H-046-008674-00-2.0 C3100&C3510 Service Manual

AUTO COAGULATION ANALYZER
SERVICE MANUAL
Beijing Precil Instrument Co., Ltd. 046-008674-00
 Description
Thanks for buying Auto Coagulation Analyzer.
Before servicing the equipment, please careful read and comprehend the content of this Service
Manual, so as to service the instrument correctly.
After reading this manual, keep it safely in an easily accessible place.
Product name: auto coagulation analyzer
Model: C3100 /C3510/C3200
Registered address: Room 203-204, 2F, Building 2,No.2 Tongji Middle Road,Beijing Economic &
Technological Development Area,Beijing,100176,China
Production address: Room 203-204, 2F, Building 2,No.2 Tongji Middle Road,Beijing Economic &
Technological Development Area,Beijing,100176,China
 Intellectual Property
This manual and the intellectual property of the product described in this manual are proprietary to
Beijing Precil Instrument Co., Ltd. (hereinafter referred to as ―Precil‖).
Copyrights @ Beijing Precil Instrument Co., Ltd.
No individual or organization is allowed to replicate, revise or translate any part of this manual
without prior written approval of Precil.
is the trademark, registered or otherwise, of Shenzhen Mindray Bio-medical Electronics
Co., Ltd. in China and other countries, which has been authorized Precil Instrument Co., Ltd. to use
under license.
 Declaration
Precil reserves the right to the final explanation of this manual.
Only under the following conditions, will Precil take responsibility for safety, reliability and
performance of the product:
Assembling, operation, expansion, recalibration, modification and repair are done by the personnel
approved by Precil.
The relevant electrical equipment conforms to the national standards.
Operation of the product proceeds in accordance with this manual.
 Maintenance Service
Free services:
Any product covered by the warranty service terms of Precil is accompanied with free services.
Paid services:
For any product not covered by the warranty service terms of Precil, Precil will charge a fee for its
service;
Even within the warranty period, service still requires a fee if the damage is caused by the following
factors: man-made damage; improper usage; power grid voltage exceeding the voltage specified for
the equipment; uncontrollable natural disaster; replacement with an accessory or consumable part
that is not approved by Precil or the equipment is serviced by the personnel not authorized by
Precil.
 Return Procedure
If you do need to return the product to Precil, please follow the procedure below:
1. Right of return: contact the after-sales service department of Precil and inform Precil of the
product serial number which is marked on the external shipping case. If the serial number is
not clearly discernable, return of the product will not be accepted. Please indicate the model
and serial number of the product and briefly explain the reason for return.
2. Freight: if the product is delivered to Precil for service, the freight (including the customs fees)
will be borne by the user.
After-sales Service Department

After-sales Service Department of Beijing Precil Instrument Co., Ltd
Room 203-204, 2F,Building 2,No.2 Tongji Middle Road,Beijing Economic & Technological
Development Area,Beijing,100176,China
Customer service hotline: 400-818-0609
Tel.: +86-10-62971818
Fax: +86-10-62974796 exit 25
Warning
■ If the hospital or organization responsible for using this instrument does not have a satisfactory
service/maintenance plan, anomalous failure of the instrument may occur and personal health may be
jeopardized.
■ Make sure this analyzer is used under the conditions specified in this manual. If the operation conditions are
breached, the analyzer may not operate correctly, the measurement result may be unauthentic and the
analyzer components and personal health may be harmed.
Attention
■ This analyzer can only be operated by trained examination specialists or trained doctor, nurse or laboratorian.
Revision History
Version Content of revision Person Time of revision
1.0 Service Manual Rev. 1 Wang Haoyu 2015.10.19
Revise service manual according to current instrument

