AU 400

T H E V I S I B L E D I F F E R E N C E

A N A L Y S E R S Y S T E M F O R

C L I N I C A L C H E M I S T R Y
 O U T S T A N D I N G E N G I N E E R I N G

I N A C O M P A C T A N A L Y S E R

1 Refrigerated reagent
compartment
2

2 Washing station

3 Mixer
3 4

4 Cuvette wheel

5 ISE unit

6
6 Sample applicator

7 Sample feeder 1 5

8 STAT sample rotor 8

The Olympus AU 400 analyser system for clinical chemistry

Outstanding Te c h n o l o g y a n d Multiplemodule con-

performance innovation trol with 32 bit RISC chips
ensures precise control with
The new AU 400 Outstandingengineer- high throughput. Ease of
system is a fully automated, ing includes the unique operation is assured with
random access clinical Spot Photometry measure- mouse-control Windows
chemistry analyser with all ment system that uses data software and touchscreen.
the benefits of Olympus in digital format and trans-
S y s t e m s C o m p a t i b i l i t y. mission through fibre optics Afull range of
to eliminate electromagnetic Olympus System Reagents
With a throughput of interference and signal developed in tandem with
400 photometric tests per drift. the analyser range provides
hour the system provides optimised measurement for
high performance analysis, Improved measure- routine and specialist tests.
i n c l u d i n g S TAT a n d I S E ment enables reduced reac-
c a p a b i l i t y, i n a c o m p a c t tion volumes and delivers
package for small and savings in reagent and run-
medium size laboratories. ning costs.
 M I N I M U M C O N S U M P T I O N

W I T H M A X I M U M P E R F O R M A N C E

The AU 400 analyser system stands out due to the

economy and high efficiency of a Random-Access System
combined with effort-saving handling and an exceptional
reliability:

Economy
• Minimised consumption of liquid
stable reagents
• Reaction volume down to 150 µl
• Throughput of 800 tests per hour
Precision due to spot photometry
system
with ISE

Performance
• Spot photometry system gives
unrivalled accuracy
• Interference-free fibre optic data
transfer

Ease of use
• Bar-coded reagents and primary
c u p s f o r ro u t i n e a n d S TAT s a m p l e s
• GUI menus and user definable
routines in Windows NT® software
 C O N T R O L , F L E X I B I L I T Y

A N D R E L I A B I L I T Y

automatically adjusts to
match the dispensed volume.
Safety features include clot
detection and crash pre-
vention.

Volume
variation of
results is minimized and
more accurate measurement
is provided on reaction
volumes as little as 150 µl.

Contamination is
eliminated with a triple
washing station. Cuvettes
are washed with detergent
twice and rinsed with puri-
fied water four times in
C o o l e d r o t o r f o r S T A T, Q C a n d c a l i b r a t o r s
each cycle. Time for mixing
and cleaning steps has been
reduced to 4.5 seconds.
Overall flexibility
Windows NT® based
The AU 400 combines software
flexible analysis with
sophisticated control and The
latest software
m e a s u r e m e n t r e l i a b i l i t y. across the range of Olympus
analysers provides easy to
S TAT s a m p l e s c a n use Windows-based mouse
be quickly processed at any control. Pull down menus
Tr i p l e w a s h i n g s t a t i o n
time. Barcoded primary and help functions ensure
tubes or special sample that basic operation can be
cups are placed in a dis- mastered within minutes.
t i n g u i s h e d S TAT r o t o r w i t h Modem support for conti-
22 positions. nuous communication and
service is provided.
Optimized
technologies

C omputer controlled
liquid dispensing provides
speed and positional ad-
Maintenance support
justment. Probe tip speed
control prevents liquid
splashing. Probe depth
 C O M P L E T E S Y S T E M

D E V E L O P M E N T

Over 80 tests are

available including Sub-
strates, Enzymes, Specific
Proteins, DAU, TDM and
Homogeneous Immuno
Assays.

