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    Stained RBC Examination: Demonstrates Partially or Completely Sickled, Crescent-Shaped Cells

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    Jor Garcia
    Diagnostic tests for sickle cell disease include a complete blood count showing reticulocytosis and leukocytosis during crises, a stained blood smear exhibiting sickled red blood cells, and hemoglobin electrophoresis to differentiate between sickle cell trait and anemia. Iron levels, ferritin, and vitamin B12 absorption tests help evaluate related anemia issues. Screening tests like sickle cell tests and sickledex determine hemoglobin S presence but hemoglobin electrophoresis is needed to distinguish conditions.

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    Stained RBC Examination: Demonstrates Partially or Completely Sickled, Crescent-Shaped Cells

    Uploaded by

    Jor Garcia
    14 views1 page
    Diagnostic tests for sickle cell disease include a complete blood count showing reticulocytosis and leukocytosis during crises, a stained blood smear exhibiting sickled red blood cells, and hemoglobin electrophoresis to differentiate between sickle cell trait and anemia. Iron levels, ferritin, and vitamin B12 absorption tests help evaluate related anemia issues. Screening tests like sickle cell tests and sickledex determine hemoglobin S presence but hemoglobin electrophoresis is needed to distinguish conditions.

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    Diagnostic tests for sickle cell disease include a complete blood count showing reticulocytosis and leukocytosis during crises, a stained blood smear exhibiting sickled red blood cells, and hemoglobin electrophoresis to differentiate between sickle cell trait and anemia. Iron levels, ferritin, and vitamin B12 absorption tests help evaluate related anemia issues. Screening tests like sickle cell tests and sickledex determine hemoglobin S presence but hemoglobin electrophoresis is needed to distinguish conditions.

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    Download as DOCX, PDF, TXT or read online from Scribd
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    14 views1 page

    Stained RBC Examination: Demonstrates Partially or Completely Sickled, Crescent-Shaped Cells

    Uploaded by

    Jor Garcia
    Diagnostic tests for sickle cell disease include a complete blood count showing reticulocytosis and leukocytosis during crises, a stained blood smear exhibiting sickled red blood cells, and hemoglobin electrophoresis to differentiate between sickle cell trait and anemia. Iron levels, ferritin, and vitamin B12 absorption tests help evaluate related anemia issues. Screening tests like sickle cell tests and sickledex determine hemoglobin S presence but hemoglobin electrophoresis is needed to distinguish conditions.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Diagnostic Tests

    CBC: Reticulocytosis (count may vary from 30%–50%); leukocytosis (especially in vaso-occlusive crisis)

    Stained RBC examination: Demonstrates partially or completely sickled, crescent-shaped cells


    Iron levels and total iron-binding capacity (TIBC): deficits occur with iron deficiency anemia

    Serum ferritin(Ferritin is iron-storage protein produced by liver, spleen, bone marrow) - Low with depletion of total
    iron reserves
    Sickle cell test: screening test to evaluate hemolytic anemia.
    Sickle-turbidity tube test (Sickledex): Routine screening test that determines the presence of hemoglobin S (HbS)
    but does not differentiate between sickle cell anemia and trait.
    Sickle cell test: screening test to evaluate hemolytic anemia, detect HbS
    Hemoglobin electrophoresis: Identifies any abnormal hemoglobin types and differentiates between sickle cell trait
    and sickle cell anemia. Results may be inaccurate if patient has received a blood transfusion within 3–4 mo
    before testing.
    Schilling Test
     Measures vitamin B12 absorption before and after intrinsic factor administration
     Includes 24-hour urine collection
     Used to differentiate between pernicious anemia and intestinal malabsorption

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