Antimicrobial WhitePaper PerkinsWill

A PERKINS +WILL WHITE PAPER /
Healthy Environments:
Understanding Antimicrobial
Ingredients in Building
Materials
MARCH 2017
Healthy Building Network

Perkins+Will
Understanding Antimicrobial
Ingredients in Building Materials
Melissa Coffin, Operations Manager, Healthy Building Network
Tom Lent, Policy Director, Healthy Building Network
Susan Sabella, Chief Operations Officer, Healthy Building Network
Jim Vallette, Research Director, Healthy Building Network
Bill Walsh, Founder and President of the Board of Directors, Healthy Building Network
Mary Dickinson, Co-Director Materials Performance Lab and Regional Sustainable Design Leader, Perkins+Will
Suzanne Drake, Co-Director Materials Performance Lab, Senior Associate, Perkins+Will
Robin Guenther, Principal, Perkins+Will
Max Richter, Co-Director Materials Performance Lab, Associate, Perkins+Will
Brodie Stephens, General Counsel, Perkins+Will
2 Understanding Antimicrobial Ingredients in Building Materials

ABOUT THE AUTHORS
As a research-driven architecture firm, Perkins+Will has created a practice where design, technology,
and research converge to create places that improve how we live and work. To help keep us at the
forefront of innovative design, we believe that it is essential to make focused investments in thought
leadership in order to solve our clients increasingly complex challenges and advance our profession.
Toward that end, the Perkins+Will Science Fellow program was initiated in 2014. In 2015, in lieu of
awarding an individual researcher the fellowship, the Healthy Building Network was engaged to aid our
efforts to better understand the impacts our buildings have on human and environmental health.
The Healthy Building Network is a research-based not-for-profit organization focused on advancing

the best environmental, health and social outcomes by reducing chemical hazards in the products that
make up our built environment. The Pharos Project (a web-based building material evaluation system)
and the Healthy Building News (since 2002) are just two means by which they have achieved deep
respect within the design and construction industry. Perkins+Will and the Healthy Building Network
possess many complementary synergies between our organizations, including core values around
the Precautionary Principle, transparency, and optimism about the power of design to make positive
change. The Science Fellowship program provided our organizations the perfect opportunity to see
where those synergies could lead.
Special thanks to our peer reviewers

Caroline Cox, Director, Center for Environmental Health
Casey Johnson, Business Development Manager/ Sustainable Director North America,

Forbo Flooring Systems
Jennifer MacDaniel, Project Principal, Kaiser Permanente
Dr. Ted Schettler, Science Director, Science and Environmental Health Network
Dr. David Walinga, Senior Health Officer, Natural Resources Defense Council
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Table of Contents
Purpose Statement 6
Executive Summary 7
Introduction8
Antimicrobials Become Mainstream 10
Costs to Human Health 14
a. Triclosan 14
b. Silver Ions 15
c. Copper 17
d. Quaternary Ammonia Compounds 18
e. Formaldehyde Donors 18
Costs to Public Health 19
Costs to Environmental Health 21
Antimicrobials in Healthcare Facilities 23
Conclusion27
Endnotes28
Appendix A: Health & Environmental Hazards Associated with Antimicrobials 33

Found in Building Products
Appendix B: Preservatives Versus Health Claims: Decoding Antimicrobial Marketing 37
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Purpose Statement
The aims of this paper are to present current information about reported or potential health and
environmental impacts of antimicrobial substances as commonly used within the building industry,
and to assist architects, designers, building owners, tenants, and contractors in understanding those
impacts. This paper is a compilation of information, and does not represent new research.
Perkins+Will strives to make use of this information to inform recommendations to each of our clients,
based on their individual project needs. In general, when we find evidence of the potential for harm
in the lifecycle of products that we specify, including to the environment, occupants, installers,
fabricators, or factory workers, we prefer to proceed with caution in regard to the use of that product.
Antimicrobials, as a class of chemicals, have been flagged in recent years as substances of concern,
most recently in September 2016 when the Food and Drug Administration ruled that companies
will no longer be able to market certain antibacterial washes that are currently in widespread use.
We always work with our clients to find the best possible solutions for their project; sometimes,
criteria other than health or environmental impacts (such as cost, availability, durability, or future
maintenance, to name a few) drive the final decisions.
The purpose of this paper is to provide useful information for our colleagues and clients to consider
in relation to the use of antimicrobials in the building industry. This paper summarizes our present
thinking about the current use of antimicrobials in the building industry, and our current conclusion
that they should be approached with skepticism and caution.
As in all matters regarding caution in relation to human and environmental health, we believe that
the precautionary principle is appropriate as a tool for us to use in discussing design alternatives with
our clients. Where there is information that credibly suggests the possibility of a negative human or
environmental health impact in relation to a particular design choice, then we strive to advise our
clients of that risk, and to see whether other alternatives exist.
The purpose of this paper is to provide useful

information to our colleagues and clients to consider
in relation to the use of antimicrobials in the building
industry. This paper summarizes our present thinking
about the current use of antimicrobials in the building
industry, and our conclusion that they should be
approached with skepticism and caution at this time.

Executive Summary
Building products incorporating antimicrobial additives are becoming increasingly prevalent. Paints,
and other touchable surfaces such as countertops, and virtually any product considered as an interior
finish may contain one or a combination of antimicrobials. These agents are considered pesticides,
but their identityand related hazardscan be difficult for the average person to discover. This lack
of transparency creates a hurdle for the informed selection of products with reduced negative impacts.
No evidence yet exists to demonstrate that products intended for use in interior spaces that
incorporate antimicrobial additives actually result in healthier populations. Further, antimicrobials may
have negative impacts on both people and the environment.1 Their widespread use may be associated
with microbial resistance to these agents, and potentially to therapeutic antibiotics. Evidence is
growing that antimicrobial additives can migrate from the products in which they are incorporated,
finding their way into wastewater systems and the larger environment with unknown ecological
implications, but with reasonable cause for concern.
Following the lead of the Centers for Disease Control and Prevention, 2 the Food and Drug
Administration, 3 and other credible institutions, 4 Perkins+Will will be placing Products Marketed as
Antimicrobial on its Precautionary List (transparency.perkinswill.com). Perkins+Will project teams
should advise our clients of reasonable alternatives where appropriate.
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Introduction
Antimicrobial substances are, by definition and design, substances that are toxic to certain
organisms: bacteria, viruses, fungi, or protozoacollectively known as microbes. Certain substances,
nanoparticles, and metals can all be used as antimicrobials in everyday products, including those
used to construct and finish buildings. However, because their purpose is to kill and control a
target organism, antimicrobial additives are by definition pesticides,5 and as such may impact our
environment and our health beyond their intended purpose.
Words for the Wise

We use the term antimicrobial throughout this paper because it is commonly
understood across audiences. But there are other terms used to describe these
additives that you should be looking for during product selection.
Other terms you may come across that indicate an antimicrobial additive may be
present include (but are not limited to):
Anti-bacterial, Anti-fungal, and Anti-viral: used to describe antimicrobial

substances targeted at a particular type of microbe
Biocide or Biocidal
Microbiocide, Microbiocidal, or Microbicidal
Pesticide
Microbes are sometimes commonly referred to as germs because they can cause many familiar
illnesses, such as the flu (the influenza virus) or athletes foot (caused by the Trichophyton rubrum
fungus). However, while people may associate microorganisms categorically with disease or unsanitary
conditions, each microorganism is different. Not every microorganism can cause illness, and some,
such as the microorganisms in our gut, are beneficial to human health.6
An increasing body of scientific evidence is demonstrating that widespread use of antimicrobials may
have negative impacts on the environment,7 and potentially on human health in the long term. 8 This
growing evidence brings with it a renewed focus on whether the inclusion of antimicrobial substances
into building products provides any positive health benefits to outweigh potential negative impacts.

As part of an effort to offer hospitals guidance on proper infection control, the Centers for Disease
Control (CDC) reviewed the widespread use of products treated with antimicrobial additives in
2003. The agency concluded that even in hospitals, antimicrobial additives have not been proven
to show a benefit to human health. The resulting guidance document, specifically for hospital use,
states unequivocally that no evidence is available to suggest that use of [products impregnated
with antimicrobial additives] will make consumers and patients healthier or prevent disease. No data
support the use of these items as part of a sound infection-control strategy.9
In September 2016 the Food and Drug Administration (FDA) concluded the most extensive review to
date of data on the efficacy of antimicrobial additives in hand soaps and washes. After studying the
issue for nearly 40 years,10 the FDA determined that manufacturers have failed to show any evidence
that these additives provide a benefit to human health.11
Antimicrobial additives used in building products are outside the jurisdictions of the CDC and the FDA
because they are regulated by the US Environmental Protection Agency (EPA). However, this is merely
a bureaucratic distinction. Available evidence supports the same conclusion drawn by the EPAs sister
agencies: antimicrobials do not provide health benefits. When this lack of benefit is measured against
the many costs of antimicrobials, it is clear that the best policy is to avoid products marketed as being
antimicrobial whenever possible.
Consumers may feel a misplaced confidence in antimicrobial products, in part, because of confusing
and in some instances misleading12 marketing materials made possible by the extremely complex
regulation governing antimicrobials in building products. The source of this confusion is that some
products require an antimicrobial additive because it acts as a preservative, and claim no human
health benefits. In other cases, even though a preservative only protects the product from decay
or spoilage, the EPAs legal parameters allow antimicrobial products to be marketed in ways that
consumers may interpret as providing a health benefit. For a more detailed discussion of preservatives
and marketing claims, see Appendix B.
Available evidence supports the same conclusion drawn by the

EPAs sister agencies: antimicrobials do not provide health benefits.
When this lack of benefit is measured against the many costs of
antimicrobials, it is clear that the best policy is to avoid products
marketed as being antimicrobial whenever possible.
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The Precautionary List:

Antimicrobials Become
Products Marketed As Mainstream
Antimicrobial
The availability of products with antimicrobial additives is a relatively
A lack of transparency about new phenomenon. Consumer products is one example of the growth
which products include of antimicrobial products generally, with just a few dozen in 1994,
antimicrobials, and for what to more than 2,000 in 2014.13 The International Antimicrobial
purpose, makes it very difficult to Council (IAC), a trade association for the industry, expects the
implement a list-based approach global market for antimicrobial coatings to reach $4.5 billion by
based on specific chemicals. 2020. This estimate includes a large segment of coatings used in
medical devices, but is also being driven by a growing US market
Further, trying to distinguish for products aimed at improving indoor air quality. In 2013, 39%
between products which are of antimicrobial coatings were sold in North America.14 Table 1
incorporating antimicrobials for provides a selection of antimicrobial additives commonly found in
legitimate preservation purposes many types of building products.
from those that are making See Appendix A for information on the health and environmental
health claims (see Appendix hazards associated with each additive.
B), or making misleading claims,
A recent survey sponsored by makers of antimicrobials found more
requires a fair amount of time
than 60 percent of [consumers] polled indicated a very high concern
and expertise.
about bacteria, parasites, dust, mold in the home and in food, as
Because products which include well as viral and airborne infections. These same respondents
antimicrobials for preservation expressed an interest in expanding the use of antimicrobial additives
purposes rarely advertise their to intimate items in their lives, including bedding and articles of
inclusion, Perkins+Will design clothing.17 Another survey found that 89% of respondents were
interested in purchasing antimicrobial countertops.18
teams can avoid products using
antimicrobials for any other Fueled by consumer interest, the inclusion of an antimicrobial
purpose by simply avoiding additive has been positioned as a differentiator in the marketplace.
products marketing themselves For example, antimicrobial maker Microban lists a case study on its
as antimicrobial. website where a manufacturer looking for a way to innovate and
differentiate from their competition incorporated an antimicrobial
ingredient into its engineered stone countertop product. The
countertop company saw a 38% rise in annual revenue, and a 48%
increase in market share.19 Product literature boasts that this is the
only countertop on the market with built-in antimicrobial protection,
which battles odor-causing bacteria and stain-causing mildew.20

Table 1. Selection of Antimicrobials Found in Building Products15
Abbreviation, Antimicrobial, CAS No. Used In
BBIT (2-Butyl-1,2-benzisothiazolin-3-one) Sealants, Adhesives, Caulks, Wallboard, Ceiling Tiles

CAS: 4299-07-4
BIT (1,2-Benzisothiazolin-3-one) Paints, Adhesive

CAS: 2634-33-5
Boric Acid Wood Products

CAS: 12179-04-3
CMIT or CIT (Methylchloroisothiazolinone) Paints/Stains, Adhesives, Caulks, Grout, Wood Products

CAS: 26172-55-4
Copper Knobs/Handles, Touchable Surfaces, Ceiling Tiles

CAS: 7440-50-8
CTAC (1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride) Adhesives, Caulks, Grouts, Concrete Admixes, Paints

CAS: 4080-31-3
DCOIT (4,5-dichloro-2-octyl-2H-isothiazol-3-one) Caulks, Sealants, Grouts

CAS: 64359-81-5
DDAC (Alkyl didecyl dimethyl ammonium chloride) Wood Products

CAS: 7173-51-5
Elemental Silver / Silver Nanoparticles Upholstery & Fabrics, Hardware, Touchable Surfaces, Tile
CAS: 7440-22-4 Installation Products, Ceramic Tile, Countertops, Adhesives,
Sealants, Paints, Carpets, Textiles
Formaldehyde Released into wet-applied products by certain preservative

CAS: 50-00-0 additives16
IPBC (3-iodo-2-propynyl butylcarbamate) Paints/Stains, Wire & Cable, Carpets, Textiles, Wood Products
CAS: 55406-53-6
MIT (Methylisothiazolinone) Paints/Stains, Adhesives, Caulks, Grout, Wood Products

CAS: 2682-20-4
OBPA (Oxybisphenooxyarsine) Flexible PVC, Adhesives, Coatings, Textiles

CAS: 58-36-6
OIT (2-n-octyl-4-isothiazolin-3-one ) Adhesives, Textiles, Wood Products

CAS: 26530-20-1
Propiconazole Wood Products, Paints, Coatings, Caulks, Adhesives

CAS: 60207-90-1
QACs (Quaternary Ammonia Compounds)

CAS: specific to individual substances Disinfection Products, Wood Products, Specialty Paints
Silver Zeolite
CAS: 130328-18-6 Paints, Carpet Fibers, Wallpaper, Adhesives, Fabrics/Textiles
Triclosan (2,4,4-trichloro-2- hydroxy-diphenyl-ether) Textiles, Plastic Sheets/Parts, Adhesives, Caulk, Coatings,

CAS: 3380-34-5 Tile Installation Products, Hardware, Ceramic Tile, Carpets,
Countertops
ZPT (Zinc pyrithione) Fabrics/Textiles, Wall Coverings, Adhesives, Caulks, Sealants,

CAS: 13463-41-7 Grouts, Joint Compounds
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ANTIMICROBIALS BECOME MAINSTREAM
Likewise, commercial door hardware is available with a coating impregnated with antimicrobial
agents to give peace of mind in areas where vigilance in the war against [microbes] is critical.21
This use has recognizable appeal as an application of antimicrobials, since a door knob is likely
touched by many hands over the course of a day, and germs could be spread as a result. However, the
antimicrobial additive functions as a preservative only, and its presence in the composition of the
hardware can only protect the hardware itself from mold, mildew, and odor-causing bacteria. 22
A similar application of antimicrobials can be seen with light switches and covers that are coated
with an antimicrobial additive. 23 In one example, product literature promotes independent laboratory
testing showing the additive is effective against bacteria such as the drug-resistant strain of
staphylococcus commonly referred to as MRSA, while only briefly confirming elsewhere, in smaller
text, that the antimicrobial additive is present only as a preservative that protects the switch and cover
from mold, mildew, and other microbes that may jeopardize the integrity of the product.24
In all three of these instances, antimicrobials functioning as preservatives were added to building
products to protect the product itself from attack by microbes. One could argue that in each of these
examples, the typical consumer may have purchased the product assuming that their health may be
improved or protected as a result. In fact, the Federal Trade Commission (the federal agency tasked
with ensuring truth in advertising) warned the EPA of this very issue in 1994. 25
See Appendix B for more information on marketing claims.
Likewise, commercial door hardware is available

with a coating impregnated with antimicrobial
agents to give peace of mind in areas where
vigilance in the war against [microbes] is critical.

This opportunity for consumers to be confused about antimicrobials exists because of a lack of
disclosure that antimicrobial ingredients are present, their specific identity, the purpose they serve
in the product, and the potential health and environmental hazards they pose. In some instances,
products will display an EPA registration number which can be searched for and found in the agencys
online Pesticide Product Label System (PPLS) database. 26 Positive searches in the PPLS will
retrieve the label for the antimicrobial ingredient in question and provide its identity. The label will
also include the limitations of its efficacy, and a list of materials into which it can be incorporated.
However, it can be nearly impossible to know when antimicrobials are present in a product as
preservatvies, and in those cases, which antimicrobials are used.
In theory, several of the most popular disclosure tools in the building industry should allow researchers
to determine if antimicrobials are used in a product.
The Pharos Project database, Health Product Declaration, and the International
Living Future Institutes Declare label program, all require that every intentional
ingredient be itemized in order to earn full disclosure status.
Safety Data Sheets (commonly referred to as SDS or MSDS sheets)

only require disclosure of hazardous ingredients over 1% of the product
composition, or .1% for ingredients with specific hazards. 27
However, in practice these programs can miss antimicrobials added further up the supply chain, prior
to their incorporation in the final product. For example, a preservative incorporated into a nylon
carpet fiber might not be reported (or even known) by manufacturers using that fiber in an assembled
carpet. 28 Further, Safety Data Sheets may not list antimicrobial ingredients if they are under the
reporting thresholds and/or do not carry the specific hazards considered.
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Costs to Human Health

Antimicrobials are by definition pesticides, and therefore can pose inherent hazards to human health
and the environment. 29 30 Appendix A summarizes health hazards and typical applications of a number
of antimicrobials that are used in building products; here, five antimicrobials with broad applications
are explored in greater detail.
Triclosan
Triclosan (2,4,4-trichloro-2-hydroxy-diphenyl-ether, CAS #3380-34-5) is one of the antimicrobial
additives subject to the FDAs 2016 ban in soaps and handwashes. 31 It is an antimicrobial effective
against a broad spectrum of bacteria and fungi. It was first introduced to the market in 1964, and
remains in use in large quantities today. Building products that may contain triclosan include
countertops and table tops, textiles, and cementitious products such as concrete, mortar or grout. 32
The Centers for Disease Control has stated that the human health effects from exposure to low
environmental levels of triclosan are unknown... More research is needed to assess the human health
effects of exposure to triclosan.33 Triclosan is part of a family of molecules called organohalides;
other organohalides were used extensively as pesticides in the 1930s and 1940s before being banned
or phased out over concern for their toxicity to humans and the environment. 34
Triclosan is part of a family of molecules called

organohalides; other organohalides were used
extensively as pesticides in the 1930s and 1940s
before being banned or phased out over concern for
their toxicity to humans and the environment.

