SAFETY DATA SHEET

Creation Date 20-Apr-2010 Revision Date 29-Mar-2024 Revision Number 4

1. Identification
Product Name (+/-)-Propylene oxide

Cat No. : 30765

CAS No 75-56-9
Synonyms 1,2-Epoxypropane; Methyloxirane

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Company
Thermo Fisher Scientific Chemicals, Inc.
30 Bond Street
Ward Hill, MA 01835-8099
Tel: 800-343-0660
Fax: 800-322-4757

Emergency Telephone Number

For information US call: 001-800-227-6701 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No. US:001-800-424-9300 / Europe:001-703-527-3887

2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable liquids Category 1

Acute oral toxicity Category 4
Acute dermal toxicity Category 3
Acute Inhalation Toxicity - Vapors Category 3
Serious Eye Damage/Eye Irritation Category 2
Germ Cell Mutagenicity Category 1B
Carcinogenicity Category 1B
Specific target organ toxicity (single exposure) Category 3
Target Organs - Respiratory system.

Label Elements

Signal Word
Danger

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Hazard Statements
Extremely flammable liquid and vapor
Harmful if swallowed
Causes serious eye irritation
May cause respiratory irritation
May cause genetic defects
May cause cancer
Toxic in contact with skin or if inhaled

Precautionary Statements
Prevention
Obtain special instructions before use
Do not handle until all safety precautions have been read and understood
Use personal protective equipment as required
Wash face, hands and any exposed skin thoroughly after handling
Do not eat, drink or smoke when using this product
Avoid breathing dust/fume/gas/mist/vapors/spray
Use only outdoors or in a well-ventilated area
Wear eye/face protection
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Keep cool
Response
IF exposed or concerned: Get medical attention/advice
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Call a POISON CENTER or doctor/physician
Skin
Call a POISON CENTER or doctor/physician if you feel unwell
Wash contaminated clothing before reuse
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Ingestion
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
Rinse mouth
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store locked up
Store in a well-ventilated place. Keep container tightly closed
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
Hazardous polymerization may occur
WARNING. Cancer - https://www.p65warnings.ca.gov/.

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3. Composition/Information on Ingredients
Component CAS No Weight %
Propylene oxide 75-56-9 >95

4. First-aid measures
General Advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is
required.

Eye Contact In the case of contact with eyes, rinse immediately with plenty of water and seek medical
advice.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical
attention is required.

Inhalation Remove to fresh air. If not breathing, give artificial respiration. Do not use mouth-to-mouth
method if victim ingested or inhaled the substance; give artificial respiration with the aid of a
pocket mask equipped with a one-way valve or other proper respiratory medical device.
Immediate medical attention is required.

Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and . Inhalation of high vapor concentrations may cause symptoms like headache, dizziness,
effects tiredness, nausea and vomiting
Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may
be used to cool closed containers.

Unsuitable Extinguishing Media No information available

Flash Point -37 °C / -34.6 °F

Method - No information available

Autoignition Temperature 430 °C / 806 °F

Explosion Limits
Upper 37 vol %
Lower 2.3 vol %
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Extremely flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to
source of ignition and flash back.

Hazardous Combustion Products

Carbon monoxide (CO). Carbon dioxide (CO2).
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA

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Health Flammability Instability Physical hazards

3 4 2 N/A

6. Accidental release measures

Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Remove all
sources of ignition. Take precautionary measures against static discharges. Keep people
away from and upwind of spill/leak. Evacuate personnel to safe areas.
Environmental Precautions Should not be released into the environment.

Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.

7. Handling and storage

Handling Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on
clothing. Use only under a chemical fume hood. Do not breathe mist/vapors/spray. Do not
ingest. If swallowed then seek immediate medical assistance. Keep away from open
flames, hot surfaces and sources of ignition. Use spark-proof tools and explosion-proof
equipment. Use only non-sparking tools. To avoid ignition of vapors by static electricity
discharge, all metal parts of the equipment must be grounded. Take precautionary
measures against static discharges.

