Chem Written Report

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NUCLEIC ACIDS

The name “nucleic” derives from the fact that they were discovered within the cell nucleus. They were
discovered by the Swiss biochemist Friedrich Miescher in 1869.

Nucleic acids are class of biomolecules that are found in all living organism and are responsible for the
storage of genetic information. They are also responsible for protein synthesis.

Nucleic Acids have two types: DNA and RNA

DNA (deoxyribonucleic acid) is the most famous nucleic acid. It is part of chromosomes which contain
the genes. And the genes are ultimately responsible for the synthesis of proteins. Most, if not all, of
these proteins are enzymes, each catalysing a specific chemical reaction occurring in the organism.

DNA has two direct purposes: It must generate new DNA through replication so that new generations of
cells will have the information necessary to their survival; and it must generate RNA.

RNA (ribonucleic acid) is involved in the direct synthesis of proteins, called translation. These proteins
are essential for the maintenance of life.

Nucleic acids are made up of monomers called nucleotides. Nucleotides are made up of 3 components:
a 5 carbon sugar or pentose, a phosphate functional group, and a nitrogenous base.

There are 5 different nitrogenous bases present in a nucleotide namely; Adenine, Guanine, Cytosine,
Thymine, and Uracil; and two different sugars which are the Ribose for RNA and Deoxyribose for DNA.

Nitrogen bases are reservoir of genetic information. The bases fall into 2 categories: Purine and
Pyrimidine.

The Purines are composed of two fused rings incorporating two nitrogen atoms in each ring such as in
the cases of adenine and guanine.

The Pyrimidine is composed of a single ring with 2 nitrogen atoms in the ring structure such as in
cytosine, thymine and uracil.

Nucleotides are linked together by dehydration synthesis or polymerization reactions between the sugar
of one nucleotide and the phosphate group of a second nucleotide. Nucleotides are linked together by a
phosphodiester bond. In the process, a sugar-phosphate backbone is formed.

DNA is composed of 2 strands arranged as a right-handed helix. The strands are also anti-parallel,
meaning that they are oriented in opposite directions.

The 2 strands are held together by hydrogen bonds. Guanine forms hydrogen bonds with Cytosine and
Adenine bonds with Thymine. This complementary base pairing links the strands together. It also plays
an important role in the replication of the DNA molecule.
RNA differs from DNA in that the base Adenine bonds with Uracil instead of Thymine. It is usually single
stranded and does not typically form a helix. Because of this, it is less stable than DNA and is usually
more temporary. While DNA stores the information needed to construct a protein, RNA functions in
regulating the expression of this information in the protein synthesis process.

Not all nucleic acids are involved in information processing in the cell. ATP or adenosine triphosphate is
a modified nucleotide that plays a central role in energy processing within cells. ATP is composed of the
nitrogenous base, adenine, bounded to the sugar ribose just like in RNA. However, 3 phosphate groups
can be added to the molecule.

The bonds between the phosphate groups are high energy bonds. These molecules serve as temporary
energy batteries for the cell. When energy is needed, the terminal phosphate group is removed,
releasing energy and forming adenosine diphosphate which my then be recharged by the energy
pathways of the cell.

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