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    Ayurvedic Insights of Avascular Necrosis of Femoral Head

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    IJAR JOURNAL
    Avascular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, steroids, following trauma or unclear (idiopathic) etiology, affecting mostly the middle aged population. Clinically AVNFH is associated with impaired blood supply to the femoral head resulting in bone necrosis and collapse.In Ayurveda, there is no direct reference of disease resembling to Avascular necrosis of femoral head, hence it can be understand on the basis of Vikaraprakriti of disease

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    Ayurvedic Insights of Avascular Necrosis of Femoral Head

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    IJAR JOURNAL
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    Avascular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, steroids, following trauma or unclear (idiopathic) etiology, affecting mostly the middle aged population. Clinically AVNFH is associated with impaired blood supply to the femoral head resulting in bone necrosis and collapse.In Ayurveda, there is no direct reference of disease resembling to Avascular necrosis of femoral head, hence it can be understand on the basis of Vikaraprakriti of disease

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    AYURVEDIC INSIGHTS OF AVASCULAR NECROSIS OF FEMORAL HEAD

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    Avascular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, steroids, following trauma or unclear (idiopathic) etiology, affecting mostly the middle aged population. Clinically AVNFH is associated with impaired blood supply to the femoral head resulting in bone necrosis and collapse.In Ayurveda, there is no direct reference of disease resembling to Avascular necrosis of femoral head, hence it can be understand on the basis of Vikaraprakriti of disease

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    © All Rights Reserved
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    57 views4 pages

    Ayurvedic Insights of Avascular Necrosis of Femoral Head

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    IJAR JOURNAL
    Avascular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, steroids, following trauma or unclear (idiopathic) etiology, affecting mostly the middle aged population. Clinically AVNFH is associated with impaired blood supply to the femoral head resulting in bone necrosis and collapse.In Ayurveda, there is no direct reference of disease resembling to Avascular necrosis of femoral head, hence it can be understand on the basis of Vikaraprakriti of disease

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    © All Rights Reserved
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    of 4

    ISSN: 2320-5407 Int. J. Adv. Res.

    9(07), 51-54

    Journal Homepage: - www.journalijar.com

    Article DOI: 10.21474/IJAR01/13098


    DOI URL: http://dx.doi.org/10.21474/IJAR01/13098

    RESEARCH ARTICLE
    AYURVEDIC INSIGHTS OF AVASCULAR NECROSIS OF FEMORAL HEAD

    Surendra Kumar1 and Gopesh Mangal2


    1. Ph.D. Scholar, Panchakarma Dept., National Institute of Ayurveda, Jaipur, India.
    2. Associate Professor, PG Department of Panchkarma, National Institute of Ayurveda, Jaipur, India.
    ……………………………………………………………………………………………………....
    Manuscript Info Abstract
    ……………………. ………………………………………………………………
    Manuscript History Avascular necrosis of the femur head (AVNFH) is a debilitating
    Received: 05 May 2021 disease caused due to the use of alcohol, steroids, following trauma or
    Final Accepted: 10 June 2021 unclear (idiopathic) etiology, affecting mostly the middle aged
    Published: July 2021 population. Clinically AVNFH is associated with impaired blood
    supply to the femoral head resulting in bone necrosis and collapse.In
    Key words:-
    Avascular Necrosis, Ayurveda, Ayurveda, there is no direct reference of disease resembling to
    Asthimajjagata Vata Avascular necrosis of femoral head, hence it can be understand on the
    basis of Vikaraprakriti of disease caused by vitiation of Dosa,
    Adhisthana (abodesite) and Hetu (causes of vitiation of Dosa). In the
    present study an effort has been made to understand AVN on the
    ground of Ayurveda.

    Copy Right, IJAR, 2021,. All rights reserved.


    ……………………………………………………………………………………………………....
    Introduction:-
    Avascular necrosis of femoral head (AVNFH) is a progressive, multifactorial and challenging clinical problem that
    is on the rise mostly affecting the middle aged male population in the most productive age group of 25–50years.
    Clinically, AVNFH is a pathological state with multiple etiologies associated with a reduction in the vascular supply
    to the subchondral bone of the femoral head. This results in osteocyte death and progressive collapse of the articular
    surface followed by degenerative arthritis of the hip joint. 1It is of two types- traumatic and non trauamtic.