Storage. Keep containers tightly closed in a dry, cool and well-ventilated place. Flammables area.
Keep away from heat, sparks and flame. Incompatible Materials. Strong oxidizing agents.
Acids. Bases. Amines. copper. Copper alloys. Peroxides.

8. Exposure controls / personal protection

Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH Mexico OEL (TWA)

Propylene oxide TWA: 2 ppm (Vacated) TWA: 20 ppm IDLH: 400 ppm TWA: 2 ppm
(Vacated) TWA: 50 mg/m3
TWA: 100 ppm
TWA: 240 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration
NIOSH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Use only under a chemical fume hood. Ensure that eyewash stations and safety showers
are close to the workstation location. Use explosion-proof electrical/ventilating/lighting
equipment. Ensure adequate ventilation, especially in confined areas.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.

Recommended Filter type: low boiling organic solvent. Type AX. Brown. conforming to EN371.

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Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties

Physical State Liquid
Appearance Colorless
Odor aromatic
Odor Threshold No information available
pH No information available
Melting Point/Range -112 °C / -169.6 °F
Boiling Point/Range 34 °C / 93.2 °F
Flash Point -37 °C / -34.6 °F
Evaporation Rate No information available
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 37 vol %
Lower 2.3 vol %
Vapor Pressure 590 mbar @ 20 °C
Vapor Density 2.0
Specific Gravity 0.830
Solubility Soluble in water
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 430 °C / 806 °F
Decomposition Temperature No information available
Viscosity 0.32 mPa s at 20 °C
Molecular Formula C3 H6 O
Molecular Weight 58.08

10. Stability and reactivity

Reactive Hazard Yes

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products. Excess heat. Keep away from open flames, hot surfaces and
sources of ignition.

Incompatible Materials Strong oxidizing agents, Acids, Bases, Amines, copper, Copper alloys, Peroxides

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization Hazardous polymerization may occur.

Hazardous Reactions None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Propylene oxide LD50 = 520 mg/kg ( Rat ) LD50 = 1244 mg/kg ( Rabbit ) 9.48 mg/L ( Rat ) 4 h

Toxicologically Synergistic No information available

Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes and respiratory system

Sensitization No information available

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Carcinogenicity May cause cancer. The table below indicates whether each agency has listed any
ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Propylene oxide 75-56-9 Group 2B Reasonably A3 X A3
Anticipated
IARC (International Agency for Research on Cancer) IARC (International Agency for Research on Cancer)
Group 1 - Carcinogenic to Humans
Group 2A - Probably Carcinogenic to Humans
Group 2B - Possibly Carcinogenic to Humans
NTP: (National Toxicity Program) NTP: (National Toxicity Program)
Known - Known Carcinogen
Reasonably Anticipated - Reasonably Anticipated to be a Human
Carcinogen
ACGIH: (American Conference of Governmental Industrial A1 - Known Human Carcinogen
Hygienists) A2 - Suspected Human Carcinogen
A3 - Animal Carcinogen
ACGIH: (American Conference of Governmental Industrial Hygienists)
Mexico - Occupational Exposure Limits - Carcinogens Mexico - Occupational Exposure Limits - Carcinogens
A1 - Confirmed Human Carcinogen
A2 - Suspected Human Carcinogen
A3 - Confirmed Animal Carcinogen
A4 - Not Classifiable as a Human Carcinogen
A5 - Not Suspected as a Human Carcinogen
Mutagenic Effects May cause heritable genetic damage

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Respiratory system

STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and Inhalation of high vapor concentrations may cause symptoms like headache, dizziness,
delayed tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information

Ecotoxicity
Do not empty into drains. .

