Eeg Book
Eeg Book
Eeg Book
Electroencephalography
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The College of Physicians and Surgeons of Ontario
Mission Statement
To fulfil its goals, the College endeavours to: While the College exists to serve the public interest,
it is also responsive to the medical profession. To
• establish and apply standards which ensure that
accomplish this, the College sets out to:
only qualified physicians are licenced to practise
in Ontario • maintain the confidence and trust of the
profession by ensuring that it is, and is seen to
• provide pertinent information about physicians
be, fair and accessible to physicians
to the public and health care organizations
• consult with other medical organizations on
• investigate and resolve complaints about
initiatives of common interest
physicians
• recognize its obligation to members of the
• maintain a disciplinary process for dealing with
profession for the sound fiscal management of
allegations of misconduct and incompetence
the cost of self-governance.
• monitor the quality of medical practice through The mandate of the College, defined in legislation
programs such as peer assessment and regulations established by the Government of
• promote professional development activities Ontario, is administered independent of Government
such as continuing medical education direction. The College aims to:
• facilitate the establishment and application of • assure government that it is fulfilling its
practice parameters mandate
• consult the public and profession on issues of • consider undertaking specific initiatives at the
concern request of government
• provide advice on current and emerging needs in • act as an advocate for the people of Ontario in
medical education addresing issues of public protection and quality
of medical care with government.
• participate in the accreditation of training
programs for physicians
• provide advice to government on health issues.
Guidelines for Clinical Practice
& Facility Standards
Electroencephalography
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First Edition, September 2000:
Members of the Electroencephalography Task Force:
Dr. Donald G. Brunet, Co-Chair Kingston, Ontario
Dr. G. Bryan Young, Co-Chair London, Ontario
Dr. Warren T. Blume London, Ontario
Dr. Joseph Bruni Toronto, Ontario
Dr. Rosalind M. Curtis North York, Ontario
Dr. J.C. Martin del Campo North York, Ontario
Dr. Hiren B. Desai Windsor, Ontario
Dr. Qais Ghanem Ottawa, Ontario
Dr. Richard M. Gladstone North York, Ontario
Dr. Warren C. Goldstein Richmond Hill, Ontario
Dr. Paul A. Hwang North York, Ontario
Dr. Daniel L. Keene Ottawa, Ontario
Ms Brenda Mason, RET Mississauga, Ontario
Dr. Arline McLean North York, Ontario
Mr. Kent McNeill, RET London, Ontario
Dr. Keith L. Meloff Toronto, Ontario
Ms Maria Moncada, RET Toronto, Ontario
Dr. Colin Shapiro Toronto, Ontario
Ms Patricia Tremaine, RET Ottawa, Ontario
Dr. Marvin B. Weber North York, Ontario
Dr. Sharon Whiting Ottawa, Ontario
Dr. Michael J. Winger Windsor, Ontario
Guidelines for Clinical Practice and Facility Standards for Electroencephalography iii
Chapter 12 Adult and Adolescent Neurological Disorders
Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Reasonable Probability of Useful Clinical Information . . . . . .41
First Seizure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Epilepsy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Intractable Symptoms to Assess
Possible Non-Epileptic Events . . . . . . . . . . . . . . . . . . . . . 42
Follow-up . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42
Stopping Anticonvulsant Therapy . . . . . . . . . . . . . . . . . . 42
Seizure Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42
Myoclonus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Stupor and Coma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Brain Death . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Head Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Neurodegenerative Disorders-Dementia . . . . . . . . . . . . .43
Creutzfeldt-Jakob Disease . . . . . . . . . . . . . . . . . . . . . . . 44
Herpes Simplex Virus Encephalitis . . . . . . . . . . . . . . . . . 44
Atypical Transient Ischemic Attack to
Evaluate Partial Seizures . . . . . . . . . . . . . . . . . . . . . . . . 44
Third-Party Referrals . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
Low Probability of Useful Clinical Information . . . . . . . . . . . .44
Follow-up in Asymptomatic Patients . . . . . . . . . . . . . . . . 44
Family Studies Except in a Research Environment . . . . .45
Syncope, Presyncope and Dizziness . . . . . . . . . . . . . . .45
Assessing Cerebrovascular Disease
Unless Complicated by Seizures . . . . . . . . . . . . . . . . . . . 45
Classifying Headaches . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Tremor, Spasms, and Tic Disorders . . . . . . . . . . . . . . . . 46
Brain Injury after Mild Head Trauma or “Whiplash” Injury 46
Chronic Fatigue Syndrome and Daytime Sleepiness . . .46
Endnotes
Endnotes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61
References
Appendix IV References
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
Note: Members of the Task Force were not compensated for their work. The College did not have a role in the
collection, analysis, or interpretation of the data. The College did provide administrative support to the
Task Force. It also printed and distributed the clinical practice guidelines and facility standards. The
College did not solicit external funding.
Guidelines for Clinical Practice and Facility Standards for Electroencephalography vii
Task Force Objectives and Principals
The purpose of the EEG Guideline Development Task Force was to
develop clinical practice guidelines for the practice of
electroencephalography (EEG) for all populations including neonates,
children, and adults. The document covers medical conditions referred to
out-of-hospital and hospital-based EEG labs and addressed the role in
psychiatric disorders as a special area.
The Task Force had the following directives:
• this continuous quality improvement endeavour gives primacy to the
revered medical principle, “first, do no harm”. That is, EEG testing should
be performed in a safe manner. Thus, there should be no risk from
infectious or electrical hazards or other potential dangers.
• EEG should be useful in patient care. Electroencephalograms should only
be done for appropriate indications. Volume II outlines the clinical
conditions for which there is reasonable or low probability of useful clinical
information resulting from an EEG.