    Causes
    Dislocation or fracture of the thigh bone (femur).
    This type of injury can affect the blood supply to the bone, leading to trauma-related avascular necrosis. AVN may
    develop in 20% or more of people who dislocate a hip.

    Chronic corticosteroid use.


    Long-term use of these inflammation fighting drugs, either orally or intravenously, is associated with 35% of all
    cases of non traumatic AVN. Although the reason for this is not completely understood, doctors suspect these drugs
    may interfere with the body's ability to break down fatty substances. These substances collect in the blood vessels --
    making them narrower -- and reduce the amount of blood to the bone.

    Excessive alcohol use.


    Much like corticosteroids, excessive alcohol may cause fatty substances to build in the blood vessels and decrease
    the blood supply to the bones.

    Blood clots, inflammation, and damage to the arteries. All of these can block blood flow to the bones.

    Corresponding Author:- Surendra Kumar 51


    Address:- Ph.D. scholar, Panchakarma Dept., National Institute of Ayurveda, Jaipur, India.
    ISSN: 2320-5407 Int. J. Adv. Res. 9(07), 51-54

    Other conditions associated with non traumatic AVN include:


    1. Gaucher disease, an inherited metabolic disorder in which harmful quantities of a fatty substance accumulate in
    the organs
    2. Sickel cell disease
    3. Pancreatitis, inflammation of the pancreas
    4. HIV infection
    5. Radiation therapy or chemotherapy
    6..Autoimmune diseases
    7. Decompression sickness, a condition that occurs when the body is subjected to a sudden reduction in surrounding
    pressure, causing the formation of gas bubbles in the blood.

    Symptoms of Avascular Necrosis


    In its early stages, AVN typically cause no symptoms; however, as the disease progresses it becomes painful. At
    first, you may experience pain when you put pressure on the affected bone. Then, pain may become more constant.
    If the disease progresses and the bone and surrounding joint collapse, you may experience severe pain that interferes
    with your ability to use your joint. The time between the first symptoms and collapse of the bone may range from
    several months to more than a year.2

    Pathogenesis
    The pathogenesis of osteonecrosis is an area of controversy. Most experts believe that it is the result of the combined
    erects of genetic predisposition, metabolic factors and local factors, affecting blood supply, such as vascular
    damage, increased inter osseous pressure, and mechanical stresses. The mechanism responsible for the osseous
    infarction is fat embolism and intravascular flat globules are often found in resected femoral heads in idiopathic
    necrosis. It probably begins by and interruption of the blood circulation within the bone, subsequently the adjacent
    area becomes hyperaemic, resulting in de- mineralizationin trabecular thinning and later incollapse. 3

    Treatment
    Treatment has been facilitated by using a widely accepted international classification system, effective earlier
    diagnosis using MRI and more aggressive surgical management. No universally satisfactory therapy has been
    developed, even for early disease. It is essential that AVN of the femoral head is diagnosed early because
    delayingthis disease by joint preserving measures have a much better prognosis and because the results of joint
    replacement are poorer in young individuals. 4

    Ayurvedic View
    There is no direct reference available in our literature which corresponds to AVN of femoral head. But with the help
    of Hetu, Dosha and Dhatu involvement we can make Samprapti of the disease. Hetu plays an significant role in the
    pathogenesis of any disease. Various factors liable for vitiation of Vata and Pitta, along with the factors guilty for
    vitiation of Asthivaha and Majjavaha Srotas are responsible for pathogenesis of AVN. Astangahridaya describes the
    factors responsible for provocation of Vata and Pitta.5Due to vitiation of Vata Dosha there is Dushti of Vyanavayu
    which is responsible for normal circulation of blood through vessels results in improper flow of blood through bone
    tissues which causes Toda, Ruka, Sausirya, Vataprakopaka Laksanas. Pitta Dosha Dushti is responsible for Rakta
    Dushti due to Ashrayaashrayibhava6 and its Updhatu Sira which causes impaired vascular supply resulting in
    Kotha (osteonecrosis) of Asthidhatu.

    Similarly, dietary factors such as intake of Abhisyandi and incompetent foods (Virudhaahara) that are responsible
    for Majjavahasrotodusti7, indirectly provokes Vata due to Srotoavrodha produced by Ama formation resulting in
    impaired work of Vyanavayu. Indulgence in unwholesomedietary and lifestyle factors cause vitiation of
    Asthivahasrotas; for e.g., overexercise, concussionand violent flexion directly leads to provocation of Vata, resulting
    in Asthiksaya.8which produce symptoms like Asthitoda and Asthishoolala prominently appears in AVN also. In later
    stage of AVN, if not treated earlier, there is an involvement of Majja in which symptoms of Majjaksaya like
    Asthisausirya (osteoporosis), Siryantaivacasthini (eleterioration of bone ) and Durbalaasthi (weakness of bone)
    appear causing death of bone tissue and collapse of bone.

