Isbesartan is an angiotensin II receptor antagonist used to treat hypertension and reduce the risk of nephropathy in adults and children over 6 years old. It works by blocking the binding of angiotensin II to receptors, causing vasodilation and lowering blood pressure. It is rapidly absorbed after oral administration, has a half-life of 11-15 hours, and is primarily excreted in the feces. Common side effects include upper respiratory infection, fatigue, and diarrhea. Overdose may cause hypotension, syncope, and tachycardia. Nursing considerations include monitoring blood pressure and electrolytes.
Isbesartan is an angiotensin II receptor antagonist used to treat hypertension and reduce the risk of nephropathy in adults and children over 6 years old. It works by blocking the binding of angiotensin II to receptors, causing vasodilation and lowering blood pressure. It is rapidly absorbed after oral administration, has a half-life of 11-15 hours, and is primarily excreted in the feces. Common side effects include upper respiratory infection, fatigue, and diarrhea. Overdose may cause hypotension, syncope, and tachycardia. Nursing considerations include monitoring blood pressure and electrolytes.
Isbesartan is an angiotensin II receptor antagonist used to treat hypertension and reduce the risk of nephropathy in adults and children over 6 years old. It works by blocking the binding of angiotensin II to receptors, causing vasodilation and lowering blood pressure. It is rapidly absorbed after oral administration, has a half-life of 11-15 hours, and is primarily excreted in the feces. Common side effects include upper respiratory infection, fatigue, and diarrhea. Overdose may cause hypotension, syncope, and tachycardia. Nursing considerations include monitoring blood pressure and electrolytes.
Isbesartan is an angiotensin II receptor antagonist used to treat hypertension and reduce the risk of nephropathy in adults and children over 6 years old. It works by blocking the binding of angiotensin II to receptors, causing vasodilation and lowering blood pressure. It is rapidly absorbed after oral administration, has a half-life of 11-15 hours, and is primarily excreted in the feces. Common side effects include upper respiratory infection, fatigue, and diarrhea. Overdose may cause hypotension, syncope, and tachycardia. Nursing considerations include monitoring blood pressure and electrolytes.
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Isbesartan
Generic Name Isbesartan
Brand Name Apo-lrbesartan, Avapro
Classification PHARMACOTHERAPEUTIC: Angiotensin II receptor
antagonist. CLINICAL: Antihypertensive General Action Blocks vasoconstriction, aldosterone-secreting effects of angiotensin II, inhibiting binding of angiotensin II to AT1 receptors. Therapeutic Effect: Produces vasodilation, decreases peripheral resistance, decreases B/P. Pharmocokinetics Route Onset Peak Duration PO 1–2 hrs Greater than 24 hrs Rapidly, completely absorbed after PO administration. Protein binding: 90%. Metabolized in liver. Recovered primarily in feces and, to a lesser extent, in urine. Not removed by hemodialysis. Halflife: 11–15 hrs.
Interactions DRUG: Diuretics produce additive hypotensive effects.
Potassium-sparing diuretics, potassium supplements may increase risk of hyperkalemia. NSAIDs may decrease antihypertensive effect. HERBAL: Ephedra, ginseng, yohimbe may worsen hypertension. Garlic may increase antihypertensive effect. FOOD: None known. LAB VALUES: May slightly increase serum BUN, creatinine. May decrease Hgb. Indications/Routes/Dosage Hypertension PO:
ADULTS, ELDERLY, CHILDREN 13 YRS AND OLDER:
Initially, 75–150 mg/day. May increase to 300 mg/day. CHILDREN 6–12 YRS: Initially, 75 mg/day. May increase to 150 mg/day. Nephropathy PO: ADULTS, ELDERLY: Target dose of 300 mg once daily. Dosage in Renal/Hepatic Impairment No dose adjustment. Availability (Rx) Tablets: 75 mg, 150 mg, 300 mg. Side effects Occasional (9%–3%): Upper respiratory tract infection, fatigue, diarrhea, cough. Rare (2%–1%): Heartburn, dizziness, headache, nausea, rash. Adverse Effects/Toxic Overdose may manifest as hypotension, syncope, and Reactions tachycardia. Bradycardia occurs less often. Nursing Considerations Obtain B/P, apical pulse immediately before each dose, in addition to regular monitoring (be alert to fluctuations). If excessive reduction in B/P occurs, place pt in supine position, feet slightly elevated. Question possibility of pregnancy (see Pregnancy Category). Assess medication history (esp. diuretic therapy).
INTERVENTION/EVALUATION Maintain hydration (offer
fluids frequently). Assess for evidence of upper respiratory infection. Assist with ambulation if dizziness occurs. Monitor electrolytes, renal function, urinalysis, B/P, pulse. Assess for hypotension.
PATIENT/ FAMILY TEACHING: May cause fetal or neonatal
morbidity or mortality. • Avoid tasks that require alertness, motor skills until response to drug is established (possible dizziness effect); ensure appropriate birth control measures are in place. • Report any sign of infection (sore throat, fever). •Avoid exercising during hot weather (risk of dehydration, hypotension).