Electrolyte Imbalance
Electrolyte Imbalance
Electrolyte Imbalance
Etiology 6 Ds: WATER loss Diuresis Dehydration Diabetes insipidus (DI) Docs iatrogenic Diarrhea Disease kidney Also: Hypertonic Na gain aldosteron/ADH Pure water loss DI Hypotonic fluid loss intake, diarrhea, burns, osmotic dieresis ( mannitol, glucose in DKA)
Treatment Hypotonic Saline D5Q Oral water GRADUALLY over 48 72 hrs to prevent cerebral edema
Na
ADH Osmolality: High > 295 hyperglycemia, hypertonic infusion Normal 280 - 295 triglyceride Low < 280 Volume: 1. Hypervolemic renal failure, nephrotic syndrome, cirrhosis, CHF, hypothyroidism, 2. Euvolemic SIADH, renal failure, drugs 3. Hypovolemic Diuretics ( HCTZ), diarrhea, vomiting, third spacing, dehydration, DKA, 1 adrenal insufficiency Hemolysis Excretion renal insufficiency, drugs (spironolactone, ACEI, NSAIDS), hypoaldosteronism, renal tubular acidosis Cellular shifts rhabdomyolysis, insulin deficiency, acidosis, drugs (digitalis, BB) exercise Iatrogenic
Na < 135
Hypotonic + : 1. Hypervolemic Water restriction, diuretics 2. Euvolemic water restriction 3. Hypovolemic NS If tx to rapidly central pontine myelinolysis
K>5 ECG TALL, peaked T waves, wide QRS, PR prolongation, loss P waves cardiac arrest
C BIG K (mnemonic) Calcium gluconate ECG cardiac cell membrane stabilization Bicarbonate Insulin Glucose Kayexalate remove K + Albuterol Dialysis if severe
Transcellular shifts insulin, BB, alkalosis GI losses diarrhea, chronic laxative, vomiting, NG suction Renal losses diuretics, DKA, Mg CHIMPANZEES MALIGNANCY, PTH Calcium supplementation Hyperparathyroidism/hyperthyroi dism Iatrogenic/Immobility Milk alkali syndrome Pagets disease Adrenal insufficiency/Acromegaly Neoplasm Zollinger Ellison syndrome Excess vit A Excess vit D Sarcoidosis PTH MG Vit D Acute pancreatitis DiGeorges syndrome infants + tetany
Ca
Muscle weakness Cramps Ileus Hypotension Reflexes Fatigue BONES osteopenia, fractures STONES kidney GROANES constipation Psych OVERTONE weakness, fatigue, MS
K < 3.6 24 hrs UA ECG U waves, T wave flatting, ST depression, AV block arrest >10.2 ECG Q - T
K repletion + Mg repletion
IV hydration followed by Furosemide (Loops lose calcium) Severe calcitonin, bisphosphonates, glucocorticoids, dialysis AVOID HCTZ b/c Ca tubular reabsorption
Ca
Ca < 8.5 Abdominal cramps Tetany Perioral + acral paresthesias CHVOSTEKS sign facial spasm from tapping of the facial nerve TROUSSEAUS sign carpal spasm after arterial occlusion by BP cuff ECG prolonged QT Recalculate Ca for low Albumin
Mg
IV or oral supplements
DKA Pancreatitis
PR and QT