c for automatic spectral range selection without the need of venting the spectrometer vacuum optics.

VERTEX 80v Vacuum FT-IR Spectrometer

IFS 125 Series

The IFS 125 is built for performance with each instrument component optimized to approach the theoretical limit of sensitivity. It offers the highest spectral resolution available down to 0,001 cm -1, a resolving power of up to 10 6 and the wide wavelength range from 5 cm -1 in the far-IR/THz to 50,000 cm -1 in the UV. The mobile IFS 125/M is dedicated to gas phase absorption studies, requently applicable to atmospheric research.
IFS 125HR

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Remote Sensing
HI 90 Hyperspectral Imaging System
Atmospheric, environmental research, volcanology, industrial surveillance and homeland security outline the wide range of applications of the new HI 90, Hyperspectral Imaging system. The HI 90 is ideally suited for real-time identification, quantification, and visualization of gas clouds. In addition, algorithms based on a combination of image processing and spectral analysis can be applied allowing for the system to be used in a range of imaging applications for solids and liquids.

HI 90 Hyperspectral Imaging System

SIGIS 2 Scanning Imaging Remote Sensing System

SIGIS 2 is a remote sensing system that allows identification, quantification, and visualization of gas clouds from long distances. The system maps a predefined area and results of the analysis are visualized by the video image, overlaid by a chemical image. The SIGIS 2 can be used for environmental applications, atmospheric research, volcanology, and industrial facility surveillance. The SIGIS 2 is currently being deployed by emergency response forces in Austria, Denmark, Germany, and Italy.

SIGIS 2 Scanning Imaging Remote Sensing System

EM 27 Remote Sensing FT-IR

Providing laboratory grade performance, the EM27 remote sensing FT-IR can easily be deployed in the field for various environmental air monitoring applications. Emissions from smoke stacks and waste disposals, hazardous emissions from chemical accidents can be observed with an operating range of up to several kilometers.

EM 27 Remote Sensing FT-IR

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FT-Raman
The Raman effect is based on the inelastic scattering of monochromatic light with matter. As the complementary vibrational technique of IR spectroscopy Raman provides detailed molecular structure information. Bruker Optics added FT-Raman capabilities to its product line shortly after the technique was first reported in late 1980s.

MultiRam
The MultiRAM is a stand-alone highperformance FT-Raman spectrometer. It has a large sample compartment to utilize an extensive range of pre-aligned sampling accessories.

MultiRam Stand-Alone FT-Raman

RAM II FT-Raman Module

Designed as an add-on module, Brukers RAM II is a dual-channel FT-Raman unit that can be coupled to the VERTEX series multi range FT-IR spectrometers.

RAM II coupled to VERTEX 70 FT-IR

Low Temperature Silicon QC

The CryoSAS is a high-sensitivity system for the quality control of solar and electronic grade silicon material according to international standards. Although sample cooling to very low temperatures is required, the fully automated system is easy to operate, and does not require cryogenic liquids.
CryoSAS

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FT-IR & Raman Microscopy

Sample visualization is the important first step in the analysis of almost any sample. Infrared and Raman spectroscopy are versatile and powerful analytical techniques that can be applied to micro-analysis. Brukers FT-IR and Raman microscopes are built on state-of-the-art optical microscopy platforms that provide optimal sample visualization and also feature chemical imaging and mapping. Areas of applications include material science, forensics, mineralogy, failure analysis, content uniformity, sample homogeneity and quality control.

HYPERION Series
Featuring full automation, infrared chemical imaging, crystal-clear sample viewing and a wide variety of IR and visible objectives, the HYPERION series provide everything needed to conduct the most demanding micro-analysis easily and efficiently. It can be coupled to TENSOR and VERTEX Series FT-IR Spectrometers. The HYPERION 3000 represents the pinnacle of infrared microspectroscopy, incorporating state-of-the-art Focal Plane Array detectors for the most demanding infrared imaging applications. High-resolution chemical images can be collected in a matter of seconds.

HYPERION 3000 coupled to TENSOR 27

SENTERRA
Brukers SENTERRATM is an easy to use Raman microscope that combines many novel features such as the patented SureCal permanent calibration, fluorescence rejection and on-demand confocal depth profiling. With a wide variety of excitation lasers providing high-spectral resolution, it is ready to challenge any microanalysis research applications.