2.0 Li Zhihong 2018.09.28
configuration, till online design change E-2018-008
Contents
CHAPTER 1 MANUAL OVERVIEW...................................................................................................................... 1
1.1 SCOPE OF APPLICATION ....................................................................................................................................... 1
1.2 MANUAL GUIDE .................................................................................................................................................. 1
1.3 COMMON OPERATIONS ........................................................................................................................................ 1
1.4 SYMBOLS ................................................................................................................................................................... 2
CHAPTER 2 PRODUCT SPECIFICATION ........................................................................................................... 5
2.1 INSTRUMENT NAME............................................................................................................................................. 5
2.2 OPERATION CONDITIONS ..................................................................................................................................... 5
2.3 TECHNICAL PARAMETERS ................................................................................................................................... 6
2.4 SAFETY CATEGORY ............................................................................................................................................ 9
CHAPTER 3 SOFTWARE SYSTEM ..................................................................................................................... 11
3.1 GENERAL .......................................................................................................................................................... 11
3.2 UPDATE OF HOST SOFTWARE ............................................................................................................................ 11
3.3 PC SOFTWARE INSTALLATION AND UPDATE ...................................................................................................... 13
3.4 SETTING OF CONNECTION BETWEEN PC AND HOST........................................................................................... 13
3.5 LIS COMMUNICATION SETTING ......................................................................................................................... 14
3.6 DEBUGGING ...................................................................................................................................................... 14
3.7 DEBUGGING SETTING ........................................................................................................................................ 17
3.8 MAINTENANCE ................................................................................................................................................. 18
3.9 SELF-TEST......................................................................................................................................................... 18
3.10 CALIBRATION ................................................................................................................................................... 20
CHAPTER 4 OPERATING PRINCIPLES ............................................................................................................ 22
4.1 DUAL BEAD MAGNETIC METHOD....................................................................................................................... 22
4.2 IMMUNO-TURBIDIMETRIC METHOD ................................................................................................................... 22
4.3 CHROMOGENIC SUBSTRATE METHOD ................................................................................................................ 23
CHAPTER 5 HYDRAULIC SYSTEM ................................................................................................................... 24
5.1 BLOOD CONSUMPTION ...................................................................................................................................... 24
5.2 INCUBATION AND MEASUREMENT TIME ............................................................................................................ 24
5.3 HYDRAULIC SYSTEM TEMPERATURE CONTROL ................................................................................................. 24
5.4 REAGENT CONSUMPTION .................................................................................................................................. 24
5.5 DESCRIPTION AND FUNCTIONS OF HYDRAULIC SYSTEM ELEMENTS ................................................................... 24
5.6 DETAILED DESCRIPTION OF HYDRAULIC SYSTEM .............................................................................................. 26
CHAPTER 6 HARDWARE SYSTEM.................................................................................................................... 29
6.1 GENERAL .......................................................................................................................................................... 29
6.2 MAIN CONTROL PANEL AND CPU CARRIER PLATE ............................................................................................ 29
6.3 HYDRAULIC SYSTEM DRIVE BOARD .................................................................................................................. 33
6.4 CUVETTE DRIVE BOARD .................................................................................................................................... 35
6.5 PROBE DRIVE BOARD ........................................................................................................................................ 38
6.6 TEMPERATURE CONTROL DRIVE BOARD............................................................................................................ 40
6.7 OPTICAL RECEIVER (SUITABLE FOR C3510/C3200 MODEL) .............................................................................. 44
6.8 OPTICAL RECEIVER (SUITABLE FOR C3100 MODEL) .......................................................................................... 46
6.9 OPTICAL TRANSMITTER (SUITABLE FOR C3510/C3200 MODEL) ....................................................................... 48
6.10 OPTICAL TRANSMITTER (SUITABLE FOR C3100 MODEL) ................................................................................... 49
6.11 PROBE PANEL.................................................................................................................................................... 50
6.12 CARD READER................................................................................................................................................... 52
6.13 BIG HEATER ...................................................................................................................................................... 53
6.14 INTERFACE BOARD ............................................................................................................................................ 54
6.15 SAMPLE STAND POSITION DETECTOR (ONLY SUITABLE FOR C3510).................................................................. 56
CHAPTER 7 MECHANICAL SYSTEM................................................................................................................ 57
7.1 C3510 INSTRUMENT COMPOSITION ................................................................................................................... 57
7.2 C3510 LAYOUT ................................................................................................................................................. 58
7.3 C3100 INSTRUMENT COMPOSITION ................................................................................................................... 61
7.4 C3100 LAYOUT ................................................................................................................................................. 62
I
CHAPTER 8 ASSEMBLY REPLACEMENT ....................................................................................................... 67