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Propylene oxide EC50: = 240 mg/L, 96h LC50: = 215 mg/L, 96h static EC50 = 3300 mg/L 160 min EC50: = 350 mg/L, 48h
(Pseudokirchneriella (Lepomis macrochirus) (Daphnia magna)
subcapitata)

Persistence and Degradability Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

Component log Pow

Propylene oxide 1

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13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

14. Transport information

DOT
UN-No UN1280
Proper Shipping Name PROPYLENE OXIDE
Hazard Class 3
Packing Group I
TDG
UN-No UN1280
Proper Shipping Name PROPYLENE OXIDE
Hazard Class 3
Packing Group I
IATA
UN-No UN1280
Proper Shipping Name PROPYLENE OXIDE
Hazard Class 3
Packing Group I
IMDG/IMO
UN-No UN1280
Proper Shipping Name PROPYLENE OXIDE
Hazard Class 3
Packing Group I
15. Regulatory information
United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory

Active-Inactive Flags
Propylene oxide 75-56-9 X ACTIVE -

Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed

TSCA - Per 40 CFR 751, Regulation of Certain Chemical Not applicable

Substances & Mixtures, Under TSCA Section 6(h) (PBT)

TSCA 12(b) - Notices of Export Not applicable

International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Propylene oxide 75-56-9 X - 200-879-2 X X X X X KE-24565

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product contains a chemical
or chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.

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Component CAS No Weight % SARA 313 - Threshold SARA 313 - Reporting

Values % threasholds
Propylene oxide 75-56-9 >95 0.1 % -

SARA 311/312 Hazard Categories

Should this product meet EPCRA 311/312 Tier reporting criteria at 40 CFR 370, refer to Section 2 of this SDS for appropriate
classifications.

CWA (Clean Water Act)

Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants
Substances Quantities
Propylene oxide X 100 lb - -

Clean Air Act

Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors
Propylene oxide X -

OSHA - Occupational Safety and Not applicable

Health Administration

CERCLA
This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive
Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and
Reauthorization Act (SARA) (40 CFR 355).

Component Hazardous Substances CERCLA Extremely SARA Reportable Quantity

RQs Hazardous Substances (RQ)
RQs
Propylene oxide 100 lb 100 lb 100 lb
45.4 kg

California Proposition 65 This product contains the following Proposition 65 chemicals.

Component CAS No California Prop. 65 Prop 65 NSRL Category

Propylene oxide 75-56-9 Carcinogen - Carcinogen
U.S. State Right-to-Know
Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Propylene oxide X X X X X

U.S. Department of Transportation

Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland This product contains the following DHS chemicals:
Security Legend - STQs = Screening Threshold Quantities, APA = A placarded amount

Component DHS Chemical Facility Anti-Terrorism Standard

Propylene oxide Release STQs - 10000lb
Other International Regulations

Mexico - Grade Severe risk, Grade 4

Authorisation/Restrictions according to EU REACH

Component CAS No REACH (1907/2006) - REACH (1907/2006) - REACH Regulation (EC

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Annex XIV - Substances Annex XVII - Restrictions 1907/2006) article 59 -

Subject to Authorization on Certain Dangerous Candidate List of
Substances Substances of Very High
Concern (SVHC)
Propylene oxide 75-56-9 - Use restricted. See item SVHC Candidate list -
28. Carcinogenic (Article 57a)
(see link for restriction SVHC Candidate list -
details) Mutagenic (Article 57b)
Use restricted. See item
29.
(see link for restriction
details)
Use restricted. See item
75.
(see link for restriction
details)

After the sunset date the use of this substance requires either an authorization or can only be used for exempted uses, e.g. use in
scientific research and development which includes routine analytics or use as intermediate.

REACH links
https://echa.europa.eu/authorisation-list
https://echa.europa.eu/substances-restricted-under-reach
https://echa.europa.eu/candidate-list-table

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of

Pollutant Potential Hazardous
Substances (RoHS)
Propylene oxide 75-56-9 Listed Not applicable Not applicable Not applicable

Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?
Not applicable

Other International Regulations

Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Propylene oxide 75-56-9 5 tonne 50 tonne Not applicable Not applicable

16. Other information

Prepared By Health, Safety and Environmental Department
Email: chem.techinfo@thermofisher.com
www.thermofisher.com

Creation Date 20-Apr-2010

Revision Date 29-Mar-2024
Print Date 29-Mar-2024
Revision Summary New emergency telephone response service provider.

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information

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relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of SDS

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