Release Notes

Chromeleon 7.2 SR1 MUa • July 2014

 Chromeleon 7.2 SR1 MUa

Table of Contents
1 Introduction 1
1.1 Maintenance Updates 1
1.2 Release Notes 1
1.3 Other Documentation 1
1.4 Installation 1

2 What’s New in Chromeleon 7.2 SR1 MUa 2

2.1 Thermo Scientific Instrument Drivers 2
2.1.1 Vanquish – New Drivers [SWFR-554] 2
2.1.2 TSQ Quantiva LCMS Driver – New Driver [SWFR-670] 2
2.1.3 TRACE 1300 GC - Updated Driver [SWFR-801] , [SWFR-1009] 2
2.1.4 TSQ Series GCMS Driver - Updated Driver [SWFR-861], [SWFR-862] 2
2.1.5 AI/AS 1310 Autosampler – Updated Driver [CM7-16739] 3
2.1.6 ASE-350 Driver - Updated Driver [CM7-9640] 3
2.2 New Client Features 3
2.2.1 QD Processing Method Template [SWFR-814] 3
2.2.2 UHPLC Speed Up Wizard [CM7-16795] 3
2.2.3 Peak Scoring [CM7-16501] 3

3 Limitations and Known Issues 4

3.1 Functional Differences between Chromeleon 7.2 SR1 MUa and Chromeleon 6.8 4
3.2 Memory Leak on XP systems [CM7-10745] 4
3.3 Performance of Microsoft SQL Server 4
3.4 TriPlus RSH and TriPlus 100 LS 4
3.5 Agilent ICF 4
3.6 Waters Acquity Framework 4
3.7 Agilent 5890 DICE Card 4
3.8 Agilent 7890 GC Sampler Positions 5

4 Resolved Issues 5

5 Known Issues 7

6 Backward/Forward Compatibility Issues 8

6.1 Thermo Scientific TriPlus RSH 8
6.2 Thermo Scientific TriPlus LS-100 8
6.3 Thermo Scientific TSQ Quantiva 8

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 Chromeleon 7.2 SR1 MUa

1 Introduction

1.1 Maintenance Updates

Maintenance Updates (MU) contain the setup package with the files relating to Maintenance Updates only. Thus, with a
Maintenance Update, it is necessary to have a full version of Chromeleon and the current Service Release installed first.

1.2 Release Notes

These Release Notes list the new features and improvements of the current Maintenance Update release only.
For information on extensions and enhancements in previous Chromeleon releases, please refer to the Release Notes of
the respective Chromeleon release.

1.3 Other Documentation

Chromeleon 7.2 software and any related Service Releases (including Maintenance Updates and Hotfixes) have been
designed, tested, validated, and distributed according to Thermo Fisher Scientific Software Development Cycle guidelines
modelled after ISO9001:2008. Therefore a separate certificate of validation is not required for this Maintenance Update.
The following documents have been updated with this release:
• List of Supported Instruments - Chromeleon 7.2 SR1 MUa

• Online Help (distributed with this release)

1.4 Installation
Before you install this Maintenance Update, verify that Chromeleon 7.2 CDS SR1 is installed. To install this Maintenance
Update, run the following program from the distribution:
CM72SR1MUa_Setup.exe

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Chromeleon 7.2 SR1 MUa

2 What’s New in Chromeleon 7.2 SR1 MUa

2.1 Thermo Scientific Instrument Drivers

Note: This chapter lists new and updated drivers added in Chromeleon 7.2 SR1 MUa. For details on supported options,
required licenses, installation and control, refer to the online help.

2.1.1 Vanquish – New Drivers [SWFR-554]

Vanquish is the new Thermo Scientific HPLC platform consisting of several modules. This Maintenance Update will
introduce drivers and client functionality required to support the new platform.

New Vanquish Autosampler Driver

This release will include support for the new Vanquish Autosampler module. Included in this will be the optional
Charger module allowing the user to select from up to 20 further plate positions.

New Vanquish Binary Pump Driver

This release will include support for the new Vanquish Binary Pump module. Included in this will be the support
for selection of solvents via options such as A1, A2, B1, B2 etc. as well as the increased pressure range
available (up to 1500 bar).

