2-Propanol

GESTIS Substance Database

2-Propanol

IDENTIFICATION

IDENTIFICATION
2-Propanol
Isopropyl alcohol
Isopropanol
Dimethylcarbinol

ZVG No: 11190

CAS No: 67-63-0
EC No: 200-661-7
INDEX No: 603-117-00-0

CHARACTERISATION

SUBSTANCE GROUP CODE

142200 Alcohols

STATE OF AGGREGATION
The substance is liquid.

PROPERTIES
colourless
alcohol-like odour

CHEMICAL CHARACTERISATION
Highly flammable liquid.

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Vapours form explosive mixtures with air.

Mixable with water.
Highly volatile.
Acute or chronic health hazards result from the substance.
(see: chapter REGULATIONS).

Substance information in Wikipedia

FORMULA

C3H8O
C3H8O

Molar mass: 60,10 g/mol

Conversion factor (gaseous phase) at 1013 mbar and 20 °C:
1 ml/m³ = 2,50 mg/m³

PHYSICAL AND CHEMICAL PROPERTIES

MELTING POINT
Melting point: -88 °C
Reference: 00440

BOILING POINT
Boiling Point: 82 °C
Reference: 00440

DENSITY
DENSITY
Value: 0,78 g/cm³
Temperature: 20 °C
Reference: 00440

RELATIVE VAPOUR DENSITY

Ratio of the density to dry air at the same temperature and pressure
Value: 2,07
Reference: 00440

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RELATIVE DENSITY OF THE VAPOUR-AIR-MIXTURE

Ratio of the density to dry air at 20 °C and standard pressure
Value: 1,05
Reference: 99999

VAPOUR PRESSURE
Vapour pressure: 42,6 hPa
Temperature: 20 °C
Reference: 00446

Vapour pressure: 77,7 hPa

Temperature: 30 °C
Reference: 00446

Vapour pressure: 136 hPa

Temperature: 40 °C
Reference: 00446

Vapour pressure: 229 hPa

Temperature: 50 °C
Reference: 00446

FLASH POINT
Flash point: 12 °C
Closed cup
Reference: 00440

IGNITION TEMPERATURE
Ignition temperature: 425 °C
Temperature class: T2
Reference: 00440

EXPLOSION DATA
Lower explosion limit:
2 vol.%
50 g/m³
Upper explosion limit:
13,4 vol.%
335 g/m³
Lower explosion point:
10 °C
Reference: 00440

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Max. exper. safe 0,97 mm

gap (MESG):
at 40 °C
Reference: 00440

Max. exper. safe 0,91 mm

gap (MESG):
at 100 °C
Reference: 00440

Max. exper. safe 0,85 mm

gap (MESG):
at 150 °C
Reference: 00440

SOLUBILITY IN WATER
entirely mixable with water
Reference: 07796

PARTITION COEFFICIENT (octanol/water)

log Kow: 0,05
Recommended value of LOG KOW Databank.
Reference: 02070

HAZARDOUS REACTIONS
Thermal decomposition:
Decomposition when heated.

Decompositon products:
propanal
propane
propene
ethane
ethene
acetylene
formaldehyde
water

Hazardous chemical reactions:

Risk of explosion in contact with:
strong oxidizing agents
nitric acid
oxygen
hydrogen peroxide
barium perchlorate

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sodium dichromate
phosgene/iron salt
nitrogen dioxide
trinitro methan

The compound forms explosive peroxides.

The substance can react dangerously with:
alkali/alkaline earth metals
aluminium
amines
chlorine
strong acids
aldehydes
aluminium triisopropoxide
chlorine compounds
chromium trioxide
iron
potassium-tert.-butoxide
oleum
palladium + hydrogen
phogene
phosphorus trichloride

FURTHER INFORMATION
Conductivity: 5,8 * 10 Exp -06 S/m
Temperature: 25 °C
Reference: 08086

TOXICOLOGY / ECOTOXICOLOGY

TOXICOLOGICAL DATA
LD50 oral rat
Value: 5050 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 8, 1978.

LD50 dermal
Species: Rabbit
Value: 12800 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 100, 1974.

Reference: 02071

ECOTOXICOLOGICAL DATA

LC50 Fish (96 hours)

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Minimum: 4200 mg/l

Maximum: 11100 mg/l
Median: 9640 mg/l
Study number: 5
Reference for median:
Brooke, L.T., D.J. Call, D.L. Geiger, and C.E. Northcott 1984. Acute Toxicities of
Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 1. Center for
Lake Superior Environmental Stud., Univ.of Wisconsin-Superior, Superior, WI :414

LC50 Crustaceans (48 hours)

Minimum: 1400 mg/l
Maximum: 1400 mg/l
Median: 1400 mg/l
Study number: 1
Reference for median:
Blackman, R.A.A. 1974. Toxicity of Oil-Sinking Agents. Mar.Pollut.Bull. 5:116-118

Reference: 02072

OCCUPATIONAL HEALTH AND FIRST AID

ROUTES OF EXPOSURE
Main Routes of exposure:
The main route of exposure for isopropyl alcohol (IPA) under industrial conditions is via
the respiratory tract.[07620]

