CPU – COLLEGE OF PHARMACY

PHAR1102 – PHARMACEUTICAL CALCULATIONS AND TECHNIQUES

LABORATORY

ACTIVITY 8: Doses
Objective:
1. Demonstrate knowledge and familiarity with different dosage forms and in
interpreting doses and dosage regimens, and apply these in solving problems.
2. Apply knowledge and analytical skills in calculating for the dose and related
calculations.

Introduction:
The dose is the amount of drug taken at any one time. This can be expressed as
the weight of drug (e.g., 250 mg), volume of drug solution (e.g., 10 mL, 2 drops), the
number of dosage forms (e.g. 1 capsule, 1 suppository) or some other quantity (e.g. 2
puffs).
The dosage regimen is the frequency at which the drug doses are given.
Examples include 2.5mL twice a day, one tablet three times a day, one injection every
four weeks.
The total daily dose is calculated from the dose and the number of times per day
the dose is taken.
The dosage form is the physical form of a dose of drug. Common dosage forms
include tablets, capsules, creams, ointments, aerosols and patches. Each dosage form
may also have a number of specialized forms such as extended-release, buccal,
dispersible and chewable tablets.
The strength is the amount of drug in the dosage form or a unit of the dosage
form (e.g., 500 mg capsule, 250 mg/5 mL suspension).
Reference: https://www.drugs.com/dosage/

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PHAR1102 – PHARMACEUTICAL CALCULATIONS AND TECHNIQUES
LABORATORY

Name: Hexalane E. Labrador Section:1B Group: 3

ACTIVITY 8: Doses
Objective:
1. Demonstrate knowledge and familiarity with different dosage forms and in
interpreting doses and dosage regimens, and apply these in solving problems.
2. Apply knowledge and analytical skills in calculating for the dose and related
calculations.

I. Look for 20 different types of medicines and complete the table below:
Dose per
Brand Dosage Therapeutic
No. Generic Name Dosage
Name Forms Category
Form
Ex. Capsule:
500mg
Capsule
Amoxicillin Himox Suspension: Antibiotic
Suspension
125mg/ 5mL,
250mg/ 5mL
1. Tablet: 10mg;
Cetirizine Zyrtec Tablet, Syrup Antihistamine
Syrup: 5mg/5mL

Tablet: 200mg,
2. Tablet, 400mg, 600mg; Analgesic, Anti-
Ibuprofen Advil
Suspension Suspension: inflammatory
100mg/5mL

3. Tablet: 25mg,
Sertraline Zoloft Tablet Antidepressant
50mg, 100mg

Capsule: 20mg;
4. Proton Pump
Omeprazole Prilosec Capsule, Tablet Tablet: 20mg,
Inhibitor
40mg

5. Tablet: 5mg,
Amlodipine Norvasc Tablet Antihypertensive
10mg

Tablet: 25mcg,
6. Thyroid
Levothyroxine Synthroid Tablet 50mcg, 100mcg,
Hormone
200mcg

7. Tablet: 500mg,
Metformin Glucophage Tablet Antidiabetic
850mg, 1000mg

Inhaler: 90mcg
per actuation;
8. Inhaler, Nebulizer
Albuterol Ventolin Nebulizer Bronchodilator
Solution
Solution:
2.5mg/3mL

9. Tablet: 10mg;
Loratadine Claritin Tablet, Syrup Antihistamine
Syrup: 5mg/5mL

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PHAR1102 – PHARMACEUTICAL CALCULATIONS AND TECHNIQUES
LABORATORY
10. Tablet: 25mg,
Losartan Cozaar Tablet Antihypertensive
50mg, 100mg

Tablet: 10mg,
11. Statin (Lipid-
Atorvastatin Lipitor Tablet 20mg, 40mg,
lowering)
80mg

12. Tablet: 75mg,

Clopidogrel Plavix Tablet Antiplatelet
300mg

Capsule: 12.5mg;
13.
Hydrochlorothiazide Microzide Capsule, Tablet Tablet: 12.5mg, Diuretic
25mg

Capsule: 10mg,
14. 20mg; Tablet:
Fluoxetine Prozac Capsule, Tablet Antidepressant
10mg, 20mg,
40mg

Tablet: 1mg, 2mg,

15. 2.5mg, 3mg, 4mg,
Warfarin Coumadin Tablet Anticoagulant
5mg, 6mg, 7.5mg,
10mg

Capsule: 100mg,
16. 300mg, 400mg;
Gabapentin Neurontin Capsule, Tablet Anticonvulsant
Tablet: 600mg,
800mg

17. Tablet: 20mg,

Furosemide Lasix Tablet Diuretic
40mg, 80mg

Tablet: 10mg;
Chewable Tablet:
18. Tablet, Chewable Leukotriene
Montelukast Singulair 4mg, 5mg;
Tablet, Granules Inhibitor
Granules: 4mg
per packet

Capsule: 250mg,
500mg;
19. Capsule,
Cephalexin Keflex Suspension: Antibiotic
Suspension
125mg/5mL,
250mg/5mL

20. Film-coated Tablet:

Co-Amoxiclav Rafonex Antibiotic
Tablet 500mg/125mg

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PHAR1102 – PHARMACEUTICAL CALCULATIONS AND TECHNIQUES
LABORATORY
II. Take your own weight and height. Look for a pharmaceutical preparation either in a
tablet or capsule dosage form. Take note of its dose, and record everything below:

Name of Patient: Hexalane E. Labrador Age:18 Sex:Female

Weight: 88.185 lbs 40 kg
Height: 49.2 in 124.5 cm

Name of Drug: Cefuroxime axetil

Dosage form: Film-coated tablet
Strength: 500mg
Dose: Adult: 500mg 2x a day

Compute for your own dose using the following methods:

1. Young’s Rule
FINAL ANSWER: 306.45 mg
SOLUTION:

2. Clark’s Rule
FINAL ANSWER:291.79 mg
SOLUTION:

3. Cowling’s Rule
FINAL ANSWER: 416.67 mg
SOLUTION:

4. Fried’s Rule
FINAL ANSWER:761.33 mg
SOLUTION:

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5. BSA Using Nomogram

FINAL ANSWER:535 mg
SOLUTION:

6. BSA using Mosteller

FINAL ANSWER:535 mg
SOLUTION:

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