Silver Ions
Silver-impregnated zeolite and silver nanoparticles (nanosilver) are effective as antimicrobials because
they release silver ions, which are lethal to target organisms. As silver reacts with oxygen (oxidizes) it
releases ions (charged atomic particles) that kill bacteria and yeasts. 35 The antimicrobial properties
of silver have long been known. Ancient writings describe the storage of food and water in silver
containers to prevent spoilage. 36 The FDA approved the use of silver-based compounds for use in
medical prevention of infection in the 1920s, and their use continues today in the healthcare sector. 37
Silver ion coatings are increasingly used in hardware, switches, window treatments, cubicle curtains
and textiles to provide antimicrobial properties. Silver-containing environmental surfaces and textiles
in healthcare settings are promoted as products that may help reduce hospital-acquired infections by
reducing microbial loads. Silver zeolites, glass-like structures of earthen particles and silver ions, 41
are a common antimicrobial compound used in hardware coatings in building construction and
interior applications. 42
Silver zeolite has not yet been classified for human health or environmental hazards by an
authoritative agency. However, that may soon change. In 2014, The Swedish Chemicals Agency
proposed that silver zinc zeolite be classified as a reproductive toxicant, after an assessment done
as part of an ongoing review program presented reviewers with a relatively clear cut case that the
substance could be harmful to reproductive health. 43 In the dossier prepared in support of silver
zeolites reclassification, results of animal testing are cited as evidence that the substance should be
considered a suspected carcinogen, an eye and skin irritant, capable of causing damage to unborn
children, and capable of causing damage to internal organs. 44 If adopted, the classification as a
reproductive toxicant would make silver zinc zeolite a banned substance under the European Unions
Biocidal Products Regulation. 45
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COSTS TO HUMAN HEALTH
What is Nanosilver?
What is true about elemental silver and silver-based compounds may not be
true for nanosilverextremely small silver particles measuring approximately
one billionth of a meter. (For scale, note that a human hair is 100,000
nanometers wide.) At the nanoscale, materials begin to behave in ways that can
be quite different from their conventionally-sized counterparts.
It is clear that nanosilver is an effective antimicrobial, but what is not clear

is whether it is the inherent qualities of silver that make it effective, or
whether the tiny size or shape of the particles is responsible. It could be
both. In experiments with nanosilver particles and algae, researchers found
that nanosilver is more effective than conventional silver at disrupting the
photosynthesis of the algae, and at smaller doses. The study did not help the
researchers understand exactly why this is, but one theory is that nanoparticles
act as a Trojan horse, entering a cell by bypassing its barriers to normal-sized
silver, and then releasing silver ions that damage cell machinery.38
A 2015 GreenScreen Assessment of nanosilver found it to be toxic to aquatic

ecosystems, persistent in the environment, and hazardous to organ systems. 39
Engineered nanoparticles as a class are still too new to be well understood.

The National Institute for Environmental Health Sciences (NIEHS) reports that,
While engineered nanomaterials provide great benefits, we know very little

about the potential effects on human health and the environment.Nano-
sized particles can enter the human body through inhalation and ingestion and
through the skin. Fibrous nanomaterials made of carbon have been shown to
induce inflammation in the lungs in ways that are similar to asbestos.40
Despite a lack of understanding of their impacts, products made with these

particles are already on the market and being used by consumers and the
medical community for a host of purposes. The NIEHS, National Institute
for Occupational Safety and Health, and Centers for Disease Control and
Prevention are working collaboratively to assess the impacts of these materials
through mathematical modeling and studies on live organisms.

Copper
Like silver, the antimicrobial properties of copper have been Researchers continue to study copper-based antimicrobials
known for centuries, and like silver, it is the ions the metal in laboratory settings to ascertain the limits to their
releases that give it those properties. Its medical use as applications. A 2016 Health Care Without Harm review
an agent of microbial control began after observing that of these studies concluded that, while copper alloy touch
those who worked with copper appeared to be immune from surfaces reduce microbial populations in lab tests, the
cholera during outbreaks in the 1800s. Laboratory testing only study yet to provide evidence that these surfaces
has demonstrated that copper, and metal alloys containing result in reduced rates of infection has been disputed
copper, are effective against some bacteria, yeasts, and as showing a low quality of evidence. Likewise, the
viruses. 46 The Copper Development Association, a trade antimicrobial efficacy of textiles containing copper...can
association for copper manufacturers, has registered six vary considerably and interpretation of results of laboratory
copper alloys with the EPA to be used as antimicrobials in testing is subjective.51
touch surfacesrailings, door hardware, etc. 47
Copper can also be incorporated into polymers to provide an

antimicrobial effect in non-metallic items. 48 Sanitaryware
coatings containing copper claim to suppress[es]
the growth of algae, mold, mildew, fungi and bacteria
which cause unpleasant odors, discoloration, staining,
deterioration or corrosion.49 Such coatings can be used on
bathroom fixtures (for example a urinal in a public restroom)
or in ceramic tiles.50
...while copper alloy touch surfaces reduce microbial

populations in lab tests, the only study yet to provide
evidence that these surfaces result in reduced rates of
infection has been disputed as showing a low quality
of evidence.
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COSTS TO HUMAN HEALTH
Quaternary Ammonia Compounds Formaldehyde donors

Quaternary ammonia compounds (QACs) have been used Some of the antimicrobials used as preservatives in
in cleaning products since the 1930s and are effective wet-applied products can include formaldehyde donors
against a broad spectrum of bacteria.52 Still widely used as or formaldehyde releasers, which are chemicals
disinfectants in hospitals, QACs are organic (carbon-based) that decompose over time to release small amounts of
molecules that contain a positively charged nitrogen and are formaldehyde into the product.57 Formaldehyde has long
paired with a negatively charged halide or sulfide ion. This been used as a preservative, perhaps most notably in tissue
variability means there are many substances defined as a samples in laboratories.58 Formaldehyde donors preserve
QAC, and that each substance has a unique antimicrobial wet-applied products by slowly releasing small amounts of
effect. As a category, QACs are generally effective against formaldehyde into the product over time, increasing its shelf
bacteria, fungi, and certain viruses.53 QACs can be found in life.59 CTAC (also known by the name Quaternium 15 or
building products, in wood preservatives,54 or more recently, 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride)
in specialty paint.55 is a widely used formaldehyde-donor, for example.60 There
is some concern that use of such formaldehyde releasing
The National Institutes of Health has designated QACs
preservatives (along with many other sources of exposure
categorically as being asthmogenic (causing asthma, not
to formaldehyde) may be contributing to increased
just triggering an asthma attack), irritating (to eyes or skin),
rates of formaldehyde sensitivity in the US population;
flammable and corrosive, harmful to aquatic ecosystems,
however no direct link has yet been demonstrated.61 While
and persistent in the environment. The agency also
formaldehyde is also a recognized carcinogen,62 the ability
recommends that products with these ingredients not be
of small exposures to cause the disease has not been
used where antimicrobial protection is unnecessary.56
determined.63

Costs to Public Health
This widespread use of antimicrobials may be contributing to the emergence of microbes
resistant to them, and more worryingly, resistant to some therapeutic antibiotics used in
the healthcare system.
Antimicrobial resistance occurs when an antimicrobial agent is applied to a microbial

population, but does not kill all of the organisms. The surviving organisms develop an
immunity to the antimicrobial, and go on to reproduce and pass along this immunity.64
Through mutation, some of [the exposed microbes] progeny emerge with resistance to the
antibacterial agent aimed at it, and possibly to other antimicrobial agents as well.65
Antimicrobial resistant organisms are already being found for the additives discussed above.
While not yet widely studied, antimicrobial resistance to silver-based additives has been
reported in strains of Salmonella typhimurium, E. coli, and other bacteria, after exposure to
antimicrobial silver in wound dressings.66
Microbes resistant to triclosan are also appearing. A recent study found the presence of
triclosan in the body can actually promote Staph infections.70 In laboratory experiments
with E. coli, researchers were able to isolate organisms with low, medium, and high levels
of resistance to triclosan. In one experiment, 100 times the concentration of triclosan was
required to kill a resistant strain of E. coli as compared to a strain not yet exposed to the
antimicrobial. These resistant E. coli also showed resistance to a new antibiotic being tested
at the time of the experiment.71
Antimicrobial resistance occurs when an

antimicrobial agent is applied to a microbial
population, but does not kill all of the organisms.
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COSTS TO PUBLIC HEALTH
Of major concern is the possibility that triclosan resistance

may contribute to reduced susceptibility to clinically important
What About the antimicrobials, due to either cross-resistance or co-resistance
Financial Costs? mechanisms. Although the number of studies elucidating the
association between triclosan resistance and resistance to
In its 2013 survey of consumers, other antimicrobials in clinical isolates has been limited, recent
the Dow Chemical Company laboratory studies have confirmed the potential for such a link
found that, consumers are in Escherichia coli and Salmonella enterica. Thus, widespread
willing to pay premiums of 5 to use of triclosan may represent a potential public health risk in
20 percent for particular apparel regard to development of concomitant resistance to clinically
and home furnishings items important antimicrobials.72
with... antimicrobial properties.67
Quaternary ammonia compounds (QACs) may also cause
That price premium also exists antimicrobial resistance when used improperly. In a 2012
in the building products sector. study, researchers exposed E. coli bacteria to increasing
Kaiser Permanente cited the concentrations of three different types of QACs for seven
increased cost of antimicrobial days. They found that regardless of which QAC was used, the
products as part of its rationale exposures led to E. coli populations that had become resistant
for implementing a 2015 to several families of antibiotics. The authors warn that use
ban of antimicrobial building of QACs in too small of doses may lead to the emergence of
products. 68 Further, the cost antibiotic-resistant bacteria and may represent a public health
of an antimicrobial paint used risk.73 A 2004 article coauthored by consumer product giant
by a recent Perkins+Will client Procter & Gamble warned, The use of QACs in the home
was nearly 160% higher than will expose a wide range of environmental and potentially
the cost of a standard paint. 69 pathogenic bacteria to these antimicrobials, often at sublethal
This differential may be fairly concentrations, making the home a potentially high-risk
inconsequential when used in environment for resistance selection.74 A new wall paint on the
small quantities, but will add up market, with television advertising aimed at the general public
quickly when larger spaces are highlighting its continuous protection against bacteria,
considered, and when the costs contains QACs.75
of regularly repainting with this
more expensive product over
time are factored in.

