SDS - Merck-Pte-Ltd - 94790-37-1 - 851006 - 20180911 - en Hbtu

SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006

Revision Date 11.09.2018 Version 4.1
SECTION 1. Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier
Catalogue No. 851006
Product name HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium

hexafluorophosphate Novabiochem®
REACH Registration Number A registration number is not available for this substance as the
substance or its use are exempted from registration according to
Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage
does not require a registration or the registration is envisaged for a
later registration deadline.
CAS-No. 94790-37-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses Peptide synthesis, Chemical for synthesis

For additional information on uses please refer to the Merck Chemicals
portal (www.merckgroup.com).
1.3 Details of the supplier of the safety data sheet
Company Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

Responsible Department LS-QHC * e-mail: prodsafe@merckgroup.com
1.4 Emergency telephone Please contact the regional company representation in your country.
number
SECTION 2. Hazards identification

2.1 Classification of the substance or mixture
Classification (REGULATION (EC) No 1272/2008)
The Safety Data Sheets for catalogue items are available at www.merckgroup.com
Page 1 of 15
SAFETY DATA SHEET

Flammable solid, Category 1, H228

Skin irritation, Category 2, H315
Eye irritation, Category 2, H319
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008)
Hazard pictograms
Signal word
Danger
Hazard statements
H228 Flammable solid.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statements
Prevention
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
Reduced labelling (≤125 ml)

Hazard pictograms
Page 2 of 15
SAFETY DATA SHEET

Signal word
Danger
CAS-No. 94790-37-1
2.3 Other hazards

None known.
SECTION 3. Composition/information on ingredients

3.1 Substance
Formula C₁₁H₁₆N₅O*F₆P C₁₁H₁₆F₆N₅OP (Hill)
EC-No. 423-020-5
Molar mass 379,25 g/mol
Hazardous components (REGULATION (EC) No 1272/2008)

Chemical name (Concentration)
CAS-No. Registration number Classification
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (<= 100 % )
94790-37-1 *)
Flammable solid, Category 1, H228
Skin irritation, Category 2, H315
Eye irritation, Category 2, H319
*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article
2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later
registration deadline.
For the full text of the H-Statements mentioned in this Section, see Section 16.
3.2 Mixture
Not applicable
SECTION 4. First aid measures

4.1 Description of first aid measures
Page 3 of 15
SAFETY DATA SHEET

After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/
shower.
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
irritant effects
4.3 Indication of any immediate medical attention and special treatment needed
No information available.
SECTION 5. Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Water, Foam, Carbon dioxide (CO2), Dry powder
Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture

Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Fire may cause evolution of:
Oxides of phosphorus, nitrogen oxides, Hydrogen fluoride
5.3 Advice for firefighters

Special protective equipment for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
Page 4 of 15
SAFETY DATA SHEET

Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.
SECTION 6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure
adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area,
observe emergency procedures, consult an expert.
Advice for emergency responders:
Protective equipment see section 8.
6.2 Environmental precautions

Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation
of dusts.
6.4 Reference to other sections

Indications about waste treatment see section 13.
SECTION 7. Handling and storage

7.1 Precautions for safe handling
Advice on safe handling

Observe label precautions.
Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.
Page 5 of 15
SAFETY DATA SHEET

Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and
face after working with substance.
7.2 Conditions for safe storage, including any incompatibilities

Storage conditions
Dry.
Tightly closed. Keep away from heat and sources of ignition.
Recommended storage temperature see product label.
7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.
SECTION 8. Exposure controls/personal protection

8.1 Control parameters
8.2 Exposure controls
Engineering measures
Technical measures and appropriate working operations should be given priority over the use of
personal protective equipment.
See section 7.1.
Individual protection measures

Protective clothing needs to be selected specifically for the workplace, depending on
concentrations and quantities of the hazardous substances handled. The chemical resistance of
the protective equipment should be enquired at the respective supplier.
Eye/face protection
Safety glasses
Hand protection
full contact:
Page 6 of 15
SAFETY DATA SHEET

Glove material: Nitrile rubber

Glove thickness: 0,11 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0,11 mm
Break through time: > 480 min
The protective gloves to be used must comply with the specifications of EC Directive
89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),
KCL 741 Dermatril® L (splash contact).
This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied
by us and for the designated use. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Other protective equipment

protective clothing
Respiratory protection
required when dusts are generated.
Recommended Filter type: Filter P 2 (acc. to DIN 3181) for solid and liquid particles of harmful
substances
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective
devices are carried out according to the instructions of the producer. These measures have to be
properly documented.
Environmental exposure controls

Do not let product enter drains.
Risk of explosion.
SECTION 9. Physical and chemical properties

9.1 Information on basic physical and chemical properties
Page 7 of 15
SAFETY DATA SHEET

Form powder
Colour light yellow
Odour odourless
Odour Threshold Not applicable
pH 4,1
at 1,6 g/l
Melting point 250 °C
Boiling point No information available.
Flash point No information available.
Evaporation rate No information available.
Flammability (solid, gas) The substance or mixture is a flammable solid with the
category 1.
Lower explosion limit No information available.
Upper explosion limit No information available.
Vapour pressure No information available.
Relative vapour density No information available.
Density No information available.
Relative density No information available.
Page 8 of 15
SAFETY DATA SHEET

Water solubility 1,6 g/l
Partition coefficient: n- No information available.

octanol/water
Auto-ignition temperature No information available.
Decomposition temperature No information available.
Viscosity, dynamic No information available.
Explosive properties Not classified as explosive.
Oxidizing properties none
9.2 Other data
none
SECTION 10. Stability and reactivity

10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally be
assumed.
10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions

Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid

no information available
10.5 Incompatible materials

no information available
Page 9 of 15
SAFETY DATA SHEET

10.6 Hazardous decomposition products

in the event of fire: See section 5.
SECTION 11. Toxicological information

11.1 Information on toxicological effects
Acute oral toxicity

LD50 Rat: > 2.000 mg/kg
(External MSDS)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and

gastrointestinal tract.
Acute inhalation toxicity
Symptoms: Possible damages:, mucosal irritations
Acute dermal toxicity

This information is not available.
Skin irritation
Causes skin irritation.
Eye irritation
Causes serious eye irritation.
Sensitisation
Germ cell mutagenicity

Carcinogenicity
Reproductive toxicity
Page 10 of 15
SAFETY DATA SHEET

Teratogenicity
Specific target organ toxicity - single exposure

Specific target organ toxicity - repeated exposure

Aspiration hazard
11.2 Further information

Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
SECTION 12. Ecological information

12.1 Toxicity
12.2 Persistence and degradability
Biodegradability
0 %; 28 d
(External MSDS)
Not readily biodegradable.
12.3 Bioaccumulative potential
12.4 Mobility in soil
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.
12.6 Other adverse effects
Additional ecological information
Depending on the concentration, phosphorus and/or nitrogen compounds may contribute to the
eutrophication of drinking- water supplies.
Discharge into the environment must be avoided.
Page 11 of 15
SAFETY DATA SHEET

SECTION 13. Disposal considerations

Waste treatment methods
See www.retrologistik.com for processes regarding the return of chemicals and containers, or
contact us there if you have further questions.
SECTION 14. Transport information

Land transport (ADR/RID)
14.1 UN number UN 1325
14.2 Proper shipping name FLAMMABLE SOLID, ORGANIC, N.O.S. (2-(1H-

BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM
HEXAFLUOROPHOSPHATE)
14.3 Class 4.1
14.4 Packing group II
14.5 Environmentally hazardous --
14.6 Special precautions for yes

user
Tunnel restriction code E
Inland waterway transport (ADN)
Not relevant
Air transport (IATA)

14.3 Class 4.1
Page 12 of 15
SAFETY DATA SHEET

14.6 Special precautions for no

user
Sea transport (IMDG)

14.3 Class 4.1
14.6 Special precautions for yes

user
EmS F-A S-G
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not relevant
SECTION 15. Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
EU regulations
Major Accident Hazard SEVESO III
Legislation Not applicable
Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at
work.
Regulation (EC) No 1005/2009 on substances that not regulated

deplete the ozone layer
Regulation (EC) No 850/2004 of the European not regulated

Parliament and of the Council of 29 April 2004 on
persistent organic pollutants and amending
Directive 79/117/EEC
Page 13 of 15
SAFETY DATA SHEET

Substances of very high concern (SVHC) This product does not contain substances
of very high concern according to
Regulation (EC) No 1907/2006 (REACH),
Article 57 above the respective regulatory
concentration limit of ≥ 0.1 % (w/w).
National legislation
Storage class 4.1B
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out.
SECTION 16. Other information
Full text of H-Statements referred to under sections 2 and 3.

Training advice
Provide adequate information, instruction and training for operators.
Labelling
Hazard pictograms
Signal word
Danger
Hazard statements
Page 14 of 15
SAFETY DATA SHEET


Precautionary statements
Prevention
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.
Response
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P313 Get medical advice/ attention.
P370 + P378 In case of fire: Use powder for extinction.
Key or legend to abbreviations and acronyms used in the safety data sheet
Used abbreviations and acronyms can be looked up at www.wikipedia.org.
Regional representation
This information is given on the authorised Safety Data Sheet for your country.
The information contained herein is based on the present state of our knowledge. It characterises the product with
regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.
Page 15 of 15

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SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

SECTION 1. Identification of the substance/mixture and of the company/undertaking

Catalogue No. 851006

Product name HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium

Identified uses Peptide synthesis, Chemical for synthesis

1.3 Details of the supplier of the safety data sheet

Company Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

SECTION 2. Hazards identification

Catalogue No. 851006

Flammable solid, Category 1, H228

2.2 Label elements

Reduced labelling (≤125 ml)

Catalogue No. 851006

2.3 Other hazards

SECTION 3. Composition/information on ingredients

Formula C₁₁H₁₆N₅O*F₆P C₁₁H₁₆F₆N₅OP (Hill)

Molar mass 379,25 g/mol

Hazardous components (REGULATION (EC) No 1272/2008)

SECTION 4. First aid measures

Catalogue No. 851006

After inhalation: fresh air.

SECTION 5. Firefighting measures

Unsuitable extinguishing media

5.2 Special hazards arising from the substance or mixture

5.3 Advice for firefighters

Catalogue No. 851006

SECTION 6. Accidental release measures

Advice for emergency responders:

Protective equipment see section 8.

6.2 Environmental precautions

6.3 Methods and materials for containment and cleaning up

6.4 Reference to other sections

SECTION 7. Handling and storage

Advice on safe handling

Advice on protection against fire and explosion

Catalogue No. 851006

7.2 Conditions for safe storage, including any incompatibilities

Tightly closed. Keep away from heat and sources of ignition.

Recommended storage temperature see product label.

7.3 Specific end use(s)

SECTION 8. Exposure controls/personal protection

8.2 Exposure controls

See section 7.1.

Individual protection measures

Catalogue No. 851006

Glove material: Nitrile rubber

Other protective equipment

Environmental exposure controls

SECTION 9. Physical and chemical properties

Catalogue No. 851006

Colour light yellow

Odour Threshold Not applicable

Melting point 250 °C

Boiling point No information available.

Flash point No information available.

Evaporation rate No information available.

Lower explosion limit No information available.

Upper explosion limit No information available.