Metabolic pathway simulations

danny.kunz@gmx.de

„Apocrine“
Bromhidrosis

Butyrate

[EC 6.2.1.2 ACSM]

Butanoyl-CoA

Propionyl-CoA
[EC 4.4.1.1]
Cysteine Pyruvate Crotonyl-CoA
[EC 4.4.1.1] NH3 H2S
„Apocrine“
2-amino-3- 2-amino-
carboxymuconat- muconate- Valine Bromhidrosis
Cystathionine 2-amino- 3-Hydroxy-
Kynurenin semialdehyde
6-semialdehyde muconate butanoyl-CoA
... [EC 4.1.1.45] [EC 1.2.1.3] ...
Pyruvate Glutamate
...

Isobutyryl-CoA Propionate
Acetoacetyl-CoA
Mangan,
magnesia or [EC 6.2.1.1 ACSS, EC 6.2.1.17]
copper ... Quiniolate Picolinate ...
Serine
Glutathione L-γ-Glutamylcysteine Methyl- Propinoyl-CoA
Ethanol malonate- [EC 1.2.1.27]
5-Hydroxy- 5-Hydroxy- semialdehyde
Glycine Tryptophan Kynurenine
5,2- [EC 1.2.1.3]
[EC 6.2.1.1 ACSS]
Methylene- Histidine Tryptophan ... Tyrosine [EC 1.14.16.1] Phenylalanine Acetate
THF [EC 1.2.1.3, EC 1.2.1.5] Methyl-
Acetyl-CoA [EC 6.4.1.3]
Vitamine B6 Acetaldehyde malonate
[EC 3.1.2.1]
[EC 2.1.2.1 SHMT]
[EC 2.1.2.10] [EC 4.1.1.22, EC 4.1.1.28] TMAU NEGATIVE [EC 4.1.1.28] [EC 4.1.1.28] [EC 4.1.1.28] [EC 4.1.1.25, EC 4.1.1.28] [EC 4.1.1.28]
[EC 6.2.1.x ???]
FECAL / UNKNOWN
S-Amino- THF TMAU2 DEPRESSIVE / IBS ACETIC
TCA
[EC 5.1.99.2] [EC 5.1.99.1]
Lipoylprotein methyldihydro- cycle
lopoylprotein
FECAL Histamine Tryptamine
5-Hydroxy-
Tyramine Phenylethylamine Succinyl-CoA R-Methyl- S-Methyl-
Kynurenamine malonyl-CoA
malonyl-CoA
S-Adenosyl-
Serotonin
Formate methionine
TMAU2
FISHY Glycine [EC 2.1.1.8 HNMT]
S-Adenosyl-
Formaldehyde
homocysteine [EC 1.4.3.4] [EC 1.4.3.4, EC 1.4.3.21] [EC 1.4.3.4, EC 1.4.3.21]
Homocysteine
[EC 1.5.8.3 SARDH, EC 1.5.3.1 PIPOX] Primary [EC 1.4.3.22 DAO]
homocysteine
Choline Betaine production N-methyl-
[EC 1.2.1.8] pathways in liver
Acetylcholine histamine
betaine- [EC 2.1.1.5 BHMT,
[EC 1.4.3.4]
aldehyde EC 2.1.1.10 BHMT2,
Dimethyl EC 2.1.1.13 MTR] Methyl- 4-Hydroxy-
Imidazole- Indole-3-
glycine imidazole- phenylacet Phenylacetaldehyde
acetaldehyde acetaldehyde
acetaldehyde aldehyde
CDP-choline Sarcosine 4,6-Dihydroxy-
[EC 1.2.1.5] [EC 1.2.1.3] [EC 1.2.1.3] [EC 1.2.1.5] [EC 1.2.1.5]
Phosphocholine quinoline
Methyl- Indole- 4-Hydroxy-
Methionine Imidazole-4-
imidazole- acetate phenylacet Phenylacetate
acetate
Lecithin acetic acid ate
S-Adenosyl-
homocysteine

[EC 2.1.1.17 PEMT]

Dimethyl-
Phosphatidyl- S-Adenosyl-
ethanolamine methionine
Homocysteine
S-Adenosyl-
[Ptdss1]
homocysteine

[EC 2.1.1.17 PEMT]

Monomethyl- S-Adenosyl-
Phosphatidyl- methionine
ethanolamine S-Adenosyl-
homocysteine

[EC 2.1.1.17 PEMT]

S-Adenosyl-
methionine
Phosphatidyl- Phosphatidyl-L-
L-Serine ethanolamine