    Acharya Dalhan has mentioned that Purishdhara kala and Asthidhara kala are one and the same.9Hence causative
    factors responsible for vitiation of Purishvahasrotas also guilty for producing pathogenesis of Asthikshaya. The
    causative factors for vitiation of Purisavahasrotas are suppression of natural urges like defecation, excessive eating,

    52
    ISSN: 2320-5407 Int. J. Adv. Res. 9(07), 51-54

    overeating during indigestion, weak digestive power and thin body constitution. Suppression of urge of defecation
    leads to Udavarta and ultimately to provocation of Vata.10

    Management
    In Ayurveda, the treatment of AVN includes: 1)Nidanaparivarjana (avoidance of etiological factors), 2) Sodhana
    (biopurification), 3) Samana (palliative treatment), 4) Rasayana (rejuvenation) and 5) Pathyapathya (properdiet).

    l. Nidanaparivarjana: - The person suffering from AVN must avoid excess in etiological factors which provok
    Vata, Pitta, along with Asthivaha, Majjavaha and Purishavahasrotas and also some psychic factors such as· worry,
    fear, grief, anger, etc. Hence the physician should not recommend Tiksna drugs. Excessive biopurification and injury
    to vital organs should also be prohibited along with opposing treatment, as they lead to Asthiksaya.

    2. Biopurification:- Taking into consideration vitiation of Vata and Pitta as Vikaraprakrti, Asthi and latter on Majja
    is the main Adhisthana (site) resulting in Asthiksaya and Majjaksaya in the pathogenesis of AVN, the treatment plan
    of Vata and Pitta Upakrama along with Asthimajjaksaya Chikitsopakrama should be applied in this
    disease.11Acharya Hemadri has also supported this. Vagbhata describes Mridu Samsodhana as the line of treatment
    in vitiation of' Vata. Mriduvirechana (by Erandataila with milk, decoction of Aragvadhapatra, Triphalachurna or
    decoction of Draksha) can be used for Mala and Vataanulomana. Similarly, Mriduvirechana is also helpful for
    pacifying Pitta as it is specific Sodhana procedure for Pitta.

    3. Palliative treatment:- This can be done by using Saman Ausadhis which are Vata Pittaghna and
    Raktasuddhikara in nature. Some Saman Ausadhis are detailed below:

    Panchatiktagana:-
    This contains Patola (Trichosanthes cucumerina), Vasa (Justiciabeddomei), Guduchi (Tinospora cordifolia), Nimba
    (Azadirachta indica) and Katuka (Picrorhiza kurrooa)12 A combination of these drugs is useful because of its Tikta
    Rasa, Amapacaka and Raktapittasamaka properties. There are various formulations with these drugs like
    Panchatiktaghrta Guggulu, Panchatikta Ghrita, etc.

    • External and internal oleation therapies arc helpful inAVN.


    External:- Abhyanga by Kshirabalataila, Chandanabalalaksaditaila, Dhanvantarataila, Balaguduchyaditaila,
    Balasvagandhaditaila, Laksaditaila, Mahalaksaditaila, etc. are used for pacification of the vata, Pindataila
    (A.H.Ci.22/22) is a good pain reliever inAVN.
    Internal: - Gandhatailam (AH.D.27/41) is Asthisthairyakrit and is useful for pacifying Vata and Pittajanitavikara.

    • Ghee formulations: - Panchatikta Guggulughrita, Patoladighrita. Mahatiktakaghrita. Panchatiktakaghrita,


    Tiktakaghrita and Indukantaghrita.

    • Guggulu Kalpa: - Various Guggulu formulations mentioned in the treatment of fractures and disorders of Vata can
    be given to the AVN patients who suffer from different types of pain. These preparations are: Abhaguggulu,
    Mahayogarajaguggulu, Laksadiguggulu, Adityapakaguggulu and Yogarajaguggulu.
    Kshirapaka: - Arjunakshirapaka (Arjuna -Terminalia cuneata, is rich in calcium) and Asvagandhaksirapaka.

