03.cleveland Clinic of Pediatrics - Selected Questions PDF
03.cleveland Clinic of Pediatrics - Selected Questions PDF
03.cleveland Clinic of Pediatrics - Selected Questions PDF
a) In comparison with whole-cell vaccines, acellular pertussis vaccines have superior efficacy.
b) Acellular vaccines are less reactogenic than whole-cell vaccines.
c) Immunocompromised children should not be vaccinated with acellular pertussis vaccines.
d) Both a and b.
a) 7-valent conjugate vaccine is indicated for all children 2 years of age and older.
b) 23-valent polysaccharide vaccine is not immunogenic in children younger than 2 years.
c) Children with congenital immunodeficiencies should receive polysaccharide pneumococcal
vaccination rather than conjugate vaccine.
d) Polysaccharide pneumococcal vaccine is associated with significant adverse reactions, as
compared to conjugate vaccine.
23. A 7-month old infant on parenteral feeding is transferred to your hospital. During the
examination, you note perioral and perianal scaling and erythema.
This most likely is a manifestation of a deficiency of:
a. Vitamin D
b. Zinc
c. Vitamin A
d. Selenium
e. Copper
4. Which of the following statements are true for children?
a) Approximately 90% of infants of mothers with chronic hepatitis B infection acquire the
infection at birth, even if vaccine and Ig are administered within the first 48 hours of birth.
b) The risk for maternal to infant transmission of HCV is increased in mothers who are
coinfected with HIV or who have a high viral load of HCV at the time of delivery.
c) Currently, no effective treatment is available for chronic HBV infection in children.
d) Hepatitis E infection is acquired primarily by parenteral exposure.
e) Both b and d.
a. Vitamin A
b. Vitamin B12
c. Vitamin D
d. Vitamin E
e. Zinc
7. An otherwise healthy 6-day-old white female infant is brought to your office for evaluation of
blood in the stool. She was delivered at home without complication and has been exclusively
breast-fed. She has not been examined previously by a physician. On examination, she has what
appear to be areas of ecchymosis over the buttocks and lower extremities. She is mildly
tachycardic and her stool is grossly bloody. Physical examination is otherwise normal.
Of the following, what is the most likely diagnosis?
a. Sepsis
b. Salmonella infection
c. Hemorrhagic disease of the newborn
d. Physical abuse
e. Colonic polyposis
8. A 14-year-old girl presents with an 8-month history of intermittent low-grade fevers and right
lower quadrant pain. Her appetite has been decreasing, as pain worsens with eating. Her weight
and height have decreased from the 50th percentile to below the 10th percentile for her age over
the past 2 years and her parents are concerned that she has developed an eating disorder. On
examination, the patient has mild right lower quadrant pain and fullness. No peritoneal signs are
present. Her stool is Hemoccult positive.
Of the following, the most appropriate initial diagnostic test would be:
a) Low C3 level
b) Calcium oxalate crystals on urinalysis
c) Urine with a specific gravity of 1.020 and a pH of 5.0, and a red blood cell cast on
microscopic examination
d) Evidence of hemolytic anemia with anisocytosis and poikilocytosis and very few platelets
demonstrated on a smear
10. Which of the following statements is false regarding congenital nephrotic syndrome?
a) The prognosis is dismal, with death often occurring within the first year.
b) It can be inherited as an autosomal-recessive trait.
c) It is associated with an abnormally large placenta.
d) It is associated with polyhydramnios.
e) Major causes of death are early renal failure and hyperkalemia.
3. Which of the following tests best differentiates subacute thyroiditis from Graves disease?
a) Free T4
b) TSH
c) Radioactive iodide uptake scan
d) Erythrocyte sedimentation rate
5. A low total T4 level and a normal TSH level in an otherwise healthy child is most likely
caused by:
5. Which of the following potential side effects has not been attributed to growth hormone
treatment?
a) Hepatitis
b) Pseudotumor cerebri
c) Growth of nevi
d) Slipped femoral capital epiphysis
13. You are called to the neonatal nursery to see a jittery newborn. The examination reveals a
healthy-looking infant except for microphallus and jitteriness. His blood glucose is 15 mg/dL.
An intravenous bolus of 10% dextrose in water is given and an infusion of dextrose in water is
administered. The next most appropriate step is to:
14. A 4-year-old child is brought to the emergency department with tetany. The serum calcium
level is 6.0 mg/dL, phosphate 9.6 mg/dL, and alkaline phosphatase 586 U/dL.
All of the following statements are true regarding pseudohypoparathyroidism, except:
3. A full-term newborn with a history of polyhydramnios presents shortly after birth with
tachypnea, asymmetric breath sounds, and a scaphoid abdomen. An arterial blood gas study
reveals hypoxemia and a mixed metabolic and respiratory acidosis.
