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    Replication Gizmo

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    The document describes the key players involved in DNA replication. It lists the functions of topoisomerase, single-stranded binding proteins, DNA helicase, the replication fork, DNA polymerases I, II, and III, RNA primase, the RNA primer, Okazaki fragments, DNA ligase, telomeres, telomerase, and nucleases. Each player's role in unwinding, unzipping, priming, synthesizing, proofreading, and joining the DNA strands during replication is explained.

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    Replication Gizmo

    Uploaded by

    api-522847737
    164 views5 pages
    The document describes the key players involved in DNA replication. It lists the functions of topoisomerase, single-stranded binding proteins, DNA helicase, the replication fork, DNA polymerases I, II, and III, RNA primase, the RNA primer, Okazaki fragments, DNA ligase, telomeres, telomerase, and nucleases. Each player's role in unwinding, unzipping, priming, synthesizing, proofreading, and joining the DNA strands during replication is explained.

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    The document describes the key players involved in DNA replication. It lists the functions of topoisomerase, single-stranded binding proteins, DNA helicase, the replication fork, DNA polymerases I, II, and III, RNA primase, the RNA primer, Okazaki fragments, DNA ligase, telomeres, telomerase, and nucleases. Each player's role in unwinding, unzipping, priming, synthesizing, proofreading, and joining the DNA strands during replication is explained.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    164 views5 pages

    Replication Gizmo

    Uploaded by

    api-522847737
    The document describes the key players involved in DNA replication. It lists the functions of topoisomerase, single-stranded binding proteins, DNA helicase, the replication fork, DNA polymerases I, II, and III, RNA primase, the RNA primer, Okazaki fragments, DNA ligase, telomeres, telomerase, and nucleases. Each player's role in unwinding, unzipping, priming, synthesizing, proofreading, and joining the DNA strands during replication is explained.

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    Replication Gizmo – Jason Bao

    Take an image of your completed molecule after replication


    THEN label all of the pieces of that molecule
    NEXT draw in the replication enzymes/players
    FINALLY write out either in sentence form or table diagram that describes the function of
    each player
    Topoisomerase/Gyrase Enzyme that unwinds/unties the knots that
    form in DNA (the supercoiling)
    Single stranded binding proteins (ssbp’s) Proteins that bind to the single strands of
    DNA and act as a physical barrier to prevent
    the DNA from reforming its double helix
    DNA Helicase Enzyme that unzips the two strands of the
    helix by breaking the hydrogen bonds
    between the purines and pyrimidines
    Replication Fork Structure that forms when helicase unzips the
    DNA of two branches of single stranded DNA
    (where the replication of DNA actually
    occurs)
    DNA Polymerase I Enzyme that removes the RNA primer (“pops
    it off”) and replaces it with synthesized DNA,
    but leaves phosphodiester gaps towards the 3’
    end
    DNA Polymerase II Enzyme that proofreads the replication and
    catalyzes exonuclease activity to repair errors
    DNA Polymerase III The main enzyme that adds the appropriate
    nucleotides in the 5’ – 3’ direction
    RNA Primase Enzyme that creates/synthesizes the necessary
    RNA primers to allow DNA Polymerase III to
    begin its chain
    RNA Primer The temporary RNA chain to allow for DNA
    Polymerase III to initiate nucleotide
    polymerization
    Okazaki Fragments The pieces in which the lagging,
    discontinuous strand is synthesized in
    DNA Ligase Enzyme that seals the gap between two
    strands of DNA with a phosphodiester bond
    between the phosphate group of one strand
    and the deoxyribose group of another strand
    (joins the Okazaki fragments)
    Telomere Ends of eukaryotic chromosomes with special
    nucleotide sequences that protect genes from
    being eroded through multiple rounds of
    DNA replication
    Telomerase Enzyme that adds a short molecule of RNA as
    a template to extend the 3’ end, creates room
    for primase and DNA Polymerase III to
    extend 5’
    Nuclease Enzymes that repair DNA errors by splitting
    phosphodiester bonds and performing either
    mismatch or excision repair based on the
    extent of the damage.

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