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Drug List

The document provides information on the uses, dosages, routes of administration, onset times, and other details for various anesthetic agents divided into categories including barbiturates, benzodiazepines, opioids, induction agents, muscle relaxants, local anesthetics, anticholinergics, cholinesterase inhibitors, adrenergic agonists, gastrointestinal drugs, and adjunct anesthetics. For each agent, information is given on its half-saturation, total volume, use, dose, metabolism, excretion, and dosing interval.

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166 views8 pages

Drug List

The document provides information on the uses, dosages, routes of administration, onset times, and other details for various anesthetic agents divided into categories including barbiturates, benzodiazepines, opioids, induction agents, muscle relaxants, local anesthetics, anticholinergics, cholinesterase inhibitors, adrenergic agonists, gastrointestinal drugs, and adjunct anesthetics. For each agent, information is given on its half-saturation, total volume, use, dose, metabolism, excretion, and dosing interval.

Uploaded by

peachandmints
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as XLSX, PDF, TXT or read online on Scribd
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Uses and Dosage of Barbiturates

Agent HS Total Volume Use Route Dose (mg/kg) Onset


Thiopental induction iv 3-6 30-60 sec
sedation iv 0.5-1.5 30-60 sec

Uses and Dosage of Benzodiazepines


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Diazepam 5 mg Premedication oral 0.2-0.5 15-45 min
5 mg/ml Sedation iv 0.04-0.2 1-5 min
Induction iv 0.3-0.6 1-5 min
Midazolam 5 mg/ml 1 ml Premedication im 0.07-0.15 15 min
Sedation iv 0.01-0.1 2-3 min
Induction iv 0.1-0.4 2-3 min
Lorazepam 2 mg Premedication Oral 0.05 45 min

Uses and Dosage of Opioids


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Morphine 1 mg/ml Premedication im 0.05-0.2
Intra op analgesia iv 0.1-1 15-30 min
Post op analgesia iv 0.03-0.15 15-30 min
Pethidine 10 mg/ml Premedication im 0.5-1 rapid
Intra op analgesia iv 2.5-5 rapid
Post op analgesia iv 0.2-0.5 rapid
Fentanyl 50 mcg/ml 2 ml Pre Induction iv 1-3 mcg/kg 6 min
Intra op analgesia iv 2-150 mcg/kg 6 min
Post op analgesia iv 0.5-1.5 mcg/kg 6 min

Uses and Dosage of Ketamine, Etomidate and Propofol


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Ketamine 50 mg/ml Induction iv 1-2 30 sec
Induction im 3-5
Analgesia iv 0.05-0.1 30 sec
Etomidate 2 mg/ml Induction iv 0.2-0.5 30-60 sec
Propofol 10 mg/ml 20 ml Induction iv 1-2.5 30-45 sec
Maintenance iv 50-200 mcg/kg 30-45 sec
Sedation iv 25-100 mcg/kg 30-45 sec

Uses and Dosage of Muscle Relaxants


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Succinylcholine 20 mg/ml Intubation iv 1-1.5 30-60 sec
Maintenance iv 0.15 30-60 sec
Infusion iv 2-15 30-60 sec
Rocuronium 10 mg/ml 5 ml Intubation iv 0.6-1.2 1-2 min
Maintenance iv 0.15 1-2 min
Infusion iv 3-12 mcg/min 1-2 min
Atracurium 10 mg/ml Intubation iv 0.4-0.5 2-2.5 min
Maintenance iv 0.1 2-2.5 min
Infusion iv 4-12 mcg/min 2-2.5 min

Uses and Dosage of Local Anesthetic


Agent HS Total Volume Use Route Toxic (mg/kg) Onset
Bupivacaine 5 mg/ml All iv 3 15-30 min
Lidocaine 20 mg/ml All iv 4.5 45-90 sec

Uses and Dosage of Anticholinergic


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Atropine 0.5 mg/ml iv 0.01-0.02 < 1 hr

Uses and Dosage of Cholinesterase Inhibitors


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Neostigmin 1 mg/ml Reverse Relaxants iv 0.04-0.08 5-10 min

Uses and Dosage of Adrenergic Agonist


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Clonidine 0.5 mg/ml Antihipertensive iv 1-3 mcg/kg < 1 hr
Intrathecal 75-150 mcg < 1 hr
Epidural 30 mcg/hr < 1 hr
Ephedrine 50 mg/ml Hypotension iv 0.1 rapid

Uses and Dosage of Gastro Intestinal Related Drugs


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Ranitidin 25 mg/ml Increase Gastric pH iv 1 - 2.5 1-2 hr
Omeprazole 20 mg Increase Gastric pH po 0.35 1 hr
Metoclopramide 10 mg/ml Anti Emetic iv 0.25 - 1.8 1-3 min

