SAFETY DATA SHEET

Creation Date 16-Jun-2009 Revision Date 24-Dec-2021 Revision Number 7

1. Identification
Product Name Acetonitrile

Cat No. : AC268270000; AC268270010; AC268270025; AC268270040

CAS No 75-05-8
Synonyms AN; Methyl cyanide; Ethanenitrile

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Company
Fisher Scientific Company Acros Organics
One Reagent Lane One Reagent Lane
Fair Lawn, NJ 07410 Fair Lawn, NJ 07410
Tel: (201) 796-7100

Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887

2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable liquids Category 2

Acute oral toxicity Category 4
Acute dermal toxicity Category 4
Acute Inhalation Toxicity - Vapors Category 4
Serious Eye Damage/Eye Irritation Category 2

Label Elements

Signal Word
Danger

Hazard Statements
Highly flammable liquid and vapor
Causes serious eye irritation

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Harmful if swallowed, in contact with skin or if inhaled

Precautionary Statements
Prevention
Wash face, hands and any exposed skin thoroughly after handling
Do not eat, drink or smoke when using this product
Wear protective gloves/protective clothing/eye protection/face protection
Use only outdoors or in a well-ventilated area
Do not breathe dust/fume/gas/mist/vapors/spray
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Response
Get medical attention/advice if you feel unwell
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Call a POISON CENTER or doctor/physician if you feel unwell
Skin
Call a POISON CENTER or doctor/physician if you feel unwell
Wash contaminated clothing before reuse
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Ingestion
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
Rinse mouth
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store in a well-ventilated place. Keep cool
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
None identified

3. Composition/Information on Ingredients
Component CAS No Weight %
Acetonitrile 75-05-8 >95

4. First-aid measures
General Advice Immediate medical attention is required. Show this safety data sheet to the doctor in
attendance.

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Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Immediate medical attention is required.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical
attention is required.

Inhalation Remove to fresh air. If breathing is irregular or stopped, administer artificial respiration. Do
not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial
respiration with the aid of a pocket mask equipped with a one-way valve or other proper
respiratory medical device. Immediate medical attention is required.

Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and Difficulty in breathing. Symptoms of overexposure may be headache, dizziness, tiredness,
effects nausea and vomiting: Metabolism may release cyanide, which may result in headache,
dizziness, weakness, collapse, unconsciousness, and possible death: Inhalation of high
vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea
and vomiting
Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray. CO 2, dry chemical, dry sand, alcohol-resistant foam. Water mist may be used
to cool closed containers.

Unsuitable Extinguishing Media Water may be ineffective, Do not use a solid water stream as it may scatter and spread fire

Flash Point 12.8 °C / 55 °F

Method - No information available

Autoignition Temperature 525 °C / 977 °F

Explosion Limits
Upper 16 vol %
Lower 3 vol %
Oxidizing Properties Not oxidising

Sensitivity to Mechanical Impact No information available

Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Flammable. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Containers may
explode when heated. Vapors may form explosive mixtures with air.

Hazardous Combustion Products

Hydrogen cyanide (hydrocyanic acid). Nitrogen oxides (NOx). Carbon monoxide (CO). Carbon dioxide (CO2).
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA
Health Flammability Instability Physical hazards
2 3 0 N/A

6. Accidental release measures

Personal Precautions Remove all sources of ignition. Take precautionary measures against static discharges.
Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Ensure

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adequate ventilation. Use personal protective equipment as required.

Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological
Information.

Methods for Containment and Clean Remove all sources of ignition. Take precautionary measures against static discharges.
Up Provide adequate ventilation. Use spark-proof tools and explosion-proof equipment. Soak
up with inert absorbent material. Keep in suitable, closed containers for disposal. Prevent
product from entering drains.

7. Handling and storage

Handling Wear personal protective equipment/face protection. Ensure adequate ventilation. Keep
away from open flames, hot surfaces and sources of ignition. Take precautionary measures
against static discharges. Do not get in eyes, on skin, or on clothing. Do not breathe
mist/vapors/spray. Use spark-proof tools and explosion-proof equipment. Use only
non-sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts
of the equipment must be grounded.

Storage. Keep container tightly closed in a dry and well-ventilated place. Keep away from heat,
sparks and flame. Flammables area. Incompatible Materials. Strong oxidizing agents.
Strong acids. Reducing Agent. Bases.

8. Exposure controls / personal protection

Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA)
Acetonitrile TWA: 20 ppm (Vacated) TWA: 40 ppm IDLH: 137 ppm IDLH: 25 TWA: 20 ppm
Skin (Vacated) TWA: 70 mg/m3 mg/m3
(Vacated) TWA: 5 mg/m3 TWA: 20 ppm
(Vacated) STEL: 60 ppm TWA: 34 mg/m3
(Vacated) STEL: 105 mg/m3
TWA: 40 ppm
TWA: 70 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration
NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations
and safety showers are close to the workstation location. Use explosion-proof
electrical/ventilating/lighting equipment.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures When using do not eat, drink or smoke. Provide regular cleaning of equipment, work area
and clothing.