Compatibility across
all systems

Ma j o r s a v i n g s i n
costs, logistics, storage
space and efficiency are
delivered by using the same
reagents across Olympus
systems, even in complex
laboratory settings.
Olympus System Reagents
Olympus flexible
racks are designed for all
primary tubes in the range
of 11.5 mm – 16 mm dia-
m e t e r.

The AU 400 has the

family hardware and soft-
ware, and uses the same
reagents, as the larger
A U 6 0 0 , A U 8 0 0 a n d A U 10 0 0
analysers.
Reagent compartment for 15 ml, Olympus flexible racks
30 ml and 60 ml vials
This system compa-
tibility approach will be
continued in future analyser
An expanding range The TRIS automatic developments from Olympus.
of reagents i d e n t i f i c a t i o n b a r- c o d i n g
system includes batch and
Olympus liquid stable expiry details to meet labo-
reagents are developed in ratory procedural require-
t a n d e m w i t h t h e c o m p a n y ’s ments.
range of clinical chemistry
analysers. Formula, con- Reagent vials of either
centration and packaging 15 ml, 30 ml or 60 ml vol-
are perfectly matched to the ume featuring long on-board
AU 400. s t a b i l i t y.
 A U 4 0 0 S Y S T E M R E A G E N T S –
S P E C I F I C A L L Y M A T C H E D

OLYMPUS SYSTEM REAGENTS

Substrates Enzymes
Albumin ACP
Alpha Amylase ALP
Bicarbonate CHE
Bilirubin total CK
Bilirubin direct CK-MB
Calcium GGT
Calcium Arsenazo GOT (AST)
Cholesterol GPT (ALT)
The Olympus System Reagents – Creatinine HBDH
an expanding range of reagents
Glucose LDH
Glucose HK Lipase
HDL-Cholesterol
Iron
LDL-Cholesterol
Magnesium ISE
Phosphate Chloride
Phospholipide Potassium
Total Protein Sodium
Triglycerides
Urinary Protein
UIBC
Urea
Uric Acid

Homogeneous
Immuno Assays Specific Proteins
Apo A1 alpha-1-Antitrypsin
Apo B alpha-1-Glycoprotein
ASL β-2-Microglobulin
C3 Ceruloplasmin
C4 Haptoglobin
CRP Microalbumin
IgA Myoglobin
IgG Prealbumin
IgM
Ferritin
RF
Transferrin

DAU TDM
Amphetamine Amikacin
Barbiturates Carbamazepine
Benzodiazepines Digitoxin
Beta Blockers Digoxin
Cannabinoids Gentamicin
Cocain Metabolite Phenytoin
Cotinine Phenobarbital
Methadone Theophylline
Methamphetamine Tobramycin
Opiates Valproic Acid
PCP
Thiazides
Urine pH
 O L Y M P U S S Y S T E M S U P P O R T –
A R A N G E O F C U S T O M E R S E R V I C E

The combination of Olympus analysers and the special-

ly matched Olympus System Reagents represent only a
proportion of Olympus Diagnostica. Our commitment to the
provision of a total system and the increasing demands of
the modern major laboratory has led to the development of
a comprehensive range of services.

Application consultancy

We p r o v i d e h e l p f o r r e q u e s t s c o n c e r n i n g r e a g e n t s o r o n
how to conduct tests through our application specialists. In
cases where an application problem cannot be solved over
t h e t e l e p h o n e , w e g i v e d i r e c t a s s i s t a n c e i n y o u r l a b o r a t o r y.

Operator training

Ourspecialists will teach you all the necessary basic

knowledge about operation, application and user main-
tenance. In addition customised on-site training is of course
available.

Delivery service

Y o u r o r d e r i s h a n d l e d b y u s i m m e d i a t e l y. R e a g e n t s
delivery within 24 hours is possible and in true “emergen-
cies” priority dispatch ensures the best possible delivery
time.

Te c h n i c a l e q u i p m e n t s e r v i c e

Our support team of field based engineers and specia-

lists is further enhanced by expert telephone assistance from
a specialist who can provide immediate advice on technical
problems and how to get the best out of your Olympus
system.