• electroencephalograms should be performed in an accurate, careful and
responsible manner by technologists who are competent, using adequate
equipment.
• electroencephalograms should be interpreted carefully and reported
promptly by competent electroencephalographers. The report should
contain a description of the characteristics of the recording. The clinical
interpretation or the conclusion should correlate the clinical features with
the findings on the EEG tracing.
Subgroup 1
The assessment of patients for possible testing, the clinical indications for
EEG testing and the role of general practitioners/family physicians,
specialists, and laboratory medical directors in the ordering process.
Subgroup 2
The standards for EEG laboratories to interpret and report results.
Subgroup 3
EEG outcome assessment and the utility of EEGs to the ordering
physician in care management.
Acknowledgements
The College acknowledges the efforts of the EEG Task Force in
preparing this document for the profession. The members of this Task
Force are listed on the edition page on the opposite side of the Front Title
Page.
The EEG Task Force acknowledges Drs. Don Low, Elizabeth
Richardson, and Bryan Young for preparing the Infection Control
Guidelines for Facilities Performing Electrophysiologic Studies. These
guidelines were distributed to all providers of EMG, EEG, and Sleep
Medicine facilities in March 1996 and supplement the Infection Control
in the Physician’s Office (January 1999) document published by The
College.
Volume 1
Facility Standards
2 The College of Physicians and Surgeons of Ontario
Chapter 1 Staffing a Facility
Overview
This chapter addresses the minimum qualification standards of the
electroencephalographer and electroencephalography technologist. The
objectives are to ensure that these individuals:
• possess a minimum standard of performance, ensuring accuracy, and
clinical usefulness of recording and reporting
• are knowledgeable regarding measures that ensure safety of the patient.
Electroencephalographers
Note: Trainees are urged to consult CSCN guidelines for requirements for this examination.
Locum Tenens
A locum tenens is defined as a physician who undertakes the professional
duties of another physician during the latter's absence.
Note: A locum tenens who functions in an acute hospital setting or out-of-hospital clinic should possess the
same qualifications required for electroencephalographers.
Laboratory Director
The laboratory has appointed a physician to be the Laboratory Director.
The Laboratory Director meets the criteria for an
electroencephalographer and is ultimately responsible for advising the
health facility on the professional aspects of services provided in the
laboratory. These responsibilities include, but are not limited to, the
following:
• appropriate design, staffing, and equipping the health facility to ensure
patient comfort, safety, and the proper performance and reporting of
electroencephalographic services
• qualifications and the work of other physicians and technologists employed
in the facility
• performance of electroencephalographic services to ensure that these
services are performed safely, accurately, and reliably
• accuracy and reliability of the equipment used for electroencephalographic
services
• proper design of electroencephalographic services requisitions and reports
Note: CBRET provides the only qualifying examination that is available to technologists in Ontario.
Note: Technologists who have not undergone the recommended training programs but who have been in
practice for at least 5 years may take the examination until 2004.
Training
Electroneurodiagnostic training occurs in laboratories directed by a
qualified electroencephalographer in association with at least one CBRET
registered technologist.
Overview
This chapter addresses the EEG recording including techniques,
equipment, electrical control, and safety.
The recommendations of the CSCN and the CAET document Minimal
Technical Standards EEG/EMG 1991-1993 are followed, with the
addition of the following facility standards.
Note: We recommend that most montages include over 70% of the electrodes of the International 10-20
System of Electrode Placement. A single montage that includes all the electrodes is acceptable in the
neonatal period.
Sampling Rate
To ensure an adequate waveform recording, a minimum sampling rate of
200 samples per second for each channel is used, but higher rates are
preferred. The sampling rate should be even multiples of 50 or 64 Hz.
When sampling at 200 Hz, an anti-aliasing filter of 70 Hz should be used,
with a roll-off of at least 12 dB/octave. Higher sampling rates require a
proportionately higher anti-aliasing filter setting.
A low frequency filter of 0.16 Hz should be available; as should a 60 Hz
notch filter, for use when required. Digitization at voltage level of 12 bits
or greater with the ability to resolve voltage to 0.5µV is recommended.
Common mode rejection is 100 dB or greater at each amplifier input.
Interchannel cross-talk must be less than 1%, i.e., 40 db down or less.
Displaying Recordings
Technology is capable of displaying the recording on a video screen as
well as on paper. With horizontal scaling, one second of time occupies
25-35 mm and contains at least 120 data points/channel; scaling at 0.5, 2,
and 4 times should be feasible. On the vertical display, a minimum
spacing of 10 mm between channels for a display of 16 or 18 channels is
recommended.
Screen Resolution
Adequate screen resolution is at least 4 pixel resolution per vertical
millimetre. We recommend that the screen have at least 1024 x 768
pixels. Playback systems should show the montage, filter, and sensitivity
settings, vertical voltage scale and horizontal time marking scale,
technologist comments, event markers (e.g., for hyperventilation), and
page number or time. The playback unit should also allow for montage
selection changes and post-hoc alterations in sensitivity and filter
settings.
Electrical Safety
Electroencephalographic equipment meets the minimal standards of
Canadian Standards Association (CSA).
Equipment is purchased from nationally recognized manufacturers of
electroencephalographs. If all components for a machine are not from the
same manufacturer, the machine is tested and approved by a qualified
biomedical engineer before it is used. If this is not feasible, facilities
should not use a multi-component machine and must purchase their
equipment from a single recognized electroencephalograph manufacturer.
Needle Electrodes
Needle electrodes are not used routinely and are never used in out-of-
hospital laboratories. If exceptional clinical circumstances require their
use, (e.g., burns to the head or certain intra-operative procedures)
sterilized, single-use needle electrodes are used and disposed of after the
recording.
