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"STEM CELL BANKING AND REGENERATIVE MEDICINE:

IMPLICATIONS FOR NURSING PRACTICE"

A Minute Research
Presented to the Faculty of the
College of Liberal Arts, Sciences, and Education
Calayan Educational Foundation, Inc.
Lucena City

In Partial Fulfillment
of the Requirements for the Subject
STS 100 - Science, Technology,
and Society

Submitted by:

Mark Joseph Aviso

Marjhell Thea Gamogamo
Ma. Noella Leynes
Rubyliza Nojor Traqueña

May 2023
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INTRODUCTION

Stem cells are excellent candidates for cell therapy and regenerative
medicine due to their capacity for self-renewal and differentiation into various cell
lineages. Many nations have focused their primary research initiatives on this area
due to the potential it holds. In 2018, the entire world focused on the recently
developed human embryonic stem cells (hESCs) and the implications for cellular
research and therapy, drug discovery, and developmental studies. Researchers may
save money and be confident that the stem cell lines they intend to use are of high
quality if they used a stem cell bank that has committed to depositing cells and has
set and maintained long-term quality criteria.

This research paper shows that in nursing practice, it is important to be

aware of these emerging technologies and the potential benefits they can offer
patients. Nurses may be involved in the collection and preservation of stem cells,
as well as the care of patients undergoing regenerative medicine treatments.

By staying up-to-date on the latest advances in stem cell banking and

regenerative medicine, nurses can provide better care and support for their patients,
and help to shape the future of healthcare.
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Literature Revie
"Stem Cell Banking for Regenerative Medicine: A Review of Current Trends and
Future Directions" by Sharma et al. (Journal of Stem Cell Research & Therapy,
2017): This review article provides an overview of the current trends in stem cell
banking, including different types of stem cell banks, challenges, and future
prospects for regenerative medicine. The study titled "Stem Cell Banking for
Regenerative Medicine: A Review of Current Trends and Future Directions" by
Sharma et al. (Journal of Stem Cell Research & Therapy, 2017) provides an
overview of the current trends and future prospects of stem cell banking in the
context of regenerative medicine.
• The review article discusses numerous elements of stem cell banking, such
as distinct kinds of stem cell banks, difficulties, and possible uses in
regenerative medicine. It emphasizes the significance of stem cell banking
as a method for protecting valuable stem cell sources for potential
therapeutic uses.

• The author goes over the many stem cell banks that are out there, including
hybrid models, commercial banks, and public banks. To guarantee the
accuracy and security of stem cell samples kept in these banks, they
underline the necessity for standardization and quality control procedures.

• The article also discusses the difficulties of stem cell banking, such as
moral issues, regulatory restrictions, and the lack of a variety of trustworthy
cell sources. In the context of stem cell banking, it examines the
significance of informed consent, privacy protection, and the creation of
ethical standards.

• The study also emphasizes how stem cell banking could be used in
regenerative medicine. It covers the application of stored stem cells in
tissue engineering, personalized medicine, and therapeutic treatments. The
authors also go over recent developments in cryopreservation methods and
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the use of induced pluripotent stem cells (iPSCs) as trends in stem cell
banking.

• The study concludes with a thorough analysis of stem cell banking for
regenerative medicine. It highlights the value of stem cell banking in
protecting priceless cell sources and examines the present state and
anticipated developments in this area, advancing regenerative medicine.

These are just a few of the many literatures that can provide baseline data to
nursing about stem cell banking and regenerative medicine regarding tout’s role:
students about stem cell therapy regarding “Stem Cell Banking for Regenerative
and Personalized Medicine” by David T. Harris (Journal of Biomedicine, 2014)
The study's overall findings highlight the role that stem cell banking could play in
developing regenerative and customized therapy. To enhance the handling,
processing, and therapeutic uses of stem cells, it highlights the need for more
research and development in this area. “Stem Cells Applications in Regenerative
Medicine and Disease Therapeutics (PMC)” by Paul J. Higgins (International
Journal of Cell Biology2016) This review outlines the most recent advancement in
transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs,
UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review
also discusses stem cell’s regenerative application in wildlife conservation
“Advances in regenerative therapy: A review of the literature and future
directions” by Negi, et al. (2020) The review focuses on adipose tissue-derived
MSCs (ASCs), with the unique properties such as easier accessibility and
abundance, excellent proliferation and differentiation capacities, low
immunogenicity, immunomodulatory and many other trophic properties. The
suitability and application of the ASCs, and strategies to improve the innate
regenerative capacities of stem cells in general are highlighted among others.
“Stem cells: past, present, and future (Stem Cell Research & Therapy)” Zabrze’s et
al (2019) The review is summarized by challenges that stem cell therapy must
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overcome to be accepted worldwide. A wide variety of possibilities makes this

cutting-edge therapy a turning point in modern medicine, providing hope for
untreatable diseases.

