Dosages EUCAST Clinical Breakpoint Tables v. 10.

0, valid from 2020-01-01

EUCAST breakpoints are based on the following dosages (see section 8 in Rationale Documents). Alternative dosing regimens which result in equivalent exposure are acceptable. The table
should not be considered an exhaustive guidance for dosing in clinical practice, and does not replace specific local, national, or regional dosing guidelines. However, if national practices
significantly differ from those listed below, EUCAST breakpoints may not be valid. Situations where less antibiotic is given as standard or high dose should be discussed locally or regionally.

Uncomplicated UTI: acute, sporadic or recurrent lower urinary tract infections (uncomplicated cystitis) in patients with no known relevant anatomical or functional abnormalities within the
urinary tract or comorbidities.

Penicillins Standard dose High dose Uncomplicated UTI Special situations

Benzylpenicillin 0.6 g (1 MU) x 4 iv 1.2 g (2 MU) x 4-6 iv Meningitis caused by S. pneumoniae :
For a dose of 2.4 g (4 MU) x 6 iv, isolates with MIC≤0.06 mg/L are susceptible.

Pneumonia caused by S. pneumoniae: breakpoints are related to dosage:

For a dose of 1.2 g (2 MU) x 4 iv, isolates with MIC ≤0.5 mg/L are susceptible.
For a dose of 2.4 (4 MU) g x 4 iv or 1.2 g (2 MU) x 6 iv, isolates with MIC ≤1 mg/L are
susceptible.
For a dose of 2.4 g (4 MU) x 6 iv, isolates with MIC ≤2 mg/L are susceptible.
Ampicillin 2 g x 3 iv 2 g x 4 iv Meningitis: 2 g x 6 iv

Ampicillin-sulbactam (2 g ampicillin + 1 g sulbactam) x 3 iv (2 g ampicillin + 1 g sulbactam) x 4 iv

Amoxicillin iv 1 g x 3-4 iv 2 g x 6 iv Meningitis: 2 g x 6 iv

Amoxicillin oral 0.5 g x 3 oral 0.75-1 g x 3 oral 0.5 g x 3 oral H. influenzae: High dose only
Amoxicillin-clavulanic acid iv (1 g amoxicillin + 0.2 g clavulanic acid) (2 g amoxicillin + 0.2 g clavulanic acid)
x 3-4 iv x 3 iv
Amoxicillin-clavulanic acid oral (0.5 g amoxicillin + 0.125 g (0.875 g amoxicillin + 0.125 g clavulanic (0.5 g amoxicillin + 0.125 g Amoxicillin-clavulanic acid has separate breakpoints for systemic infections and
clavulanic acid) x 3 oral acid) x 3 oral clavulanic acid) x 3 oral uncomplicated UTI. When amoxicillin-clavulanic acid is reported for uncomplicated
UTI, the report must make clear that the susceptibility category is only valid for
uncomplicated UTI.
H. influenzae : High dose only
Piperacillin 4 g x 3 iv 4 g x 4 iv Pseudomonas spp.: High dose only
Piperacillin-tazobactam (4 g piperacillin + 0.5 g tazobactam) (4 g piperacillin + 0.5 g tazobactam) Pseudomonas spp.: High dose only
x 3 iv x 4 iv
Ticarcillin 3 g x 4 iv 3 g x 6 iv Pseudomonas spp.: High dose only
Ticarcillin-clavulanic acid (3 g ticarcillin + 0.1-0.2 g clavulanic (3 g ticarcillin + 0.1 g clavulanic acid) x Pseudomonas spp.: High dose only
acid) x 4 iv 6 iv

Phenoxymethylpenicillin 0.5-2 g x 3-4 oral None

depending on species and/or infection
type

Oxacillin 1 g x 4 iv 1 g x 6 iv
Cloxacillin 0.5 g x 4 oral or 1 g x 4 iv 1 g x 4 oral or 2 g x 6 iv
Dicloxacillin 0.5-1 g x 4 oral or 1 g x 4 iv 2 g x 4 oral or 2 g x 6 iv
Flucloxacillin 1 g x 3 oral or 2 g x 4 iv 1 g x 4 oral or 2 g x 6 iv
(or 1 g x 6 iv)

Mecillinam oral None None 0.2-0.4 g x 3 oral

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Dosages EUCAST Clinical Breakpoint Tables v. 10.0, valid from 2020-01-01