In patient preparation, the use of blunt tip needles is not recommended.
To reduce skin impedance, the use of abrasive gels applied with a cotton-
tipped applicator is preferred. However, if the clinical situation, e.g.,
there is difficulty in adequately reducing the impedance, warrants the use
of such needles for lowering impedances, sterilized disposable blunt tip
needles are used for each patient and discarded after each use. 3
Note: Please refer to Appendix I, Infection Control Guidelines for Facilities Performing Electrophysiological
Studies, March 1996.
Note: Electrode caps or similar commercial products should be avoided when the patient has scalp lesions or
potentially transmissible viral disorders (Acquired Immune Deficiency Syndrome (AIDS), serum
hepatitis, Creutzfeldt-Jakob disease, or any systemic infection.)
Note: These guidelines meet the standards defined by the College of Physicians and Surgeons of Ontario in
Infection Control Guidelines for Facilities Performing Electrophysiological Studies, March 1996.
For ill in-patients, the technologist consult with the nursing staff
concerning any special infection control requirements for the patient.
Fastidious, frequent cleaning of the electrodes and cap between patients is
recommended. The manufacturer recommends that only liquid
dishwashing detergent be used for cleaning after routine use to remove
electrode gel. Gel buildup causes excessively high impedances and
electrode artifacts. The gel and debris may also need to be mechanically
removed with an “orange stick” or cotton swab.
The cap straps are washed with a brush and soapy water separately at
least once weekly. If the cap is soiled with blood or other body fluids, we
recommend that it be cleaned with Metri-Zyme® or an equivalent
enzymatic detergent and then again washed promptly and thoroughly
with liquid dishwashing detergent, rinsed well, blotted, and air-dried.
Contaminated liquids are disposed of according to the facility standards.
As some sterilizing techniques can injure the fabric of the cap, facilities
must be more selective in the patients than for standard EEG. Electrode
caps or similar commerical products are suitable for routine out-patient
use, provided patients do not have scalp lesions, dementia, or potentially
transmissible viral diseases.
Electrode caps are acceptable for in-patient use, provided they are not
used for prolonged recordings and that the guidelines for patients with
scalp lesions and infectious diseases are enforced.
Overview
The Laboratory Director has the primary responsibility for the
development and maintenance of the laboratory manual.
Overview
Requisition records and reports are maintained by the facility.
EEG Requisition
The EEG requisition contains the following clinical details:
• reasons for requesting the test
• medications the patient is taking
• clinical history
• any special precautions (e.g., infection with human immunodeficiency,
hepatitis viruses, allergies)
• any requests for special procedures or special electrode positions.
The requisition is completed and signed by the referring physician prior
to the test being performed.
Informed Consent
All patients, or their substitute decision-makers, should make an informed
decision before having an EEG performed. For routine EEGs, written
consent is not necessary. The patient/substitute decision maker should
receive adequate information including:
• the purpose of the EEG examination (being as specific as necessary)
• the nature of the test
• the procedures used
• the potential risks and benefits.
Competent patients should be informed that they have the right to consent
to or refuse the test in whole or in part at any time during the procedure.
When activating procedures (e.g., reducing medications, depriving
patients of sleep, or using sedative drugs) place the patient at risk of
having seizures, excessive sedation or other complications, we
recommend that the patients or their care-givers be at least verbally
informed of these risks.
We strongly recommend that a fact sheet that gives the above-mentioned
general information be provided to the patient for elective EEGs.
Note: In special situations, e.g., invasive procedures (i.e., inserting sphenoidal electrodes), written consent is
strongly recommended.
EEG Reports
Contents
The EEG reports contain the following:
• date of receipt of requisition
Note: In emergency situations, where the electroencephalographer is not immediately available and with the
previous agreement of the electroencephalographer, an electroencephalography technologist may inform
the referring physician of the EEG findings. The technologist must record the technologists’ preliminary
report given to the physician for later review. In these situations, however, the electroencephalographer
is ultimately responsible for reviewing these interpretations in a timely fashion and reporting any
Timelines
Routine EEGs are reported in a timely fashion. Non-urgent EEGs are
usually interpreted within five working days. Typed, signed reports are
usually sent to the referring physician within 10 days of the EEG.
Note: If the results of the EEG suggest a medical emergency or a problem that needs urgent attention, the
results are promptly conveyed by telephone or by some other means to the referring physician. When the
referring physician requires the written report urgently, the typed report may be sent as “dictated but not
signed”, providing a signed report will follow within 10 days.
Overview
Every laboratory has an ongoing quality improvement/management
program in place which is designed to objectively and systematically
monitor and evaluate the quality and appropriateness of services, to
improve services, and to resolve identified concerns. The program
includes means for staff to review the results of quality improvement
activities, to plan corrective actions, and to monitor the effectiveness of
actions taken, if required.
Overview
Long term EEG monitoring in intensive care units represent a new area of
EEG application and there are special concerns and considerations which
are addressed in this chapter which are not addressed elsewhere in this
document.
These guidelines are derived from the International Federation of Clinical
Neurophysiology (IFCN) recommended standards for
electrophysiological monitoring in comatose and other unresponsive
states. Long-term EEG monitoring involves recording either continuously
or intermittently over at least six hours.
Infection Control
Infection control guidelines for facilities performing electrophysiologic
studies are outlined in Appendix I, Infection Control Guidelines for
Facilities Performing Electrophysiological Studies, March 1996.
Note: In the neonatal intensive care unit, the problem of volatile vapours from diethyl ether in the collodion
technique can be addressed by either opening one end of the isolette until the collodion has dried or
applying the electrodes while the baby is on a warming tray that is open to the air. Once the diethyl ether
has dried, the baby can be recorded in a closed isolette/incubator.
