DRUG STUDY

GENERIC NAME MECHANISM OF ACTION SIDE EFFECTS NURSING RESPONSIBILITY

The vaccine produces an active immune
Human Tetanus Immunoglobulin response of the body by developing antibodies  DOB or swallowing.  Observe the 14 rights in
and antitoxins against the toxoids and acellular  hives. administering medication
pertussis antigens. The immune globulin binds to  itching, especially of soles  Management of therapeutic and
tetanus toxiod, interfering with the normal or palms. adverse effects of medication
interaction of the toxoid with human tissue. This  reddening of skin, especially  Management of medication
BRAND NAME prevents the toxoid from invading the nervous around ears. adherence
system and producing painful muscle spasms as  swelling of eyes, face, or  Management of patient medication
Tetagam well as autonomic dysfunction 1. The inside of nose. self-management
Clostridium tetani bacterium is killed either via  unusual tiredness or  Management of patient education
antibiotic treatment of the host's immune system weakness, sudden and and information
and immune globulin-bound toxoid is likely severe.  Prescription management
broken down by phagocytic immune cells  Medication safety management
INDICATION ADVERSE REACTIONS  Care/transition of care coordination.
ILLUSTRATION
Postexposure Prophylaxis: Immediate Generalized Reactions: Chills,
prophylaxis after tetanus prone injuries in fever, headache, malaise, nausea,
patients not adequately vaccinated, whose vomiting, arthralgia and
immunisation status is not known with certainty, moderate back pain. Heart and
with severe deficiency in antibody production. Vascular Disorders:
Cardiovascular reactions
particularly if the product is
inadvertently injected
intravascularly. Local Reactions
at the Injection Site: Local pain,
CLASSIFICATION CONTRAINDICATIONS tenderness or swelling.

Pharmacotherapeutic Group: Immune Known hypersensitivity to any of the

sera and immunoglobulins, human tetanus components of the product.
immunoglobulin. Known hypersensitivity to human
immunoglobulins.
DOSAGE/FREQUENCY/ROUTE

1 ml (250 IU)/ Single Dose/ for IM use

 DRUG STUDY

GENERIC NAME MECHANISM OF ACTION SIDE EFFECTS NURSING RESPONSIBILITY

Tetanus Toxoid The primary action of tetanus toxin is to block Local: swelling of eyes, face, or  Observe the 14 rights in
the release of the inhibitory amino acid inside of nose administering medication
transmitters gamma-aminobutyric acid (GABA) Immune System: Chills, fever,  Management of therapeutic and
and glycine, which ultimately results in a spastic Nervous System: unusual adverse effects of medication
form of paralysis. Tetanus toxin is thought to be tiredness or weakness (sudden  Management of medication
BRAND NAME transported retrogradely to the CNS where it and severe) adherence
exerts this primary action. Respiratory: Difficulty in  Management of patient medication
Tetanus breathing or swallowing self-management
Skin: hives, itching, especially of  Management of patient education
feet or hands, eddening of skin, and information
especially around ears  Prescription management
 Medication safety management
ILLUSTRATION INDICATION ADVERSE REACTIONS
 Care/transition of care coordination.
Tetanus (tetanus toxoid) Toxoid is indicated for
The Adverse reactions may be
booster injection only for persons 7 years of age
local and include redness,
or older against tetanus (tetanus toxoid) . This
warmth, edema, induration with
vaccine is NOT indicated for primaryor without tenderness as well as
immunization. urticaria, and rash. Malaise,
transient fever, pain,
hypotension, nausea and
arthralgia may develop in some
patients after the injection.
Arthus-type hypersensitivity
CLASSIFICATION CONTRAINDICATIONS reactions, characterized by
severe local reactions (generally
Vaccines, Inactivated, Bacterial HYPERSENSITIVITY TO ANY starting 2 to 8 hours after an
COMPONENT OF THE VACCINE, injection) may occur,
INCLUDING THIMEROSAL, A MERCURY particularly in persons who have
DERIVATIVE, IS A CONTRAINDICATION received multiple prior boosters.
FOR FURTHER USE OF THIS VACCINE.
DOSAGE/FREQUENCY/ROUTE

Prophylactic Use Adult: 1500 I.U.-5000

I.U SQ/IM
 DRUG STUDY

GENERIC NAME MECHANISM OF ACTION SIDE EFFECTS NURSING RESPONSIBILITY

Purified Rabies Vaccine (Vero cell) The first human use of the purified vero cell These may include:  Observe the 14 rights in
rabies vaccine (PVRV) was authorized in 1992.  Soreness, administering medication
The WHO advises using PVRV to prevent the  redness, or  Management of therapeutic and
spread of rabies in humans since it has  swelling at the site of the adverse effects of medication
outstanding immunogenicity and safety. injection  Management of medication
BRAND NAME  Fever adherence
 Management of patient medication
Speeda self-management
 Management of patient education
and information
 Prescription management
 Medication safety management
ILLUSTRATION INDICATION ADVERSE REACTIONS
 Care/transition of care
coordination.
Active immunization against rabies Local reactions like pain,
redness, edema, pruritus and
indurations in the injection site.
The symptoms will be alleviated
without treatment after
injection.

Systemic reaction: like a little

fever, chill, asphyxia, atony,
giddy, arthralgia,
CLASSIFICATION CONTRAINDICATIONS muscle pain, gastrointestinal
disorder.
Corticosteroids, immunosuppressants. Post-exposure therapy immunization:
J07BG01 - rabies, inactivated, whole virus ; Because rabies is a fatal disease, there are no The serious adverse reactions
Belongs to the class of rabies viral vaccines. contraindications for immunization, including like rear anaphylaxis like tetter,
pregnant women. nettle rash should
Pre-exposure prophylaxis immunization: The be properly treated under the
DOSAGE/FREQUENCY/ROUTE person who is pregnant or in the active period of doctor’s instruction.
acute fever is recommended to delay the
2.5 IU and 0.5 ml of solvent/ One time use/ vaccination; the person who has serious chronic
IM disease, disease of the nervous system
hypersensitive disease or has a allergic history
of antibiotic, biological product
should avoid use