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9. Physical and chemical properties

Physical State Liquid
Appearance Colorless
Odor aromatic
Odor Threshold 170 ppm
pH No information available
Melting Point/Range -46 °C / -50.8 °F
Boiling Point/Range 81 - 82 °C / 177.8 - 179.6 °F @ 760 mmHg
Flash Point 12.8 °C / 55 °F
Evaporation Rate 5.79
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 16 vol %
Lower 3 vol %
Vapor Pressure 97 mbar @ 20 °C
Vapor Density 1.42
Specific Gravity 0.781
Solubility miscible
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 525 °C / 977 °F
Decomposition Temperature No information available
Viscosity 0.36 cP at 20 °C
Molecular Formula C2 H3 N
Molecular Weight 41.05

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products. Keep away from open flames, hot surfaces and sources of ignition.
Exposure to moisture.

Incompatible Materials Strong oxidizing agents, Strong acids, Reducing Agent, Bases

Hazardous Decomposition Products Hydrogen cyanide (hydrocyanic acid), Nitrogen oxides (NOx), Carbon monoxide (CO),
Carbon dioxide (CO2)

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Acetonitrile 450-787 mg/kg (Rat) > 2000 mg/kg ( Rabbit ) LC50 = 3587 ppm (6.022 mg/l)
2460 mg/kg ( Rat ) (Mouse) 4h
LC50 = 16,000 ppm (26.8 mg/l)
(Rat) 4h
Toxicologically Synergistic No information available
Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes

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Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Acetonitrile 75-05-8 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure None known

STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:
delayed Metabolism may release cyanide, which may result in headache, dizziness, weakness,
collapse, unconsciousness, and possible death: Inhalation of high vapor concentrations
may cause symptoms like headache, dizziness, tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information

Ecotoxicity
.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Acetonitrile Not listed LC50: = 1850 mg/L, 96h EC50 = 28000 mg/L 48 h Not listed
static (Lepomis macrochirus) EC50 = 73 mg/L 24 h
LC50: = 1000 mg/L, 96h EC50 = 7500 mg/L 15 h
static (Pimephales
promelas)
LC50: 1600 - 1690 mg/L,
96h flow-through
(Pimephales promelas)
LC50: = 1650 mg/L, 96h
static (Poecilia reticulata)

Persistence and Degradability Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

Component log Pow

Acetonitrile -0.34

13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes

Acetonitrile - 75-05-8 U003 -

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14. Transport information

DOT
UN-No UN1648
Proper Shipping Name ACETONITRILE
Hazard Class 3
Packing Group II
TDG
UN-No UN1648
Proper Shipping Name ACETONITRILE
Hazard Class 3
Packing Group II
IATA
UN-No UN1648
Proper Shipping Name ACETONITRILE
Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1648
Proper Shipping Name ACETONITRILE
Hazard Class 3
Packing Group II
15. Regulatory information
United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory

Active-Inactive Flags
Acetonitrile 75-05-8 X ACTIVE -

Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Acetonitrile 75-05-8 X - 200-835-2 X X X X X KE-00067

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313
Component CAS No Weight % SARA 313 - Threshold
Values %
Acetonitrile 75-05-8 >95 1.0

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act)

Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants
Substances Quantities
Acetonitrile - - X X

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Clean Air Act

Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors
Acetonitrile X -

OSHA - Occupational Safety and Not applicable

Health Administration

CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
substance under the Comprehensive Environmental Response Compensation and Liability
Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs

Acetonitrile 5000 lb -

California Proposition 65 This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know

Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Acetonitrile X X X X X

U.S. Department of Transportation

Reportable Quantity (RQ): Y
DOT Marine Pollutant Y
DOT Severe Marine Pollutant N

U.S. Department of Homeland This product does not contain any DHS chemicals.
Security

Other International Regulations

Mexico - Grade Serious risk, Grade 3

Authorisation/Restrictions according to EU REACH

Component REACH (1907/2006) - Annex XIV - REACH (1907/2006) - Annex XVII - REACH Regulation (EC
Substances Subject to Restrictions on Certain Dangerous 1907/2006) article 59 - Candidate
Authorization Substances List of Substances of Very High
Concern (SVHC)
Acetonitrile - Use restricted. See item 75. -
(see link for restriction details)

https://echa.europa.eu/substances-restricted-under-reach

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of

Pollutant Potential Hazardous
Substances (RoHS)
Acetonitrile 75-05-8 Listed Not applicable Not applicable Not applicable

Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Acetonitrile 75-05-8 Not applicable Not applicable Not applicable Not applicable

16. Other information

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Prepared By Regulatory Affairs

Thermo Fisher Scientific
Email: EMSDS.RA@thermofisher.com

Creation Date 16-Jun-2009

Revision Date 24-Dec-2021
Print Date 24-Dec-2021
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of SDS

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