Respiratory tract:
A mean retention rate of 58.2% in workers exposed to a maximum value of 260 ppm of
IPA was calculated on the basis of the inhaled to the exhaled IPA vapour
concentrations.
It must be considered that with regard to its high blood-air distribution coefficient and its
effective metabolisation, IPA belongs to those substances whose net resorption in the
blood changes proportionally to the ventilation rate.
At a physical load of 150 W the resorbed pollutant amount should thus increase by the
factor of 3 compared to resting conditions at the same external exposure
degree.[99997]

Skin:
Kinetic data pertaining to humans are not available.[99983]
A comparative study on rabbits on the resorption via the most diverse practice-relevant
exposure routes revealed that after equivalent (amounts of) application, the oral route
provides the highest concentrations of IPA in the blood, followed by a combined route
of inhalation and dermal exposure.[00083]
Model calculations on the basis of physicochemical parameters yielded different
assessments of the share of skin contact with regard to the overall industrial
exposure.[99997]

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Gastrointestinal tract:
Orally ingested IPA is rapidly and effectively resorbed by humans.[07619]

TOXIC EFFECTS
Main toxic effects:
Acute effects:
Irritative effects of the vapours (depending on the concentration) on the mucosae.
Irritative effects of the liquid on the eyes and the mucosae of the digestive tract;[07619]
systemic effects after massive toxicity: Disorders of the CNS and the cardiovascular
system.[07620]
Chronic effects:
Skin damage (very seldom);[00083]
No reports on systemic effects after exposure under industrial conditions.[99983]

Acute toxicity:
Acute toxicity of IPA in general was found to be low.[07619]
The eye-irritating potential on humans is known from the application as a disinfectant.
Short-term contact with splashes of the 70% solution caused immediate burning pain,
but no significant damage.
After an exposure of several minutes, individual cases involved short-term turbidity,
which was rapidly reversible.[07979]
Animal experiments do not entirely rule out corrosive effects of the undiluted substance
on the eyes.[07619]
Skin-irritating effects on volunteers could only be recognised after prior superficial
damage (abrasion) or after prior wetting over a period of10 minutes.
A sensitisation was not achieved in several tests on guinea pigs (Buehler-Test).[07934]
Information on the resorptive effects after skin contact is available neither for humans
nor from animal experiments.[99983]
The only published dermal range finding test revealed very low toxicity (LD50, rabbits:
12,870 mg per kg of bodyweight; no detailed information).
After exposure to the inhalation of the substance, a(pleasant) odour could be perceived
between 3.2 and 200 ppm.
At the same time 200 pm were indicated as the irritation threshold.[99997]
Systemic effects after the inhalation of IPA are known only from animal experiments.
On rats after a 6-hour exposure to 1,500 to 10,000 ppm of IPA, neurotoxic effects
(reduction of the motoric activity up to the symptom complex of narcotic effects, i.e.,
exhaustion and severe paralysis, respiratory disorders, loss of reflexes) were observed
in extents proportional to concentration/persistence.
The amount of 500 ppm did not show any impact.[07619]
Four hourLC50 values were determined to amount to 29,800 ppm for rats and 11,200
ppm for mice.[07934]
From a series of cases involving oral toxicities in humans; the symptom complex is well
known: Nausea, vomiting, abdominal pains, gastritis, decreased blood pressure, drop in
temperature, unconsciousness, coma, death caused by respiratory paralysis.[07619]
The amount of 0.5 l of a 70% IPA solution can be lethal.[07980]

Chronic toxicity:

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Inflammatory skin diseases from an allergic reaction were observed in rare cases of
repeated skin contact.[00083]
Independent of this fact, in Switzerland application of IPA instead of ethanol for medical
purposes and for the formulation of mouth care products, even in concentrated form,
was recommended.
However, when the substance is used as external disinfectant for larger areas, it must
be ensured that the maximally resorbed amount does not exceed 500 mg/day.[07714]
In an epidemiological study of 60 women exposed to IPA over periods of up to 17 years
(median exposure value: 106 ppm), distinctive clinical, biochemical or behavioural
findings could not be verified when compared to 48 control persons.[99997]
In workers producing IPA by the strong-acid process, because of mixed exposures
observed effects cannot be ascribed to IPA (see also ‘carcinogenicity’).
Further workplace studies are not available.[99983]
In a 13-week inhalation study on rats and mice (100, 500, 1,500, 5,000 ppm, 6hours
per day, 5days per week), narcotic effects were observed in the highest dose groups
during exposure.
Essential changes after the individual exposures could also only be objectified in the
highest dosage group and only at certain times: Changes in body weight, impairment of
motoric activities and blood counts, increased liver weights, kidney
dysfunctions).[99997]
Chronic inhalation tests under largely analogous conditions yielded similar findings.
A ‘no observed adverse effect concentration’ (NOAEC) of 500 ppm was derived for
IPA.[07619]

Reproductive toxicity, Mutagenicity, Carcinogenicity:

For classifying the reproductive toxicity and mutagenic and carcinogenic potential see
list in Annex VI of the CLP regulation / TRGS 905 / List of MAK values (see section
REGULATIONS).
(see section REGULATIONS).
Reproductive toxicity:
There is no reason to fear a risk of damage to the developing embryo or foetus when
MAK and BAT values are observed.
[05341]
Mutagenicity:
IPA did not exhibit genotoxic effects in in-vitro and in-vivo tests.[07619]
Carcinogenicity:
The carcinogenic risk associated with the production of IPA by the strong acid
procedure cannot be ascribed to a corresponding potential of IPA, but to technologically
conditioned side products.[07980]
Carcinogenicity studies on rats and mice did not reveal any carcinogenic potential of
IPA.[07619]

Biotransformation and Excretion:

Resorbed IPA possesses a considerable distribution volume (0.6–0.7 l/kg) in the
organism.
An enrichment of the substance in certain compartments does not occur. Approx. 85%
of the substance isoxidised to acetone in the liver by alcohol DHO.
In the case of a metabolic formation it is eliminated almost unchanged via the lungs, the

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kidneys and the skin, but most low concentrations are oxidised to CO2 and water.
The elimination half-life for IPA was determined to amount to 2.5-3 hours, for acetone
to approx. 22 hours. Blood-ethanol concentrations of > 0.1 per thousand inhibit the IPA
degradation to a certain extent.[07620]
The quantification of acetone in the full blood or in the urine is suitable for a biological
monitoring.[05309]

Annotation:
This occupational health information was compiled on 31.12.1999.
It will be updated if necessary.
This information was translated from German into English by Übersetzungsbüro Branco.

FIRST AID
Eyes:
Rinse the affected eye with widely spread lids for 10 minutes under running water whilst
protecting the unimpaired eye.
Arrange medical treatment.
[05118]

Skin:
Remove contaminated clothing while protecting yourself.
Rinse the affected skin areas for at least 10 to 20 minutes under running water.
Under no circumstances should alcohol, gasoline or other solvents be used.
After massive or prolonged contact (e.g., with substantially contaminated working
clothes):
Arrange for medical treatment.
[05118, 99999]

Respiratory tract:
Whilst protecting yourself remove the casualty from the hazardous area and take him to
the fresh air.
Lay the casualty down in a quiet place and protect him against hypothermia.
In the case of breathing difficulties have the casualty inhale oxygen.
If the casualty is unconscious but breathing lay him in a stable manner on his side.
Arrange medical treatment.
[00330]

Swallowing:
Rinse the mouth and spit the fluids out.
If the casualty is conscious have him drink 1 glass of water (ca 200 ml).
By no means administer alcohol.
Do not make the casualty vomit.
In case of spontaneous vomiting, position the casualty’s head in deep position or at
least place her in lateral position (aspiration hazard).
Arrange medical treatment.
[00330, 07978, 99999]

Information for physicians:

Toxicities involving IPA have be reported only in connection with oral routes of

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exposure.
Possible consequences after massive exposure can be derived solely from animal
experiments.[00083]

- Symptoms of acute toxicity:

Eyes: Irritations caused by concentrated vapours, immediate burning pain due to
concentrated solutions, reversible cornea turbidity might occur;[07979] corrosive effects
due to undiluted IPA cannot be completely ruled out;
Skin: In general, minor or no irritation; erythema or stronger perception of irritations
after contact with pre-damaged skin;[07934]
Systemic effects occur due more to simultaneous vapour inhalation than to skin
absorption (only after massive contact);[99999]
Inhalation: As of approx. 200 ppm slight, at higher [99997] concentrations more
pronounced mucosa irritations; rapid occurrence of systemic effects after massive
vapour inhalation;[07619]
Ingestion: Concentration-depending irritations of the contacted mucosae; nausea,
vomiting, possibly haematemesis, rapid occurrence of systemic effects;
Absorption: CNS disorders (lethargy, ataxia, nystagmus, dysarthria, somnolence to
coma, convulsions, areflexia), cardiovascular disorders (hypotension, low-output
syndrome, rhythm disorders -> shock -> circulatory arrest), dyspnoea to apnoea; kidney
dysfunctions (due to shock, possibly also as substance-specific effects);[07978]
Decreased blood pressure was regarded as a particularly important clinical diagnosis
parameter in cases of moderate toxicities.[00083]

- First medical assistance:

Eye contact with IPA requires in addition to thorough rinsing further treatment or a
follow-up examination by an ophthalmologist.[05118]
After successful decontamination, follow-up control with regard to a possible combined
dermal-inhalation absorption should be sufficient after skin contact.[99999]
To prevent the (improbable, but still possible) development of a lung oedema, topical
administration of glucocorticoids is required after massive vapour inhalation.[00330]
The absolute key measures to be taken in the narcotic to asphyctic toxicity stadium are
the stabilisation of the cardiovascular and respiratory functions -> more measures see
below.[07718]
Gastric irrigation after oral intake of high doses appears inadvisable due to its rapid
absorption.[07978]
The provocation of vomiting and the application of activated charcoal are questionable
(see ‘recommendations’).[99983]
Intubation should mainly be performed to avoid aspiration; the ventilation indication
depends on the condition of the patient and a blood gas analysis.
Hypotension requires the adjustment of an existing volume deficit with electrolyte and
glucose solutions and possibly through the administration of dopamine (2 - 5 µg per kg
of body weight per minute).
Ventricular extrasystole with haemodynamic disorders requires the slow i.v.
administration of 100-200 mg of lidocaine, followed by the application of 1-4 mg per
minute as a permanent infusion.
The administration of 10-20 mg diazepam is recommended in cases that require the