Costs to Environmental Health
If antimicrobials stayed put in the products incorporating them, the costs of using
antimicrobials may end with human and public health impacts. But they dontevidence
is mounting that antimicrobial additives leach out of their host products, ultimately
finding their way into the general environment. This is of particular concern with
nano-scale antimicrobials.
A recent report by the National Institute of Standards and Technology (NIST) found that
nanoparticles can migrate from flooring finishes and indoor paints after cleaning, and can
be present in interior spaces. The report includes a particular caution with regard to small
children who may crawl on such floors, presenting greater opportunity for exposure to these
particles. It also cites a lack of data about how these particles are released, accumulate, and
move within spaces as a barrier to providing a more complete health assessment.76
There is additional evidence that silver-based antimicrobials can leach out of the materials in
which they are incorporated and find their way into the environment. The Swedish Chemicals
Agency tested articles of clothing treated with silver antimicrobials and found that, while the
percentage of silver lost after washing did vary, leaching was common. In at least one case,
98% of the antimicrobial silver was lost over ten washes.77 These silver particles wash down
drains and enter water treatment facilities. Wastewater treatment sludge is sometimes spread
as crop fertilizer or used in landscaping, where they enter the surrounding ecosystem.78
As noted above, nanosilver is considered toxic to aquatic ecosystems, persistent in the
environment, and hazardous to organ systems.79
The Swedish Chemical Inspectorate noted as part of its textile study that silver
concentrations in sewage sludge in Sweden had been on the decline since the photography
industry moved away from chemical development, but that silver concentrations are starting
to accumulate once more: The fact that levels of silver are no longer declining in the
sludge is assumed to be due to increased use of silver as [an antimicrobial additive] in
various articles.80
If antimicrobials stayed put in the products incorporating

them, the costs of using antimicrobials may end with human
and public health impacts. But they dontevidence is
mounting that antimicrobial additives leach out of their
host products, ultimately finding their way into the greater
environment.
perkinswill.com 21
COSTS TO ENVIRONMENTAL HEALTH
By the late 1970s, researchers were finding triclosan The global distribution of triclosan raises concern. It is
contamination in river water and sediments, and in 2002 persistent and bioaccumulativemeaning that it will not
the US Geological Survey named triclosan as one of the break down rapidly in the environment and will increase in
most frequently found contaminants in waterways sampled concentration as it moves up the food chain, is very toxic to
across 30 states. 81 82 In a summary of literature available in aquatic environments, and has known endocrine activity. 84
2014, one researcher writes:
In a collision of unintended consequences, a recent study
[Triclosan] has been detected in drinking water found triclosan-resistant bacteria in the sediments of
resources, 75% of urine samples representative of the waterways, and indications that the presence of triclosan
U.S. population, 97% of representative U.S. breast may result in a less diverse aquatic ecosystem, with fewer
milk samples, and combined [triclosan and related algae available to support an underwater food chain. 85
compound triclocarban] constitute over 60% of the
See Appendix A for more detailed information on the
total mass of 96 pharmaceuticals detectable in
environmental hazards posed by antimicrobials used in
municipal sludge using EPA Method 1694. Indeed, the
building products.
environmental ubiquity of both chemicals has escalated
such that [triclosan, related antimicrobial triclocarban
used in cosmetics,] or both compounds are now
detectable in house dust worldwide, in ocean water, and
locations as remote as the water loop of spacecraft.83
In a collision of unintended consequences, a recent study found

triclosan-resistant bacteria in the sediments of waterways, and
indications that the presence of triclosan may result in a less
diverse aquatic ecosystem, with fewer algae available to support an
underwater food chain.

Antimicrobials in Healthcare Facilities
One sector where the use of antimicrobial building products may be especially tempting is healthcare.
In addition to their primary purpose of restoring patients to health, hospitals must also combat the
spread of hospital-acquired infections (HAIs) such as pneumonia, urinary tract infections, 86 or drug-
resistant staphylococcus (MRSA). These serious infections can be lethal. 87 An estimated one in 25
hospital patients is infected with at least one HAI at any given time in an American hospital. 88
Despite the CDCs 2003 infection control guidance to the contrary, many Perkins+Will healthcare
clients do look to antimicrobial interior finishes and fabrics as a tool in preventing HAIs. Perkins+Will
has identified the following as common factors driving this interest:
Treating patients with HAIs is Patients can look up HAI rates Hospitals fear lawsuits after
expensive and hospitals may and avoid hospitals with more patients contract HAIs.
not be reimbursed. frequent infections. Regardless of how prevalent
In 2009, the CDC estimated The Centers for Medicare and HAIs may be in a given hospital,
that direct medical care needed Medicaid Services created a every case leaves the hospital
to treat hospital-associated website to make rates of HAIs vulnerable to a potential lawsuit
infections cost as much and other information about on the grounds that the hospital
as $33 billion annually. 89 the quality of hospitals publicly was negligent in preventing
Historically, hospitals have available. Where rates of HAIs the infection.92 Hospitals carry
been compensated for these were previously unknown to insurance to protect them from
additional costs by insurance patients,91 this website creates these liabilities,93 and may
and other programs meaning another pressure point for therefore also face pressure
that, while HAIs were certainly hospitals to reduce their from their insurer to bring rates
an unwanted outcome following rates of HAIs in order to of HAIs to as close to zero
a medical procedure, the remain competitive. as possible.
hospital did not feel a financial
pressure to lower the rates of
HAIs. However, recent changes
to Medicare and provisions
under the Affordable Care Act
mean hospitals are increasingly
left to cover the costs of
treating HAIs.90
An estimated 1 in 25 hospital patients

is infected with at least one HAI at any
given time in an American hospital.
perkinswill.com 23
ANTIMICROBIALS IN HEALTHCARE FACILITIES
Hospitals Are Not Immune to Confusing

Antimicrobial Marketing
In 2014 a Florida hospital announced that they had replaced the
conventional scrubs worn by hospital staff in favor of new scrubs,
made from a fabric advertised as repellent to liquids and providing
antimicrobial protection against bacteria contributing to HAIs. 94
However, these claims appear to be based on a single study of these

garments, sponsored by their manufacturer. Researchers reported
that the treated scrubs reduced the level of MRSA organisms found
on the fabric at the end of day as compared to conventional scrubs,
but had no effect on vancomycin-resistant enterococci (VRE) or
gram-negative rod bacteria. The study concluded that further
research is needed to discover whether or not garments of this type
could be beneficial in reducing HAI rates in hospitals. 95 The study
did not address the potential for the materials in these garments to
contribute to antimicrobial resistance.
The study reveals that an antimicrobial additive used in the scrubs

is based on quaternary ammonia; however, the specific substance
is not disclosed, and the Environmental Protection Agency lists
no FIFRA registrations for the company making the scrubs. This
suggests that the manufacturer has not supplied efficacy data to the
agency in support of a health claim.
See Appendix B for more on manufacturer responsibilities with

regard to marketing claims.

When working with healthcare clients, Perkins+Will seeks to remind those who are
interested in installing antimicrobial products in their buildings that, despite the pressures
they may be facing, there continues to be no evidence that these products have any impact
on the rate of HAI occurrence or transmission. Further, the CDCs guidance on infection
control protocols states that, even in the case of patients with compromised immune
systems, the health of all patients is best ensured through proper cleaning practices and
maintenance of building engineering systems (ventilation, etc.). 96
In fact, hospitals are successfully reducing their rates of HAIs without the use of these
products. Kaiser Permanente hospitals, for example, receive the highest possible scores
for hospital safety, 97 due in part to their comprehensive approach to controlling these
infections. This approach focuses on hand hygiene and educational materials geared
toward staff. 98 As previously noted, Kaiser recently instituted a ban of building products
containing certain antimicrobial additives, offering further evidence that these substances
are not needed to successfully combat HAIs.
A 2016 publication by Health Care Without Harm concludes, While antimicrobials in

hospital furnishings may ultimately prove to be efficacious, currently the benefits, risks,
tradeoffs, and costs associated with their use are largely unknown. The authors found that
the growing use of products containing antimicrobials can also further increase the risk of
antibiotic resistance, engender a false sense of security with reduced attention to cleaning
and disinfection, and increase costs of products and materials.99
Kaiser Permanente hospitals, for example,

receive the highest possible scores for hospital
safety, due in part to their comprehensive
approach to controlling these infections.
perkinswill.com 25
Avoiding Antimicrobials in Practice

The primary challenge to avoiding antimicrobials in building products is a lack of
transparency. Particularly with regard to antimicrobial preservatives, it can be
nearly impossible to discover which products contain these additives, and which
additives are used.
Until there is better disclosure, the most foolproof approach to avoiding

antimicrobials is to avoid products marketing this attribute.
But architects and designers can also be proactive about finding antimicrobial-
free materials and finishes. Some manufacturers have eliminated antimicrobials
from some or all of their product lines. Design teams should prefer these
products whenever possible.
While there is currently no certification a product can earn verifying a lack of

antimicrobials, third parties can be a reference when selecting materials. For
example, the Healthy Hospitals Healthy Interiors initiative maintains a list of
furniture manufacturers stating that their products are free of the specific
antimicrobials triclosan and triclocarban.100 Contacting these manufacturersor
manufacturers of any product considered for a building projectto discover if
antimicrobial-free options are available is a good practice.
Another resource for architects and designers is the Pharos Project, which
identifies the common composition of more than 100 products used in building
construction and finishing. These Common Product Profiles identify when the
inclusion of antimicrobial substances is a standard practice in a given product
type.101