RamanScopeIII
SENTERRA Raman Microscope

When sample fluorescence is a problem, FT-Raman microscopy with near infrared 1064 nm excitation is frequently the only solution. RamanScopeIII can be coupled to Brukers FT-Raman spectrometers, and be combined with the SENTERRATM dispersive Raman microscope as a hybrid solution.

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FT-NIR
Discover the flexibility of Near Infrared Spectroscopy
NIR spectroscopy has largely replaced a number of wet chemical analysis methods. With the fiber optics and the integrating sphere sampling techniques, NIR spectroscopy does not require any sampling preparation. It is a fast and precise tool for the nondestructive analysis of liquids, solids and paste-like materials, saving costs by reducing time and reagent use.

TANGO
Faster, simpler, more secure - with TANGO your NIR analysis speeds up. The new TANGO from Bruker Optics has exactly what users require of an FT-NIR spectrometer suitable for food analysis: Robustness, high precision and straightforward operator guidance. The proven FT-NIR technology by Bruker was combined with an easy-to-use touch screen operation and a small footprint, perfect for those laboratories with limited space.

TANGO

MPA Multi Purpose Analyzer

Brukers dedicated FT-NIR spectrometer MPA offers everything you need for the analysis of liquids, solids, powders and tablets. Selection of the different measurement accessories is completely software controlled and validated, without the need for any manual exchange.

MPA

MATRIX Series
The award winning MATRIX series process-ready FT-NIR Spectrometers incorporate state-of-the-art optics for outstanding sensitivity and stability. Available configurations include fiber optic coupling up-to 6 probes and integrating sphere.
MATRIX-I

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Process Analytical Technologies

Today, many companies are not only striving to manufacture high-quality products, but also increase production efficiency by installing the analytical systems directly into their production plants. This improves process verifiability and gives the company the opportunity to optimize material use. Brukers technology base includes FT-IR, FT-NIR, dispersive NIR and Raman Spectroscopy. This allows us to offer a choice of analytical solutions based on applications or sampling points. The robust design of our spectrometers enable use in tough conditions in the production plant.

MATRIX-F FT-NIR Spectrometers

The award winning MATRIX-F FT-NIR spectrometers allow the direct measurement in process reactors and pipelines, leading to a better understanding and control of the process. Its innovative design provides consistent high-quality results, less downtime and direct method transfer. ATEX II 2G EEx p II T6 version available.

MATRIX-F duplex FT-NIR Spectrometer

MATRIX-MF FT-IR Spectrometers

Utilizing the information rich mid-IR region for use in both laboratory and process environments, the MATRIX-MF is a process ready spectrometer that is ideal for real-time monitoring and analysis of chemical and biological reactions. ATEX II 2G Ex px II T6 version available.
MATRIX-MF FT-IR Reaction Monitoring

FT-NIR measurement heads and probes

A wide range of fiber optic probes is available for the MATRIX-F series from immersion probes for liquids to reflection probes for solid materials. For contactless measurements, Bruker offers emission heads which collect the reflected light from the sample, also as fully ATEX certified version for gas and dust Ex-zones.
MATRIX-F ex for hazardous environments

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OPUS Spectroscopy Software

All-in-one IR and Raman spectroscopy software consisting of a suite of software packages that cover both standard and specialized applications.

Features

Running under Windows XP and Windows 7 operating system Supporting the demands of 21 CFR Part 11Electronic Records, Electronic Signatures Manipulating multiple spectra and 3D files at the same time Providing comprehensive spectra processing routines e.g. integration and baseline correction Providing easy to use, intuitive application-specific software interfaces for complete routine analysis tasks

IDENTIFICATION

Display and Processing of 3D files

OPUS-VIDEO

Wizard guides the operator through the full procedure of data acquisition Powerful autofocus functionality Acquisition of spectral data up to 10 Giga Byte IR and Raman images may be combined with high-resolution visible images and shown as 2D contour plots or as 3D topography plots Multiple data analysis functions from simple Integration to Cluster Analysis, Spectral Similarity or Factorization

Complete tools box of algorithms for substance identifications PCA including visualization by 2D and 3D score plots Hierarchical multi-level libraries to separate even similar substances Validation with independent samples: positive and negative samples

PROCESS and REACTION MONITORING

OPUS-3D

Real time evaluation using multivariate methods and on-line trending Communication protocols to DCS (OPC, Profibus DP, Modbus, 4-20 mA, ) Interactive setup of integration methods during reaction monitoring Automatic end point detection based on PCA or integration results

