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    99 Ways To Say I Love You

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    Carlos Guiteriz
    The document provides an overview of different classes of antibacterial drugs including their mechanisms of action, pharmacokinetics, adverse effects, spectra of activity, and uses. It covers beta-lactams, cephalosporins, fluoroquinolones, aminoglycosides, macrolides, tetracyclines, glycopeptides, metronidazole, lincosamides, nitrofurantoin, oxazolidinones, daptomycin, polymyxins, rifamycins, and streptogramins.

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    99 Ways To Say I Love You

    Uploaded by

    Carlos Guiteriz
    15 views9 pages
    The document provides an overview of different classes of antibacterial drugs including their mechanisms of action, pharmacokinetics, adverse effects, spectra of activity, and uses. It covers beta-lactams, cephalosporins, fluoroquinolones, aminoglycosides, macrolides, tetracyclines, glycopeptides, metronidazole, lincosamides, nitrofurantoin, oxazolidinones, daptomycin, polymyxins, rifamycins, and streptogramins.

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    99 Ways to Say I Love You

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    The document provides an overview of different classes of antibacterial drugs including their mechanisms of action, pharmacokinetics, adverse effects, spectra of activity, and uses. It covers beta-lactams, cephalosporins, fluoroquinolones, aminoglycosides, macrolides, tetracyclines, glycopeptides, metronidazole, lincosamides, nitrofurantoin, oxazolidinones, daptomycin, polymyxins, rifamycins, and streptogramins.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    15 views9 pages

    99 Ways To Say I Love You

    Uploaded by

    Carlos Guiteriz
    The document provides an overview of different classes of antibacterial drugs including their mechanisms of action, pharmacokinetics, adverse effects, spectra of activity, and uses. It covers beta-lactams, cephalosporins, fluoroquinolones, aminoglycosides, macrolides, tetracyclines, glycopeptides, metronidazole, lincosamides, nitrofurantoin, oxazolidinones, daptomycin, polymyxins, rifamycins, and streptogramins.

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    Antibacterial Drug Class Review

    “Broad-spectrum antibiotics are not a substitute for rational thought.” – anon

    For all, in general learn: spectrum of activity, pharmacology, pharmacokinetics and

    pharmacodynamics, and primary adverse effects

    Beta-Lactams

    Class effects:

    MOA

    Pharmacokinetics

    AEs

    Penicillins (PCNs)

    Natural penicillins – Penicillin G, Penicillin V

    Spectrum

    Uses, DOC

    Aminopenicillins - Ampicillin, Amoxicillin

    AEs

    Spectrum

    Uses, DOC
    Antistaphylococcal PCNs - Nafcillin, Oxacillin, Methicillin, Dicloxacillin

    PK

    AEs

    Spectrum

    Uses, DOC

    Antipseudomonal PCNs - Piperacillin, Ticarcillin, Mezlocillin, Carbenecillin

    Spectrum

    AEs

    Uses

    Beta-lactam/beta-lactamase inhibitors - Piperacillin/Tazobactam,

    Amoxicillin/Clavulanate, Ampicillin/Sulbactam,

    Ticarcillin/Clavulanate, Ceftolozane/tazobactam (2015)

    MOA

    Spectrum

    Uses

    Cephalosporins

    MOA

    Allergic cross-reactivity with PCNs

    1st Generation

    Cefazolin, Cephalexin, Cefadroxil, Cephalothin


    Spectrum

    Uses

    2nd Generation

    Cefamandole, Cefuroxime, Cefoxitin, Cefotetan, Loracarbef

    Spectrum

    Uses

    3rd Generation

    Ceftriaxone, Ceftazidime, Cefotaxime, Cefpodoxime, Cefixime

    Spectrum

    Uses

    Resistance

    4th Generation

    Cefepime

    Spectrum

    Uses

    Anti-MRSA Cephalosporin (!)

    Ceftaroline

    Spectrum

    Uses
    Cephalosporin/beta-lactamase inhibitor combination

    Ceftolozane/tazobactam

    Spectrum

    Uses

    Carbapenems – Imipenem/Cilastatin, Meropenem, Ertapenem, Doripenem

    MOA

    Spectrum

    Uses

    AEs, differences in spectrum

    Allergic potential

    Monobactams – Aztreonam; not quite beta-lactam

    Spectrum

    Allergic potential

    Uses

    Fluoroquinolones – Ciprofloxacin, Ofloxacin, Levofloxacin, Moxifloxacin, Gemifloxacin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Resistance
    Aminoglycosides – Gentamicin, Tobramycin, Amikacin, Neomycin, Streptomycin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Macrolides – Erythromycin, Clarithromycin, Azithromycin; Ketolides – Telithromycin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Non-absorbed, limited spectrum macrolide – Fidaxomicin

    Pharmacokinetics

    Spectrum

    Uses

    Tetracyclines – Tetracycline, Doxycycline, Minocycline; Glycylcyclines – Tigecycline

    MOA

    Pharmacokinetics

    AEs
    Spectrum

    Uses

    Trimethoprim/Sulfamethoxazole

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Glycopeptides – Vancomycin, Teicoplanin (not in US)

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Lipoglycopeptides – Telavancin, Oritavancin, Dalbavancin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses
    Metronidazole

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Lincosamides – Clindamycin, Lincomycin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Nitrofurantoin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Use

    Oxazolidinones – Linezolid, Tedizolid

    MOA

    Pharmacokinetics (Tedizolid eliminated hepatically only)


    AEs

    Spectrum

    Uses

    Cyclic lipopeptides - Daptomycin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Polymyxins – Colistin (colistimethate for injection), Polymyxin B

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

    Rifamycins – Rifampin, Rifabutin, Rifaximin, Rifapentine

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses
    Resistance

    Streptogramins - Quinupristin/dalfopristin

    MOA

    Pharmacokinetics

    AEs

    Spectrum

    Uses

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