8.1 C3510 DOUBLE-PROBE TRAVEL ASSEMBLY....................................................................................................... 67
8.2 C3100 DOUBLE-PROBE TRAVEL ASSEMBLY....................................................................................................... 72
8.3 C3510 SAMPLE PROBE ASSEMBLY ..................................................................................................................... 77
8.4 C3100 SAMPLE PROBE MODULE ........................................................................................................................ 79
8.5 C3510 REAGENT PROBE ASSEMBLY .................................................................................................................. 81
8.6 C3100 REAGENT PROBE MODULE ...................................................................................................................... 84
8.7 C3510/C3200 TESTING BASE PARTS.................................................................................................................. 87
8.8 C3100 TESTING BASE PARTS ............................................................................................................................. 91
8.9 CUP HOLDER TRAVEL MECHANISM ................................................................................................................... 95
8.10 TAPE RELEASER ASSEMBLY .............................................................................................................................. 97
8.11 TAPE COLLECTOR ASSEMBLY ............................................................................................................................ 98
8.12 C3510/C3200 LEFT-SIDE PUMP STAND ASSEMBLY .......................................................................................... 100
8.13 C3100 LEFT-SIDE PUMP STAND ASSEMBLY DIAGRAM...................................................................................... 101
8.14 C3510/C3200 INJECTOR ASSEMBLY................................................................................................................ 101
8.15 PERISTALTIC PUMP ASSEMBLY ........................................................................................................................ 102
8.16 C3510/C3200 SOLENOID VALVE AND DIAPHRAGM PUMP ................................................................................ 103
8.17 C3510/C3200 BUS BAR ASSEMBLY................................................................................................................. 105
8.18 C3100 BUS BAR ASSEMBLY ............................................................................................................................. 106
8.19 C3510 REAGENT ASSEMBLY ........................................................................................................................... 107
8.20 C3510 EXPLODED VIEW FOR REAGENT ASSEMBLY .......................................................................................... 109
CHAPTER 9 FAULT CODES ................................................................................................................................111
9.1 INTRODUCTION ............................................................................................................................................... 111
9.2 LIST OF FAULTS............................................................................................................................................... 111
9.3 COMMON FAULTS AND THE SOLUTIONS .......................................................................................................... 116
CHAPTER 10 ACTIVE MAINTENANCE ............................................................................................................ 123
10.1 TOOLS AND CONSUMABLES ............................................................................................................................. 124
10.2 MAINTENANCE PLAN ...................................................................................................................................... 124
10.3 STATUS CHECKING .......................................................................................................................................... 130
10.4 REGULAR REPLACEMENT ................................................................................................................................ 130
CHAPTER 11 ATTACHED LISTS ........................................................................................................................ 131
11.1 FRU LIST ........................................................................................................................................................ 131
11.2 INFORMATION ON HYDRAULIC SYSTEM DIAGRAM ........................................................................................... 131
II
Chapter 1 Manual Overview
Attention
■ Please operate in strict accordance with the instructions in the Service Manual.
1.1 Scope of application

This Service Manual is intended for reading by the personnel with the following
capabilities:
Comprehensive knowledge of electric circuits and hydraulic systems;
Comprehensive knowledge of reagents;
Comprehensive knowledge of quality control;
Comprehensive knowledge of troubleshooting;
Proficiency in operating this analyzer;
Ability to use the basic mechanical tools and to understand the relevant terminology;
Ability to operate digital voltmeter and oscilloscope proficiently;
Ability to analyze electric circuit diagrams, hydraulic system diagrams and relevant
terminology.
1.2 Manual guide
This manual contains 11 chapters and appendixes and the hydraulic system diagram therein
can be used for reference during service.
1.3 Common operations
Description Action
Click Press XX gently with a finger or single click XX with left mouse button.
Move the cursor to ―XX‖ edit box and click it and then use the keyboard or
Input soft keyboard to input data (or use the connected barcode scanner to input
barcode data).
Single click left mouse button or use the [←] [→] [Home] [End] keys to move
the cursor to what needs to be deleted and then use the [Del] key to delete the
Delete character behind the cursor or use the [BackSpace] key (the [←] key at the top
right corner in the case of soft keyboard) to delete the character before the
cursor.
Click the arrow button at either end of the scroll bar; or move the cursor to the
scroll bar, keep the left mouse button pressed and then move the scroll bar
Drag scroll bar
up/down/left/right; or use a finger to gently touch the scroll bar on the screen
and move it up/down/left/right.
Click the downward arrow button of the ―XX‖ box to show the dropdown list;
Select an opinion in XX browse the current list (by dragging the scroll bar); then click a column in the
dropdown list current list to select it, or use the [↑] [↓] [PageUp] [PageDown] keys to browse
(only for a dropdown list) the current list and press the [Enter] key to select the column where the cursor
is placed.
1
1.4 Symbols
The symbols used in this manual
Symbols Meaning
This prompts the operator to operate as per the instructions below the
Warning
symbol, otherwise personal injury may be incurred.
This prompts the operator to as per the instructions below the symbol,
Caution otherwise product failure or damage may be incurred or the test result
may be inaccurate.
Attention symbol and emphasizes the information in operation or the information
that needs particular attention from the operator.
symbol, otherwise there is potential risk of biological infectivity.
The analyzer, reagent, quality control substances or calibrators may carry the following
symbols:
Symbols Meaning
Read the attached document
Biological pollution
Alert of high temperature
Protective grounding
Alternating current
Only for in vitro diagnosis