    4. Rasayana: Various Rasayana preparations like Dvitiya Brahmarasayana, Cathurtba Triphalarasayana,


    Chavanaprasarasayana and Silajatu Rasayana with milk are useful in Asthiksaya,

    5. Pathyapathya:- AVN patients should followa healthy dietetics and lifestyle.

    o Pathya (wholesome): - Sweet taste dominant substances, rice, black gram, milk, whey,butter milk, butter, ghee,
    meat soup, anti-Vata oils, regular exercise and exposure to early morning sun rays.

    o Apathya (unwholesome):- Pungent, bitter, astringent taste dominant substances; dry, cold, light, porous property
    predominant substances; Madya (alcohol); Suskamamsa (dry meat). Suskasaka (dry vegetable); excessive eating,
    fasting, heavy exercise; excessive sexual intercourse; fighting withstronger person; day sleep, night awakening;
    suppression of natural urges; smoking andother etiological factors.

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    ISSN: 2320-5407 Int. J. Adv. Res. 9(07), 51-54

    Conclusion:-
    AVN is a osteonecrosis disease which is Kotha of Asthidhatu. Etiological factors responsible for Vitiation of Vata,
    Pitta and Rakta leads to Kshaya of Asthi and Majjadhatu. Symptoms of AVN are very much similar to
    Asthimajjakshaya and Vataprakopaka Lakashana. Administration of Vasti containing kshira, Ghrita and Tikta
    Dravyas; by oral use of Samana Dravya and Rasayana along with wholesome dietetics and lifestyle AVN can be
    managed.

    References:-
    1. Avascular Necrosis of Femoral Head: A Metabolomic, Biophysical, Biochemical, Electron Microscopic and
    Histopathological Characterization, Scientific Reports| 7: 10721 | DOI:10.1038/s41598-017-10817-w.
    2.https://www.webmd.com/arthritis/avascular-necrosis-osteonecrosis-symptoms-treatments#1
    3.Vasuray,D.Venkata Krishna Naik, J Srinivasulu,N. Satya Prasad. A Case Study onthe Effect of
    GuduchyadiYapanaVasti Inavascular Necrosis of Hip Joint.AYUSHDHARA, 2016;3(1):465-468.
    4. Chapara Aparna et al: Role Of Ayurveda In The Management Of Avascular Necrosis Of The Left Femoral Head–
    A Case Study iamj: volume 5, issue 12, december, 2017
    5. AstanghrdyaNidanaSthana chapter 1, 14-16, with the commentaries Sarvangasundara of Arundatta edited by Pt.
    Hari SadasivaSastriParadakaraBhisagacarya, ChaukhambaSurbhartiPrakashan Varanasi.
    6. Astanghrdya Sutra Sthana chapter 11, sloka 26, with the commentaries Sarvangasundara of Arundatta edited by
    Pt. Hari SadasivaSastriParadakaraBhisagacarya, ChaukhambaSurbhartiPrakashan Varanasi 2014.
    7. Charak Samhita Vimana Sthana 5/18, Vidyotani Hindi commentary edited by Pt. Kashinath Pandey and
    Dr.GorakhnathChaturvedi, ChaukhambaBharatiPrakashan 2009.
    8. Charak Samhita Vimana Sthana 5/17, Vidyotani Hindi commentary edited by Pt. Kashinath Pandey and
    Dr.GorakhnathChaturvedi, ChaukhambaBharatiPrakashan 2009.
    9. Sushruta Samhita KalpaSthan 4/40, NibandhasangrahacommentaryofDalhan edited by Vaidya Jadvji
    Trikamjiacharya, ChaukhambaBharatiPrakashan 2014.
    10. Charak Samhita Vimana Sthana 5/21, Vidyotani Hindi commentary edited by Pt. Kashinath Pandey and
    Dr.GorakhnathChaturvedi, ChaukhambaBharatiPrakashan 2009.
    11. Astanghrdya Sutra Sthana chapter 13, sloka 01, with the commentaries Sarvangasundara of Arundatta edited by
    Pt. Hari SadasivaSastriParadakaraBhisagacarya, ChaukhambaSurbhartiPrakashan Varanasi 2014.
    12. Sushruta Samhita ChikitsaSthan 35/6, NibandhasangrahacommentaryofDalhan edited by Vaidya
    JadvjiTrikamjiacharya, ChaukhambaBharatiPrakashan 2014.

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