Conclusion
In 2003 the Centers for Disease Control and Prevention reviewed the data and concluded there was no
evidence that antimicrobial additives provided a benefit, even in a hospital setting. In
2016, after studying the issue for four decades, the Food and Drug Administration came to the same
conclusion: there is no evidence that antimicrobial additives provide an added benefit.
If one scrutinizes carefully manufacturer claims and marketing, even in the healthcare setting,
one finds no field studies, and no claims that antimicrobial products reduce the need for infection
control measures.
Potential impacts to human and environmental health as a result of these additives may include
antibiotic resistance, and the appearance of antimicrobial additives in ecosystems. Because of
this, project teams should be made aware when antimicrobial products are suggested, or when
antimicrobial additives are found in any product specification. If the antimicrobial functionality is
optional, review the benefits and potential risks with the clientopting out may be the best course.
Ideally, manufacturers would clearly disclose when antimicrobials are added to building products,
the specific additives used, and their purpose within the product. Until this is standard practice, the
designers best course of action is to educate clients interested in antimicrobial products, and explain
why they may want to be avoided.
Perkins+Wills Transparency Site is being updated with a Watch Listsubstances of concern that
are generally unavoidable at this point in time. Antimicrobials, as a group, will be added to this
classification. In addition, the Precautionary List itself will soon include Products Marketed as
Antimicrobial, reflecting the position of the CDC, the FDA, and other credible organizations that have
reviewed the state of evidence on these substances and found them to be unnecessary. The growing
inclusion of antimicrobial additives is at odds with the firms commitment to the health and wellbeing
of people and planet, and with the precautionary principle, which is an integral part of the firms
approach to product evaluation.
Ultimately, the decision to include these products in projects is at the discretion of our clients. The
intentional use of antimicrobials in building products beyond what might be required for product
preservation, in our opinion, should be avoided. Many of our clients request antimicrobial qualities
for products we select; as trusted advisors to our clients, it is our responsibility to provide information
regarding the pitfalls of antimicrobials and lack of proven benefit of their use in practice.
In 2016, after studying the issue for four decades,

the Food and Drug Administration came to the same
conclusion: there is no evidence that antimicrobial
additives provide an added benefit.
perkinswill.com 27
Endnotes
1 For a list of hazards associated with a 9 U.S. Department of Health and Human 20 Cosentino. Silestone USA Bacteriostatic
selection of antimicrobial substances, see Services Centers for Disease Control Protection. Accessed March 25, 2016. http://
Appendix A. and Prevention (CDC). Guidelines for www.silestoneusa.com/what-is-silestone/
Environmental Infection Control in Health- bacteriostatic-protection/
2 Guidelines for Environmental Infection Control
Care Facilities. Centers for Disease Control
in Health-Care Facilities. Centers for Disease 21 See for example, SARGENT Manufacturing
and Prevention, 2003. http://www.cdc.gov/
Control and Prevention, 2003. http://www.cdc. Company. A Whole New Kind of Building
hicpac/pdf/guidelines/eic_in_HCF_03.pdf
gov/hicpac/pdf/guidelines/eic_in_HCF_03.pdf Security. Accessed March 29, 2016. http://
10 Greenfield, Nicole. The Dirt on Antibacterial www.sargentlock.com/solutions/microshield/
3 US Food and Drug Administration. FDA
Soaps. NRDC, March 15, 2016. https://www.
Issues Final Rule on Safety and Effectiveness 22 See for example, US Environmental
nrdc.org/stories/dirt-antibacterial-soaps
of Antibacterial Soaps. FDA News Release, Protection Agency. Agion Silver Antimicrobial
September 2, 2016. http://www.fda.gov/ 11 US Food and Drug Administration. FDA Type AL Label, October 7, 2014. https://
NewsEvents/Newsroom/PressAnnouncements/ Issues Final Rule on Safety and Effectiveness www3.epa.gov/pesticides/chem_search/
ucm517478.htm of Antibacterial Soaps. FDA News Release, ppls/088165-00002-20141007.pdf
September 2, 2016. http://www.fda.gov/
4 See for example, Kaiser Permanente. 23 See for example, Leviton Manufacturing Co.
NewsEvents/Newsroom/PressAnnouncements/
Press Release: Kaiser Permanente Antimicrobial Treated Devices. Accessed
ucm517478.htm
Rejects Antimicrobials for Infection March 28, 2016. http://www.leviton.com/
Control, December 11, 2015. https:// 12 See for example, FTC Charges Companies OA_HTML/SectionDisplay.jsp?section=66321
share.kaiserpermanente.org/article/kaiser- with Bamboo-Zling Consumers with False &minisite=10251
permanente-rejects-antimicrobials-for- Product Claims | Federal Trade Commission.
24 Leviton Manufacturing Co., Inc. Antimicrobial
infection-control/ Accessed March 30, 2016. https://www.ftc.
Treated Devices from Leviton, 2014.
gov/news-events/press-releases/2009/08/
5 US Environmental Protection Agency, OARM. http://www.leviton.com/OA_HTML/
ftc-charges-companies-bamboo-zling-
Pesticides Impact on Indoor Air Quality. ibcGetAttachment.jsp?cItemId=9SsCO-7Ck1
consumers-false-product-claims Press
Overviews and Factsheets. Accessed March nFi0WOCbfU3g&label=IBE&appName=IBE&
Release: The North Face Parent Company,
29, 2016. https://www.epa.gov/indoor-air- LEVCOMP_pses=ZG823CD6CD65D6C24894
Saniguard Marketers, and Califone Fined
quality-iaq/pesticides-impact-indoor-air-quality 60ED2083C88A81F1F11FDF76242E07E35
More Than $500,000 Over Antimicrobial
629C19E119CA10E6C19D24487FA4B8DBC
6 US Department of Health & Human Services. Claims. Accessed March 29, 2016. https://
089655CC8D5199BE0165DAD1F3D8&mini
Understanding Microbes in Sickness and in yosemite.epa.gov/opa/admpress.nsf/0/
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13 Halden, Rolf. On the Need and Speed of
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A. Scheie, E. Arne Hiby, Bjrn-Tore Lunestad,
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Even Heir, Tor ystein Fotland, Kristine 27 Heine, Lauren, Matteo Kausch, Susan
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Antimicrobial Susceptibility. Applied and
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30 US Environmental Protection Agency, OCSPP. 41 Matsumura, Yoshinobu, Kuniaki Yoshikata, 52 McBain, Andrew J., Ruth G. Ledder,
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perkinswill.com 29
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61 Anton C de Groot, Mari-Ann Flyvholm. 72 Yazdankhah, Siamak P., Anne A. Scheie, E. 82 U.S. Geological Survey. Pharmaceuticals,
Formaldehyde-Releasers: Relationship to Arne Hiby, Bjrn-Tore Lunestad, Even Heir, Hormones, and Other Organic Wastewater
Formaldehyde Contact Allergy. Contact Tor ystein Fotland, Kristine Naterstad, and Contaminants in US Streams. US Geological
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Formaldehyde-Releasers. Contact Dermatitis Resistance in Bacteria: An Overview. pubs/FS-027-02/pdf/FS-027-02.pdf
61, no. 2 (2009): 6385. doi:10.1111/ Microbial Drug Resistance (Larchmont, N.Y.)
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Regulating Triclosan and Triclocarban in the
mdr.2006.12.83.
62 International Agency for Research on Cancer. United States. Environmental Science &
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perkinswill.com 31
Appendix A
Health & Environmental
Hazards Associated with
an Abbreviated List of
Antimicrobial Additives
Found in Building
Products (alphabetical)
perkinswill.com 33
Abbreviation, Antimicrobial, CAS No. Hazard Summary Used In
BBIT (2-Butyl-1,2-benzisothiazolin-3-one) Skin Irritation, Aquatic Toxicant 1 Sealants, Adhesives, Caulks, Wallboard, Ceiling
CAS: 4299-07-4 Tiles 2
BIT (1,2-Benzisothiazolin-3-one) Eye Irritation, Skin Sensitization, Paints, Adhesive 4

CAS: 2634-33-5 Aquatic Toxicant 3
Boric Acid Developmental Toxicant, Reproductive Toxicant 5 Wood Products 6

CAS: 12179-04-3
Copper Skin Sensitizer, Organ Toxicant 7 Knobs/Handles, Touchable Surfaces, Ceiling Tiles,
CAS: 7440-50-8 For copper dust: hazards for copper above, Adhesives, Textiles, Plastic articles 9
plus Gene Mutation, Developmental Toxicant,
Mammalian Toxicant, Aquatic Toxicant 8
CMIT or CIT (Methylchloroisothiazolinone) Mammalian Toxicant, Eye Irritation, Skin Irritation Paints/Stains, Adhesives, Caulks, Grout, Wood
CAS: 26172-55-4 and Sensitization, Aquatic Toxicant 10 Products11
CTAC (1-(3-chloroallyl)-3,5,7-triaza-1- Developmental Toxicant, Skin Sensitization12 Adhesives, Caulks, Grouts, Concrete Admixes,
azoniaadamantane chloride) Paints13
CAS: 4080-31-3
DCOIT (4,5-dichloro-2-octyl-2H-isothiazol-3-one) Mammalian Toxicant, Eye and Skin Irritation, Caulks, Sealants, Grouts15
DDAC (Alkyl didecyl dimethyl ammonium chloride) Respiratory Sensitizer, Eye and Skin Irritation, Wood Products17
Elemental Silver / Silver Nanoparticles Mammalian Toxicant, Skin sensitization, Upholstery & Fabrics, Hardware, Touchable
CAS: 7440-22-4 Aquatic Toxicant 18 Surfaces, Tile Installation Products, Ceramic
For silver nanoparticles: Hazards for silver above, Tile, Countertops, Adhesives, Sealants, Paints,
plus Endocrine Disrupter, Organ Toxicant 19 Carpets, Textiles 20
Formaldehyde Carcinogen, Developmental Toxicant, Mutagen, Released into wet-applied products by certain
CAS: 50-00-0 Respiratory Sensitizer, Mammalian Toxicant, Eye preservative additives 22
Irritation, Skin Irritation, Skin Sensitization 21
IPBC (3-iodo-2-propynyl butylcarbamate) Developmental Toxicant, Eye Irritation, Skin Paints/Stains, Wire & Cable, Carpets, Textiles,
CAS: 55406-53-6 Sensitization, Organ Toxicant, Aquatic Toxicant 23 Wood Product 24
MIT (Methylisothiazolinone) Mammalian Toxicant, Skin Irritation and Paints/Stains, Adhesives, Caulks, Grout, Wood
CAS: 2682-20-4 Sensitization, Aquatic Toxicant 25 Products 26
OBPA (Oxybisphenooxyarsine) PBT, Carcinogen, Developmental Toxicant, Flexible PVC, Adhesives, Coatings, Textiles 28
CAS: 58-36-6 Neurotoxicant, Mammalian Toxicant, Organ
Toxicant, Aquatic Toxicant 27
OIT (2-n-octyl-4-isothiazolin-3-one ) Developmental Toxicant, Mutagen, Mammalian Adhesives, Textiles, Wood Products 30
CAS: 26530-20-1 Toxicant, Eye and Skin Irritation, Skin Sensitizer,
Aquatic Toxicant 29
Propiconazole Endocrine Disruptor, Aquatic Toxicant 31 Wood Products, Paints, Coatings, Caulks,
CAS: 60207-90-1 Adhesives 32
QACs (Quaternary Ammonia Compounds) Respiratory Sensitizer, Asthmagen 33 Disinfection Products, Wood Products, Specialty
CAS: specific to individual substances Paints 34
Silver Zeolite At the time of publishing, no authoritative source Paints, Carpet Fibers, Wallpaper, Adhesives,
CAS: 130328-18-6 used in the Pharos Chemical and Material Library Fabrics/Textiles 35
associates this substance with health hazards.
Triclosan (2,4,4-trichloro-2- hydroxy-diphenyl- PBT, Endocrine Disruptor, Aquatic Toxicant 36 Textiles, Plastic Sheets/Parts, Adhesives, Caulk,
ether) Coatings, Tile Installation Products, Hardware,
CAS: 3380-34-5 Ceramic Tile, Carpets, Countertops 37
ZPT (Zinc pyrithione) Reproductive Toxicant, Mammalian Toxicant, Eye Fabrics/Textiles, Wall Coverings, Adhesives,
CAS: 13463-41-7 Irritant, Skin Sensitization, Aquatic Toxicant 38 Caulks, Sealants, Grouts, Joint Compounds 39