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disruption of spasms; make sure to account for respiratory depressions.[07978]

Recommendations:
Some secondary literature sources recommend the induction of vomiting and
subsequent administration of activated charcoal after ingestion.[99983]
Both measures would as a matter of timing (ingestion -> absorption)only be effective
when they could be performed by the first aider.
However, this procedure must be advised against, because of the aspiration riskon the
one hand and because of a possible damage of the mucous membranes caused by
possibly undiluted absorbed IPA (-> haematemesis) on the other hand.[07978]
After admission to hospital the patient should undergo a haemodialysis in cases of a
hefty ingestion.
This procedure has turned out to be life-saving in several cases.
The following measures are recommended for specific paraclinical diagnostics:
Verification of IPA in the blood, possibly in the gastric contents, acetonaemia,
acetonuria, generally without acidosis; confirmation of ethanol as a possible
combination pollutant.[00083]
Unlike in cases of methanol toxicities, ethanol must not be administered after toxicities
involving IPA, since the metabolisation to the less toxic acetone conducive to patient
welfare would be substantially slowed down.[07978]

Annotation:
This first aid information was compiled on 31.12.1999.
It will be updated if necessary.
This information was translated from German into English by Übersetzungsbüro Branco.

SAFE HANDLING

TECHNICAL MEASURES - HANDLING

Workplace:
Provision of very good ventilation in the working area.
Washing facility at the workplace required.
Eye bath required. These locations must be signposted
clearly.
When handling excessive amounts of the substance an emergency shower is required.

Equipment:
Use only closed apparatus.
If release of the substance cannot be prevented, then it should be suctioned off at the
point of exit.
Consider emission limit values, a purification of waste gases if necessary.
Label containers and pipelines clearly.
Unsuitable materials:
Plastics have to be proven for their resistibility.

Advice on safer handling:

Take care to maintain clean working place.

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The substance must not be present at workplaces in quantities above that required for
work to be progressed.
Do not leave container open.
Use leak-proof equipment with exhaust for refilling or transfer.
Do not transport with/using compressed air.
Avoid splashing.
Fill only into labelled container.
Use an appropriate exterior vessel when transporting in fragile containers.

Cleaning and maintenance:

Use protective equipment while cleaning if necessary.
Only conduct maintenance and other work on or in the vessel or closed spaces after
obtaining written permission.

TECHNICAL MEASURES - STORAGE

Storage:
Do not use any food containers - risk of mistake.
Containers have to be labelled clearly and permanently.
Store in the original container as much as possible.
Use breakable containers only up to 2 litres content.
Keep container tightly closed.
Recommended storage temperature:
+5 to +30 degree C.
Store in a dry place.
Keep container in a well-ventilated place.
Store smaller vessels in cabinets with collecting tubs.
Store apart from sources of ignition and heat.
Protect from overheating/heating up.
Substance is hygroscopic, protect from moisture.
The maximum permissible stored quantities are to be found in the Technische Regel für
Gefahrstoffe "Lagerung von Gefahrstoffen in ortsbeweglichen Behältern" (TRGS 510).
Storage is not permissible in hallways, thoroughfare, stairways, public hallways and
corridors, on the roof, in attics, and in workrooms.

Conditions of collocated storage:

Storage class 3 (Flammable liquid substances)
Only substances of the same storage class should be stored together.
Collocated storage with the following substances is prohibited:
- Pharmaceuticals, foods, and animal feeds including additives.
- Infectious, radioactive und explosive substances.
- Gases.
- Other explosive substances of storage class 4.1A.
- Flammable solid substances or desensitized substances of storage class 4.1B.
- Pyrophoric substances.
- Substances liberating flammable gases in contact with water.
- Strongly oxidizing substances of storage class 5.1A.
- Ammonium nitrate and preparations containing ammonium nitrate.

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- Organic peroxides and self reactive substances.

- Non combustible acutely toxic substances of storage class 6.1B.
Under certain conditions the collocated storage with the following sub-stances is
permitted (For more details see TRGS 510):
- Oxidizing substances of storage class 5.1B.
- Noncombustible toxic or chronically acting substances of storage class 6.1D.
- Combustible solids of storage class 11.
The substance should not be stored with substances with which ha-zardous chemical
reactions are possible.

TECHNICAL MEASURES - FIRE AND EXPLOSION PROTECTION

Technical, constructive measures:
Substance is combustible.
Fire fighting equipment must be available.
The possibility of the formation of a hazardous explosive atmosphere must be
evaluated in the risk assessment. Depending on the result of the risk assessment,
measures in accordance with TRGS 722 (prevention of formation), TRGS 723
(prevention of ignition) and TRGS 724 (constructive explosion protection) may be
required.
Take precautionary measures against static discharges.
Earth all parts which can be electrically charged.

