Paclitaxel
Paclitaxel
Generic Name Pharmacologic During cell division General Indication: Hypersensitivity to CV: Ventricular tachycardia, Before:
Paclitaxel Class: paclitaxel is an Ovarian cancer, paclitaxel, or taxanes ventricular ectopy, transient Because tissue
Antineoplastic; antimicrotubular agent that breast cancer, Baseline neutrophil bradycardia, chest pain. CNS: necrosis occurs
Trade Name Taxane interferes with the Kaposi’s Fatigue, headaches, peripheral with
count less than 1500
Taxol microtubule network sarcoma, non– neuropathy, weakness, seizures. extravasation,
Therapeutic Class: essential for interphase and smallcell lung
cells/mm3
Thrombocytopenia frequently assess
Maximum Dose Antineoplastic; mitosis. This results in cancer (NSCLC) GI: Nausea, vomiting, diarrhea,
250 mg/m2 Antimicrotubule abnormal spindle formation With AIDS-related patency of a
Squamous cell taste changes, mucositis, elevations
and multiple asters during Kaposi’s sarcoma peripheral IV
head and neck in serum triglycerides.
Minimum Dose mitosis. baseline neutrophil site.
cancer
100 mg/m2 count less than 1000 Monitor for
small-cell lung Hematologic: Neutropenia,
Interferes with growth of cells/mm3. hypersensitivity
cancer anemia, thrombocytopenia.
Availability rapidly dividing cells reactions,
including cancer cells, and endometrial
Solution for injection; Interactions: especially during
powder for injection eventually causes cell cancer Body as a Whole: Hypersensitivity
Drug-drug: reactions (hypotension, dyspnea first and second
(with 900 mg human death. Additionally, the esophageal
with bronchospasm, abdominal administrations
albumin) breakup of the cytoskeleton cancer Increased myelosuppression if and extremity pain, diaphoresis, of the paclitaxel.
within nondividing cells gastric cancer cisplatin, doxorubicin is given angioedema), alopecia.
Route interrupts intracellular testicular
transport and
before paclitaxel; During:
IV cancer
communications ketoconazole can inhibit Skin: Alopecia, tissue necrosis Monitor vital
germ cell signs frequently,
metabolism of paclitaxel; with extravasation.
tumors additive bradycardia with especially during
Pharmacokinetics:
other solid the first hour of
Distribution:Greater than beta-blockers, digoxin, Urogenital: Minor elevations in
tumors: verapamil; additive risk of infusion.
90% protein bound; does kidney and liver function tests.
Leukemia, bleeding with anticoagulants, Monitor for
not cross CSF.
melanoma. nsaids, platelet inhibitors anemia,
Metabolism: In liver Patient's Indication: (including aspirin), neutropenia, and
thrombolytic agents. thrombocytopenia.
(CYP3A4, 2C8). To help treat patient’s
esophageal cancer; part of After:
Elimination: Feces 70%, patient’s chemotherapy Discontinue
urine 14%. drugs.
immediately and
manage
Half-Life: 1–9 h. symptoms
aggressively if
angioedema and
generalized
urticaria develop.