Drug Study

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IRON

INDICATION Iron deficiency anemia


Irons are used for the treatment or prophylaxis of iron-deficiency anemias.
ACTION They should not be given for the treatment of other types of anemia except
where iron deficiency is also present. Iron-deficiency anemias respond
readily to iron therapy but the underlying cause of the anemia should be
determined and treated.
Hypersensitivity. Anemia not caused by iron deficiency, evidence of iron
CONTRAINDICATIO overload or hereditary disturbances in utilization of iron.
N
Antacid, milk, tetracycline, zinc: absorption of oral iron is decreased.
DRUG Ciprofloxacin, levofloxacin, norfloxacin, tetracycline, levodopa,
INTERACTIONS penicillamine: absorption is decrease by oral iron
GI: GI discomfort, anorexia, nausea, vomiting, heartburn, constipation or
ADVERSE diarrhea, fecal impaction, dark stools, dental discoloration.
REACTION Genitourinary: Urine discoloration.
Dermatologic: Allergic reactions, contact dermatitis.
The nurse must educate or discuss using iron supplements and increasing
NURSING dietary sources of iron as indicated. Prepare for blood-typing and cross
RESPONSIBILITIES matching, and for administering packed PBCs during labor if the client has
severe anemia. 

CALCIUM
INDICATION to treat or prevent low calcium levels
Calcium carbonate is a calcium supplement, Vitamin D3 is a fat-soluble
ACTION sterol, it aids in the regulation of calcium and phosphate homeostasis and
bone mineralization.

Known or suspected digoxin toxicity; not recommended as routine treatment


CONTRAINDICATIO in cardiac arrest (includes asystole, ventricular fibrillation, pulseless
N ventricular tachycardia, or pulseless electrical activity)
Some products that may interact with this drug include: digoxin, certain
DRUG phosphate binders (such as calcium acetate), phosphate supplements (such
INTERACTIONS as potassium phosphate), sodium polystyrene sulfonate.
significant: Hypercalcemia, constipation, bloating and gas.
ADVERSE Gastrointestinal disorders: Nausea, vomiting.
REACTION
The nurse must:
NURSING
RESPONSIBILITIES - include encouraging fluid intake and ambulation. Fluids containing
sodium should be used unless contraindicated as sodium
increases calcium excretion.
- Cardiac rhythm should be monitored. 
- Calcium levels should be monitored as ordered, as well as sodium
and potassium levels due to use of diuretics.

FOLIC ACID
INDICATION treatment of megaloblastic anemias of pregnancy
Stimulates production of RBCs, WBCs, and platelets in patients with
ACTION megaloblastic anemias. Include improved symptoms of glossitis, diarrhea,
constipation, weight loss, irritability, fatigue, restless legs, diffuse muscular
pain, insomnia, forgetfulness, mental depression, pallor.
Folic acid alone for pernicious anemia or other vitamin B 12 deficiency states;
CONTRAINDICATIO normocytic, refractory, aplastic, or undiagnosed anemia.
N
may antagonize effects of folate therapy; phenytoin metabolism may be
DRUG increased, thus decreasing its levels in folate-deficient patients.
INTERACTIONS
Although doses up to 5 mg daily have been safely used in some research,
ADVERSE doses of folic acid greater than 1 mg daily might cause abdominal cramps,
REACTION diarrhea, rash, sleep disorders, irritability, confusion, nausea, stomach upset,
behavior changes, skin reactions, seizures, gas, excitability, and other side
effects.

- Obtain a careful history of dietary intake and drug and alcohol usage
NURSING prior to start of therapy. Drugs reported to cause folate deficiency
RESPONSIBILITIES include oral contraceptives, alcohol, barbiturates, methotrexate,
phenytoin, primidone, and trimethoprim. Folate deficiency may also
result from renal dialysis.
- Keep physician informed of patient's response to therapy.
- Monitor patients on phenytoin for sub therapeutic plasma Levels.

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