Quantitative Analysis and Quality Control, Process Control

QUANT

PLS tools box to setup quantitative analytical methods Automatic method development and optimization Automatic outlier recognition and removal

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Content:

X-RAY, XRF, SC-XRD, AFM, OIM MA, OES and CS/ONH

96 99 102 104 106 107 108 109 110 111 X-ray Diffraction X-ray Fluorescence Analysis Optical Emission Spectrometry CS/ONH Analysis Microanalysis Chemical Crystallography Automated Crystal-Structure Analysis Biological Crystallography Atomic Force and Scanning Probe Microscopy Stylus and Optical Metrology

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Advanced Analytical Solutions

XRD, XRF, SC-XRD, AFM, OIM MA, OES, CS/ONH

Innovation with Integrity

X-RAY, AFM, OES

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X-ray Powder Diffraction

Table-top, automated, or scientific workshorse instrumentation
X-ray diffraction expands analytical capabilities down to the nanometer range. Our highly accurate, reliable and fast diffraction solutions are accompanied by an intuitive and clearly laidout user interface, easy handling, and individual data presentation, as well as perfect integration and communication capabilities.

Applications
Crystalline phase identification Crystalline phase quantification % crystallinity Crystallite size determination Crystal structure analysis Texture and preferred orientation Microstrain Residual stress Depth profiling Polymorph screening High temperature Low temperature Humidity Phase transition Nanoparticles

D8 ADVANCE

D4 ENDEAVOR

D2 PHASER

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 with TURBO X-RAY SOURCE

Thin Film X-ray Diffraction

Quick-Change Artists without Limits
With the capabilities provided by the D8 DISCOVER, laboratory X-ray diffraction enters new frontiers in the nano-world and materials research so that synchrotron measurement campaigns become obsolete in many cases. Applications
Crystalline phase identification Crystalline phase quantification % crystallinity Crystallite size determination Crystal structure analysis Texture and preferred orientation Microstrain and relaxation Residual stress Layer thickness Layer roughness Lattice parameter Chemical composition Lateral structures Defects Depth profiling Real space mapping Microdiffraction Polymorph screening High and low temperature Humidity Phase transition Nanoparticles

for XRD2

D8 DISCOVER

D2 CRYSO

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Small Angle X-ray Scattering and X-ray Metrology

Enter the Universe of Nanostructure Analysis
The innovative Small Angle X-ray Scattering System NANOSTAR is the ideal tool for investigating precipitants in bulk materials and macromolecules like protein solutions with a size on the order of 10 to 1000 ngstrom.

Applications
Small Angle X-ray Scattering (SAXS) Grazing-incidence SAXS (GISAXS) Wide Angle X-ray Scattering (WAXS) BioSAXS Nanography Particle size Particle size distribution Particle shape Orientation distribution Particle distances High and low temperature Subsurface structure Roughness Molecular volume and mass

SAXS2

NANOSTAR U

The D8 FABLINE is the only X-ray metrology instrument with four combined applications: High-Resolution X-Ray Diffraction (HRXRD) X-ray Reflectivity (XRR) Micro X-ray Fluorescence (XRF) Grazing incidence Diffraction (GID)

D8 FABLINE

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X-ray Fluorescence Analysis

Defining the World of Elements in Seconds
X-ray fluorescence spectrometry is the most effective way to perform multielemental analysis determining concentrations in all forms of samples: solids, powders and liquids. Based on the renowned XFlash silicon drift detector technology Bruker AXS energy dispersive X-ray fluorescence (EDXRF) systems offer highest analytical precision and stability. The S2 PICOFOX allows the analysis of thin films as well as the analysis of traces down to 0.1 ppb using total reflection X-ray fluorescence (TXRF). The S2 RANGER with TouchControlTM provides you with instant answers for element concentrations from Na to U in unknown samples.

S2 PICOFOX: True Trace Element Analysis by TXRF

Applications
Fresh water, sea water Sewage, sludge Pharmaceuticals Blood, urine Proteins, macromolecules Food, dietary supplements Wine, beverages Nanoparticles Washcoats Contaminations Aerosols Thin films

S2 RANGER: EDXRF with TouchControlTM Applications

Petrochemicals Minerals and mining Slags Cement Geology Pharmaceuticals Metals and alloys Soil, sediments and waste

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Unrivalled
Excellence in WDXRF: S8 TIGER - S8 LION - S8 DRAGON
Our wavelength dispersive X-ray fluorescence (WDXRF) systems provide you with excellent analytical results for elements from Be to U in your samples. They feature high-accuracy and the best achievable precision for effective process and quality control. They are reliable and robust for all industrial applications, yet flexible and powerful for all non-routine applications in research and development.

