Scribd Logo
Upload

Welcome to Scribd!

  • 8 views

    RA Vs SLE - 2020

    Uploaded by

    IM CT
    This document compares and contrasts the key properties of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). RA is caused by chronic infection and presents with joint pain, cartilage damage, and bone destruction. It predominantly affects those over 45 years old and shows bone erosion on imaging. SLE has environmental, genetic, and immunological causes and presents with a butterfly rash and potential renal disorders. It predominantly affects those at child-bearing age and shows declines in most blood parameters except ESR. The two diseases differ in their etiology, affected ages, imaging and blood test results.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    RA Vs SLE - 2020

    Uploaded by

    IM CT
    8 views1 page
    This document compares and contrasts the key properties of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). RA is caused by chronic infection and presents with joint pain, cartilage damage, and bone destruction. It predominantly affects those over 45 years old and shows bone erosion on imaging. SLE has environmental, genetic, and immunological causes and presents with a butterfly rash and potential renal disorders. It predominantly affects those at child-bearing age and shows declines in most blood parameters except ESR. The two diseases differ in their etiology, affected ages, imaging and blood test results.

    Original Title

    RA Vs SLE -2020

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document compares and contrasts the key properties of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). RA is caused by chronic infection and presents with joint pain, cartilage damage, and bone destruction. It predominantly affects those over 45 years old and shows bone erosion on imaging. SLE has environmental, genetic, and immunological causes and presents with a butterfly rash and potential renal disorders. It predominantly affects those at child-bearing age and shows declines in most blood parameters except ESR. The two diseases differ in their etiology, affected ages, imaging and blood test results.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    8 views1 page

    RA Vs SLE - 2020

    Uploaded by

    IM CT
    This document compares and contrasts the key properties of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). RA is caused by chronic infection and presents with joint pain, cartilage damage, and bone destruction. It predominantly affects those over 45 years old and shows bone erosion on imaging. SLE has environmental, genetic, and immunological causes and presents with a butterfly rash and potential renal disorders. It predominantly affects those at child-bearing age and shows declines in most blood parameters except ESR. The two diseases differ in their etiology, affected ages, imaging and blood test results.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 1

    RA Vs.

    SLE
    Properties RA SLE
    1. Etiology Chronic Infection with arthritogenic Environmental, Genetic, hormonal &
    Agent Immunological factors
    2. Genetic HLA-DR 1 & DR 4 HLA-DR2 & DR3
    susceptibility
    3. Immune Due to chronic infection & Disturbance in apoptosis process results in
    mechanism (I.M.) appearance of denatured Ab exposure of the cellular internal contents to
    initiators the I.S. action
    4. Amplification of I.M By IL-1 & TNF-α which results in Soluble I.Cs formation in the circulation & its
    Pannus formation that acts in bone deposition in the tissues such as skin or
    erosion kidney in addition to heart lung CNS & others
    5. Diagnostic clinical Joint pain, cartilage damage, bone Butter flay skin rash (Malar or discoid), &
    features destruction and deformity Renal disorders
    6. Diagnostic Markers RF (as screening non-specific) Anti-Nuclear Ab (as screening non-specific)
    marker & Anti-CCP as specific marker while ds-DNA marker is the
    diagnostic predictive marker specific diagnosticTest
    7. Imaging Study Bone erosion & narrowing of the No bone erosion
    Results synovial space
    8. Blood Picture Leukocytosis with elevated All blood parameters decline except for ESR
    thrombocytes & ESR with anemia
    9. Complement Normal or Elevated Both decline
    component C3 & C4
    10. M:F ratio 1:3 1:9
    11. Method for ELISA for RF & Ant-CCP, SRID for Immunoflurescent Ab for ds-DNA & latex-
    detection are: C3 & C4 Synovial fluid aspiration agglutination test for ANA beside IFA for skin
    sometimes and renal Biopsy
    12. Affected Ages Above 45 years (Menopause age) Younger at Child-bearing age

    You might also like