Digital EEG
The use of digital electroencephalography is recommended for long term
monitoring.
The characteristics meet the minimal standards of the CSCN. Storage on
optical disks or CD-ROMs is acceptable. This meets the standards
established for other EEG storage. This is discussed in Chapter 4, EEG
Equipment and Recording Techniques.
Electrical Safety
Electrical equipment is checked before each recording. Current leakage
is checked at least twice yearly. Two-wire ungrounded devices, that are
not essential to patient survival, are unplugged, if agreed upon by the
attending staff. If needed, these instruments must be properly grounded
and plugged into an isolation transformer. The electroencephalograph is
plugged into a three-wired grounded outlet located in the same circuit
branch that is used to power the other instruments connected to the
patient.
Note: We recommend that electrical interference be promptly investigated, as this may indicate that there is a
current leakage.
Recording
The recording uses standardized bipolar and referential montages, with
the former arranged in straight-line longitudinal and transverse arrays.
Longer distance derivations are appropriate in recordings for suspected
brain death and in babies less than eight weeks post-term. Low frequency
(high-pass) filters are approximately 0.5 Hz.
High frequency filters are set at 70Hz; however, the use of 60 Hz digital
notch filters is acceptable. Temporary sampling is performed frequently
at the bedside but only relevant segments of the EEG are permanently
archived.
Documentation
The technologist or personnel present during the recording save portions
of the recording that contain significant clinical phenomena such as:
• seizures
• response testing
• the administration of centrally-acting drugs
• significant changes in blood pressure or blood gases during the examination.
A list of medications is noted at the start of the recording.
Overview
In this chapter, long-term EEG monitoring involves recording the patient
either continuously or intermittently over at least six hours. These
guidelines are largely derived from Guidelines: Long-Term Monitoring
for Epilepsy, published by the American Electroencephalographic
Society February, 1991 and from CAET-CSCN Minimal Technical
Standards for EEG/EMG 1993.
Infection Control
Infection control guidelines for facilities performing eletrophysiologic
studies are outlined in Appendix I, Infection Control Guidelines for
Facilities Performing Electrophysiological Studies, March 1996.
Electrodes
Three types of electrodes are used:
• beveled disk
• sphenoidal
• intracranial.
Beveled Disk
A beveled disk electrode with a hole in the top is preferred. We
recommend that the collodion technique be used.
Note: We do not recommend long-term use of nasopharyngeal, supraoptic, and auditory canal electrodes.
Intracranial
Intracranial electrodes are used mainly in specialized epilepsy centers.
Please see Chapter 7, Long-Term Monitoring for Epilepsy Patients.
EEG Amplifiers
The following are recommended performance specifications:
• low frequency response of less than or equal to 0.5 Hz
• high frequency response of 70 Hz
• noise level less than 1µV rms
• input impedance of less than 1MÛ
• common mode rejection of at least 60 dB
• dynamic range of at least 40 dB.
Pre-Amplifier Location
The closer the pre-amplifier to the signal source (i.e., the shorter the
electrode leads), the less opportunity is for artifact.
Recording Techniques
Recording techniques are as follows:
• a minimum of 16 recording channels, and up to 64 or 128 channels (if
desired) to obtain accurate localization. Two or more electro-
encephalography machines may be necessary for write-out, or the channels
can be multiplexed and recorded on tape or stored on computer disk.
• montages are selected using the electroencephalographer's discretion.
• filter and sensitivity settings: settings are adjusted to prevent blocking.
Usually the high linear frequency filter can be set at 70Hz and the low linear
frequency filter setting at 1 Hz.
• a 60 Hz notch filter is acceptable.
• monitoring the electrocardiogram, electro-oculogram, electromyogram,
respiration or peripheral events may be indicated in certain clinical
situations.
Presurgical Evaluation
For EEG transmission, standard cable (hard wire), or telemetry with at
least 16 channels of EEG data.
Note: Ambulatory EEG is not acceptable for final evaluation, but may be useful in a triage function.
Overview
Ambulatory EEG monitoring provides a continuous recording of
electrical brain activity for 12-24 hours. The following guidelines are in
keeping with the Minimal Standards Document of 1991-1993, published
by the Canadian Association of Electroneurophysiology Technologists
(CAET).
Infection Control
Infection control guidelines for facilities performing electrophysiologic
studies are outlined in Appendix I, Infection Control Guidelines for
Facilities Performing Electrophysiological Studies, March 1996.
Equipment
Recording Equipment
At least eight channels are recommended for standard cassette tape
recording. Digital recording may allow for monitoring of more channels.
Electrodes
Electrodes are applied with collodion.
Recording Procedure
We recommend that the patient and/or caregiver be given a daily log to
document a description of the clinical events as well as to note the time of
medication, meals, bedtime, etc.
The montage used for the recording is established by the
electroencephalographer.
To accurately display low frequency activity, we recommend a low
frequency filter setting of 0.3 to 0.6 Hz (time constant of 0.27 to 0.53
seconds) when the tapes are reviewed.
Reporting
A formal typewritten report is sent in a timely fashion to the referring
physician. The report documents the electrical features of the recording,
identifies any correlation between the events in the patient diary and
problems that interfere with the interpretation. A clinical interpretation
concludes the report.
Overview
The unique circumstances and findings in neonatal EEG require the use
of special techniques and additional requirements.
The use of special requirements (technical and other) are listed below and
are used in conjunction with the Minimal Standards EEG/EMG 1991-
1993 published by the Canadian Congress of Neurological Sciences and
Canadian Association of Electroneurophysiology Technologists.
Infection Control
Infection control guidelines for facilities performing electrophysiologic
studies are outlined in Appendix I, Infection Control Guidelines for
Facilities Performing Electrophysiological Studies, March 1996.