Cephalosporins Standard dose High dose Uncomplicated UTI Special situations

Cefaclor 0.25-1 g x 3 oral None Staphylococcus spp.: Minimum dose 0.5 g x 3
depending on species and/or infection
type
Cefadroxil 0.5-1 g x 2 oral None 0.5-1 g x 2 oral
Cefalexin 0.25-1 g x 2-3 oral None 0.25-1 g x 2-3 oral
Cefazolin 1 g x 3 iv 2 g x 3 iv
Cefepime 1 g x 3 iv or 2 g x 2 iv 2 g x 3 iv Pseudomonas spp.: High dose only
Cefixime 0.2-0.4 g x 2 oral None 0.2-0.4 g x 2 oral Gonorrhoea: 0.4 g oral as a single dose
Cefotaxime 1 g x 3 iv 2 g x 3 iv Meningitis: 2 g x 4 iv
S. aureus: High dose only
Cefpodoxime 0.1-0.2 g x 2 oral None 0.1-0.2 g x 2 oral

Ceftaroline 0.6 g x 2 iv over 1 hour 0.6 g x 3 iv over 2 hours S. aureus in complicated skin and skin structure infections: There is some PK-
PD evidence to suggest that isolates with MICs of 4 mg/L could be treated with high
dose.
Ceftazidime 1 g x 3 iv 2 g x 3 iv or 1 g x 6 iv Pseudomonas spp.: High dose only
Ceftazidime-avibactam (2 g ceftazidime + 0.5 g avibactam) x 3 iv over 2 hours
Ceftibuten 0.4 g x 1 oral None
Ceftobiprole 0.5 g x 3 iv over 2 hours None
Ceftolozane-tazobactam (intra- (1 g ceftolozane + 0.5 g tazobactam) x None
abdominal infections and UTI) 3 iv over 1 hour
Ceftolozane-tazobactam (hospital (2 g ceftolozane + 1 g tazobactam) None
acquired pneumonia, including x 3 iv over 1 hour
ventilator associated pneumonia)
Ceftriaxone 2 g x 1 iv 2 g x 2 iv or 4 g x 1 iv Meningitis: 2 g x 2 iv or 4 g x 1 iv
S. aureus: High dose only
Cefuroxime iv 0.75 g x 3 iv 1.5 g x 3 iv E. coli, Klebsiella spp. (except K. aerogenes ), Raoultella spp. and
P. mirabilis: High dose only
Cefuroxime oral 0.25 g x 2 oral 0.5 g x 2 oral 0.25 g x 2 oral

Carbapenems Standard dose High dose Uncomplicated UTI Special situations

Ertapenem 1 g x 1 iv over 30 minutes None
Imipenem 0.5 g x 4 iv over 30 minutes 1 g x 4 iv over 30 minutes Pseudomonas spp.: High dose only
Imipenem-relebactam (0.5 g imipenem + 0.25 g relebactam) None
x 4 iv over 30 minutes
Meropenem 1 g x 3 iv over 30 minutes 2 g x 3 iv over 3 hours Meningitis: 2 g x 3 iv over 30 minutes (or 3 hours)
Meropenem-vaborbactam (2 g meropenem + 2 g vaborbactam) x 3 iv over 3 hours

Monobactams Standard dose High dose Uncomplicated UTI Special situations

Aztreonam 1 g x 3 iv 2 g x 4 iv Pseudomonas spp.: High dose only

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Dosages EUCAST Clinical Breakpoint Tables v. 10.0, valid from 2020-01-01

Fluoroquinolones Standard dose High dose Uncomplicated UTI Special situations

Ciprofloxacin 0.5 g x 2 oral or 0.4 g x 2 iv 0.75 g x 2 oral or 0.4 g x 3 iv Pseudomonas spp.: High dose only
Staphylococcus spp.: High dose only + combination
Delafloxacin 0.45 g x 2 oral or 0.3 g x 2 iv None
Levofloxacin 0.5 g x 1 oral or 0.5 g x 1 iv 0.5 g x 2 oral or 0.5 g x 2 iv Pseudomonas spp.: High dose only
Streptococcus groups A, B, C and G: High dose only
S. pneumoniae: High dose only
Moxifloxacin 0.4 g x 1 oral or 0.4 g x 1 iv None
Norfloxacin None None 0.4 g x 2 oral
Ofloxacin 0.2 g x 2 oral or 0.2 g x 2 iv 0.4 g x 2 oral or 0.4 g x 2 iv Staphylococcus spp.: High dose only + combination