Get in touch with the power

S8 TIGER: TouchControlTM and SampleCare TM

Applications
Petrochemicals Plastics and polymers Cement Geology Metals and alloys Precious metals Minerals and mining Glass and ceramics Chemicals and catalysts Pharmaceuticals Soil, sediments and waste Foods

S8 LION and S8 DRAGON Ultimate Analytical Speed Best Precision Applications

Cement Ferrous and Non-Ferrous Metals Industrial Minerals Mining

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Micro-X-ray Fluorescence Analysis

M1 and M4 Tabletop Micro-XRF Spectrometer Series
-XRF is the method of choice for the elemental analysis of inhomogeneous or irregularly shaped samples as well as small samples or even inclusions. Brukers M1 and M4 tabletop spectrometers offer maximum versatility for all applications, whether for routine analysis in quality control or for individual setups analyzing special samples.

M4 TORNADO Applications Minerals Metals and alloys Electronic components (RoHS) Particles Forensics Layers
Art conservation, archeology

M1 MISTRAL and M1 ORA

Applications
Jewelry Metals and alloys Layers (M1 MISTRAL)

S1 TURBOSD ARTAX Applications

Non-destructive element analysis in Art conservation, archeology and archeometry Metals, alloys, sheet metal Thin layers
The Bruker handheld XRF analyzers provide quick and easy non-destructive analysis. The S1 TURBOSD and S1 SORTER enable fast analysis and ID of most alloys. The TRACER III-V and III-SD tube based systems include the Bruker /NASA joint patented vacuum system and high-resolution detector allows for laboratory grade results of elements from Mg to U.

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Optical Emission Spectrometry

Spark optical emission spectrometers (S-OES) are the ideal instruments for all types of metals. From pure metal trace analysis to high alloyed grades, spark OES covers the complete range from sub-ppm to percentage levels. All relevant elements can directly be analyzed simultaneously. Spark spectrometer instruments cover all types of metal applications. Our range of high-end instruments allows our customers to elevate their business into new levels of quality and process control.

Q4 TASMAN / Q2 ION Benchtop metals analyzer

Applications
Iron and steel and its alloys Aluminium and its alloys Copper and its alloys Nickel and its alloys Cobalt and its alloys Magnesium and its alloys Lead and its alloys Tin and its alloys Titanium and its alloys Zinc and its alloys

Q4 TASMAN (CCD)
Measuring results

Photomultiplier optic Channel photomultiplier (CPM)

Pneumatic sample clamp

Q2 ION - Ultra compact Spark-OES

Metal samples

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Q8 CORONADO Analysis automation

Applications
Process analysis of steels Process analysis of cast iron Process analysis of aluminum Process analysis of copper

Q8 MAGELLAN Stationary vacuum spectrometer

Applications
Elemental analysis of: Iron and steel alloys and its traces Nitrogen in steel Aluminium alloys and its traces Copper alloys and its traces Oxygen in copper Nickel alloys and its traces Cobalt alloys and its traces Magnesium alloys and its traces Tin alloys and its traces Lead alloys and its traces Titanium alloys and its traces

Q6 COLUMBUS (CPM)

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CS / ONH Analysis in Solids

Our innovative analysis instruments allow automatic and fast determination of Carbon, Sulfur, Oxygen, Nitrogen and Hydrogen in solids. Our instruments provide highly accurate measurement within a short analysis time and are highly reliable and userfriendly. The state-of-the-art technology allows not only the use for quality control but also in the various fields of material development. The One-4-All analysis software is clear and simply structured and universal for all instruments.

G4 ICARUS TF G4 ICARUS HF
CS analyzer with high-frequency furnace

CS analyzer with high-temperature tube furnace

G4 ICARUS HF ceramic crucible

G4 PHOENIX DH tube 30 mm

Applications
Iron, steel and alloys Aluminum and alloys Titanium and alloys Zirconium and alloys Ores, minerals Coal, coke and ash Catalysts

One-4-All software G4 ICARUS TF ceramic boat

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G8 GALILEO Applications
Iron, steel and alloys Aluminum and alloys Copper and alloys Titanium and alloys Zirconium and alloys Ores Ceramics Minerals

O, N, H analyzer

G4 PHOENIX

Determination of diffusible hydrogen

Applications
Steel Aluminum Weld material Weld seams

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Microanalysis (EDS) and Electron Backscatter Diffraction (EBSD)

Accurate, Fast and Easy to Use
The QUANTAX EDS microanalysis system works in conjunction with Scanning Electron Microscopes, as well as Transmission Electron Microscopes (TEM) with the worldwide first SDD series designed for TEM. In addition QUANTAX also provides the option of EBSD analysis with the fully integrated QUANTAX CrystAlign.