Uses and Dosage of Adjunct Anesthesia


Agent HS Total Volume Use Route Dose (mg/kg) Onset
Ketorolac 30 mg/ml Analgesia iv 0.25-1 1-3 min
Post op analgesia po 30-60 min
Tramadol 50 mg/ml Analgesia iv 1-3 45-60 min
Paracetamol 10 mg/ml Analgesia iv 10-15 15-30 min
Post op analgesia po 10-15
Ondansetron 4 mg/ml Anti Emetic iv 0.15 5 min
Naloxone 1 mg/ml Opioid Reverse iv 1-4 mcg/kg 1-2 min
Continous iv 5 mcg/kg/hr 1-2 min
Dexamethasone 5 mg/ml Anti emetic iv
Diphenhydramine
fgmikee@gmail.com
Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval
20-30 min 5.5 - 26 hr 30 sec
20-30 min

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


7-8 hr 20 - 100 hr 15 - 60 min Liver Kidney
15-60 min
15-60 min
1 hr 1.8 - 6.4 hr 30 min Liver Kidney + GI
20-40 min
20-40 min
12-24 hr 9 - 16 hr 1.5 - 2 hr Liver Kidney

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


7 hr 2 - 3 hr 20 min Liver Kidney + GI
7 hr
7 hr
2-4 hr 3 - 5 hr 30 min Liver Kidney
2-4 hr 1 min
2-4 hr 1 min
30-60 min 2 - 4 hr 30 - 60 min Liver Kidney + GI
30-60 min
30-60 min

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


5-10 min 2.5 - 3 hr 1 min Liver Kidney + GI
5- 10 min 10-15 min
5-10 min
3-5 min 75 min Liver + Plasma Kidney
20-75 min 30 - 60 min 4 - 8 min Liver Kidney
20-75 min
20-75 min

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


2-10 min 1-2 min Plasma Kidney
2-10 min
2-10 min
30-60 min 1 - 2 min 4 min Liver Kidney
30-60 min 14 - 18 min
30-60 min
20-35 min 17 - 21 min 3-5 min Plasma Kidney + GI
20-35 min
20-35 min

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


1.5-8 hr 3.5 hr 30-45 min Liver Kidney
10-20 min 1.5 - 2 hr 10-15 hr Liver Kidney

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


4 hr 2 hr 30 min Liver Kidney

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


2.5 - 4 hr 50 - 90 min 20-30 min Plasma + Liver Kidney

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


6-10 hr 12 - 33 hr 3-5 hr Liver Kidney
6-10 hr
6-10 hr
60 min 3 - 6 hr 2-4 hr Liver Kidney

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


4 - 5 hr 2 - 3 hr Liver Kidney
12-24 hr 0.5 - 1 hr 0.5 - 3.5 hr Liver Kidney
1-2 hr 5 - 6 hr Liver Kidney

Duration Half-Time Peak Plasma Metabolism Excretion Dosing Interval


6-8 hr 3.5 - 9.2 hr 1-3 min Liver Kidney + GI q6
6-8 hr 3.5 - 9.2 hr 1 hr Liver Kidney + GI q6
9 hr 5.5 - 7 hr 1.5 hr Liver Kidney q8
2-5 hr 1 - 4 hr 0.25 hr Liver Kidney q6
6 hr Liver Kidney q6
12 hr 5.7 hr Liver Kidney
30-45 min 1 - 1.5 hr Kidney
POST OP ORDER MNEMONICS
V Monitor vital signs (HR, BP, RR, spO2) q15 for 2 hours then q30 until stable
O Give Oxygen 6 LPM via face mask
S Suction if nescessary
T Give warm blankets or may add warmer if necessary
P Position supine with 30 degree head elevation
E Educate patient to take a deep breath once in a while
D Diet as tolerated
I IVFD lactated ringers 110 ml/hr (70 kg) to follow PNSS 110 ml/kg
A Medication : Ketorolac 30 mg po q8 / Paracetamol 1g po q6 / Tramadol 100 mg po q6
R Referal
EXTUBATION CRITERIA
No SUBJECTIVE
1 Clear oropharynx/hypopharynx
2 Intact gag reflex
3 Minimal end expiratory volatile anesthetics
4 Adequate pain control
5 Follows command
6 Sustained head lift for 5 sec
7 Sustained hand grasp
OBJECTIVE
Tidal Volume > 6 ml/kg
Peak voluntary negative inspiratory pressure > 20 cm H2O
Vital capacity > 10 ml/kg
Dead space to tidal volume ratio < 0.6
Sustained tetanic contraction (5sec)
T1/T4 ratio > 0.7
Alveolar-arterial PaO2 gradient (FiO2 1.0) < 350 mmHg

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