The most likely diagnosis is:
1. Of the following, the organism least likely to cause early-onset neonatal sepsis is:
a) L. monocytogenes
b) Group B streptococci
c) Streptococcus pneumoniae
d) E. coli
2. All of the following are important causes of late-onset neonatal sepsis, except:
a) Streptococcus pyogenes
b) Coagulase-negative staphylococci
c) S. aureus
d) Gram-negative bacilli
e) Candida albicans
a) Rubella
b) CMV infection
c) Syphilis
d) Toxoplasmosis
12. A 1-month-old infant is seen in the outpatient clinic for a routine visit. The mother gives a
history of poor feeding and unsatisfactory weight gain. She states that the infant's 5-year-old
sibling had a similar history at this age. On further questioning, the mother reveals that the
sibling has delayed development. On examination, the infant has facial dysmorphic features that
include maxillary hypoplasia and an absent philtrum.
Which of the following is true regarding the infant's condition?
2. All of the following cardiac conditions can present with heart failure in the first 6 weeks of
life, except:
a) Pulmonary stenosis
b) Dilated cardiomyopathy
c) Atrial septal defect
d) Hypertrophic cardiomyopathy
e) Aortic stenosis
4. The most common presentation of coarctation of the aorta in infancy and childhood is:
a) Supraventricular tachycardia
b) Syncope
c) Hypertension and absent femoral pulses
d) Endocarditis
e) Congestive heart failure
6. The most common cause of syncope in childhood is:
9. Appropriate therapy for patients who have neurocardiogenic or vasovagal syncope includes:
a) β-Blockers
b) Increased intake of fluids and sodium
c) Mineralocorticoids
d) All of the above
1.While performing ultrasonography on the mother of a 31-week fetus, an obstetrician notes that
the heart rate ranges from 62 to 66 beats/minute. The fetal growth appears normal, and no
structural cardiac anomalies are identified. On performing echocardiography, the fetal atria
appear to be contracting at 140 beats/minute, with a ventricular rate of 65 beats/minute.
Which of the following is the next step in the management of this fetus/infant?
a. Alopecia universalis
b. Cranial bruits
c. Hepatosplenomegaly
d. Rotary nystagmus
e. Sensorineural hearing loss
17. During the preschool physical examination of a 4-year-old child, you note a grade 2/6 high-
pitched continuous murmur in the third right intercostal space while the patient is in the sitting
position. The murmur is ablated by compressing the child's neck veins.
Of the following, the most likely diagnosis is:
20.Following an uncomplicated delivery, cyanosis develops in a 3.7-kg term infant during the
first hour of life. The findings at 3 hours of age include cyanosis, heart rate of 140 beats/minute,
respiratory rate of 56 breaths/minute, and no heart murmurs. The pulse oximetry reading in room
air is 70% in the right hand and 75% in the foot; with a 100% fraction of inspired oxygen (FIO2)
by head hood, the oxygen saturation remains 70% in the hand but increases to 90% in the foot.
The chest roentgenographic findings are normal.
These findings are most consistent with:
a. Short PR interval
b. Anorexia
c. Lethargy
d. Supraventricular arrhythmias
e. Ventricular arrhythmias
26. In an infant with a left-to-right shunt, which of the following is a true statement?
28.A systolic ejection murmur is detected in a highly competitive 16-year-old high school athlete
during a routine examination required before participation in sports. The electrocardiogram
demonstrates a sinus bradycardia (50 beats/minute) and borderline left ventricular hypertrophy.
Echocardiography reveals mildly enlarged left and right ventricles with a ventricular shortening
fraction of 40% (normal >28%).
Of the following, the most likely explanation for these findings is:
a. Autonomic dysfunction
b. Cardiovascular response to athletic training
c. Early evidence of dilated cardiomyopathy
d. Early evidence of hypertrophic cardiomyopathy
e. Myocarditis
a) Honeybee
b) Wasp
c) Yellow jacket
d) White-faced hornet
e) Imported fire ant
2. A 7-year-old girl presents with a history of episodic severe swelling at areas of trauma without
pruritus. Her father has a similar history. The single best screening test for her condition should
determine:
a) C3 level
b) C1 inhibitor level
c) Total serum hemolytic complement (CH50)
d) C4 level
e) Serum IgE concentration
4. Patients with which of the following reactions are candidates for bee venom skin testing and
immunotherapy?
