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    ACTIVITY NO 8 Answer PDF

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    sybyl formentera
    Glycerin suppositories can be prepared using a simple process. Glycerin and sodium stearate are heated and mixed, then poured into molds to cool. Twenty drugs were listed that are available as suppositories including analgesics, laxatives, antiemetics, and anti-inflammatories. The suppositories can be administered rectally or vaginally depending on the drug and indication. Common suppository dosage forms include those for pain relief, infection treatment, and contraception.

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    ACTIVITY NO 8 Answer PDF

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    sybyl formentera
    39 views4 pages
    Glycerin suppositories can be prepared using a simple process. Glycerin and sodium stearate are heated and mixed, then poured into molds to cool. Twenty drugs were listed that are available as suppositories including analgesics, laxatives, antiemetics, and anti-inflammatories. The suppositories can be administered rectally or vaginally depending on the drug and indication. Common suppository dosage forms include those for pain relief, infection treatment, and contraception.

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    Glycerin suppositories can be prepared using a simple process. Glycerin and sodium stearate are heated and mixed, then poured into molds to cool. Twenty drugs were listed that are available as suppositories including analgesics, laxatives, antiemetics, and anti-inflammatories. The suppositories can be administered rectally or vaginally depending on the drug and indication. Common suppository dosage forms include those for pain relief, infection treatment, and contraception.

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    © All Rights Reserved
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    39 views4 pages

    ACTIVITY NO 8 Answer PDF

    Uploaded by

    sybyl formentera
    Glycerin suppositories can be prepared using a simple process. Glycerin and sodium stearate are heated and mixed, then poured into molds to cool. Twenty drugs were listed that are available as suppositories including analgesics, laxatives, antiemetics, and anti-inflammatories. The suppositories can be administered rectally or vaginally depending on the drug and indication. Common suppository dosage forms include those for pain relief, infection treatment, and contraception.

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    FORMENTERA, SYBYL SEPTEMBER 27,2020

    ACTIVITY NO. 8
    SUPPOSITORIES

    PREPERATION OF GLYCIRIN SUPPOSITORIES

    Objective: At the end of the activity the student should be able to:
    1. Fill in the table of formulation
    2. Enumerate commercially available suppositories
    3. Identify generic and brand name of drugs and its dosage strength and method of administration
    4. Identify drug indication or category and other available dosage form of the product

    Ingredients Amount Reduced Used


    Glycerin (sp. gr = 1.263) 91g 26g Glycerin , a hygroscopic
    material, contributes to
    the laxative effect of
    the suppositories by
    drawing water from the
    intestine and also from
    its irritant action on the
    mucous lining.
    -Helps maintain the
    shape and consistency
    of the suppositories
    Soduim stearate 9g 2.57g The sodium sterate , is a
    solidifyung agent in the
    supposidtory and may
    also contribute to
    laxative action.
    Purified water 5ml 1.43ml Solvent

    To make 105 g To make 30 g

    Computation For reduced Formula:

    30g
    = 0.2857142857 Factor
    105g
    Glycerine (Sp.gr. 1.263) = 91g x 0.2857142857 = 26g
    Sodium Stearate = 9g x 0.2857142857 = 2.57g
    Purified Water = 5ml x 0.2857142857 = 1.43 ml
    Instructions: Search 20 drugs that are available as suppository and fill in the table.

    GENERIC NAME BRAND NAME DOSAGE METHOD OF IS THERE INDICATION/


    STRENGTH ADMINISTRATION OTHER ROA CATEGORY
    OF THE
    PRODUCT
    Eg. Bisacodyl Dulcolax 10mg Rectal Yes Laxative
    1.Chlorpromazine Thorazine 100mg Rectal Yes Antiemetic
    (Glaxo Smith
    kline)
    2.Hydrocortisone Anusol – HC 25mg Rectal Yes Pruritus ani
    (Salix)
    3.Hyrdromorphone Dlaudid 3 mg Rectal Yes Analgesic
    (Abbott)
    4.Indomethacin Indocin 50mg Rectal YES Anti
    inflamatory
    5.Mesalamine Canasa (Axcan 500mg Rectal Yes Anti –
    Scandipharm) inflamatory
    6.OxyMorphone Numorphan 5mg Rectal Yes Analgesic
    (Endo)
    7.Prochlorperazine Compazzine 2.5,5,25mg Rectal Yes Antiemetic
    (SmithKline
    Beecham)
    8.Promethazine Phergan 12.5,25mg Rectal Yes Antihistamine
    HCL (Wyeth)
    9. Clindamycin Cleocin 100mg Vaginal Yes Bacterial
    suppositories Vaginosis
    (pfizer)
    10.Miconazole Monistat 7 100mg Vaginal NO Antifungal
    Nitrate (Personal
    products)
    11.Progesterone Endometrin 100mg Vaginal Yes Progesterone
    12.Nnoxynol-9 Semicide 100mg Vaginal NO Nonsystemic
    vaginal reversable birth
    Contraceptive control
    Insert
    (Whitehall-
    Robins)
    13.Nonoxynol9 Encare 100mg Vaginal NO Nonsystemic
    Contraceptives reversable birth
    Inserts control
    (Blairex)
    14.Paracetamol Pandol 50mg Rectal Yes Pain /
    Antipyritic
    15.Sodium Voltaren 100 mg Rectal Yes Anti-rhumatic ,
    Diclofenac Anti-
    inflamatory and
    analgesic
    16.Domperidone Motin 10mg Rectal Yes Antienemic
    17.Sodium CEO- TWO 10mg Rectal Yes Laxative
    Bicarbonate
    18.Prochlorperazine Compro 25mg Rectal Yes Antiemetic
    19.Promethazine Phenadoz 12.5mg Rectal Yes Antihistamin
    HCL
    20.Caffeine Migerot 100.2 mg Rectal Yes Headaches/pain
    Ergotamine
    Tartrate
    SCHEMATIC DIAGRAM IN PREPERATION OF GLYCIRIN SUPPOSITORIES

    Procedure:
    1. Prepare 30g only.
    2. Heat the glycerin in a suitable container to about 120F.
    3. Dissolve the sodium stearate with gentle stirring in the heated glycerine then add purified water.
    4. Mix and immediately pour the hot mixture in a suitable mold (if made of metal) previously heated and
    is used while hot.
    5. Cool the suppository completely before removal from the mold.
    6. Packed individually with a foil. Label.

    1.
    Prepare 30g With their reduced amount.
    Heat the glycerin (blue liquid) in a suitable container
    120F to about 120F .
    . + PURIFIED
    WATER
    2.

    Dissolve the sodium stearate (Green Triangle ) with


    gentle stirring in the heated glycerine then add
    purified water.

    3. 4.
    Mix and immediately
    pour the hot mixture in a
    suitable mold (if made of
    metal) previously heated
    and
    is used while hot.

    5.

    Cool the suppository completely before removal from


    the mold.
    Packed individually with a foil. Label.

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