Aminoglycosides Standard dose High dose Uncomplicated UTI Special situations

Amikacin 25-30 mg/kg x 1 iv None Enterobacterales: High dose only
Pseudomonas spp.: High dose only
Acinetobacter spp.: High dose only
Gentamicin 6-7 mg/kg x 1 iv None Enterobacterales: High dose only
Pseudomonas spp.: High dose only
Acinetobacter spp.: High dose only
Netilmicin Under review Under review Enterobacterales: High dose only
Pseudomonas spp.: High dose only
Acinetobacter spp.: High dose only
Tobramycin 6-7 mg/kg x 1 iv None Enterobacteriales: High dose only
Pseudomonas spp.: High dose only
Acinetobacter spp.: High dose only

Glycopeptides and Standard dose High dose Uncomplicated UTI Special situations
lipoglycopeptides
Dalbavancin 1 g x 1 iv over 30 minutes on day 1 None
If needed, 0.5 g x 1 iv over 30 minutes
on day 8
Oritavancin 1.2 g x 1 (single dose) iv None
over 3 hours
Teicoplanin 0.4 g x 1 iv 0.8 g x 1 iv
Telavancin 10 mg/kg x 1 iv over 1 hour None
Vancomycin 0.5 g x 4 iv or 1 g x 2 iv None Based on body weight. Therapeutic drug monitoring should guide dosing.
or 2 g x 1 by continuous infusion

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Dosages EUCAST Clinical Breakpoint Tables v. 10.0, valid from 2020-01-01

Macrolides, lincosamides and Standard dose High dose Uncomplicated UTI Special situations
streptogramins
Azithromycin 0.5 g x 1 oral or 0.5 g x 1 iv None Gonorrhoea: 2 g oral as a single dose
Clarithromycin 0.25 g x 2 oral 0.5 g x 2 oral In some countries clarithromycin is available for intravenous administration
(0.5 g x 2).
Erythromycin 0.5 g x 2-4 oral or 0.5 g x 2-4 iv 1 g x 4 oral or 1 g x 4 iv
Roxithromycin 0.15 g x 2 oral None
Telithromycin 0.8 g x 1 oral None

Clindamycin 0.3 g x 2 oral or 0.6 g x 3 iv 0.3 g x 4 oral or 0.9 g x 3 iv

Quinupristin-dalfopristin 7.5 mg/kg x 2 iv 7.5 mg/kg x 3 iv

Tetracyclines Standard dose High dose Uncomplicated UTI Special situations

Doxycycline 0.1 g x 1 oral 0.2 g x 1 oral
Eravacycline 1 mg/kg x 2 iv None
Minocycline 0.1 g x 2 oral None
Tetracycline 0.25 g x 4 oral 0.5 g x 4 oral
Tigecycline 0.1 g loading dose None
followed by 50 mg x 2 iv

Oxazolidinones Standard dose High dose Uncomplicated UTI Special situations

Linezolid 0.6 g x 2 oral or 0.6 g x 2 iv None
Tedizolid 0.2 g x 1 oral or 0.2 g x 1 iv None

Miscellaneous agents Standard dose High dose Uncomplicated UTI Special situations
Chloramphenicol 1 g x 4 oral or 1 g x 4 iv 2 g x 4 oral or 2 g x 4 iv Neisseria meningitidis : High dose only
Colistin 4.5 MU x 2 iv None
with a loading dose of 9 MU
Daptomycin 4 mg/kg x 1 iv 6 mg/kg x 1 iv
Fosfomycin iv 4 g x 3 iv 8 g x 3 iv
Fosfomycin oral None None 3 g x 1 oral as a single dose
Fusidic acid 0.5 g x 2 oral or 0.5 g x 2 iv 0.5 g x 3 oral or 0.5 g x 3 iv
Metronidazole 0.4 g x 3 oral or 0.4 g x 3 iv 0.5 g x 3 oral or 0.5 g x 3 iv
Nitrofurantoin None None 50-100 mg x 3-4 oral Dosing is dependent on drug formulation.
Nitroxoline None None 0.25 g x 3 oral
Rifampicin 0.6 g x 1 oral or 0.6 g x 1 iv 0.6 g x 2 oral or 0.6 g x 2 iv
Spectinomycin 2 g x 1 im None
Trimethoprim None None 0.16 g x 2 oral
Trimethoprim-sulfamethoxazole (0.16 g trimethoprim + 0.8 g (0.24 g trimethoprim + 1.2 g (0.16 g trimethoprim + 0.8 g Stenotrophomonas maltophilia : High dose only
sulfamethoxazole) x 2 oral sulfamethoxazole) x 2 oral sulfamethoxazole) x 2 oral
or (0.16 g trimethoprim + 0.8 g or (0.24 g trimethoprim + 1.2 g
sulfamethoxazole) x 2 iv sulfamethoxazole) x 2 iv