a) Immediate large local swelling at the sting site with redness and swelling of the entire
extremity
b) Immediate large local reaction at the sting site with urticaria over the entire body
c) Moderate swelling at the sting site with the development of diffuse urticaria and joint pain 5
days later
d) Immediate swelling at the sting site with wheezing (in a patient with asthma)
2. A 15-month-old female infant has been hospitalized for several serious infections caused by
Staphylococcus aureus, including osteomyelitis, hepatic abscess and pneumonia with
pneumatocele formation. What is the most likely diagnosis?
a. Wiskott-Aldrich syndrome
b. Selective immunoglobulin A (IgA) deficiency
c. Leukocyte adhesion deficiency
d. Common variable immunodeficiency (CVID)
e. Chronic granulomatous disease (CGD)
7. The mother of a 3-month-old breast-fed infant asks you about recommendations for the
introduction of new foods to the infant's diet. The 4-year-old brother of the infant has a history
significant for egg allergy including an anaphylactic reaction.
What should you tell the mother?
13. A 17-year-old boy has a history of an adverse reaction to radiocontrast media (RCM) 2 years
ago that included diffuse pruritus and urticaria accompanied by hypotension.
Which statement is true regarding his adverse reaction to RCM?
14. Two days ago, an 8-year-old boy completed a 10-day course of oral amoxicillin. He also
developed fever, malaise, arthralgia of multiple joints, nausea and diarrhea two days ago. Today,
he developed urticaria.
By the Gell and Coombs classification of human hypersensitivity,
what type of adverse reaction is he experiencing?
a. Type I
b. Type II
c. Type III
d. Type IV
a) The port wine stain associated with this syndrome is commonly bilateral.
b) Ophthalmic and CNS manifestations always accompany the nevus.
c) Seizures are a common complication of the syndrome.
d) A chromosomal abnormality has been proved for this syndrome.
a) DMD
b) BMD
c) EDMD
d) Myotonic dystrophy
a) DMD
b) Myotubular myopathy
c) CMD
d) LGMD
e) Congenital fiber-type disproportion
3. A 7-year-old girl is being evaluated for repetitive episodes of vomiting, which have required
eight prior hospitalizations for intravenous rehydration. Her examination in your office is
normal. She had a brother who died at 3 days of life, and the coroner ruled that the death was due
to sudden infant death syndrome. The most likely laboratory abnormalities that would be noted
during the next exacerbation would be:
a. Elevated blood ammonia level with low blood urea nitrogen (BUN) levels
b. Elevated blood and cerebrospinal fluid (CSF) glycine levels
c. Low CSF glucose with normal blood glucose
d. Normal blood glucose level with no urine ketones
e. Elevated blood glucose level with no urine ketones
1. The skills of kicking a ball and jumping in place are gross motor milestones that occur at
which age?
a) 15 months
b) 18 months
c) 24 months
d) 30 months
a) Ride a bicycle
b) Hop on one foot
c) Skip by alternating the feet
d) Tandem walk backward
a) 8 months
b) 10 months
c) 15 months
d) 18 months
a) 15 months
b) 16 months
c) 18 months
d) 24 months
5. A vocabulary of 50 or more words and the ability to speak in two- and three-word sentences
should be acquired by what age?
a) 15 months
b) 18 months
c) 24 months
d) 30 months
6. Screening of a newborn has detected a hemoglobinopathy with Hb Bart's. All of the following
statements are true, except:
2. Which of the following are the two most important prognostic indicators in children in whom
ALL is diagnosed?
a) Lymphoma
b) Wilms tumor
c) Hepatoblastoma
d) Neuroblastoma
e) Retinoblastoma
f) None of the above
4. A chest radiograph reveals a posterior mediastinal mass. The most likely tumor diagnosis is:
a) Hodgkin disease
b) Rhabdomyosarcoma
c) Neuroblastoma
d) Ewing sarcoma
e) Lymphocytic lymphoma
a. Hepatoblastoma
b. Burkitt lymphoma
c. Hodgkin disease
d. Primitive neuroectodermal tumor (Ewing sarcoma) of the spinal cord
e. Neuroblastoma
14. Proptosis as a presenting sign is more commonly seen in which of the following pediatric
tumors:
a. Hodgkin disease
b. Retinoblastoma
c. Ewing sarcoma
d. Rhabdomyosarcoma
e. T-cell acute lymphoblastic leukemia
f. Primitive neuroectodermal tumor
16. A 15-year-old boy has difficulty breathing when lying flat in his bed. When he sits up, he has
no trouble breathing.
What would you expect to find on his physical examination?
20. Awell-appearing, well-nourished, asymptomatic 2-year-old boy presents to your office with a
large abdominal mass.
Which of the following radiographic studies is not indicated?