New Vanquish Diode Array Detector Driver

This release will include support for the new Vanquish Diode Array Detector module. This module uses new
LightPipe™ technology for improved performance.

New Vanquish Column Compartment Driver

This release will include support for the new Vanquish Column Compartment module. This module allows the
user to define up to three temperature zones for improved method development

2.1.2 TSQ Quantiva LCMS Driver – New Driver [SWFR-670]

With this Maintenance Update, the TSQ Quantiva driver version 1.1 is included.
Note:
This driver is not automatically installed with this maintenance update.
The driver version 1.1 may be incompatible with existing TSQ Quantiva units on driver version 1.0 without a hardware
update. Please contact your local MS service engineer prior to attempting an upgrade
The TSQ Endura driver, while provided with this release, has not been fully validated yet. Further information will be
provided at the conclusion of this validation.

2.1.3 TRACE 1300 GC - Updated Driver [SWFR-801], [SWFR-1009]

With this Maintenance Update, the native TRACE 1300 GC driver has been updated to add:
• Vapor Volume and Column Flow calculators to the Inlets pages of the Instrument Method editor
• Column Evaluation functionality to the Inlet ePanels

2.1.4 TSQ Series GCMS Driver - Updated Driver [SWFR-861], [SWFR-862]

With this Maintenance Update, the TSQ 8000 GCMS driver has been updated to version 3.1, which adds support for the
following models:
• TSQ 8000 Classic
• TSQ Duo
• TSQ 8000 Evo
Note:
This driver update is not automatically installed with this maintenance update. In order to use the new driver, you must:

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 Chromeleon 7.2 SR1 MUa

a) Remove the existing TSQ 8000 module from the Chromeleon Instrument Configuration
b) Uninstall the existing TSQ Driver (using the ‘Programs and Features’ page of the Control Panel)
c) Install the new TSQ Series driver by running setup.exe from the Drivers\Thermo TSQ 8000\Full\ folder of the
Chromeleon 7.2 SR1 MUa distribution.
d) Add the TSQ 8000 module back into the Chromeleon Instrument Configuration

2.1.5 AI/AS 1310 Autosampler – Updated Driver [CM7-16739]

With this Maintenance Update, the internal timing of the driver has been improved.

2.1.6 ASE-350 Driver - Updated Driver [CM7-9640]

With this Maintenance Update, the extraction volume is now recorded in the Audit Trail.

2.2 New Client Features

2.2.1 QD Processing Method Template [SWFR-814]
With this Maintenance Update, a new processing method template has been added that is designed to be used with the QD
Charge Detector. It includes a new tab that allows the use of composite scoring to help confirm peak identity based on peak
amount. It also includes a modified Calibration tab, the QD Calibration tab, that allows Normality to be set as the calibration
unit.

2.2.2 UHPLC Speed Up Wizard [CM7-16795]

With this Maintenance Update, the UHPLC method speed up wizard has been improved to give more accurate predictions.

2.2.3 Peak Scoring [CM7-16501]

With this Maintenance Update, additional result output is available when using the peak scoring feature.

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Chromeleon 7.2 SR1 MUa

3 Limitations and Known Issues

3.1 Functional Differences between Chromeleon 7.2 SR1 MUa and Chromeleon 6.8
In many ways, Chromeleon 7.2 with its associated maintenance releases has a richer feature set than Chromeleon 6.8, but
not all features of Chromeleon 6.8 are available in Chromeleon 7.2 SR1 MUa. A few Chromeleon 6.8 features remain to be
implemented on the Chromeleon 7 platform and a few will never be implemented because they are considered either
obsolete or no longer relevant. If a particular missing feature is important to you, please contact your local Thermo Fisher
Scientific representative for Dionex products to find out if that feature is in the product development plans.

3.2 Memory Leak on XP systems [CM7-10745]

A memory leak associated with the Local Security Authority Subsystem Service (LSASS) was observed and involves only
very long runs. It may cause Chromeleon to throw an OutOfMemoryException error, requiring the user to close the program.
The issue is improved if the latest Windows XP updates are installed, and is not seen in the Windows 7 environment.