The device is fully conformance with the council
directive concerning in vitro diagnostic medical devices
98/79 EC.
Serial number
Manufacturing date
Manufacturer
On (power: connection to the mains)
Off (power: disconnection to the mains)
The following definition of the WEEE label applies to

EU member states only: the use of this symbol indicates
that this product should not be treated as household
waste. By ensuring that this product is disposed of
correctly, you will help prevent bringing potential
negative consequences to the environment and human
health. For more detailed information with regard to
returning and recycling this product, please consult the
distributor from whom you purchased the product.
2
Safety precautions: during service, please observe the following precautions, to ensure
safety of both the patient and the operator.
Warning
■ If the hospital or organization responsible for using this instrument does not have a satisfactory
service/maintenance plan, anomalous failure of the instrument may occur and personal health may be
jeopardized.
■ In the vicinity of this product, use of combustible gas (e.g. anesthetic) or combustible liquid (ethanol) is
prohibited, for such substances present risk of explosion.
■ To solve a fault, the power supply must be severed. If you service the equipment while it is powered, you
risk electric shock and electric component damage.
■ Please connect the equipment to a socket that has separate fuse and protection switch. If the equipment fails
or generates overcurrent or instantaneous surge current occurs upon startup while another equipment (e.g. life
support equipment) uses the same fuse and protection switch, tripping may be incurred.
■ The service personnel must keep their clothes, hair and hands an enough distance from the sampling probe,
catcher and other moving parts, to protect themselves from being squeezed or stung by the moving parts
during service.
■ The parts carrying alarm signs will have mechanical action and may squeeze or sting human body during
operation, disassembly or service.
■ The operator is obligatory to observe the local and national regulations on discharge and disposal of outdated
reagent, liquid waste, waste samples and consumables.
■ Reagents may irrigate eyes, skin and mucosa. An operator in contact with reagents in a laboratory shall
observe the safety rules of the laboratory and wear personal protection equipment (e.g. laboratory coat and
gloves).
■ If the skin contacts a reagent, rinse the skin with water and, if necessary, seek medical attention; if a reagent
gets in eyes, rinse the eyes with water and seek medical attention.
■ Check the equipment state after repair. Make sure the equipment is safe before offering it to users.
3
Caution
■ Improper service may damage the analyzer. The service personnel must follow the instructions in the Service
Manual and perform adequate checking after service.
■ If any issue not specified in the Service Manual is encountered, please contact the after-sales service
department of Precil, so that the experts of Precil will offer suggestions.
■ During service on the electronic elements of the equipment, please remove your metal accessories, so avoid
injury to the service personnel or damage to the equipment.
■ Electrostatic discharge may damage the electronic elements. If electrostatic damage may occur during
service, please wear antistatic wristband or perform service on an antistatic work bench.
Attention
■ This instrument can be only used by medical examination specialist or trained doctor, nurse or laboratorian.
■ Samples, quality control substances, calibrators and liquid wastes have potential biological infectivity. The
service personnel in contact with such materials in a laboratory shall observe the safety rules of the
laboratory and wear personal protection equipment (e.g. laboratory coat and gloves).
■ All the components and surfaces of the analyzer have potential biological infectivity, thus safety measures
must be taken during operation and service.
■ The sampling probe is very sharp and it may carry blood sample, quality control substance, calibrator that
have potential biological infectivity, thus contact with the probe must be avoided.
4
Chapter 2 Product Specification