Sources for Appendix A
1 European Union, Regulation on the 9 Antimicrobial Copper Alloys - Group I and 20 Irgaguard B 5000 Silver-Zinc Zeolite,
Classification, Labelling and Packaging of Associated Fabricated Products Master Label, 6.20/12. https://pharosproject.net/uploads/
Substances and Mixtures (CLP) Annex 6 August 26, 2014. https://www3.epa.gov/ files/sources/1828/1397591706.pd Silvadur
Table 3-1 - GHS Hazard code criteria. http:// pesticides/chem_search/ppls/082012-00001- AQ Antimicrobial Notice of Pesticide
echa.europa.eu/web/guest/information-on- 20140826.pdf Fuji Chemical Industries. Registration, July 20, 2012. https://
chemicals/cl-inventory-database Bactekiller AC, September 29, 2004. https:// www3.epa.gov/pesticides/chem_search/
www3.epa.gov/pesticides/chem_search/ ppls/000464-00783-20120720.pdf
2 Vanquish 100 Antimicrobial Label, February
ppls/059824-00001-20040929.pdf
8, 2016. https://www3.epa.gov/pesticides/ 21 International Agency for Research on
chem_search/ppls/001258-01249- 10 Republic of Korea, GHS Classification and Cancer (IARC), http://monographs.iarc.
20160208.pdf Labelling for Toxic Chemicals, http://ncis.nier. fr/ENG/Classification/latest_classif.php
go.kr/ghs/hcs/en/search/search_en_01.jsp MAK Commission of Germany List of
3 European Union, Regulation on the
New Zealand HSNO Chemical Classifications Substances with MAK & BAT Values &
Classification, Labelling and Packaging
www.epa.govt.nz/search-databases/Pages/ Categories, http://onlinelibrary.wiley.com/
of Substances and Mixtures (CLP)
HSNO-CCID.aspx book/10.1002/3527600418/homepage/
Annex 6 Table 3-1 - GHS Hazard code
access_to_the_list_of_mak_and_bat_
criteria. http://echa.europa.eu/web/guest/ 11 Kathon 7G Antimicrobial - Notice of Pesticide
values.htm Government of Japan, GHS
information-on-chemicals/cl-inventory- Registration, April 29, 2015. https://
Classifications, http://www.nite.go.jp/en/
database MAK Commission of Germany List www3.epa.gov/pesticides/chem_search/
chem/chrip/chrip_search/intSrhSpcLst?_e_tr
of Substances with MAK & BAT Values & ppls/000464-08135-20150429.pdf
ans=&slScNm=CI_01_001&bcPtn=6; USEPA
Categories, http://onlinelibrary.wiley.com/
12 MAK Commission of Germany List of Extremely Hazardous Substances - EPCRA
book/10.1002/3527600418/homepage/
Substances with MAK & BAT Values & Section 302, https://www.epa.gov/sites/
access_to_the_list_of_mak_and_bat_values.
Categories, http://onlinelibrary.wiley.com/ production/files/2015-03/documents/list_of_
htm
book/10.1002/3527600418/homepage/ lists.pdf
4 Canguard BIT 20 AS Preservative - Notice access_to_the_list_of_mak_and_bat_values.
22 See for example, THOR Specialties, Inc
of Pesticide Reregistration, December 29, htm
Biocides Pioneers in the Development of
2010. https://www3.epa.gov/pesticides/
13 Dowicil 75 Preservative Master Label, March Protection Technology for Biocides for Dry
chem_search/ppls/000464-00719-
8, 2016. https://www3.epa.gov/pesticides/ Film Applications. Accessed March 29, 2016.
20101229.pdf Dow. Canguard BIT 20
chem_search/ppls/000464-00403- http://www.thor.com/usa/biocides.html
DPG Preservative Product Information,
20160308.pdf
April 30, 2005. http://msdssearch.dow. 23 MAK Commission of Germany List of
com/PublishedLiteratureDOWCOM/ 14 New Zealand HSNO Chemical Classifications Substances with MAK & BAT Values &
dh_005b/0901b8038005b792. www.epa.govt.nz/search-databases/Pages/ Categories, http://onlinelibrary.wiley.com/
pdf?filepath=biocides/pdfs/noreg/253-01717. HSNO-CCID.aspx book/10.1002/3527600418/homepage/
pdf&fromPage=GetDoc access_to_the_list_of_mak_and_bat_values.
15 Bioban DC 9P5 Antimicrobial Notice of
htm European Union, Regulation on the
5 European Union, Regulation on the Pesticide Registration, February 24, 2014.
Classification, Labelling and Packaging of
Classification, Labelling and Packaging of https://www3.epa.gov/pesticides/chem_
Substances and Mixtures (CLP) Annex 6
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Table 3-1 - GHS Hazard code criteria. http://
16 Association of Occupational and echa.europa.eu/web/guest/information-on-
echa.europa.eu/web/guest/information-on-
Environmental Clinics Exposure Code List, chemicals/cl-inventory-database
chemicals/cl-inventory-database
http://www.aoec.org/tools.htm
24 Filmguard IPBC 1000 Fungicidal Agent,
6 Borax 5 Mol, November 18, 2011. https://
17 Secure Label, March 6, 2009. https:// December 22, 2009. https://www3.epa.
www3.epa.gov/pesticides/chem_search/ gov/pesticides/chem_search/ppls/000464-
ppls/001624-00001-20111118.pdf
ppls/001022-00592-20090306.pdf 08123-20091222.pdf
7 Government of Japan, GHS Classifications
18 Government of Japan, GHS Classifications, 25 Republic of Korea, GHS Classification and
http://www.nite.go.jp/en/chem/ chrip/
http://www.nite.go.jp/en/chem/chrip/ Labelling for Toxic Chemicals, http://ncis.
chrip_search/intSrhSpcLst?_e_
chrip_search/intSrhSpcLst?_e_trans=&slScN nier.go.kr/ghs/hcs/en/search/search_en_01.
trans=&slScNm=CI_01_001&bcPtn=6
m=CI_01_001&bcPtn=6; New Zealand HSNO jsp MAK Commission of Germany List of
8 Dust hazards may be relevant during Chemical Classifications www.epa.govt.nz/ Substances with MAK & BAT Values &
manufacture, installation, demolition, and search-databases/Pages/HSNO-CCID.aspx Categories, http://onlinelibrary.wiley.com/
during activities such as sawing, sanding, book/10.1002/3527600418/homepage/
19 Government of Japan, GHS Classifications,
grinding, and intensive cleaning, and if the access_to_the_list_of_mak_and_bat_values.
http://www.nite.go.jp/en/chem/
product otherwise degrades during use. htm
chrip/chrip_search/intSrhSpcLst?_e_
The hazard is not otherwise expected to be
trans=&slScNm=CI_01_001&bcPtn=6 New 26 Kathon 7G Antimicrobial - Notice of Pesticide
present during normal use. New Zealand
Zealand HSNO Chemical Classifications www. Registration, April 29, 2015. https://
HSNO Chemical Classifications www.epa.
epa.govt.nz/search-databases/Pages/HSNO- www3.epa.gov/pesticides/chem_search/
govt.nz/search-databases/Pages/HSNO-CCID.
CCID.aspx; The Endocrine Disruptor Exchange ppls/000464-08135-20150429.pdf
aspx; MAK Commission of Germany List
(TEDX) http://www.endocrinedisruption.org/
of Substances with MAK & BAT Values &
popup-chemical-details?chemid=810 Linde,
Nancy. Chemical Hazard Assessment for
book/10.1002/3527600418/homepage/
Nanosilver, Metallic (CAS# 7440-22-4)
access_to_the_list_of_mak_and_bat_values.
[Modified from GreenScreen Version 1.2].
htm
NSF International, October 31, 2015. https://
perkinswill.com 35
Sources for Appendix A
27 Oregon Department of Environmental Quality, 34 NIH QACs webpage http://nems.nih.gov/soc/
Priority Persistent Pollutant (P3) List, www. Pages/Quaternary-Ammonium-Compounds-
deq.state.or.us/wq/SB737; USEPA, Risk (QACs-or-Quats).aspx US Environmental
Management Actions & TSCA Work Plans. Protection Agency. Sanitizer #1 Notice of
www.epa.gov/oppt/existingchemicals/ Pesticide Registration, October 8, 2015.
Philippe Grandjean and Phil Landrigan, https://www3.epa.gov/pesticides/chem_
Developmental neurotoxicity of industrial search/ppls/067603-00013-20151008.pdf
chemicals, List of 201 Chemicals known to
35 Fuji Chemical Industries. Bactekiller A,
be neurotoxic in man, www.fundrogertorne.
October 21, 2003. https://www3.epa.gov/
org/salud-infancia-medio-ambiente/pdf/
pesticides/chem_search/ppls/059824-
developmental-neurotoxicity-of-industrial-
00003-20031218.pdf
chemicals-grandjean-landrigan.pdf USEPA,
Extremely Hazardous Substances - EPCRA 36 Oregon Department of Environmental Quality,
Section 302, https://www.epa.gov/sites/ Priority Persistent Pollutant (P3) List, http://
production/files/2015-03/documents/ www.deq.state.or.us/wq/SB737/docs/
list_of_lists.pdf European Union, Regulation LegRpAtt20100601.pdf European Union,
on the Classification, Labelling and Packaging Regulation on the Classification, Labelling and
of Substances and Mixtures (CLP) Annex 6 Packaging of Substances and Mixtures (CLP)
Table 3-1 - GHS Hazard code criteria http:// Annex 6 Table 3-1 - GHS Hazard code criteria.
echa.europa.eu/web/guest/information-on- http://echa.europa.eu/web/guest/information-
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International Chemical Secretariat, SIN
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(Substitute It Now) List, http://sinlist.chemsec.
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ppls/005383-00125-20140102.pdf
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https://www3.epa.gov/pesticides/chem_
Substances with MAK & BAT Values &
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book/10.1002/3527600418/homepage/ 38 Government of Japan, GHS Classifications,
access_to_the_list_of_mak_and_bat_values. http://www.nite.go.jp/en/chem/chrip/chrip_
htm Republic of Korea, GHS Classification search/intSrhSpcLst?_e_trans=&slScNm=CI_
and Labelling for Toxic Chemicals, http://ncis. 01_001&bcPtn=6
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ppls/001258-00840-20141219.pdf
echa.europa.eu/web/guest/information-on-
chemicals/cl-inventory-database New Zealand
HSNO Chemical Classifications www.epa.govt.
nz/search-databases/Pages/HSNO-CCID.aspx
30 Mergal OIT Technical Notice of Pesticide

