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    6.principle of HD

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    Caerulus Fuad Abdul Baqi
    Hemodialysis removes waste and corrects electrolyte and acid-base imbalances through diffusion and ultrafiltration. Diffusion is the movement of solutes from an area of high concentration to low concentration across a semi-permeable membrane. Ultrafiltration is the movement of fluid across the membrane due to an artificially created pressure gradient. Hemodialysis uses both diffusion and ultrafiltration to clear waste and excess fluid from the blood through the dialysis filter and membrane.

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    6.principle of HD

    Uploaded by

    Caerulus Fuad Abdul Baqi
    298 views24 pages
    Hemodialysis removes waste and corrects electrolyte and acid-base imbalances through diffusion and ultrafiltration. Diffusion is the movement of solutes from an area of high concentration to low concentration across a semi-permeable membrane. Ultrafiltration is the movement of fluid across the membrane due to an artificially created pressure gradient. Hemodialysis uses both diffusion and ultrafiltration to clear waste and excess fluid from the blood through the dialysis filter and membrane.

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    6.Principle of HD

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    Hemodialysis removes waste and corrects electrolyte and acid-base imbalances through diffusion and ultrafiltration. Diffusion is the movement of solutes from an area of high concentration to low concentration across a semi-permeable membrane. Ultrafiltration is the movement of fluid across the membrane due to an artificially created pressure gradient. Hemodialysis uses both diffusion and ultrafiltration to clear waste and excess fluid from the blood through the dialysis filter and membrane.

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    Attribution Non-Commercial (BY-NC)
    Download as PPSX, PDF, TXT or read online from Scribd
    Download as ppsx, pdf, or txt
    298 views24 pages

    6.principle of HD

    Uploaded by

    Caerulus Fuad Abdul Baqi
    Hemodialysis removes waste and corrects electrolyte and acid-base imbalances through diffusion and ultrafiltration. Diffusion is the movement of solutes from an area of high concentration to low concentration across a semi-permeable membrane. Ultrafiltration is the movement of fluid across the membrane due to an artificially created pressure gradient. Hemodialysis uses both diffusion and ultrafiltration to clear waste and excess fluid from the blood through the dialysis filter and membrane.

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    Principle of Hemo (dialysis)

    HEMODIALYSIS Diffusion

    HEMOFILTRATION : Convection

    Principle of Hemodialysis
    Dialysis removes nitrogenous (and other) waste products, and corrects the electrolyte, water, and acid base abnormalities associated with renal failure. It requires the use of semi-permeable membrane which allow the passage of water and small molecular weight solutes, but not large molecules.

    Dialysis: General Principles


    Diffusion Movement of solutes from an area of greater concentration to lesser concentration Osmosis Movement of fluid from an area of lesser to an area of greater concentration of solutes.

    Ultrafiltration (water & fluid removal) Movement of fluid across a semipermeable membrane as a result of an artificially created pressure gradient.

    Diffusion

    Ultrafiltration

    Diffusion
    Membrane Membrane

    t=0 A

    t = equilibrium B

    t=0

    Ultrafiltration

    t = later

    The Process of diffusion (top) and ultrafiltration (bottom)

    Hemodialysis Filter

    Mechanisms of Solute Removal


    1. Diffusion

    2. Convection
    3. Diffusion + Convection 4. Adsorbtion

    Solute Clearance
    Blood
    Membrane Dialysate/Ultrafitrate

    Diffusive Solute Clearance


    Blood
    Membrane Dialysate/Ultrafitrate

    Diffusive Solute Clearance


    Blood
    Membrane Dialysate/Ultrafitrate

    Convection

    Adsorption

    ADSORPTION: molecular adherence to the surface

    or interior of the membrane.

    Ultrafiltration

    ULTRAFILTRATION: The movement of fluid through a membrane caused by a pressure gradient.

    Water movement during standard hemodialysis


    Intracellular fluid Extracellular fluid step3 Water movement step1
    280
    Loss of urea and water

    Dialyzer

    Osmolality 320 mosm/kg

    Osmolality 320 mosm/kg Falling to 290mosm/kg as diffusion occurs

    step2

    Compensatory refilling

    A Standard HD Delivery System


    Informational Display
    PT = Pressure Transducer Anticoagulant PT Saline

    Blood from Patient

    Blood Leak Detector

    PT

    Conductivity Meter

    Dialysate / UF Out (green / yellow) Mixing System Pre-mixed or sorbent Water, Acid Concentrate, regenerated Bicarbonate Concentrate dialysate In

    Dialysate In
    PT

    Drip Chamber

    Air Detector

    Venous clamp

    Blood return to 18 Patient

    Solute Transfer & Ultrafiltration

    C blood > C Dialysate P Dialysate P blood >

    Blood

    Dialysate

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    DIFFUSION

    DIFFUSION

    DIFFUSION

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