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    3 - Summary & MCQs PDF

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    Srinivas Pingali
    - The document discusses muscle disorders including myopathies, which are primary diseases of muscle that can be inherited or acquired. - Genetic forms of myopathy include several clinical phenotypes such as muscular dystrophy, congenital myopathy, and congenital muscular dystrophy. - Depending on the type of mutation, the disease may range from severe, as in Duchenne muscular dystrophy, to mild, as in Becker muscular dystrophy. - Acquired myopathies have diverse causes like inflammation and toxic exposures.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    3 - Summary & MCQs PDF

    Uploaded by

    Srinivas Pingali
    87 views6 pages
    - The document discusses muscle disorders including myopathies, which are primary diseases of muscle that can be inherited or acquired. - Genetic forms of myopathy include several clinical phenotypes such as muscular dystrophy, congenital myopathy, and congenital muscular dystrophy. - Depending on the type of mutation, the disease may range from severe, as in Duchenne muscular dystrophy, to mild, as in Becker muscular dystrophy. - Acquired myopathies have diverse causes like inflammation and toxic exposures.

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    3- Summary & MCQs.pdf

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    - The document discusses muscle disorders including myopathies, which are primary diseases of muscle that can be inherited or acquired. - Genetic forms of myopathy include several clinical phenotypes such as muscular dystrophy, congenital myopathy, and congenital muscular dystrophy. - Depending on the type of mutation, the disease may range from severe, as in Duchenne muscular dystrophy, to mild, as in Becker muscular dystrophy. - Acquired myopathies have diverse causes like inflammation and toxic exposures.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    87 views6 pages

    3 - Summary & MCQs PDF

    Uploaded by

    Srinivas Pingali
    - The document discusses muscle disorders including myopathies, which are primary diseases of muscle that can be inherited or acquired. - Genetic forms of myopathy include several clinical phenotypes such as muscular dystrophy, congenital myopathy, and congenital muscular dystrophy. - Depending on the type of mutation, the disease may range from severe, as in Duchenne muscular dystrophy, to mild, as in Becker muscular dystrophy. - Acquired myopathies have diverse causes like inflammation and toxic exposures.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 6

     

    Summary & MCQs 
    Objectives: 
    ● Understand the structure of the various types of  muscle fibers. 
    ● Acquire a  basic knowledge of the classification of myopathies and give  examples 
    of these disorders. 
    ● Understand  the  meaning  of  the  term  muscular  dystrophy  and  have  a  basic 
    knowledge of  the incidence and clinicopathological manifestations  of Duchenne's 
    and Becker's muscular dystrophies. 
    ● Know the  pattern of inheritance of myotonic dystrophy and its clinicopathological 
    presentations. 
     
     
     
     
     
     
     

    Red: Important​
      ​
    Gray: Extra explanation  
     

    Summary:  

    ­ Skeletal  muscle  function  can  be  impaired  ​


    secondarily  ​
    due  to  of  problems  with  muscle 

     ​
    innervation or by​  ​
    primary​myopathy that can be inherited or acquired. 

    ­ The  genetic  forms  of  myopathy  fall  into  several  fairly  distinct  clinical  phenotypes  

    including: 

    ➢ Muscular dystrophy 

    ➢ Congenital myopathy. 

    ➢ Congenital muscular dystrophy.  

    ­ Depending  on  the  type  of  mutation  the  disease  may  be severe such as Duchenne muscular 

    dystrophy, or mild like Becker dystrophy. 

    ­ Acquired myopathies have diverse causes including ​  ​
    inflammation​  ​
    and​toxic exposures​
    . 

    2 
     

     
    3 
     

    Check your understanding: 

    1. Which  one  of  the  following  is  considered  as  primary  muscle  disease  and  associated  with 
    necrosis? 
    A. Myopathies 
    B. Neuropathic changes 
    C. Cardiac muscle atrophy 
    2. Breast meat is an example of: 
    A. Slow twitch myofibers 
    B. Fast twitch myofibers 
    C. Checkerboard appearance 
    D. Muscle atrophy 
    3. The most common type of mutations in DMD and BMD: 
    A. Deletion 
    B. Point mutation 
    C. Insertion 
    D. Duplication 
    4. Abnormal  levels  of  Creatine  Kinase  can  provide  early  warning   of  a  certain  disease  such 
    as: 
    A. Acute Renal Failure & DMD 
    B. BMD & DMD 
    C. Myotonic dystrophy & BMD 
    D. Polymyositis & Heart Attack 
    5. Disuse and steroid induced atrophy primarily affect : 
    A. type 1 fibers 
    B. type 2 fibers 
    C. both fibers 
    D. none of the above 
    6. In the inflammatory myopathies, which one of the following is an autoimmune disorder: 
    A. dermatomycosis 
    B. polymyositis 
    C. Ethanol myopathy 
    D. Inclusion body myositis 
    7. A  kid found himself to be clumsy as he has just turned five. His mother decided to bring to 
    to  a  clinic  and  explained  how  her  son  couldn’t  keep  up  with  the  peers  which  made  her 
    worry. Which of the following could be the disease?  
    A. BMD 
    B. Inflammatory disease  
    C. DMD 
    D. Fatigue 