Registration, February 18, 2014. https://
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31 The Endocrine Disruptor Exchange (TEDX)

http://www.endocrinedisruption.org/
endocrine-disruption/tedx-list-of-potential-
endocrine-disruptors/overview European Union,
Regulation on the Classification, Labelling and
Packaging of Substances and Mixtures (CLP)
Annex 6 Table 3-1 - GHS Hazard code criteria
ec.europa.eu/enterprise/sectors/chemicals/
documents/classification/
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33 Association of Occupational and

Environmental Clinics Exposure Code List,
http://www.aoec.org/tools.htm

Appendix B
Preservatives Versus
Health Claims: Decoding
Antimicrobial Marketing
perkinswill.com 37
APPENDIX B
Consumers feel a misplaced confidence in antimicrobial building products, in part, because of confusing, and in some
instances, highly misleading marketing materials made possible by the extremely complex regulation governing this sector.
This regulation is known by the acronym FIFRA, which stands for the Federal Insecticide, Fungicide and Rodenticide Act,
and is overseen by the US Environmental Protection Agency.
There are several ways in which FIFRA makes it difficult for the average
person to interpret marketing materials about a products antimicrobial
properties.
1. The EPA must use a case-by-case approach 2. The language considered to be a health
to regulating pesticides.1 claim is very specific.
Rather than regulate antimicrobials by substance, In 2000 the EPA issued a notice attempting to clarify
FIFRA requires the EPA to regulate antimicrobials the distinction between products making health claims
based on how they are used in a product, and how and those considered treated articles. That notice
that product will be marketed. For example, nanoscale lists just seven scenarios where marketing language
silver has the same inherent hazards to humans and constitutes a health claim, and therefore subject to
the environment regardless of its function in a product, regulation under FIFRA:5
or the words used on a products packaging. But
1. A claim that the product controls
the EPA would only consider it subject to regulation
microorganisms that are infectious to the
if a manufacturer wanted to advertise a product
public.
incorporating it as being able to kill microbes that
could make a person sick. This is known as making a 2. Any claim that a product sterilizes, disinfects,
health claim under FIFRA. Cautious that the public kills viruses, or sanitizes.
will see these claims, feel a false sense of security,
3. A claim that uses the specific terms
and let basic sanitation habits lapse, the EPA closely
antibacterial, bactericidal, or germicidal.
monitors the language used to market these products. 2
Manufacturers must also provide documentation that 4. A claim that the product can be used against
the use of the product as intended will not present an infectious fungi.
unreasonable risk to the environment or food supply. 3
5. Claims that the product can control the spread
of allergens because it can control the growth
If the same nanoscale silver compound was added to
of mold or mildew.
an identical product, and as long as the manufacturer
did not seek to make a health claim, the product 6. Any claim that the product will have a benefit
is exempted from further regulation. This is known to public health where it is applied.
as a treated article exemption under FIFRA. The
7. Claiming that a product is antimicrobial
agency does not verify manufacturers assertions
about exempted products abilities to control target without qualifications.
organisms, nor does it evaluate them for health and
environmental impacts.4

3. The language the EPA considers to be Preservatives can also be required in solid materials.
making a health claim is also very subjective.6 For example, additives compounded into plastics
Marketing claims falling outside these parameters can act as a food source to microbes, and make it
are not considered to be health claims, unless they more vulnerable to degradation. As microbes digest
imply a health benefit. Each person may interpret these additives, the plastic can become discolored or
marketing materials differently, making the measure of brittle.11 In 2002, an industry expert reported that the
implication highly subjective. flexible polyvinyl chloride (PVC) industry consumed
most of the antimicrobial additives used in plastics
Further, the agencys guidance assumes consumers in the US. These vinyl products are vulnerable to
will recognize subtle differences in terms the public microbes that digest the plasticizers that make these
tends to think of as synonymous. For example, a products flexible.12 Polyurethanes and polyesters are
product marketing itself as antibacterial is making also especially vulnerable to microbes.13 The shape
a health claim, while the term antimicrobial is of a plastic article is another factor its ability to
considered suitable for marketing a treated article, as resist microbes, as items with more surface area will
long as the marketing specifies elsewhere that the degrade more quickly.14
microbes in question arent those that will make a Manufacturers also treat bio-based materials with
person sick. antimicrobial additives. For example, fungi present in
freshly sawn logs can create a blue stain on planks
4. While they do not benefit our health, milled from the wood, called sapstain. Sawmills
some products require antimicrobials for routinely dip or spray fresh lumber in a solution
preservation. of anti-sapstain treatments to prevent this, and to
prevent future rot from secondary fungal growth.15
The treated article exemption is intended for
Further, the addition of bio-based materials to
preservatives because in these instances, anti-
polymers (vegetable oils in plastics, wood dust in
microbials only protect the product from spoilage,
composite decking, etc.) increases vulnerability to
degradation or damage caused by microorganisms.
microbial action, and these products may require
These microbes can use a wide variety of substances
higher levels of preservatives than would have been
as food,7 and only require water to begin to grow and
necessary otherwise.16
multiply, often negatively impacting the aesthetic and/
or performance characteristics of a product. 8 Because
of their water content, wet-applied products (paints,
coatings, etc.) are inherently vulnerable to microbes.
As a result, water-based paints, adhesives, and other
wet-applied products typically contain preservatives
to prevent microbial activity during the products
storage,9 or to protect the surface of the paint, caulk,
etc., once it has been applied and has dried.10
perkinswill.com 39
APPENDIX B
FIFRA provides an opportunity for manufacturers to mislead advises that they be cleaned just as frequently as standard
consumers about the benefits of antimicrobial products, hardware would be, 22 so it is unclear what advantage this
whether they intend to do so or not. antimicrobial additive provides in practice.
The term registration can be interpreted by A third example of this phenomenon is of light switches
consumers to be an indication of the EPAs seal of and covers that are coated with an antimicrobial additive. 23
approval. Product literature highlights independent laboratory testing
showing the additive is effective against bacteria such as
All substances that can be used as pesticides need to
MRSA (a drug-resistant strain of staphylococcus), while
be registered with the EPA. The agency then gives the
only briefly confirming elsewhere, in smaller text, that the
substance a unique registration number, and adds it to a
antimicrobial additive is present only as a preservative
database. (The EPA estimates that 275 substances are
that protects the switch and cover from mold, mildew, and
registered with the Agency as pesticides.)17 Advertising can
other microbes that may jeopardize the integrity of the
include statements that a building product contains an EPA
product.24 This disclaimer confirms that despite listing
registered antimicrobial and is resistant to X, Y, or Z. While
infectious MRSA as a microbe targeted by the antimicrobial
a consumer may interpret this to mean that the EPA has
additive, the additive is a preservative only, and is not
reviewed the antimicrobial in question and has issued a
formally making a health claim under FIFRA.
registration as an indication that it is effective, beneficial, or
even harmless, the reality is that the EPA registration simply The EPA is concerned about the growing use of a wide
indicates that the antimicrobial additive is considered a variety of antimicrobial claims made in marketing materials.
pesticide by the agency. The agency takes very seriously public health claims it
finds to be unsubstantiated. 25 At the time of publication, a
Remember that in the case of treated articles, the EPA does
search of the EPAs database of Administrative Enforcement
not verify manufacturer claims of efficacy against microbes,
Dockets related to FIFRA infractions returned 1,000 case
or evaluate its health or environmental impacts.18
numbers, dating back to 2000. 26
Antimicrobial ingredients may be added to building
In a 1998 bulletin, the agency warned:
products as preservatives even though the products do
not require preservationas a marketing ploy. EPA is concerned about these statements because,
in addition to being unlawful, they are also potentially
For example, looking for a way to innovate and differentiate
harmful to the publicif people believe that the
from their competition, a countertop company incorporated
product has a self-sanitizing quality, they may not
an antimicrobial into an engineered stone product. Despite
practice standard hygiene to prevent the transmission
the fact that this additive is a preservativeand has no
of harmful germs. Consequently public health may be
benefit to human healththe company saw a 38% rise
less protected. For that reason, EPA advises consumers
in annual revenue, and a 48% increase in market share.19
not to rely on antibacterial claims as a substitute for
Since the antimicrobial was added to the product in an
following common-sense hygienic practices. EPA
effort to innovate and differentiate, and research
does not know whether these treated products work
finds that engineered stone countertops do not uniformly
as claimed.27
require a preservative, 20 it is difficult to believe that this
antimicrobial was a necessary additive.
In another example, door hardware coated with

antimicrobials are available. The antimicrobial is a
preservative only, and is added to protect the hardware
from mold, mildew, and odor-causing bacteria. 21 How
endemic is the problem of moldy door knobs that this
coating is necessary? The manufacturer of the hardware