Precaution on handling:
The vapour-air-mixture is explosive.
Area with explosion risk.
Keep at a distance from sources of ignition (e.g. electrical devices, open flames, heat
sources, sparks).
Observe the smoking prohibition!
Absolutely no welding in the working area.
Only work with vessels and lines after these have been thoroughly rinsed.
Work done with fire or open flame should only be carried out with written permission if
the risk of fire or explosion cannot be completely eliminated.
Use caution with empty vessels; explosion is possible in case of ignition.
Do not use any tools that cause sparks.
It must be avoided that gases or vapours can escape into other rooms where sources
of ignition are present.

ORGANISATIONAL MEASURES
Instruction on the hazards and the protective measures using instruction manual (
TRGS 555) are required with signature if just more than one minor hazard was
detected.
Instruction must be provided before employment and then at a minimum of once per
annum thereafter.
An escape and rescue plan must be prepared when the location, scale, and use of the
work-site so demand.
It must be assured that the workplace limit values are being maintained. If the limit

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values are exceeded, additional protection measures are necessary.

The measurements must be recorded and kept on file.
Observe the restrictions on juvenile employment as defined in the
"Jugendarbeitsschutzgesetz".
Only employees are permitted to enter the work areas. Signposting to this effect must
be displayed.

PERSONAL PROTECTION
Body protection:
Wear an apron or a lab coat.
Wear flameproof, antistatic protective clothing.

Respiratory protection:
In an emergency (e.g.: unintentional release of the substance, exceeding the
occupational exposure limit value) respiratory protection must be worn. Consider the
maximum period for wear.
Respiratory protection: Gas filter A, Colour code brown.
Use insulating device for concentrations above the usage limits for filter devices, for
oxygen concentrations below 17% volume, or in circumstances which are unclear.

Eye protection:
Sufficient eye protection must be worn.
Wear glasses with side protection.

Hand protection:
The use of resistant protective gloves is recommended.
Skin protection cremes do not protect as effectively against the substance as protective
gloves. Therefore suitable protective gloves should be preferred as far as possible.
The following materials are suitable for protective gloves (Permeation time >= 8 hours):
Nitrile rubber/Nitrile latex - NBR (0,35 mm)
Butyl rubber - Butyl (0,5 mm)
Fluoro carbon rubber - FKM (0,4 mm)
Protective gloves of the following materials should not be worn longer than 4 hours
continually (Permeation time >= 4 hours):
Polychloroprene - CR (0,5 mm)
Following materials are unsuitable for protective gloves because of degradation, severe
swelling or low permeation time:
Natural rubber/Natural latex - NR
Polyvinyl chloride - PVC
The times listed are suggested by measurements taken at 22 °C and constant contact.
Temperatures raised by warmed substances, body heat, etc. and a weakening of the
effective layer thickness caused by expansion can lead to a significantly shorter
breakthrough time. In case of doubt contact the gloves' manufacturer. A 1.5-times
increase / decrease in the layer thickness doubles / halves the breakthrough time. This
data only applies to the pure substance. Transferred to mixtures of substances, these
figures should only be taken as an aid to orientation.

Occupational hygiene:

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Take heed of usual occupational hygiene measures when handling chemical

substances, espacially wash the skin with soap and water before breaks and at the end
of work and apply fatty skin-care products after washing.
Avoid contact with eyes. In case of contact rinse the affected eye(s).
Avoid inhalation of vapour or mist.
Change clothing that has become wet and do not reuse until completely dry.
Increased risk of combustion from wicking.

DISPOSAL CONSIDERATIONS
Hazardous waste according to Waste Catalogue Ordinance (AVV).
If there is no way of recycling it must be disposed of in compliance with the respective
national and local regulations.

Collection of small amounts of substance:

Place in a collection container for halogen-free organic solvents and solutions of
halogen-free organic substances.
Collection vessels must be clearly labelled with a systematic description of their
contents. Store the vessels in a well-ventilated location. Entrust them to the appropriate
authorities for disposal.

ACCIDENTAL RELEASE MEASURES

Shut off all sources of ignition.
Evacuate area. Warn affected surroundings.
Wear respiratory protection, eye protection, hand protection and body protection (see
chapter Personal Protection).
Absorb any spilt liquid with an absorbent (e.g. diatomite, vermiculite, sand) and dispose
of according to regulations.
Use non-sparking tools.
Afterwards ventilate area and wash spill site.

Endangerment of watert:
Low hazard to waters. Inform the responsible authorities when very large quantities get
into water, drainage, sewer, or the ground.

FIRE FIGHTING MEASURES

Classes of fires:
B liquid or melting substances

Suitable extinguishing media:

Water (spray - not splash)
Dry extinguishing powder
Carbon dioxide
Fight large fire with alcohol resistant foam or water spray.

Instructions:
Cool surrounding containers with water spray.

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If possible, take container out of dangerous zone.