Equipment
Electroencephalograms consist of at least 16 channels of simultaneous
recording, including or in addition to four or more channels devoted to
extracerebral variables such as electro-oculogram, electrocardiogram,
electromyogram and respiration.
Electrodes
Electrodes are applied with either paste or collodion. Paste is preferred
since fumes from acetone and collodion may be offensive and hazardous
when dealing with neonates in isolettes/incubators.
Patient Preparation
In addition to routine clinical history, the technologist documents on the
requisition, the gestational and conceptional age of the patient, relevant
birth history including Apgar scores, medication, body temperature, and
current clinical status.
The technologist communicates with the nursing staff and/or caregivers
and advises them of the length of time required for the procedure in order
to facilitate scheduling of care.
Infants should be comfortable and well fed prior to the electrode
application and recording.
Note: A variety of paper speeds, including 15 mm/sec, are recommended to facilitate interpretation.
Response Testing
Stimulation is carried out in stuporous or comatose infants over 28 weeks
conceptional age, when there is evidence of an invariant EEG pattern or
lack of state change.
Stimulation is performed near the end of the recording. Response testing
includes, somatic stimulation (rubbing face, squeezing nailbed), auditory
stimulation (clapping or calling in baby’s ear) and passive eye opening
and closing during the recording are recommended.
Extra-Cerebral Monitoring
Eye movements (EOG), respiration and heart rate (EKG) are recorded as
a minimum.
Submental electromyogram (EMG) is recorded whenever possible.
Upper and lower airway monitoring is used in infants with suspected
apnea.
Activation
Photic Stimulation
The use of photic stimulation in neonates is not clinically necessary or
recommended.
Sleep
It is recommended to include spontaneous, natural sleep in the recording.
It is rarely necessary or recommended to use sedation to obtain a sleep
recording in a neonate.
Reporting
A formal typewritten report should be sent in a timely manner to the
referring physician. The electroencephalographer should comment on the
features of active and quiet sleep, wakefulness and reactivity in the body
of the report. Following this, a clinical interpretation should be given,
with conclusions and recommendations.
Volume 2
Overview
This volume contains general recommendations for ordering and
interpreting an electroencephalogram (EEG) and related tests. These
guidelines are not meant to override clinical judgement in EEG for an
individual patient. Rather, they represent a consensus statement
concerning the utility of EEG in common conditions.
Before ordering an EEG, the physician should have a general
understanding about the information provided by a recording. An EEG
provides information about the physiological state of the brain. The
signals recorded vary with age, state of consciousness, and the
medications taken by the patient being tested. It may provide localizing
information when the patient has partial epilepsy. It provides quite
different, and often complementary, information compared to computed
tomography or magnetic resonance images of the brain.
Applications of EEG
New applications of electroencephalography continue to be refined such
as the application of quantitative methods of analysis, long term EEG
monitoring in the intensive care unit, and recordings for pre-surgical
evaluation of epilepsy. The indications for EEG discussed in this chapter
represent the present common applications of the test and will change as
new scientific information about EEG is published.
A normal EEG recording should not be interpreted as “ruling out”
conditions such as epilepsy. For instance, in patients with epilepsy, it is
not unusual to find a normal EEG between seizures and sometimes no
EEG changes can be detected on the scalp surface during a seizure.4
Abnormalities may be found in asymptomatic individuals or in
association with common conditions like migraine headaches. The
clinician is best suited to determine the significance of EEG findings as
they relate to the results of history, physical examination, and other
laboratory studies.
In considering a referral for an EEG, the Task Force recommends that:
• the referral should ask a question about brain physiology that EEG can
reasonably answer such as whether there is paroxysmal activity suggestive
of epilepsy or diffuse slowing which is compatible with a dementia
Note: To ensure that the EEG interpretations are as reliable and reproducible as possible, the recording must be
performed by a highly skilled and qualified technologist. This individual must be able to modify the test
conditions to maximize the information obtained during the recording and to reduce artifacts in the EEG
that originate outside the brain.
Note: There is a paucity of Class I evidence from randomized controlled clinical trials in EEG. Most of the
following recommendations result from a consensus opinion of the Task Force 2.
Overview
The administration of sedative drugs is seldom necessary for EEG
recordings. Other methods of obtaining co-operation of the patient or of
obtaining a sleep recording should be considered or attempted before
sedative drugs are used.
Overview
This chapter addresses general indications for EEGs in adults and
adolescents, and is divided into two major sections:
• reasonable probability
• low probability of useful clinical information.
First Seizure
Approximately half the patients referred for an EEG after a first tonic-
clonic seizure have a normal recording in the waking state. Recordings
with sleep can often detect relevant abnormalities missed if only an
awake recording is done. Some types of epileptiform patterns are best
studied during sleep. Patients with partial seizures especially those
originating in the temporal or frontal lobes may not show abnormalities in
the surface recorded EEG. Special electrodes may be necessary to
evaluate these areas.
Epilepsy
Follow-up
For many types of epilepsy, there is low correlation between the
occurrence of seizures and epileptiform discharges in the EEG. However,
in some types such as absence seizures with 3 Hz spike and wave EEG
pattern, treatment response can be confirmed with the EEG.
For patients with poorly controlled tonic-clonic seizures, a recording
during follow-up may disclose focal changes not previously seen. These
observations may influence drug selection and suggest the need for
neuroimaging.
Note: For patients who are seizure-free, an EEG is not a useful routine test.
Seizure Surgery
EEG recordings done in epilepsy surgery centres are an important
component in the patient evaluation. These recordings usually include
long-term EEG monitoring sometimes with surgically implanted
electrodes. Repeated out-patient recordings may be necessary to
establish that a consistent epileptogenic focus is present.
