Scribd Logo
Upload

Welcome to Scribd!

  • 41 views

    Drying Dry: Process Optimization With Dry Running Vacuum Pumps

    Uploaded by

    Alexander Rivillas
    The document discusses drying processes for pharmaceutical applications and how optimizing vacuum control can improve drying efficiency. It describes how precisely controlling vacuum levels throughout the drying phases, including using vacuum pump speed to identify phase changes, allows drying time to be reduced by 40%. This optimization strategy improves drier capacity and results in faster returns on investment. Installing SIHI dry running vacuum pumps enables effective and corrosion-resistant drying even of corrosive products or gases.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Drying Dry: Process Optimization With Dry Running Vacuum Pumps

    Uploaded by

    Alexander Rivillas
    41 views1 page
    The document discusses drying processes for pharmaceutical applications and how optimizing vacuum control can improve drying efficiency. It describes how precisely controlling vacuum levels throughout the drying phases, including using vacuum pump speed to identify phase changes, allows drying time to be reduced by 40%. This optimization strategy improves drier capacity and results in faster returns on investment. Installing SIHI dry running vacuum pumps enables effective and corrosion-resistant drying even of corrosive products or gases.

    Original Title

    SIHI Article Drying Dry

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses drying processes for pharmaceutical applications and how optimizing vacuum control can improve drying efficiency. It describes how precisely controlling vacuum levels throughout the drying phases, including using vacuum pump speed to identify phase changes, allows drying time to be reduced by 40%. This optimization strategy improves drier capacity and results in faster returns on investment. Installing SIHI dry running vacuum pumps enables effective and corrosion-resistant drying even of corrosive products or gases.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    41 views1 page

    Drying Dry: Process Optimization With Dry Running Vacuum Pumps

    Uploaded by

    Alexander Rivillas
    The document discusses drying processes for pharmaceutical applications and how optimizing vacuum control can improve drying efficiency. It describes how precisely controlling vacuum levels throughout the drying phases, including using vacuum pump speed to identify phase changes, allows drying time to be reduced by 40%. This optimization strategy improves drier capacity and results in faster returns on investment. Installing SIHI dry running vacuum pumps enables effective and corrosion-resistant drying even of corrosive products or gases.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    Drying dry

    Process optimization
    With dry running vacuum pumps

    Pharmaceutical drying applications require


    reproducible quality at controlled operating
    conditions. For the operator it is important to get
    a fast return on investment by running the drying
    installation at most effective conditions. The only
    possibility is the right combination of drier and
    vacuum unit.

    SIHIdry H750 with gas ballast,


    best choice to handle corrosive media

    The building 417 with handle very corrosive not possible to run This indicates exactly
    its spherical drier gases without any below the vapour the end of main drying
    installation has become corrosion problems. For pressure of the solvent. phase.
    a representative object a good drying result, a Therefore the controller With final pressure of
    -2
    for the pharmaceutical precise vacuum setting forces the pump to its 10 mbar the vacuum
    intermediates producer is important. The main maximum suction pump can now speed
    Siegfried Ltd (Zofingen, phase of drying is capacity. This results up and do the capillary
    Switzerland). Already characterized by into a too fast drying phase in shortest
    the first batches which reducing the pressure at evaporation of the time.
    were produced on the a fixed temperature to solvents. The
    new drier, indicated that the corresponding evaporation heat is Drying time is
    the drying time was solvent vapour pressure. taken out of the product reduced by 40%
    shortened extensively. The solvent starts to which cools down
    Pit Hofer, project leader evaporate and can be extremely until to During a dissertation
    at Siegfried believes, evacuated. Often there freezing. in some cases. this operation mode
    that the time reduction are condensers installed Another effect is the was scientifically
    is manly driven by the upstream of the vacuum building up of analysed. An important
    drier and the new dry pump. Most of the impermeable layers on result was: Comparing
    running vacuum pump vapour condenses and the surface covering the the optimised cycle
    dry can be drained out. The vapour in deeper layers. time using the speed
    SIHI .
    vacuum pump has to This leads to bad drying characteristic of an
    Accurate vacuum handle only air leakage results. exact controlled
    control and non-condensable Important for a good vacuum pump instead
    vapour. drying result is a precise of time driven drying
    One important In the following phase of vacuum control during steps allows to shorten
    application of the multi capillary drying, vapour the main drying phase the drying time by 40%.
    purpose cGMP and which is “physically” kept and the knowledge of its This strategy leads to
    FDA certified drying in the capillaries is dried end to start the capillary optimised drier
    installation is, to dry out. During this phase it drying phase in time. capacities.
    corrosive products. is useful to work on To find the right point a Meanwhile existing
    Therefore the 2400 l maximum vacuum to useful tool is to observe vacuum systems at
    spherical dryer is made overcome the “binding the vacuum pump other Sigfried drier
    of Hastelloy. The forces” of solvents inside speed. At the end of the positions are changed
    vacuum pump is the capillaries. main drying phase less over to SIHI dry running
    equipped with a special A mistake frequently vapour is handled. This vacuum pumps. This is
    developed gas ballast done during the first leads automatically to a a cost effective way to
    system which allows to phase is to work on a lower vacuum pump increase the plant
    too low vacuum set speed as the required drying capacity just by
    value. For the pump it is volume flow is lower. reducing drying time.

    Pharma + Food 06/2003

    You might also like