Sources for Appendix B
1 The ACTA Group, L.L.C. Recent Regulatory 12 Markarian, Jennifer. Antimicrobial Plastics 24 Leviton Manufacturing Co., Inc. Antimicrobial
Developments. Accessed April 12, 2016. Additives: Trends and Latest Developments Treated Devices from Leviton, 2014.
http://www.actagroup.com/regulatory- in North America. Plastics, Additives http://www.leviton.com/OA_HTML/
developments/update/monthly-update- and Compounding 4, no. 12 (December ibcGetAttachment.jsp?cItemId=9SsCO-7Ck1
april-2015 2002): 1821. doi:10.1016/S1464- nFi0WOCbfU3g&label=IBE&appName=IBE&
391X(02)80162-3. LEVCOMP_pses=ZG823CD6CD65D6C24894
2 US Environmental Protection Agency, OARM.
60ED2083C88A81F1F11FDF76242E07E35
Consumer Products Treated with Pesticides, 13 Gadd, Geoffrey Michael. Fungi in
629C19E119CA10E6C19D24487FA4B8DBC
April 1998 (1). Biogeochemical Cycles. Cambridge University
089655CC8D5199BE0165DAD1F3D8&mini
Press, 2006.
3 US Environmental Protection Agency, site=10251
OA. Summary of the Federal Insecticide, 14 Chalmers, John M., and Robert J. Meier.
25 US Environmental Protection Agency. Press
Fungicide, and Rodenticide Act. Overviews Molecular Characterization and Analysis of
Release: The North Face Parent Company,
and Factsheets. Accessed March 29, 2016. Polymers. Elsevier, 2008.
Saniguard Marketers, and Califone Fined
https://www.epa.gov/laws-regulations/
15 Szenasy, Erika. Assessing the Potential More Than $500,000 Over Antimicrobial
summary-federal-insecticide-fungicide-and-
Impact of the Antisapstain Chemicals, DDAC Claims. Accessed March 29, 2016. https://
rodenticide-act
and IPBC, in the Fraser River. Environment yosemite.epa.gov/opa/admpress.nsf/0/
4 Schettler, Ted. Antimicrobials in Hospital Canada, April 1, 1999. https://pharosproject. AC0C1AF1625888608525771B00561E83
Furnishings: Do They Help Reduce Healthcare- net/uploads/files/sources/1828/1329771116.
26 US Environmental Protection Agency. EPA
Associated Infections? Health Care Without pdf
Administrative Enforcement Dockets - FIFRA.
Harm. Accessed March 30, 2016 (16). https://
16 Markarian, Jennifer. Rethinking Biocides for Accessed March 25, 2016. https://yosemite.
noharm-uscanada.org/sites/default/files/
Plastics. Compounding World, July 2013. epa.gov/OA/RHC/EPAAdmin.nsf/Advanced%20
documents-files/3854/Antimicrobials%20
Search?SearchView&Query=fifra&SearchM
Report%202016_0.pdf 17 US Environmental Protection Agency, OCSPP.
ax=0
What Are Antimicrobial Pesticides? Overviews
5 US Environmental Protection Agency.
and Factsheets. Accessed March 28, 2016. 27 US Environmental Protection Agency, OARM.
Pesticide Registration Notice 2000. US EPA,
https://www.epa.gov/pesticide-registration/ Consumer Products Treated with Pesticides,
March 6, 2000.
what-are-antimicrobial-pesticides April 1998.
6 US Environmental Protection Agency.
18 Schettler, Ted. Antimicrobials in Hospital
Pesticide Registration Notice 2000. US EPA,
Furnishings: Do They Help Reduce Healthcare-
March 6, 2000.
Associated Infections? Health Care Without
7 Gerritsen, Lonne. Evaluation Manual for the Harm. Accessed March 30, 2016 (16). https://
Authorisation of Plant Protection Products and noharm-uscanada.org/sites/default/files/
Biocides. Board for the Authorisation of plant documents-files/3854/Antimicrobials%20
protection products and biocides, January Report%202016_0.pdf
2013. http://ctgb.nl/docs/default-source/
19 Microban International. Silestone Case
toetsingskader-biociden/Evaluation-Manual-
Study. Accessed March 29, 2016. http://
biocides-EU-part/b_7_efficacy_pt6_in_can_
www.microban.com/about-microban/case-
preservatives_eu_em_1-.pdf?sfvrsn=2
studies/silestone-case-study.
8 Nichols, Dean. Antimicrobial Additives
20 Healthy Building Network. Common
in Plastics and the European Biocidal
Product: Engineered Stone. Pharos Project,
Products Directive. Plastics, Additives and
2016. https://pharosproject.net/material/
Compounding 4, no. 12 (December 2002):
show/2078889
1417. doi:10.1016/S1464-391X(02)80161-1.
21 See for example, US Environmental
9 Gerritsen, Lonne. Evaluation Manual for the
Protection Agency. Agion Silver Antimicrobial
Authorisation of Plant Protection Products and
Type AL Label, October 7, 2014. https://
Biocides. Board for the Authorisation of plant
protection products and biocides, January
ppls/088165-00002-20141007.pdf
2013. http://ctgb.nl/docs/default-source/
toetsingskader-biociden/Evaluation-Manual- 22 SARGENT Manufacturing Company,. A Whole
biocides-EU-part/b_7_efficacy_pt6_in_can_ New Kind of Building Security. Accessed
preservatives_eu_em_1-.pdf?sfvrsn=2 March 29, 2016. http://www.sargentlock.com/
solutions/microshield/
10 European Commission. What Are Biocides
and How Widely Are They Used? Accessed 23 See for example, Leviton Manufacturing Co.
March 28, 2016. http://ec.europa.eu/health/ Antimicrobial Treated Devices. Accessed
opinions/en/biocides-antibiotic-resistance/l- March 28, 2016. http://www.leviton.com/
3/1-definition-antimicrobials.htm OA_HTML/SectionDisplay.jsp?section=66321
&minisite=10251
11 Chalmers, John M., and Robert J. Meier.
Molecular Characterization and Analysis of
Polymers. Elsevier, 2008.
perkinswill.com 41
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A PERKINS +WILL WHITE PAPER /

Healthy Building Network

Tom Lent, Policy Director, Healthy Building Network

Susan Sabella, Chief Operations Officer, Healthy Building Network

Jim Vallette, Research Director, Healthy Building Network

Suzanne Drake, Co-Director Materials Performance Lab, Senior Associate, Perkins+Will

Robin Guenther, Principal, Perkins+Will

Max Richter, Co-Director Materials Performance Lab, Associate, Perkins+Will

Brodie Stephens, General Counsel, Perkins+Will

2 Understanding Antimicrobial Ingredients in Building Materials

The Healthy Building Network is a research-based not-for-profit organization focused on advancing

Special thanks to our peer reviewers

Casey Johnson, Business Development Manager/ Sustainable Director North America,

Jennifer MacDaniel, Project Principal, Kaiser Permanente

Antimicrobials Become Mainstream 10

Costs to Human Health 14

d. Quaternary Ammonia Compounds 18

Costs to Public Health 19

Costs to Environmental Health 21

Antimicrobials in Healthcare Facilities 23

Appendix A: Health & Environmental Hazards Associated with Antimicrobials 33

Appendix B: Preservatives Versus Health Claims: Decoding Antimicrobial Marketing 37

The purpose of this paper is to provide useful

6 Understanding Antimicrobial Ingredients in Building Materials

Words for the Wise

Anti-bacterial, Anti-fungal, and Anti-viral: used to describe antimicrobial

Microbiocide, Microbiocidal, or Microbicidal

8 Understanding Antimicrobial Ingredients in Building Materials

Available evidence supports the same conclusion drawn by the

The Precautionary List:

10 Understanding Antimicrobial Ingredients in Building Materials

Abbreviation, Antimicrobial, CAS No. Used In

BBIT (2-Butyl-1,2-benzisothiazolin-3-one) Sealants, Adhesives, Caulks, Wallboard, Ceiling Tiles

BIT (1,2-Benzisothiazolin-3-one) Paints, Adhesive

Boric Acid Wood Products

CMIT or CIT (Methylchloroisothiazolinone) Paints/Stains, Adhesives, Caulks, Grout, Wood Products

Copper Knobs/Handles, Touchable Surfaces, Ceiling Tiles

CTAC (1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride) Adhesives, Caulks, Grouts, Concrete Admixes, Paints

DCOIT (4,5-dichloro-2-octyl-2H-isothiazol-3-one) Caulks, Sealants, Grouts

DDAC (Alkyl didecyl dimethyl ammonium chloride) Wood Products

Formaldehyde Released into wet-applied products by certain preservative

MIT (Methylisothiazolinone) Paints/Stains, Adhesives, Caulks, Grout, Wood Products

OBPA (Oxybisphenooxyarsine) Flexible PVC, Adhesives, Coatings, Textiles

OIT (2-n-octyl-4-isothiazolin-3-one ) Adhesives, Textiles, Wood Products

Propiconazole Wood Products, Paints, Coatings, Caulks, Adhesives

QACs (Quaternary Ammonia Compounds)

Triclosan (2,4,4-trichloro-2- hydroxy-diphenyl-ether) Textiles, Plastic Sheets/Parts, Adhesives, Caulk, Coatings,

ZPT (Zinc pyrithione) Fabrics/Textiles, Wall Coverings, Adhesives, Caulks, Sealants,

ANTIMICROBIALS BECOME MAINSTREAM

See Appendix B for more information on marketing claims.

Likewise, commercial door hardware is available

12 Understanding Antimicrobial Ingredients in Building Materials

Safety Data Sheets (commonly referred to as SDS or MSDS sheets)

Costs to Human Health

Triclosan is part of a family of molecules called

14 Understanding Antimicrobial Ingredients in Building Materials

COSTS TO HUMAN HEALTH

It is clear that nanosilver is an effective antimicrobial, but what is not clear