Poison & Antidote Chart IWK Regional Poison Cen PDF

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Poison & Antidote Chart

Note: This document pertains only to the antidotes contained in the antidote kit. Many other antidotes exist: if information is
required, contact the poison centre at 1-800-565-8161

Poison Antidote

Acetaminophen Acetylcysteine

Anesthetics, local Lipid emulsion (Fat Emulsion)

Aniline Methylene blue

Anticholinesterases (i.e. organophosphates) Atropine, Pralidoxime (2-PAM)

Antidepressants, Cyclic (TCAs) Sodium bicarbonate, Lipid emulsion

Antidepressants, noncyclic (i.e., SSRIs, SNRIs, bupropion, Sodium bicarbonate, Lipid emulsion
venlafaxine, etc)

Arsenic Dimaval

Benzodiazepines Flumazenil

Beta-blockers Atropine, Insulin, Calcium, Glucagon (adjunctive therapy


only), Lipid emulsion

Black Widow spider Black Widow spider antivenin (Antivenin Latrodectus


Mactans)

Calcium channel blockers Atropine, Insulin, Calcium, Lipid emulsion

Cyanide Hydroxocobalamin (Cyanokit), Sodium thiosulfate

Digoxin Atropine, Digoxin immune Fab

Ethylene glycol Fomepizole, Pyridoxine, Sodium bicarbonate

Glycol Ethers Fomepizole

Hydrofluoric acid burns Calcium gluconate

Iron Deferoxamine (Desferrioxamine)

Isoniazid Pyridoxine

Lead Dimaval

Mercury (inorganic or elemental) Dimaval

Methanol Fomepizole

Mushrooms, Hepatotoxic (i.e., Amanita phalloides) Acetylcysteine

Mushrooms, Seizure-inducing (gyromitra or hydrazine- Pyridoxine


containing mushrooms)

Nitrates Methylene blue

Nitrites Methylene blue

Opioids Naloxone

Organophosphate insecticides Atropine Pralidoxime (2-PAM)

Salicylates Sodium bicarbonate

Sodium channel blocking drugs* (wide QRS) Sodium bicarbonate, Lipid emulsion

Sulfonylurea (oral hypoglycaemic) Octreotide

* Sodium channel blockers encompass many classes of drugs which can result in widening of the QRS and hypotension with
toxicity. Examples of these drugs include: Amantadine, Carbamazepine, Chloroquine, Class IA antiarrythmics Class IC
antiarrythmics , Citalopram, Cocaine, Cyclic antidepressants, Diltiazem, Diphenhydramine, Dimenhydrinate,
Hydroxychloroquine, Loxapine, Orphenadrine, Phenothiazines, Propranolol, Propoxyphene, Quinine, Verapamil

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