3.3 Performance of Microsoft SQL Server

On SQL Server, if several users perform certain operations simultaneously, some of these tasks may fail and need to be
restarted. Affected operations (especially with large sequences) include upload of finished sequences, and deleting and
copying sequences. Oracle is not affected.

3.4 TriPlus RSH and TriPlus 100 LS

If an “Open Instrument View“ dialog is used with an instrument containing a TriPlus RSH or TriPlus 100 LS, then closing this
view may cause Chromeleon to stop working. A workaround for this is to open the view from the Instruments category of the
Console.

3.5 Agilent ICF

For limitations regarding the Agilent Instrument Control Framework, please refer to section 5 of the document Chromeleon
and Agilent ICF - Quick Start Guide.pdf, found in the \Documents\ folder of the Chromeleon 7.2 SR1 DVD.

3.6 Waters Acquity Framework

There are several known issues with the Waters Acquity Framework. These are:
• Should a Waters instrument detect an IP address conflict during start up, the Chromeleon driver will log the error
message in the Audit Trail. If this message is ignored, it will be displayed again after 2 hours, which can result in a
running sample being aborted.
• Localization to a non-English regional setting for the PC (e.g., German) does not function correctly for the timed events
table, e.g., using a Waters 2998 PDA detector and setting a timed event in the program file (e.g., wavelength change at
5 minutes). The event is recorded, but without the event time.
• Waters 2489 PDA detector: After changing the Instrument Method from single to dual-wavelength mode (without
changing Channel A wavelength), the data rate for Channel B is set incorrectly and incomplete data collection occurs.
• After removing the Sample Organizer from the Instrument Configuration, the plate setup is not updated correctly.
Manually updating the plate settings in the plate setup configuration dialog avoids this issue.

3.7 Agilent 5890 DICE Card

Please note the following when using the19257 DICE card with the Agilent 5890 GC:

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 Chromeleon 7.2 SR1 MUa

• Control and acquisition using the DICE card is only supported via the serial interface. The GPIB interface is not
supported.
• Digital data acquisition via the serial interface of the DICE card is only supported for a single channel; dual channel
digital acquisition is not supported.
• Currently, it is possible to select certain illegal combinations in the Configuration Dialog such as:
o Digital acquisition with the 19254 card. This is not supported.
o Digital acquisition on one detector and analog acquisition on the other. Acquisition needs to be exclusively
digital or exclusively analog.

• When using the DICE card to acquire data digitally, the 5890 INET mode must be set to “GLOBAL” not “LOCAL”.
Failure to do so will result in a “No response from GC” message following the AcqOn command in the audit trail.
Note that when performing analog acquisition, the 5890 INET mode should still be set to “LOCAL” (as described in
the online help).
To change this setting:
1. Remove both ends of the cable.
2. On the 5890 keypad, press CLEAR and then press the "." key. The following information appears on the
display: CALIB AND TEST [0-9].
3. Press 3. CONFIGURE NETWORK appears on the display.
4. Press ENTER.
5. If the information LOCAL ADDR: appears on the display, then Press OFF to change the setting to
GLOBAL ADDR:.
6. Press CLEAR to exit the menu.

3.8 Agilent 7890 GC Sampler Positions

There is a backwards compatibility issue that affects the Agilent 7890 GC Sampler Positions:
When using a 7890 GC in combination with a 7693 sampler, certain positions in the sampler could give a
misspelled value to a move command. This has now been corrected and could in rare cases lead to Instrument
Method files needing to be updated to avoid errors.

4 Resolved Issues
This chapter describes the issues that have been resolved with the release of Chromeleon 7.2 SR1 MUa.
Many trivial and minor issues have been resolved, but are not mentioned here. If you require information about the status of
an issue observed in a prior Chromeleon 7 release, but it is not listed here, please contact your local Thermo Fisher
Scientific representative for more information.
The numbers in the first column of the table below refer to the Thermo Fisher Scientific tracking IDs.