Brain Death
An EEG can be used to assess brain death. However, current protocols
for determining brain death do not include EEG criteria. 5 The EEG
evaluation of brain death, such as an isoelectric EEG, is very unreliable in
patients who are less than three months old. If a confirmation test for
brain death is required, a test directly assessing cerebral blood flow is
superior to EEG.
Head Injury
In an acute severe head injury, an EEG gives little useful information. In
some patients, status epilepticus may occur without tonic-clonic
movements resulting in a depression in level of consciousness. An EEG
would be necessary to detect this event. This may be more applicable to
patients with a co-existing spinal cord injury. Patients in an intensive
care unit, who are paralyzed and ventilated, may be studied by EEG to
evaluate seizure activity that would not otherwise be clinically evident.
Neurodegenerative Disorders-Dementia
The EEG changes in dementia approximately parallel the severity and
rate of decline in mental functioning. An EEG is more useful than
conventional neuroimaging to quantify these changes. An abnormally
slow EEG may help in differentiating a degenerative disorder from
pseudodementia caused by depression. The presence of focal
Creutzfeldt-Jakob Disease
A fairly specific pattern of periodic sharp waves can be seen in up to 70
percent of patients with this rapidly progressive form of dementia.
Repeated recordings are often necessary to study the evolution of EEG
changes and exclude other disorders.
Third-Party Referrals
There are many situations in which a person with or without neurological
symptoms may be directed to have an EEG study to comply with
regulations. The physician must be satisfied that there is a valid reason to
perform this test. As in the usual clinical situation, referrals for these
studies should contain complete and relevant health information to allow
the electroencephalographer to make an interpretation of the results.
Classifying Headaches
There are no specific features seen in an EEG that would assist in
classifying common types of headaches such as migraine, tension, or
analgesic-dependent headaches. Classifying of the common types of
headache remains a clinical decision6.
Although there can be EEG changes in the vicinity of a brain tumour, an
EEG will be normal in many patients with tumour and should not be
relied upon to exclude this diagnosis. Neuro-imaging is the test of choice
when a tumour or other space-occupying lesion is being considered.
Overview
The indications for EEG in neonates, infants, and children are similar to
those for adults with the additional recommendations discussed in this
chapter.
Neonatal Seizures
Seizures in the newborn period may be subtle; signs may include
bicycling, lip smacking, or apnea spells. An EEG can be useful in
diagnosing and classifying these events. In myoclonic, tonic-clonic, and
partial motor seizure, an EEG can describe the extent of epileptiform
activity in the brain, thereby assisting with treatment planning. In
neonatal apnea, the EEG only rarely shows epileptiform activity that is
responsible for apnea. It should be recognized that the EEG may be
normal during typical neonatal seizures. An EEG during administration
of pyridoxine for suspected pyridoxine-responsive seizures is also very
useful.
Neonatal Infections
Infections in the neonate may be complicated by seizures. Also in herpes
simplex virus encephalitis there be may EEG patterns that suggest this
diagnosis.
Classifying Headaches
The same considerations noted about headache in adults apply to
children. An EEG cannot exclude a brain tumour.
Behavioural Disorders
An attack of anger, rage, or violent behaviour in a child sometimes raises
the question of focal epilepsy. Such problems in the absence of other
indications of epilepsy are not indications for an EEG.
Breath-holding Attacks
These symptoms are usually diagnosed by patient history and
examination. The EEG is normal between attacks. Atypical symptoms
that raise the question of seizures or marked parental anxiety can be
indications for an EEG.
Substance Abuse
There are no diagnostic changes in this patient group apart from changes
associated with overdose of drugs such as benzodiazepines or tricyclic
antidepressants.
Overview
The appropriate use of EEG in psychiatric disorders is more difficult to
define than for most neurological disorders. The definition of psychiatric
diseases continues to be refined. Despite much research, the biological
basis of many conditions remains elusive.
EEG Research
EEG was first discovered in a psychiatric hospital and psychiatrists
remain a common source of EEG referrals. There are numerous studies
concerning EEG findings in various mental disorders, yet few definite
conclusions can be drawn about the specificity and sensitivity of EEG
studies or the impact of EEG in psychiatric diagnosis and treatment.
The limitation of most research in this field is the retrospective nature of
the data collected. Furthermore, the degree of clinical rigor in evaluating
general medical and neurological problems is not addressed in many of
these studies. Consequently, a recommendation concerning the use of
EEG in psychiatry cannot be made to cover all settings.
Note: There was also interest in the use of overnight sleep studies when evaluating depression.
Overview
Ambulatory EEG records eight or more channels of EEG and ECG
continuously for up to 24 hours, using a small data recorder and miniature
EEG amplifiers. The patient may take the equipment home but must
report to the laboratory for an electrode and battery change every 24
hours.
The recordings are reviewed by an EEG technologist and
electroencephalographer to correlate EEG changes with symptoms
recorded by the patient or other observer in a diary. Most systems have
an alarm button that can be pressed on the recorder to give a precise
correlation on the tape with an event.
As in a standard EEG, competent technical ability is required to place the
electrodes firmly on the scalp and to teach the patient the procedures to be
followed.
The advantage of this technique is that a prolonged recording may allow
the physician to correlate EEG waveforms and symptoms to make a more
accurate diagnosis of intermittent neurological symptoms. The study
should be preceded by awake and sleep standard EEG recordings to
determine where any abnormalities may be located in order to plan the
recording montage using only seven or eight EEG channels.
Limitations
The disadvantages and limitations of the technique are considerable and
include the following:
• the patient is away from the laboratory so that the condition of the electrode-
scalp electrical connection cannot be assessed or artifacts corrected.