Heating causes a rise in pressure, risk of bursting and
explosion.
Shut off sources of ignition.
Beware of backfire.
Use only explosion proved equipment.
Do not allow runoff to get into the sewage system.

Special protective equipment:

In the case of a fire hazardous substances can be released.
Carbon monoxide and carbon dioxide
Wear self-contained breathing apparatus.

REGULATIONS

EUROPEAN GHS CLASSIFICATION AND LABELLING

Classification:
Flammable liquids, Category 2; H225
Eye irritation, Category 2; H319
Specific Target Organ Toxicity (single exposure), Category 3; H336

Signal Word: "Danger"

Hazard Statement - H-phrases:

H225: Highly flammable liquid and vapour.
H319: Causes serious eye irritation.
H336: May cause drowsiness or dizziness.

Precautionary Statement - P-phrases:

P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition
sources. No smoking.
P240: Ground and bond container and receiving equipment.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.

Manufacturer's specification by Merck

Reference: 01211
State: 2018
Checked: 2020

The substance is listed in appendix VI, table 3 of CLP regulation.

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The given classification can deviate from the listed classification, since this
classification is to be complemented concerning missing or divergent danger classes
and categories for the respective substance.

Reference: 99999

GHS-CLASSIFICATION OF MIXTURES
The classification of mixtures containing this substance results from Annex 1 of
Regulation (EC) 1272/2008.

Reference: 99999

WORKPLACE LABELLING ACCORDING TO GERMAN ASR A1.3

Prohibition label:

No open flame; fire, open ignition sources and smoking

prohibited

No admittance for unauthorized persons

Warning label:

Caution - inflammable material

Precept label:

Use safety goggles

GERMAN WATER HAZARD CLASS

Substance No: 135
WGK 1 - low hazard to waters
Classification according to the announcement of the list of substances hazardous to
water in the Federal Register of 10.08.2017, last update 06.08.2020

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TECHNICAL INSTRUCTIONS ON AIR QUALITY CONTROL (TA LUFT)

Chapter 5.2.5 Organic Substances.
The following values, specified as overall carbon, are in all not allowed to be exceeded
in exhaust gas:
Mass flow: 0,50 kg/hr
or
Mass conc.: 50 mg/m³
At old units with an annual mass flow till 1,5 Mg/a, specified as total carbon, the
emissions in exhaust gas are not allowed to exceed 1,5 kg/h.

TRANSPORT REGULATIONS

UN Number: 1219
Shipping name: Isopropanol
Hazard Identification Number: 33
Class: 3 (Flammable Liquids)
Packing Group: II (medium danger)
Danger Label: 3

Classification F1
code:

Tunnel restrictions:
Transports in bulk or in tanks: passage forbidden through tunnels of category D and E.
Other transports: passage forbidden through tunnels of category E.

Reference: 07902

TRGS 900 - GERMAN OCCUPATIONAL EXPOSURE LIMIT VALUES

200 ml/m³
500 mg/m³

Peak limitation: Excursion factor 2

Duration 15 min, mean; 4 times per shift; interval 1 hour
Category II - Substances with systemic effects

There is no reason to fear a risk of damage to the developing embryo or foetus when
AGW and BGW are adhered to.

Source: DFG

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2-Propanol

RECOMMENDATIONS OF MAK-COMMISSION
This data is recommended by scientific experience and is not established law.

200 ml/m³
500 mg/m³

Peak limitation: Excursion factor 2

Duration 15 min, mean; 4 times per shift; interval 1 hour
Category II - Substances with systemic effects

Pregnancy: Group C
There is no reason to fear damage to the embryo or foetus when MAK and BAT values
are observed.

GERMAN BIOLOGICAL EXPOSURE INDICES

Parameter: Acetone
Value: 25 mg/l
Assay material: Whole blood
Sampling time: end of exposure/end of shift
Reference: 05347

Parameter: Acetone
Value: 25 mg/l
Assay material: Urine
Sampling time: end of exposure/end of shift
Reference: 05347

DIRECTIVE 2012/18/EU (Seveso III)

Annex I Part 1 Section: P5a
Flammable liquids Category 2 or 3 (or other liquids with a flash point ≤ 60 °C),
maintained at a temperature above their boiling point
Qualifying quantity for the application of
Lower-tier requirements: 10 t
Upper-tier requirements: 50 t

Annex I Part 1 Section: P5b

Flammable liquids Category 2 or 3 (or other liquids with a flash point ≤ 60 °C), where
particular processing conditions, such as high pressure or high temperature, may
create major-accident hazardsor-accident hazards
Qualifying quantity for the application of
Lower-tier requirements: 50 t
Upper-tier requirements: 200 t