ID Description
CM7-16963 Client - Studio - Processing Method - The number of Custom Variables of type "List" in the
component table was limited to 30.

CM7-16873 Instruments - ICS-4000 - When using an instrument with an AS-DV module, an error could be seen
if clicking on the AS-DV icon after creating an instrument method.
CM7-16799 Instruments - UltiMate Drivers - VWD-3x00 - When using a very low data collection rate,
occasionally the injection could abort unexpectedly.

CM7-16764 Admin Console - Scheduler - In some circumstances a task scheduled to be performed daily would
skip a day.

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Chromeleon 7.2 SR1 MUa

ID Description
CM7-16740 Client - Console - Custom Variables Manager - Under certain circumstances, using an injection
custom variable in a sequence could cause an unhandled exception

CM7-16676 Client - Studio - Reporting - When using unidentified peak groups in an integration table including all
channels, some of the peaks were not displayed correctly.

CM7-16646 Data Processing: Incorrect results reported for peaks of an unidentified peak group when multiple
data channels exist and reports include ‘fixed channel’ results

CM7-16597 When configuring the WPS-3000 using internal Fraction Collection, the Fraction Collection ePanel
did not appear.

CM7-16592 MSQ: Online chromatogram plot (TIC) on ePanel was not available because of missing Filter tab

CM7-16424 Instruments - MS Drivers - When using a TSQ-8000, attempting to change the instrument
configuration would lead to errors.

CM7-15151 Studio: XICs and Mass Spectra Could Not Be Extracted While an Injection Was Still Acquiring

CM7-15033 Services - General - After a network failure which disrupted communication between instrument PCs
and the Domain Controller, a sequence could be aborted. This was reported with an incorrect error
message leading the user to incorrect conclusions regarding the cause of the abort.
CM6-22881 Instruments – Third Party Drivers - HP68xx GC: GC Hardware kept running even if a sequence was
stopped manually

CM6-22433 Server - General - When using a WPS-3000, occasionally the tray description would be truncated,
causing a problem with the rack view

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 Chromeleon 7.2 SR1 MUa

5 Known Issues
This chapter describes the known issues that have not been resolved with the release of Chromeleon 7.2 SR1 MUa.
The numbers in the first column of the table below refer to the Thermo Fisher Scientific tracking IDs.

ID Description
CM7-16685 Instruments - MS Drivers - When editing the instrument method of the Mass Spectrometer driver it is
possible that the method is marked as changed even if there are no changes. In doubt, please save
the instrument method.
CM7-16154 Instruments – MS Drivers - When creating an Instrument Method for the TSQ Quantiva, the MS run
time is not the same as the Chromeleon run time. The user should enter the correct run time on the
MS page of the wizard.
CM7-16030 Instruments - MS Drivers - When using a TSQ Quantiva, the standby state reports that the
instrument is on.

CM7-15632 Instruments - MS Drivers - When removing the source from a TSQ Quantiva in mid-acquisition, the
sequence does not abort

CM6-22760 Server - Thermo GC Drivers - TRACE 1300 - The autozero function is not working correctly for the
FID, NPD, ECD and FPD detector types.

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Chromeleon 7.2 SR1 MUa

6 Backward/Forward Compatibility Issues

6.1 Thermo Scientific TriPlus RSH

The updated driver for this instrument, included in this Maintenance Update, is incompatible with firmware older than version
2.0
Note: It is necessary that the firmware be updated to the latest version in order to control the instrument with this
software release.

6.2 Thermo Scientific TriPlus LS-100

The updated driver for this instrument, included in this Maintenance Update, is incompatible with firmware older than version
2.0
Note: It is necessary that the firmware be updated to the latest version in order to control the instrument with this
software release.

6.3 Thermo Scientific TSQ Quantiva

The driver version 1.1 for this instrument, included in this Maintenance Update, may not be compatible with existing TSQ
Quantiva mass spectrometers running driver version 1.0 without a hardware update. Please contact your local MS service
engineer before attempting to upgrade the unit.
Note: New TSQ Quantiva modules from the factory are not affected by this issue

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