Applications
Metals and alloys Semiconductors Layers and coatings Minerals Glasses Nano-materials Plastics and organic solids Biological samples Forensics

QUANTAX 800

e -Flash detector series

XFlash 5030/5060 T for TEM

XFlash 5000 series for SEM

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Chemical Crystallography
Systems as individual as your research
Single Crystal X-ray diffraction is the method of choice for determining the 3-dimensional structure of any kind of chemical compound. The method provides accurate and precise measurements of molecular dimensions in a way that no other investigative technique can begin to approach. Our D8 Crystallography Solutions, the D8 QUEST and the D8 VENTURE, are designed to offer highest standards of quality, performance, and reliability. Both feature the new PHOTON 100 detector, a 10x10-cm2 CMOS active pixel sensor X-ray detector. This new air-cooled detector is combined with the most flexible and precise sample motion available. A wide selection of dedicated X-ray sources including sealed tube, microfocus tube and rotating anodes completes these systems to give you the best structure possible. The compact D8 QUEST hosts single source and is setup for excellent sample access and reachability. The D8 VENTURE provides a more spacious enclosure, which also allows for solutions including two X-ray sources. This highly versatile setup enables the scientist to switch between Mo- or Cu-radiation, e.g. for absolute structure determination just with a mouse click.

D8 VENTURE

Applications
Structure determination of new molecules and minerals Absolute structure determination on molybdenum and copper radiation Integrated treatment of twinned samples Electron charge-density studies by high-anglediffraction Structural investigation of high-pressure phases Modulated structures Diffuse scattering

D8 QUEST

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Automated Crystal-Structure Analysis

Walk-up X-ray Structure Determination for Chemists
Bruker AXS SMART X2S is the first benchtop X-ray crystallography system for fully automated 3D chemical structure determination. It is designed for use by chemists, who need unambiguous answers to their structural questions. The SMART X2S takes small molecule structure determination to the next level of convenience by automating the previously difficult aspects of X-ray structure determination, from sample loading through data collection all the way to report generation and data archiving. Its compact design, low maintenance, low cost of ownership, easy and intuitive operation through a touch screen graphical interface are truly groundbreaking.

SMART X2S

Features
Structural information for routine samples when you need it quickly, reliably and cost effectively Crystal-in, Structure-out Automation Unambiguous synthesis control for working chemists Perfectly complements MS, NMR, FT-IR and Raman

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Biological Crystallography
Best in-house data - guaranteed
Modern beamlines are designed to collect data from large numbers of ever smaller crystals, and facilitate data collection from crystals with very large unit cell dimensions. These requirements are similarly driving the development of the D8 Structural Biology for the home-lab solutions in the same direction, where X-ray flux on the crystal is comparable with that achieved at bending magnet beamlines. The high X-ray flux sources are combined with highly precise and easy to use sample stages and rounded up by the new, air-cooled CMOS-based PHOTON 100 detector. The D8 QUEST features a new generation of IS sealed tube microfocus source, while the more spacious D8 VENTURE hosts the TURBO X-RAY SOURCE (TXS) microfocus rotating anode in addition. Demanding SAD-phasing experiments, measuring even an extremely small anomalous signal can be carried out routinely, while high-throughput crystal screening is more efficient than ever before.

Features
High-intensity microfocus TXS or High-brilliance IS microfocus source Large 100-cm2 PHOTON CMOS-detector KAPPA goniostat for easy sample mounting and high-data multiplicity Three years of warranty on the IS and the PHOTON 100 Completely air-cooled configurations available Minimal down-time Lowest cost of ownership Excellent sample access and sample visibility Intuitive PROTEUM2 software package

D8 VENTURE with microfocus TXS

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Atomic Force and Scanning Probe Microscopy

Analyze Nanometer Size Surface Structures within Minutes
Bruker's atomic force microscopes (AFMs) drive the world's leading-edge research in life science, materials science, semiconductor, electrochemistry, and many other applications. The MultiMode 8 and Dimension Icon systems are the latest generation of the world's most widely selected AFMs, offering true atomic resolution for materials research in air or liquids. The BioScopeTM CatalystTM features the most complete integration available between AFMs and high-end inverted and confocal microscopes, and has been specifically engineered to image samples under biologically relevant conditions.