Annex I Part 1 Section: P5c

Flammable liquids, Category 2 or 3 not covered by P5a and P5b

IFA GESTIS-Substance Database 19/25 16.10.2020

2-Propanol

Qualifying quantity for the application of

Lower-tier requirements: 5000 t
Upper-tier requirements: 50000 t

RESTRICTIONS OF USE / BANS OF USE

REACH Regulation (EC) No 1907/2006 Annex XVII
Annex XVII, Point 3
1. The putting into circulation and the utilisation of the substance is not allowed in
decorative objects, games and joke articles.
2. Substances labelled with H304 which can be utilised as fuels in decorative lamps
and are put in circulation in amounts of 15 l or less must not contain a dye and/or a
perfume.
Further information on prohibitions can be taken from the regulation.
Annex XVII, Point 40
Shall not be used, as substance or as mixtures in aerosol dispensers
where these aerosol dispensers are intended for supply to the general
public for entertainment and decorative purposes such as the following:
— metallic glitter intended mainly for decoration,
— artificial snow and frost,
— “whoopee” cushions,
— silly string aerosols,
— imitation excrement,
— horns for parties,
— decorative flakes and foams,
— artificial cobwebs,
— stink bombs.
Further information on prohibitions and exceptions can be taken from the regulation.

Annex XVII to Regulation (EC) No 1907/2006, consolidated version (BAUA) (only in

German)

Consumer Goods Ordinance

Attachment 1 to § 3, Point 5
The substance must not be utilised for the production or treatment of joke articles.

TECHNICAL RULES FOR HAZARDOUS SUBSTANCES

TRGS 201
Einstufung und Kennzeichnung bei Tätigkeiten mit Gefahrstoffen; Ausgabe Februar
2017, zuletzt geändert und ergänzt April 2018

TRGS 400
Gefährdungsbeurteilung für Tätigkeiten mit Gefahrstoffen; Ausgabe Juli 2017

TRGS 555
Betriebsanweisung und Information der Beschäftigten; Ausgabe Februar 2017

IFA GESTIS-Substance Database 20/25 16.10.2020

2-Propanol

TRGS 600
Substitution; Ausgabe Juli 2020

TRGS 402
Ermitteln und Beurteilen der Gefährdungen bei Tätigkeiten mit Gefahrstoffen: Inhalative
Exposition; Ausgabe Januar 2010, zuletzt geändert und ergänzt Oktober 2016

TRGS 500
Schutzmaßnahmen; Ausgabe September 2019

TRGS 509
Lagern von flüssigen und festen Gefahrstoffen in ortsfesten Behältern sowie Füll- und
Entleerstellen für ortsbewegliche Behälter; Ausgabe September 2014, zuletzt berichtigt,
geändert und ergänzt Oktober 2020

TRGS 510
Lagerung von Gefahrstoffen in ortsbeweglichen Behältern; Ausgabe Januar 2013,
geändert und ergänzt November 2014, berichtigt November 2015

TRGS 800
Brandschutzmaßnahmen; Ausgabe Dezember 2010

TRGS 720
Gefährliche explosionsfähige Gemische - Allgemeines; Ausgabe Juli 2020

TRGS 721
Gefährliche explosionsfähige Gemische - Beurteilung der Explosionsgefährdung;
Ausgabe März 2006, zuletzt berichtigt, geändert und ergänzt Oktober 2020

TRGS 722
Vermeidung oder Einschränkung gefährlicher explosionsfähiger Atmosphäre, Ausgabe
März 2012

TRGS 723
Gefährliche explosionsfähige Gemische - Vermeidung der Entzündung gefährlicher
explosionsfähiger Gemische; Ausgabe Juli 2019, zuletzt berichtigt, geändert und
ergänzt Oktober 2020

TRGS 724
Gefährliche explosionsfähige Gemische - Maßnahmen des konstruktiven
Explosionsschutzes, welche die Auswirkung einer Explosion auf ein unbedenkliches
Maß beschränken, Ausgabe Juli 2019

TRGS 906
Verzeichnis krebserzeugender Tätigkeiten oder Verfahren nach § 3 Abs. 2 Nr. 3
GefStoffV; Ausgabe Juli 2005, zuletzt geändert und ergänzt März 2007
Starke-Säure-Verfahren bei der Herstellung von Isopropylalkohol

REGULATIONS OF GERMAN ACCIDENT INSURERS

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2-Propanol

DGUV Regel 112-190

Benutzung von Atemschutzgeräten, Ausgabe Dezember 2011
http://publikationen.dguv.de/dguv/pdf/10002/r-190.pdf
(in German only)

DGUV Regel 112-195

Benutzung von Schutzhandschuhen, Aktualisierte Nachdruckfassung Oktober 2007
http://publikationen.dguv.de/dguv/pdf/10002/bgr195.pdf
(in German only)

LINKS

International Limit Values

OECD Screening Information DataSet (SIDS)
The MAK Collection for Occupational Health and Safety
DGUV Information 213-098: List of substances - lesson in schools (in German only)

REFERENCES

Reference: 00001
IFA: Erfassungs- und Pflegehandbuch der GESTIS-Stoffdatenbank (nicht öffentlich)
Data acquisition and maintenance manual of the GESTIS substance database
(non-public)

Reference: 00083
Environmental Health Criteria (Serie), WHO, Genf

Reference: 00330
U. Welzbacher "Neue Datenblätter für gefährliche Arbeitsstoffe nach
Gefahrstoffverordnung" Loseblattsammlung mit Ergänzungslieferungen, WEKA-Verlag,
Augsburg

