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    MSCCH 502

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    20tamilselvi-ugche
    This document outlines the syllabus for Organic Chemistry I, which is part of the M.Sc. Chemistry program. The course is divided into two blocks. Block 1 covers topics like bonding in organic molecules, including conjugation, resonance, aromaticity, and non-covalent bonding. It also addresses reaction mechanisms, reactive intermediates like carbocations and carbanions, and linear free energy relationships. Block 2 focuses on stereochemistry, including chirality, isomerism, stereochemical descriptors, and determining absolute and relative configuration. It also covers topics like stereoselectivity and the stereochemistry of compounds containing elements like phosphorus, nitrogen and sulfur. The document lists several recommended textbooks for the course.

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    MSCCH 502

    Uploaded by

    20tamilselvi-ugche
    64 views2 pages
    This document outlines the syllabus for Organic Chemistry I, which is part of the M.Sc. Chemistry program. The course is divided into two blocks. Block 1 covers topics like bonding in organic molecules, including conjugation, resonance, aromaticity, and non-covalent bonding. It also addresses reaction mechanisms, reactive intermediates like carbocations and carbanions, and linear free energy relationships. Block 2 focuses on stereochemistry, including chirality, isomerism, stereochemical descriptors, and determining absolute and relative configuration. It also covers topics like stereoselectivity and the stereochemistry of compounds containing elements like phosphorus, nitrogen and sulfur. The document lists several recommended textbooks for the course.

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    MSCCH-502

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    This document outlines the syllabus for Organic Chemistry I, which is part of the M.Sc. Chemistry program. The course is divided into two blocks. Block 1 covers topics like bonding in organic molecules, including conjugation, resonance, aromaticity, and non-covalent bonding. It also addresses reaction mechanisms, reactive intermediates like carbocations and carbanions, and linear free energy relationships. Block 2 focuses on stereochemistry, including chirality, isomerism, stereochemical descriptors, and determining absolute and relative configuration. It also covers topics like stereoselectivity and the stereochemistry of compounds containing elements like phosphorus, nitrogen and sulfur. The document lists several recommended textbooks for the course.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    64 views2 pages

    MSCCH 502

    Uploaded by

    20tamilselvi-ugche
    This document outlines the syllabus for Organic Chemistry I, which is part of the M.Sc. Chemistry program. The course is divided into two blocks. Block 1 covers topics like bonding in organic molecules, including conjugation, resonance, aromaticity, and non-covalent bonding. It also addresses reaction mechanisms, reactive intermediates like carbocations and carbanions, and linear free energy relationships. Block 2 focuses on stereochemistry, including chirality, isomerism, stereochemical descriptors, and determining absolute and relative configuration. It also covers topics like stereoselectivity and the stereochemistry of compounds containing elements like phosphorus, nitrogen and sulfur. The document lists several recommended textbooks for the course.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    Syllabus

    M.Sc. (Chemistry) Programme


    ( SEMESTER – I )
    Organic Chemistry – I
    Programme Code- (MSCCH -21)
    Course Code – (MSCCH -502 )

    Block 1 Nature of Bonding in Organic Molecules


    Unit 1: Nature of Bonding in Organic Molecules
    Delocalized chemical bonding: conjugation, cross-conjugation, resonance, hyper conjugation,
    tautomerism, Energy levels of 𝜋 orbitals, Huckel’s rule, aromaticity, anti-aromaticity and homo-
    aromaticity, benzenoid and non-benzonoid aromatic compounds, alteranant and non-alteranant
    hydrocarbons. Annulenes. Non-covalent bonding – addition compounds, crown ether complexes,
    cryptands, inclusion compounds, catenanes, rotaxanes and ionic liquids.

    Unit 2: Structure and Reactivity


    Types of reaction mechanisms, types of reactions, kinetic and thermodynamic control,
    Hammond’s postulate, Curtin-Hammond principle. Reaction co – ordinate, potential energy
    diagrams, transition states and intermediates. Methods of determining mechanisms, isotopes
    effects.
    Unit 3: Reactive Intermediates
    Generation, structure, stability and reactivity of carbocations, carbanions, carbon radicals, singlet
    and triplet carbenes and nitrenes. Effect of structure on reactivity: resonance and field effects,
    steric effects and quantitative treatment. The Hammett equation and linear free energy
    relationships, substituent and reaction constants, Taft equation.
    Block 2: Stereochemistry
    Unit 4: Stereochemistry 1
    Stereogenicity, chirality and prochirality, Enantiomerism, Diastereomerism and meso isomerism
    and racemic modification. Configuration and conformation. Stereochemical descriptors: D, L; R,
    S; E, Z; syn, anti, etc. Axial, planar and helical chirality. Steroprojections – Fischer, Sawhorse,
    Newman and wedge projections and their interconversions. Absolute and relative configurations
    and their determination; molecules with one, two or more chiral centres. Simple chemical
    correlation of configurations with examples, quasiracemates. Stereochemistry and configurations
    of allenes, spiranes, alkylidine cycloalkanes, adamantanes, catenanes, bbiphenyls
    (atropisomerism), bridged biphenyls, ansa compounds and cyclophanes.
    Unit 5: Stereochemistry 2
    Topocity and prochirality: Topocity of ligands and faces and their nomenclature. Cram’s, and
    Prelog’s. Stereoselectivty and stereospecificity and enatiomeric diastereomeric excess,
    Asymmetric induction. Configuration, conformation and stability of cyclohexanes, cyclohexene
    (mono and disubstituted), cyclohexanones, halocyclohexanones, decalins. Qualitative correlation
    between conformation and reactivity, Stereochemistry of Compounds having P, N and S.

    Book Suggested:
    1. Carey, F.A. & Sundberg, R. J. Advanced Organic Chemistry, Parts A & B, Plenum: U.S.
    (2007).
    2. Eliel, E.L. Stereochemistry of Carbon Compounds Textbook Publishers (2003).
    3. Finar, I. L. Organic Chemistry Vol. 1, Longman (1998).
    4. Lowry, T. H. & Richardson, K.S. Mechanism and Theory in Organic Chemistry Addison –
    Wesley Educational Publishers, Inc. (1981).
    5. Nasipuri. D. N. Stereochemistry of Organic Compounds: Principles & Applications South
    Asia Books (1994).
    6. March, J. Advanced Organic Chemistry John Wiley & Sons (2004).
    7. Kalsi, P.S. Stereochemistry: Conformation and Mechanism, 7th Edition New Age
    International, Delhi (2008).
    8. Sengupta.

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