DIMENSION Icon

The N8 range of instruments provides a complete set of solutions for atomic force and scanning probe microscopy (SPM). All systems are based on the unique NANOS SPM head, which uses an interferometric detection principle, enabling optically navigated AFM.

New N8 NEOS, AFM and optical microscope

Automated AFM / AFP Systems Automated atomic force microscopy and atomic force profiling (AFP) support routine analysis in many different industrial applications, like in-line semiconductor, data storage and MEMS. The systems provide the highest level of measurement performance for a variety of automated and semi-automated metrology applications, performing Atomic Force Profilometry, Critical Dimension AFM scanning, TappingMode for roughness metrology, and deep trench AFM scan modes.

InSight 3DAFM

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Stylus and Optical Metrology

Optical Interferometric Profilers White light interferometric (WLI) optical profilers from Bruker are optimized to address a wide range of advanced production QA/QC and R&D precision machining and manufacturing applications within the high-brightness LED, solar, ophthalmic, semiconductor, medical device and academic research markets. Based on ten generations of proprietary technology advances, Bruker's WLI profilers feature patented, higher brightness dual-LED illumination that, when combined with the systems' superior vertical resolution, provide the high-sensitivity and stability necessary for precision, non-contact 3D surface metrology in applications and environments that are challenging for other metrology systems.

CONTOUR GT-K1

NPFLEX

Stylus Profilers Bruker's stylus profilers are the culmination of four decades of proprietary stylus profiler technology. These surface profilers provide repeatable, accurate measurements on varied surfaces, from traditional 2D roughness surface characterization and step height measurements to advanced 3D mapping and film stress analyses.

Dektak 150

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Trademarks
trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker reg. trademark of Bruker reg. trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker trademark of Bruker reg. trademark of Linus Torvalds Metabolic Profiler trademark of Bruker OS X reg. trademark of MacIntosh ParaVision reg. trademark of Bruker PatternJet trademark of Bruker PharmaScan reg. trademark of Bruker SampleCase trademark of Bruker SampleJet trademark of Bruker SampleTrack trademark of Bruker SampleXpress trademark of Bruker SFG Profiling trademark of Bruker SmartProbe trademark of Bruker SpecJet trademark of Bruker SuperX-FT trademark of Bruker Syngo reg. trademark of Siemens TopSpin trademark of Bruker UltraShield trademark of Bruker UltraStabelized trademark of Bruker USR trademark of Bruker WINDOWS NT reg. trademark of Microsoft WINDOWS 2000 reg. trademark of Microsoft Xenon trademark of Bruker Amix Ascend Assure Avance B-ACS BGA-S BioSpec ClinScan CMC CryoPlatform CryoProbe DICE ELEXSYS EMXmicro EMXplus e-scan HyperQuant HyperSense Icon NMR IntraGate JuiceScreener LINUX amaZon ETD autoflex speed BigAnchorChip BioTools Biotyper Compass Compass OpenAccess GenoTools LIFT maXis impact MetaboliteTools microflex LT micrOTOF II micrOTOF-Q II PAN PolyTools Profile Analysis ProteinScape Sepsityper Smartbeam solariX Super Clean TargetAnalysis ultrafleXtreme HYPERION MATRIX QuickSnap RockSolid SENTERRA UltraScan D8 DIFFRAC SampleCare TouchControl TOPAS XFlash QUANTAX BioScope Catalyst Icon MultiMode Dimension TappingMode Dektak trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik reg. trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Daltonik trademark of Bruker Optics trademark of Bruker Optics trademark of Bruker Optics trademark of Bruker Optics trademark of Bruker Optics trademark of Bruker Optics trademark of Bruker AXS trademark of Bruker AXS trademark of Bruker AXS trademark of Bruker AXS trademark of Bruker AXS reg.trademark of Bruker AXS reg.trademark of Bruker AXS trademark of AFM system trademark of AFM system reg. trademark of AFM system reg. trademark of AFM system reg. trademark of AFM system brand trademark of AFM technique reg. trademark of SOM system brand

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