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    Factsheet43 PDF

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    Rabbie Jay

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    Factsheet43 PDF

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    Factsheet43 PDF

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    Department of Human Genetics

    Division of Medical Genetics


    www.genetics.emory.edu

    The Genetics of Blood Type©2006


    Blood type is an example of a trait determined by a single gene. Each of us has two copies of the
    gene for blood type on chromosome pair number 9. One copy is inherited from our mother, the other
    from our father. There are three versions (called “alleles”) of this gene: A, B, and O. A person’s
    blood type is determined by which allele he/she inherits from each parent.

    The genetic constitution of an organism is called the “genotype”. The “phenotype” refers to the
    visible properties of an organism that are produced by the interaction of the genotype and the
    environment. In this case, the A, B, O allele combination a person has is their genotype, while their
    blood type is their phenotype. This table shows the different possibilities:

    Allele Allele Child’s Child’s


    Inherited Inherited Genotype Blood Type
    From One From the (Phenotype)
    Parent Other Parent
    A A AA A
    B B BB B
    B A AB AB
    A B AB AB
    A O AO A
    B O BO B
    O O OO O

    You can see that the A and B genes are “co-dominant”. In other words, if both an A and B allele are
    inherited, both are expressed. O is a recessive allele. If an A or B gene is inherited along with the O
    gene, the A or B gene determines the person’s blood type. A person is type O only if he/she inherits
    two O genes.

    Depending upon parental blood types, a variety of blood type combinations are possible in their
    children (that do not necessarily match their own). This table shows the possible combinations:

    Parent’s Blood Type & Other Parent’s Blood Type & Possible Blood Types
    Possible Alleles Possible Alleles of Children
    Type A: alleles are AA or AO Type A: alleles are AA or AO Type A or Type O
    Type A: alleles are AA or AO Type B: alleles are BB or BO Type AB, Type A, Type B, or
    Type O
    Type A: alleles are AA or AO Type AB: alleles are AB Type AB, Type A, or Type B
    Type A: alleles are AA or AO Type O: alleles are OO Type A or Type O
    Type B: alleles are BB or BO Type B: alleles are BB or BO Type B or Type O
    Type B: alleles are BB or BO Type AB: alleles are AB Type AB, Type A, Type B
    Type B: alleles are BB or BO Type O: alleles are OO Type B or Type O
    Type AB: alleles are AB Type AB: alleles are AB Type AB, Type A, or Type B
    Type AB: alleles are AB Type O: alleles are OO Type A or Type B
    Type O: alleles are OO Type O: alleles are OO Type O
    The “positive” or “negative” part of a person’s blood type is determined by a separate gene, called
    the Rh factor. Each of us has two copies of the gene for the Rh factor, on chromosome pair number
    1. There are two versions (alleles) of the Rh factor gene: positive and negative. A person’s Rh
    status is determined by which allele he/she inherits from each parent. This table shows the different
    possibilities:

    Allele Inherited Allele Inherited From Child’s


    From One Parent the Other Parent Rh Type
    + + +
    - - -
    + - +

    You can see that the Rh-positive gene is dominant over the Rh-negative gene. A person’s Rh type
    is negative only if they inherit two Rh-negative genes.

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