Scribd Logo
Upload

Welcome to Scribd!

  • 11 views

    Anti - Histamine

    Uploaded by

    Shayan Shayan
    This document summarizes first and second generation antihistamines. It notes that first generation antihistamines can penetrate the blood brain barrier and cause sedation and psychomotor impairment due to their anticholinergic effects. They are used to treat allergic conditions by blocking histamine H1 receptors and to prevent adverse effects of histamine releasers. Second generation antihistamines have higher H1 receptor selectivity and no anticholinergic side effects. Some also inhibit late phase allergic reactions. Terfenadine has risks of cardiac issues in overdose while astemizole is the slowest and longest acting agent.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Anti - Histamine

    Uploaded by

    Shayan Shayan
    11 views4 pages
    This document summarizes first and second generation antihistamines. It notes that first generation antihistamines can penetrate the blood brain barrier and cause sedation and psychomotor impairment due to their anticholinergic effects. They are used to treat allergic conditions by blocking histamine H1 receptors and to prevent adverse effects of histamine releasers. Second generation antihistamines have higher H1 receptor selectivity and no anticholinergic side effects. Some also inhibit late phase allergic reactions. Terfenadine has risks of cardiac issues in overdose while astemizole is the slowest and longest acting agent.

    Original Title

    2. Anti- Histamine

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document summarizes first and second generation antihistamines. It notes that first generation antihistamines can penetrate the blood brain barrier and cause sedation and psychomotor impairment due to their anticholinergic effects. They are used to treat allergic conditions by blocking histamine H1 receptors and to prevent adverse effects of histamine releasers. Second generation antihistamines have higher H1 receptor selectivity and no anticholinergic side effects. Some also inhibit late phase allergic reactions. Terfenadine has risks of cardiac issues in overdose while astemizole is the slowest and longest acting agent.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    11 views4 pages

    Anti - Histamine

    Uploaded by

    Shayan Shayan
    This document summarizes first and second generation antihistamines. It notes that first generation antihistamines can penetrate the blood brain barrier and cause sedation and psychomotor impairment due to their anticholinergic effects. They are used to treat allergic conditions by blocking histamine H1 receptors and to prevent adverse effects of histamine releasers. Second generation antihistamines have higher H1 receptor selectivity and no anticholinergic side effects. Some also inhibit late phase allergic reactions. Terfenadine has risks of cardiac issues in overdose while astemizole is the slowest and longest acting agent.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 4

    Autacoid : Anti - Histamine

    H
    , Antagonists :

    actions
    • These
    drugs competitively antagonize of
    Histamine at H
    , Receptors .

    Classified into first


    Generation & Second Generation
    compounds ( on the basis of CNS penetration and

    anticholinergic properties )

    FA ] First Generation Anti - Histaminic

    •
    Can penetrate Blood brain barrier and result in

    sedation &
    Psychomotor impairment .

    •
    Have
    Anticholinergic activity .
    Uses :

    conditions (
    (a) via H
    ,
    Blocking :
    ci,
    Allergic itching ,

    urticaria ,
    hay fever )
    Iii ' Insect bite and to
    prevent
    adverse
    effects due to

    histamine releaser s .

    (b) via
    Anticholinergic properties :
    ci, Common cold

    dis Motion sickness

    Liii , Parkinsonism
    (in Acute muscular

    dystonia .

    (c) Other Uses : in


    Idiopathic purilis
    Cinnarizine
    (
    in is
    useful in
    Vertigo .

    Adverse Effects :

    ( is Sedation

    ciii
    Psychomotor
    iii,
    Impairment
    in
    Anticholinergic effects
    ( dryness of mouth blurred vision
    , ,
    urinary
    retention , constipation )
    [ B.) Second Generation Anti -
    Histamine :

    •
    59 As are those H, Receptor blockers marketed
    after 1980 which have one or more
    of
    the
    followings :

    cis Absence
    of Cms
    depressant property
    iii.
    Higher H
    ,
    selectivity No anticholinergic
    : side
    effe
    cts
    Additional
    -

    iii.
    antiallergic mechanisms
    apart
    from histamine blockade : some also inhibit

    late Phase Rkn


    Allergic .
    .

    * Terfenadine - Fastest
    acting antihistaminic
    drugs .

    •
    In overdose ,
    it
    delayed rectifier
    blocks cardiac

    Kt channels and
    may
    result
    Polymorphic
    in

    Ventricular
    Tachycardia ( Prolong QT interval )
    Astemizole Slowest and
    iii. -

    longest Acting agent .


    c
    MedNotes [ www.mednotes.in ]
    Full MedNotes : mednotesebooks.company.site
    App Available on PlayStore

    You might also like