Electrodes and recording leads can become disconnected or give rise to
unusual artifactual waveforms that can be confused with abnormalities.
While training and experience can overcome some of these difficulties,
these problems remain with each recording.
• artifacts related to chewing, swallowing, eye movements or other head and
neck movements are not visible to the recording technologist and therefore
can be difficult to differentiate from brainwaves
• there is a high cost to acquire and service the equipment.
Note: The diagnostic yield of these recordings is low and as in the standard EEG, these recordings cannot be
used to exclude epileptic seizures.
Note: Intensive EEG and video monitoring may be considered as a more reliable alternative test. The patient
must have frequent symptoms to ensure that there is a reasonable chance of evaluating them in one or
two days of recording.
Overview
Quantitative EEG refers to 20 or more channels of EEG subjected to
computerized spectral analysis and the results compared to a database of
normal EEG recordings matched for age and other characteristics. Often
multi-channel evoked potentials are also performed as part of the test.
Other forms of analysis may also be done such as correlation or
coherence between channels.
Advantages
The advantage of this test is information about the EEG and evoked
potentials which allows precision of data description that cannot be
performed with standard visual analysis.
Limitations
Unfortunately, artifacts cannot be entirely removed from this type of
recording before starting the analysis and the results must be reviewed
with a standard paper/ink or digital EEG to avoid misinterpretation of the
data. Superb technical work is necessary as well as familiarity with both
EEG and evoked potentials.
There is insufficient data about normal multichannel long-latency
evoked, potential changes in them with medications, and other patient
variables. There are no valid clinical studies showing the sensitivity and
specificity of these recordings in diagnostic situations. 12
Spectral analysis may improve the sensitivity of the standard EEG in
cerebrovascular disease.13 There are no studies of the sensitivity and
specificity of these techniques in psychiatric disorders or head trauma.
At the present time, there are no accepted indications for this test,
although much research is being done in this area, especially concerning
major psychiatric conditions.
Overview
Intensive EEG or video monitoring provides prolonged EEG data. It is
usually performed for many days to provide a correlation between
symptoms and brain electrical signals. Under the appropriate supervised
clinical setting, and on the information needed, the test may be done as an
out-patient or as an in-patient. Depending on the objectives of the
study, invasive electrodes may be used, for example, in pre-surgical
monitoring for epilepsy.
Note: These techniques are expensive and should only be performed in highly selected patients in which there
is some likelihood of a change in treatment plan after the test.
Note: There is usually little value in a videotape recording during a standard EEG unless the patient is having
active, frequent symptoms or the events in question can be provoked. A prolonged outpatient EEG with
video monitoring may have some application in paediatric epilepsy.14
Endnotes
1 A search of MEDLINE was conducted for the years 1966-1997 using
a keyword search with the terms:
•electroencephalography
•EEG and standards or indications
•clinical practice guidelines or CPG
•psychiatry
•paediatrics
•specific disorders (seizures, epilepsy, headache, syncope).
MEDLINE review of all abstracts containing EEG for 1995, 1996 for
relevant content
Standard textbooks on Electroencephalography were reviewed.
2 A consensus was reached by a majority vote. No formal consensus
reaching methods were used.
3 Ratified by recommendations at the 1996 CAET meeting on minimal
standards for EEG.
4 Desai, B.T., Porter, R.J., Penry, J.K., Psychogenic Seizures. “A
study of 42 Attacks in Six Patients with Intensive Monitoring”. Arch
Neurol (1982) vol. 39 pg. 202-209.
5 Canadian Congress of Neurological Sciences (CCNS). “Guideline
for the diagnosis of brain death”. Canadian Journal of Neurological
Sciences 1987; 14;653-54.
6 Gronseth, G.S., Greenberg, M.K. “The utility of the
electroencephalogram in the evaluation of patients presenting with
headache: a review of the literature”. Neurology 1995; 47:1263-7.
7 Camfield, P., Gordon, K., Camfield, C., Tibbles, J., Dooley, J.,
Smith, B. “EEG results are rarely the same if repeated within six
months in children with epilepsy”. Canadian Journal of
Neurological Sciences 1995; 22:297-300.
8 Boutros, N.N. “A review of indications for routine EEG in clinical
psychiatry”. Hospital and Community Psychiatry 1992; 43:716-719.
9 Hughes, J.R. “The EEG in psychiatry: An outline with summarized
points and references”. Clinical Electroencephalography 1995;
26:92-101.
Background
Infection control is a discipline integral to the practice of medicine. At all
levels of operation, the tenets of infection control minimize the risk of
infection. In a physician's office, just as in a hospital or at a community
public health level, pathogenic microbes can be spread unnecessarily,
and guidelines must be in place to prevent this from occurring. An added
risk exists in those facilities which use needle electrodes. Needle
electrodes pose a threat of bloodborne disease transmission to the patient
because of contaminated equipment, and to the health care workers who
might be exposed to blood due to sharp injuries.
Precautions
Universal Precautions acknowledge that blood and certain body fluids are
infected and can transmit bloodborne pathogens. It should be regarded as
the minimum standard of practice for preventing transmission of
bloodborne pathogens in all health care settings.
Body Substance Precautions acknowledge that all body substances may
be infectious, so precautions should be taken for contact with any body
substance.
Common to both programs, however, is that all patients can harbour
bloodborne infections, whether symptomatic or not; therefore, a
consistent approach or standard precautions for the handling of blood and
body substances from all patients is recommended. The use of gloves and
other barrier precautions form the basis of these practices.
Staff training
Staff should clearly be competent in the area of expertise in which they
are practising. As well, staff should understand their role in the infection
control strategy, the infection control practices to be followed during the
course of their work, and the protocol to be followed in the event of an
occupational exposure incident.
