Major Depression: Mental Disorders (DSM) and International Classification of Diseases (ICD) Diagnostic Criteria

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Major depression

In depressive episodes, the individual suffers from depressed mood and/or loss of interest and
enjoyment, and a number of other psychological and somatic symptoms. These include reduced
energy, concentration/attention and self-esteem; ideas of guilt/unworthiness; bleak or pessimistic
views of the future; ideas or acts of self-harm/suicide; and disturbed sleep and appetite. The lowered
mood varies little from day-to-day and is often unresponsive to circumstances. It interferes with
functioning and must last for at least 2 weeks to meet the Diagnostic and Statistical Manual of
Mental Disorders (DSM) and International Classification of Diseases (ICD) diagnostic criteria.

Depressive episodes can be classified as mild, moderate or severe.

Mild depression—the individual is usually distressed by symptoms and has some difficulty carrying
out usual activities.

Moderate depression—several symptoms may be present to a marked degree and the individual
usually has considerable difficulty continuing with usual activities.

Severe depression—the individual usually shows either considerable distress or agitation, or


retardation, and is unlikely to be able to continue usual activities beyond a minimal extent. Somatic
symptoms are prominent and suicide is a particular risk. Major depression with melancholia is a form
of severe depression characterised by psychomotor retardation or agitation, loss of pleasure in all or
almost all activities, marked weight loss and a lack of reactivity of mood. Psychotic symptoms can
occur in severe depression. In primary care or community (outpatient) practice, severe major
depression is uncommon (less than 5% of those presenting with depression) and psychotic
depression is rare.

In primary care severe major depression is uncommon and psychotic depression is rare.

Dysthymic disorder
Dysthymic disorder is characterised by enduring, often fluctuating, low mood (of at least 2 years
duration), but with insufficient symptoms to meet the criteria for major depression. Underlying
personality vulnerabilities are common, and antidepressants are less predictably effective than in
major depression.

Adjustment disorder with depressed and/or anxious mood


Adjustment disorder with depressed and/or anxious mood is a period of distress and emotional
disturbance (usually interfering with social functioning) following a significant stressful life event.
However, the duration and severity of symptoms do not meet the criteria for another depressive or
anxiety disorder. Some degree of personal vulnerability may be present, but the disorder would not
be expected without the life event. Such symptoms may resolve spontaneously, or benefit from
short-term counselling or supportive psychotherapy. There is no evidence that antidepressants are
helpful. For discussion of adjustment disorder with anxious mood, see Adjustment disorder with
anxious mood.

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