Reference: 00440
Datenbank CHEMSAFE, Version 2016.0, DECHEMA-PTB-BAM

Reference: 00446
Datenbank CHEMSAFE, DECHEMA-PTB-BAM. Dampfdruckdaten berechnet aus
Antoine-Konstanten

Reference: 01211
GHS-Sicherheitsdatenblatt, Merck
GHS Material Safety Data Sheet, Merck

Reference: 02070
LOG KOW Databank, compiled by Dr. James Sangster, Sangster Research
Laboratories, Montreal, Canada, distributed by Technical Database Services (TDS),

IFA GESTIS-Substance Database 22/25 16.10.2020

2-Propanol

New York

Reference: 02071
Toxicological Data, compiled by the National Institute of Health (NIH), USA, selected
and distributed by Technical Database Services (TDS), New York, 2009

Reference: 02072
Ecotoxicological Data, compiled by the US Environmental Protection Agency (EPA),
selected and distributed by Technical Database Services (TDS), New York, 2009

Reference: 05118
Kühn-Birett-Merkblätter: 118. Ergänzungslieferung; 06/99

Reference: 05185
Kühn-Birett-Merkblätter: 185. Ergänzungslieferung; 05/2005

Reference: 05300
TRGS 510 "Lagerung von Gefahrstoffen in ortsbeweglichen Behältern" Ausgabe
Januar 2013, in der Fassung vom 30.11.2015

Reference: 05309
TRGS 903 "Biologische Grenzwerte" in der jeweils gültigen Fassung

Reference: 05341
TRGS 900 "Arbeitsplatzgrenzwerte" in der zum Bearbeitungszeitpunkt gültigen
Fassung

Reference: 05347
TRGS 903 "Biologische Grenzwerte (BGW)" Ausgabe Februar 2013; zuletzt geändert
Februar 2020

Reference: 05350
TRGS 900 "Arbeitsplatzgrenzwerte" Ausgabe Januar 2006, zuletzt geändert und
ergänzt Oktober 2020

Reference: 06002
L. Roth, U. Weller
"Gefährliche Chemische Reaktionen" Loseblattsammlung mit Ergänzungslieferungen
"Dangerous chemical reactions" loose-leaf collection with supplement deliveries
ecomed-Verlag

Reference: 07580
Bekanntmachung der Liste der wassergefährdenden Stoffe im Bundesanzeiger vom
10.08.2017, zuletzt geändert 06.08.2020

Reference: 07619
DFG: Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten; Verlag
Chemie

Reference: 07620

IFA GESTIS-Substance Database 23/25 16.10.2020

2-Propanol

DFG: Arbeitsmedizinisch-toxikologische Begründungen von BAT-Werten; Verlag

Chemie

Reference: 07635
AUERDATA 98

Reference: 07714
H. P. Fiedler "Lexikon der Hilfsstoffe für Pharmazie, Kosmetik und angrenzende
Gebiete" 3. überarbeitete und ergänzte Auflage

Reference: 07718
R. Ludewig, KH. Lohs "Akute Vergiftungen" 8. Auflage, Gustav Fischer Verlag, Jena
1991

Reference: 07795
H. Geerißen "GloSaDa 2000 Plus - Glove Safety Data"

Reference: 07796
L. Roth "Wassergefährdende Stoffe" Loseblattsammlung mit Ergänzungslieferungen,
ecomed-Verlag

Reference: 07902
BAM: Datenbank Gefahrgut-Schnellinfo

Reference: 07934
IUCLID-Datensätze 1996, European Commission JRC

Reference: 07978
Klaus Albrecht: Intensivtherapie akuter Vergiftungen; Verlag Ullstein-Mosby; Berlin
1997

Reference: 07979
W.M. Grant, J.S. Schuman: Toxicology of the eyes; 4th Edition, Charles C Thomas
Publisher, Springfield, Illinois; 1993

Reference: 07980
IARC - International Agency for research on cancer: Monographs on the evaluation of
carcinogenic risks to humans WHO, Lyon; Serie

Reference: 08086
BG RCI Merkblatt T 033 / DGUV Information 213-060: "Vermeidung von Zündgefahren
infolge elektrostatischer Aufladung", Stand 8/2016

Reference: 08112
DFG Deutsche Forschungsgemeinschaft: MAK- und BAT-Werte-Liste 2020,
Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Mitteilung 56;
GMS PUBLISSO

Reference: 99983
Liste arbeitsmedizinisch-toxikologischer Standardwerke (2)

IFA GESTIS-Substance Database 24/25 16.10.2020

2-Propanol

List of standard references regarding occupational health and toxikology (2)

Reference: 99997
Projektgebundene arbeitsmedizinisch-toxikologische Literatur (1)
Project related bibliographical references regarding occupational health and toxikology
(1)

Reference: 99999
Angabe des Bearbeiters
Indication of the editor

This substance datasheet was created with greatest care. Nevertheless no liability irrespective of legal basis can
be accepted.

IFA GESTIS-Substance Database 25/25 16.10.2020