Note: There is, therefore, no longer any place for needle electrodes for electroencephalography.
If disk electrodes are used and the patient's skin is intact, they should be
treated as non-critical medical instruments (see Appendix II, Classifying
Medical Instruments) and undergo cleaning and intermediate-level
disinfection (see Appendix III, Decontamination Procedures).
If the patient's skin is not intact, they must be treated as semi-critical
instruments (see Appendix II, Classifying Medical Instruments) and
undergo cleaning and sterilization. If sterilization may damage the
instrument then high-level disinfection (see Appendix III,
Decontamination Procedures) must be used as a minimum standard.
If needle electrodes must be used, as in electromyography, single use
disposable electrodes are recommended. The cost of disposable needles
is usually less than the staff and equipment costs and technical
difficulties involved in needle electrode reuse. If needle electrodes must
be reused because of cost considerations (i.e., concentric needles),
cleaning and sterilization using an appropriate method is mandatory after
each use. However in a case of suspected or proven Creutzfeldt-Jakob
disease, only single use disposable electrodes must be used.
Note: If the health care worker's hands has dermatitis or non-intact skin, gloves must be worn to protect the
patient as well as the provider.
Surface skin oils, perspiration and dirt are removed from a patient prior to
nerve conduction studies by cleansing with soap and water or alcohol
swabbing and drying. Skin abrasion should be performed only if
necessary because of technical difficulties. Abrasion creates non-intact
skin and electrodes touching it require cleaning and sterilization. If
sterilization may damage the instrument then high-level disinfection must
be used as a minimum standard.
Before needle examination or the use of subdermal clip electrodes, the
site is scrubbed with an antimicrobial solution such as tincture of iodine
1%-2%, 70% isopropyl alcohol or chlorhexidine. It must be applied with
friction in a circular motion for a minimum of 30 seconds starting at the
intended site and working outward. The solution is allowed to air dry
before electrode insertion.
Monitoring program
Each facility has a system in place to monitor the infection control
strategy and practices used in the office. This includes monitoring of
staff compliance with the infection control practices as well as time/
temperature, chemical and/or biological monitoring of the sterilization
process.
Decontamination Procedures
Decontamination procedures are as follows:
• Cleaning: mechanically removing all organic material using soap and water
or by ultrasonic machines. Organic material interferes with the sterilization
or disinfection process.
• Sterilization: kills all forms of microbial life; including spores. This can be
accomplished by the use of a steam autoclave.
• High level disinfection: kills all forms of microbials but may not be able to
kill large numbers of bacterial spores. This can be accomplished by boiling
or by chemicals such as, glutaraldehyde, 6% hydrogen peroxide or sodium
hypochlorite.
• Intermediate level disinfection: does not kill large numbers of bacterial
spores. Some examples of intermediate level disinfectants are:
- 70 to 90% ethanol and isopropanol
- phenols and phenolics
- sodium hypochlorite.
Class I evidence 38 E
classifying medical instruments 69, 73 EEG Guideline Development Task
cleaning 10, 68, 69, 70, 71, 73, 75 Force i, ii, iv
cleaning electrode caps 10 EEG recordings 8, 10, 21, 31, 38, 39
clinical practice guidelines i, ii EEG recordings, comatose patients 23
clinical practice guidelines, purpose ii EEG recordings, digital EEG 22
Clinical Quality Improvement EEG recordings, documentation 23
Committee, development EEG recordings, electrical safety 22
guidelines iii EEG recordings, infection control 21
College of Physicians and Surgeons of EEG recordings, intensive care
Ontario, mission statement units 21
(inside front cover) 2 EEG recordings, neonatal 21
College of Physicians and Surgeons, EEG recordings, recording 23
quality assessments 19 EEG recordings, reporting
College of Physicians and Surgeons, requirements 24
role i EEG recordings, staff qualifications 23
coma 17, 43 EEG recordings, techniques 27
comatose infants 33 EEG recordings, transcripts 24
comatose patients 23, 43 EEG, amplifiers 26, 55
compact disk read-only-memory 8 EEG, applications 37
computed tomography 37 EEG, clinical indications iv, 37
contaminated liquids 11 EEG, definition iii
continuing medical education 5 EEG, guidelines 37, 38
Creutzfeldt-Jakob disease 10, 44, 69 EEG, laboratories iii
critical instruments 69 EEG, new equipment 7
CSA (see Canadian Standards EEG, referral survey 52
Association) 9 EEG, reporting 15, 16
EEG, standards iv
D EEG, storage 26
daytime sleepiness 46 electrical safety 9, 22
decontamination procedures 69, 75 electrode caps 10
degenerative disorders 43, 52 electrode caps, cleaning 10
delirium 52 electrode caps, patients with
dementia 11, 37, 43, 52 communicable diseases 10
depression 43, 51, 52, 53 electrode caps, prolonged use 11
developmental disorders 49 electrode placement 7, 10, 22
digital EEG v, 8, 9, 22, 32, 57 electrodes iii, 7, 9, 10, 11, 13, 16, 17, 21,
disinfection 68, 69, 70, 71, 73, 75 22, 29, 30, 31, 41, 42, 55, 59, 67,
disk electrodes 21, 69 68, 69, 71
displaying recordings 8 electrodes, single-use 9
dizziness 45 electroencephalogram ii, iii
documentation 13, 15, 23, 28 electroencephalogram, definition iii
double gloving 13 electroencephalographers i, ii, v, 3, 4, 5
electroencephalography ii, iii
environmental cleaning 68, 71
V
vertigo 45
video monitoring 56, 59
volatile vapours 21
W
waveform recording 8
whiplash 46
written consent 16