7generic Name
7generic Name
7generic Name
Ketorolac
BRAND NAME:
Toradol
CLASSIFICATION:
Nonsteroidal anti-inflammatory agents, nonopioid analagesics
DOSAGE:
30mg/amp1 amp IM
MECHANISM OF ACTION:
- Inhibits prostaglandin synthesis, producing peripherally mediated analgesia
- Also has antipyretic and anti-inflammatory properties.
- Therapeutic effect:Decreased pain
INDICATION:
Short term management of pain (not to exceed 5 days total for all routes
combined)
CONTRAINDICATIONS:
- Hypersensitivity
- Cross-sensitivity with other NSAIDs may existPre- or perioperative use
- Known alcohol intolerance
Use cautiously in:
1) History of GI bleeding
2) Renal impair-ment (dosage reduction may be required)
3) Cardiovascular disease
SIDE EFFECTS/ ADVERSE EFFECTS:
- CNS:
1) drowsiness
2) abnormal thinking
3) dizziness
4) euphoria
5) headache- RESP:
1) asthma
2) dyspnea
- CV:
1) edema
2) pallor
3) vasodilation
- GI:
1) GI Bleeding
2) abnormal taste
3) diarrhea
4) dry mouth
5) dyspepsia
6) GI pain
7) nausea
- GU:
1) oliguria
2) renal toxicity
3) urinary frequency
- DERM:
1) pruritis
2) purpura
3) sweating
4) urticaria
- HEMAT:
1) prolonged bleeding time
- LOCAL:
1) injection site pain
- NEURO:
1) paresthesia
- MISC:
1) allergic reaction, anaphylaxis
NURSING IMPLICATIONS/RESPONSIBILITIES:
- Patients who have asthma, aspirin-induced allergy, and nasal polyps are at
increased risk for developing hypersensitivity reactions. Assess for rhinitis,
asthma, and urticaria.
- Assess pain (note type, location, and intensity) prior to and 1-2 hr following
administration.
Serc (Betahistine
Dihydrochloride) Drug Study
Brand Name: Serc
Generic Name: Betahistine Dihydrochloride
Classification: Antiemetic and Antivertigo
Availability: Tablet: 8mg, 16mg, 24mg
Action: It has a histamine-like action. It is readily absorbed from the gastrointestinal
tract. It is converted to two metabolites and peak concentrations in blood of the two
metabolites are achieved within 3 to 5 hours. Most of a dose is excreted in the urine, in
the form of the metabolites, in about 3 days.
The mechanism of action of betahistine is not known. Pharmacological testing in
animals has shown that the blood circulation in the striae vascularis of the inner ear
improves, probably by means of a relaxation of the precapillary sphincters of the
microcirculation of the inner ear.
In pharmacological studies, betahistine was found to have weak H 1 receptor agonistic
and considerable H3 antagonistic properties in the central nervous system and
autonomic nervous system. Betahistine was also found to have a dose dependent
inhibiting effect on spike generation of neurons in lateral and medial vestibular nuclei.