Scribd Logo
Upload

Welcome to Scribd!

  • 262 views

    Zileuton

    Uploaded by

    api-3797941
    Zileuton is an antasthmatic drug that selectively blocks leukotriene formation to inhibit inflammation, edema, mucus secretion and bronchoconstriction associated with asthma. It is indicated for the prophylaxis and long-term treatment of asthma in adults and children over 12 years old. Common side effects include headache, dizziness, nausea, diarrhea and elevated liver enzymes. It is contraindicated in pregnancy and hepatic impairment due to liver toxicity risks.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd

    Zileuton

    Uploaded by

    api-3797941
    262 views3 pages
    Zileuton is an antasthmatic drug that selectively blocks leukotriene formation to inhibit inflammation, edema, mucus secretion and bronchoconstriction associated with asthma. It is indicated for the prophylaxis and long-term treatment of asthma in adults and children over 12 years old. Common side effects include headache, dizziness, nausea, diarrhea and elevated liver enzymes. It is contraindicated in pregnancy and hepatic impairment due to liver toxicity risks.

    Original Title

    zileuton

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Zileuton is an antasthmatic drug that selectively blocks leukotriene formation to inhibit inflammation, edema, mucus secretion and bronchoconstriction associated with asthma. It is indicated for the prophylaxis and long-term treatment of asthma in adults and children over 12 years old. Common side effects include headache, dizziness, nausea, diarrhea and elevated liver enzymes. It is contraindicated in pregnancy and hepatic impairment due to liver toxicity risks.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    262 views3 pages

    Zileuton

    Uploaded by

    api-3797941
    Zileuton is an antasthmatic drug that selectively blocks leukotriene formation to inhibit inflammation, edema, mucus secretion and bronchoconstriction associated with asthma. It is indicated for the prophylaxis and long-term treatment of asthma in adults and children over 12 years old. Common side effects include headache, dizziness, nausea, diarrhea and elevated liver enzymes. It is contraindicated in pregnancy and hepatic impairment due to liver toxicity risks.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 3

    zileuton

    (zye loot' on)


    Zyflo

    Pregnancy Category C

    Drug classes
    Antasthmatic
    Leukotriene formation inhibitor

    Therapeutic actions
    Selectively and competitively blocks the receptor that inhibits leukotriene formation, thus
    blocking many of the signs and symptoms of asthma (neutrophil and eosinophil
    migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary
    permeability, and smooth muscle contraction). These actions contribute to inflammation,
    edema, mucus secretion and bronchoconstriction caused by cold air challenge in patients
    with asthma.

    Indications
    • Prophylaxis and long-term treatment of bronchial asthma in adults and children >
    12 yr

    Contraindications and cautions


    • Contraindicated with hypersensitivity to zileuton or any of its components; acute
    asthma attacks; status asthmaticus; pregnancy and lactation, severe hepatic
    impairment.
    • Use cautiously with hepatic impairment.

    Available forms
    Tablets—600 mg

    Dosages
    ADULTS AND PATIENTS > 12 YR
    600 mg PO qid for a total of 2,400 mg/day.
    PATIENTS WITH HEPATIC IMPAIRMENT
    Use caution, contraindicated if liver enzymes > 3 times normal.

    Pharmacokinetics
    Route Onset Peak
    Oral Rapid 1.7 hr

    Metabolism: Hepatic; T1/2: 2.5 hr


    Distribution: Crosses placenta; enters breast milk
    Excretion: Metabolism

    Adverse effects
    • CNS: Headache, dizziness, myalgia
    • GI: Nausea, diarrhea, abdominal pain, vomiting, elevation of liver enzymes
    • Other: Generalized pain, fever, myalgia

    Interactions
    Drug-drug
    • Increased effects of propranolol, theophylline, warfarin; monitor patient and
    decrease dose as appropriate
    Drug-food
    • Bioavailability decreased markedly by the presence of food; administer at least 1
    hr before or 2 hr after meals

    Nursing considerations
    Assessment
    • History: Hypersensitivity to zileuton; impaired hepatic function; lactation;
    pregnancy; acute asthma or bronchospasm
    • Physical: T; orientation, reflexes; R, adventitious sounds; GI evaluation; liver
    function tests

    Interventions
    • Obtain baseline hepatic function tests before beginning therapy; monitor liver
    enzymes on a regular basis during therapy; discontinue drug and consult
    prescriber if enzymes rise more than three times normal.
    • Administer without regard to food.
    • Ensure that drug is taken continually for optimal effect.
    • Do not administer for acute asthma attack or acute bronchospasm.

    Teaching points
    • Take this drug regularly as prescribed; do not stop taking this drug during
    symptom-free periods; do not stop taking this drug without consulting your health
    care provider. Continue taking any other antasthmatics that have been prescribed
    for you.
    • Do not take this drug for an acute asthma attack or acute bronchospasm; this drug
    is not a bronchodilator; routine emergency procedures should be followed during
    acute attacks.
    • Avoid the use of over-the-counter drugs while you are using this medication;
    many of them contain products that can interfere with or cause serious side effects
    when used with this drug. If you feel that you need one of these products, consult
    your nurse or physician.
    • These side effects may occur: Dizziness (use caution when driving or performing
    activities that require alertness); nausea, vomiting (eat frequent small meals; take
    drug with food); headache (analgesics may be helpful).
    • Report fever, acute asthma attacks, flulike symptoms, lethargy, pruritus, changes
    in color of urine or stool.

    Adverse effects in Italic are most common; those in Bold are life-threatening.

    You might also like