Individual laboratory and contract concepts

The
sales representative, assigned to you, will
structure made-to-measure system solutions for you.
 AU 400 Specifications

Analytical system Fully automated, for routine, STAT, urine and homogeneous Immuno Assays
Analytical methods Clinical chemistry and immunological parameters. End point, kinetic assays,
fixed-time-kinetics, optionally ISE
Simultaneously processed analytes Up to 51 photometric tests + 3 ISE
Throughput 400 photometric tests / hour; maximum of 800 with ISE
Sample feeder Racks with 10 samples each (bar-codes on primary tubes and on racks);
capacity of 80 samples; continuous loading
Sample tubes In primary and secondary tubes; diameter from 11.5 to 16 mm;
height from 55 to 102 mm
STAT samples Up to 22 positions for STAT samples, bar-coded primary tubes
Sample volume 2 – 50 µl in 1 µl steps (1– 50 µl for repeats)
Reagent supply Refrigerated (4° C – 12° C); 76 positions for R1 / R2
Reagent volume 1. reagent: 25 – 300 µl; 2. reagent: 25 – 300 µl; (in 1 µl steps)
Total reaction volume 150 – 550 µl
Reaction cuvette Quartz cuvettes
Reaction time Up to 8 minutes, 40 seconds
Reaction temperature 37° C
Mixing method With rotating paddles after dispensing sample and reagent
Photometry system Direct assay through the reaction cuvette (0 – 2.5 OD) mono-, bichromatic
measurements possible
Wave length 13 different wave lengths between 340 – 800 nm
Cuvette cleaning Comprehensive cleaning with detergents
Calibration Linear and non linear (linear interpolation), refrigerated calibrator positions
Data processing Calculated parameters, blank value correction and correlation. Definition of normal
value range, measuring range, pathological values and repeats. Quality controls,
printout of abnormal values, pending sample work list and repeat run sample list
Test requisition Individual and profile test requisition via on-line, mouse, function keys or optional
touch screen
Safety Clot detection and crash prevention for sample and reagent dispenser
On-line Full uni- and bidirectional communication possible
Software Windows-NT®

European Headquarters: OLYMPUS DIAGNOSTICA GmbH, Wendenstraße 14-18, D-20097 Hamburg,

Tel. (0 40) 2 37 73-0, Fax (0 40) 2 37 73-7 83, http://www.olympus-diagnostica.com
OLYMPUS D.O.O.ZA TRGOVINU, Jurjevska 15, 10000 Zagreb/Croatia, Tel.: (385-1) 4899003, Fax: 420888
OLYMPUS AUSTRIA GmbH, Shuttleworthstraße 25, 1210 Vienna/Austria, Tel.: (43-1) 291010, Fax: 29101222
OLYMPUS DIAGNOSTICA GMBH (Irish Branch), Lismeehan, O’Callaghan’s Mills, County Clare/Ireland, Tel.: (353-65) 6831100, Fax: 6831122
OLYMPUS C&S, V Jircharich 10, 11121 Prague 1/Czech Republic, Tel.: (420-2) 24917777, Fax: 2491-5080/-4234
OLYMPUS FRANCE, Silic 165, 74 rue d’Arcueil, 94533 Rungis-Cedex/France, Tel.: (33-1) 45602300, Fax: 46866562
OLYMPUS DIAGNOSTIC SYSTEMS (U.K.), Great Western Industrial Park, Dean Way, Southall, UBS 4SB UK, Tel.: (44-171) 250 4800, Fax: 250 4801
OLYMPUS ITALIA S.R.L., Via Modigliani 45, 20090 Segrate (Milano)/Italy, Tel.: (39-02) 269721, Fax: 26972488
OLYMPUS OPTICAL POLSKA Sp. z o.o., ul. Swietojerska 5/7, 00-236 Warszawa/Poland, Tel.: (48-22-831) 15 17, Fax: 04 53