    4 
     

    8. Which of the following causes muscle atrophy:  
    A. Excessive exercise  
    B. Eating high sugar food  
    C. Inflammation 
    D. High steroid intake  
    9. Which of the following may take the form of acute or chronic proximal muscle weakness: 
    A. Inflammatory myopathy 
    B. Ethanol myopathy 
    C. Thyrotoxic myopathy 
    D. Drug myopathy 
    10. Inherited  diseases  that  result  in  progressive  muscle  injury  in  patients  who usually appear 
    normal at birth: 
    A. Muscular dystrophies 
    B. Congenital muscular dystrophies 
    C. Congenital myopathies 
    D. Myopathies 
    11. Which of the following is The dystrophin gene  
    A. Xp21 
    B. Xp22 
    C. Xq21 
    D. Xq22 
    12. Which of the clinical features below is related to mitochondrial myopathies: 
    A. Manifest in early childhood 
    B. Manifest in early adulthood. 
    C. Distal muscle weakness 
    D. B & C 
    13. Which of the following is inherited only as an autosomal dominant form: 
    A. Emery­dreifuss muscular dystrophy 
    B. Facioscapulohumeral dystrophy. 
    C. Limb­girdle muscular dystrophy 
    D. All of the above 
    14. Simple disuse of type II fibers will cause: 
    A. Muscle hypertrophy 
    B. Muscle spasm 
    C. Neurogenic atrophy 
    D. Muscle atrophy 
    15. Immune  mediated  muscle  injury  and  inflammation  are  characteristics  of  which  of  the 
    following: 
    A. Infectious myopathy 
    B. DMD 
    C. BMD 
    D. All of the above 

    5 
     

    Contact us​
    :  ​
    Pathology435@gmail.com
     

    Team members 

    Nouf Altwaijri  Wael Al Oud 
    Aljohara Almazroue   Abdulaziz AlHammad 
    Dalal AlHuzaimi  Abdulaziz Redwan 
    Deema Alfaris  Abdullah AlGhizzi 
    Ghaida Aljamili  Abdulrahman Thekry 
    Haifa Bin Taleb  Ahmad Alkhiary 
    Lina Alshehri  Ahmed Alrwaly 
    Lina Ismael  Ahmed Al Yahya 
    Munerah AlOmari  Ammar Almansour 
    Nojood Alhaidari  Anas Ali 
    Nouf Alabdulkarim  Faris Alwarhi 
    Ola Alnuhayer  Khalid Ali Alghsoon 
    Raghad Almansour  Mana AlMuhaideb 
    Samar AlOtaibi  Naif Alhadi 
    Shahad Albeshr  Saleh Alkhalifa 
    Shahad Aldakhyil  Rayan Almuneef 

    ً
     .‫ﺍﻟﺠﻨﺔ‬ ‫ﺇﻟﻰ‬ ‫ﻃﺮﻳﻘﺎ‬ ‫ﺑﻪ‬ ‫ﻟﻪ‬ ‫ﺍﷲ‬ ‫ﺳﻬﻞ‬  ً
    ‫ﻋﻠﻤﺎ‬ ‫ﺑﻪ‬ ‫ﻳﻠﺘﻤﺲ‬  ً
    ‫ﻃﺮﻳﻘﺎ‬ ‫ﺳﻠﻚ‬ ‫ﻣﻦ‬ :‫ﻭﺳﻠﻢ‬ ‫ﻋﻠﻴﻪ‬ ‫ﺍﷲ‬ ‫ﺻﻠﻰ‬ ‫ﻗﺎﻝ‬

    .‫ﺩﻋﻮﺍﺗﻨﺎ ﻟﻜﻢ ﺑﺎﻟﺘﻮﻓﻴﻖ‬

    6 

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