Definition of Terms
Stem cells are the fundamental cellular entities that possess the capacity to
differentiate into various specialized cell types and have the ability to self-
renew, enabling them to replenish and repair damaged tissues and organs.

Regenerative medicine is an interdisciplinary field that focuses on developing

innovative approaches to repair, replace, or regenerate damaged or diseased
tissues and organs using stem cells, biomaterials, and tissue engineering
techniques.
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METHODOLOGY

Research Design
For this study on the current state of stem cell research, a descriptive
research design will be employed. Descriptive research aims to describe and
summarize the characteristics, behaviors, and phenomena of a particular
population or situation. In this case, the research design will focus on providing
an overview of the implications of nursing practice with stem cell research.
Population and sampling
The population for this study includes relevant published studies,
articles, and literature related to Stem Cell Implications for Nursing Practice.
The sampling method will involve conducting a systematic review of
the literature from electronic databases such as PubMed, Scopus, and Web of
Science. The inclusion criteria will encompass studies published between 2014
and 2023, written in English, and providing insights into stem cell banking and
regenerative medicine. The sampling process will involve the screening of
titles, abstracts, and full texts to select relevant studies for the review.

Data Analysis
The data analysis process will involve several steps:

1. Data Collection: Relevant information and data from the selected studies will
be collected, including findings, conclusions, and identified promises and
challenges associated with stem cell research.

2. Data Organization: The collected data will be organized systematically

based on the identified promises and challenges. This step will involve
categorizing the data into themes or subtopics to facilitate analysis and
synthesis.
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3. Data Synthesis: The synthesized data will be analyzed to identify common

themes and patterns related to the promises and challenges of stem cell
research. This analysis will involve summarizing the main findings from the
literature and highlighting key points related to each theme.

4. Interpretation: The synthesized data will be interpreted to draw conclusions

and provide insights into the current state of stem cell research. This step will
involve critically analyzing the findings and discussing their implications in
the context of the research objectives.

5. Reporting: The data analysis results will be reported comprehensively,

including a narrative synthesis of the promises and challenges associated with
stem cell research. The findings will be presented clearly and organized,
supported by references to the selected studies.
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CONCLUSION

In the creation and use of regenerative and personalized medicine techniques,

the capacity to store autologous stem cells for future use has the potential to be a
crucial lynchpin. The most affordable sources of stem cells for practically
everyone are CB, CT-MSC, and AT-MSC. More than 30,000 stem cell
transplants and countless regenerative therapies have used cord blood banking,
which has been around for more than 20 years and is well-established and
regulated. Over the past 5-7 years, cord tissue banking has become a possibility
in addition to cord blood banking. Even while its connection to cord blood
entities gives the impression that it is regulated, it actually is not. Its relevance to
the clinic appears to be less broad, though, and other MSC sources might
eventually take its place. Adipose tissue banking, which has just become
available, allows one to easily and affordably store virtually endless amounts of
stem cells for use in the future. Over 100 FDA-approved therapeutic
applications have used AT-MSCs in clinical trials for more than ten years. For
the majority of regenerative and personalized medicine applications, this
specific stem cell type may soon displace BM-MSC as the primary stem cell
source.

For many years, cord blood stem cells have been the subject of ongoing clinical
trials to treat a variety of conditions, including cerebral palsy, peripheral
vascular disease, and both malignant and non-malignant blood disorders. The
separation, characterization, and exploitation of MSC discovered in CT have just
lately been the focus of studies. In reality, after substantial in vitro cell
proliferation and though to a lesser extent than AT-MSC, CT stem cells are only
now entering clinical trials. The need for cell growth draws attention to one of
the main drawbacks of CT-MSC: limited cell yield upon isolation, necessitating
considerable (and costly) ex vivo multiplication prior to clinical usage. But
during the past ten years, AT-MSC has participated in more than 100 clinical
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trials and is a well-known company. Nearly every patient has access to AT-
MSCs, and it is simple to collect hundreds of millions of stem cells for use right
away in clinical settings. However, CB can also be utilized for stem cell
transplants to treat blood (malignant and genetic) and immunological problems,
although MSC often cannot. MSC (from whichever source) are likely the most
valuable stem cells for regenerative medicine applications. Orthopedic,
cardiovascular, and neurological applications of regenerative medicine are most
likely to be carried out, which means that MSC banking will be more significant
during a person's lifespan than other types of stem cell banking. However, stem
cells should generally be stored when still young and healthy because they
appear to perform poorly in these conditions when they are older or taken from
patients with long-term chronic and inflammatory disorders. Finally, the entire
stem cell banking (and use) process lacks a rational and transparent regulatory
framework people and the regenerative medicine industry as a whole at danger.
In order for this clinical endeavor to fulfill its potential and assist individuals
who have the largest and most urgent need, something urgently needs to be
done.
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