2.1 Instrument name
Name: Auto Coagulation Analyzer
Model: C3100/C3510/C3200
2.2 Operation conditions
2.2.1 Environmental requirements
Table 2-1 Operation environment for the instrument
Normal operation environment Storage environment
Ambient temperature 10℃~30℃ -20℃~55℃
Relative humidity No more than 70% 15%~85%
Atmospheric pressure 86kPa~106kPa 50kPa~106kPa
2.2.2 PC configuration
To ensure proper operation of the instrument, the computer controlling the instrument must
have a legitimate operating system installed, said system being Windows7 or above.
Recommended configuration of the computer:
Table 2-2 Computer configuration
Operating system Windows 7 or above
Version 32-bit/64-Bit
Processor At least Intel ® Core TMi3 processor
RAM No less than 4 GB
Hard disk space No less than 500 GB
CD drive CD-ROM or DVD-ROM drive
RS232 interface /
Ethernet network card 2
2.2.3 Power supply requirements
1. This instrument requires voltage:AC100-240V,frequency: 50Hz/60Hz,power: 200VA,
and a single-phase power supply circuit that has total load current no less than 5A.
2. If possible, the user should furnish the instrument with single-phase stabilized-voltage
power supply that has smoothing function, with 1kw power; if the budget allows, it is
recommended to use 1kw online uninterruptible power supply (UPS) instead of single
stabilized-voltage power supply.
3. After power-off, the surge occurring upon reconnection of power supply is very likely
to damage the instrument, thus install an AC contactor of more than 5A at the power
supply circuit at the front of the instrument to provide power-off protection for the
instrument. If only stabilized-voltage power supply is available, please do install the
AC contactor; for a user having uninterruptible power supply (UPS), we also
recommend AC contactor.
4. Please furnish the instrument with a separate ground wire of R<4Ω grounding
resistance; use multimeter AC voltage profile to measure the voltage difference
between the neutral line (N) and ground wire (G) of the power supply circuit. The
measurement method is shown in Figure 3. The voltage difference value must be
stable and less than 5V. Record the values as outlined in Table 2.
5
Figure 2-1 N-G voltage test method

If the test result indicates the voltage difference is more than 5V, this may be the
result of bad grounding or load imbalance of the three-phase supply in the building
where the laboratory is located. If it is difficult to adjust the three-phase power supply
load, it is necessary to install single-phase dry-type isolation transformer (1kw,
transformation ratio 1:1) and to connect separate ground wire and neutral line in
parallel at the output end of the isolation transformer. (According to the power supply
specification, it is not allowed to connect ground wire and neutral line in parallel
without routing them through the isolation transformer, for such connection type may
incur severe power supply accident)
5. The instrument is directly connected to the stabilized-voltage power supply, thus
please prepare a 10A high-quality multifunctional supply terminal block (at least four
international standard outlets) to connect the computer system and printer.
The power supply connection sequence of the abovementioned devices:
Mains input—air switch (no leakage protection)—stabilized-voltage power
supply/uninterruptible power supply (UPS)—AC contactor—isolation transformer
(installed if the N-G voltage test result is unacceptable)—auto coagulation
analyzer—computer system.
Table 2-3 Neutral line (N) and ground wire (G) voltage test record
Voltage (AC V) 9:00AM 13:00PM 16:00PM
Day 1
Day 2
Day 3
2.3 Technical Parameters

2.3.1 Basic parameters
 Bare weight: 62Kg(C3100); 58Kg(C3510); 60Kg(C3200).
 Analyzer dimension (L×W×H): 583mm×691mm×589mm(C3100);
618mm×692mm×605mm(C3510,C3200).
6
 Detection channel and wavelength: 4 detection channels for dual bead magnetic method;
several detection channels for Immuno-turbidimetric method(ie. 2 channels for C3100,4
channels for C3200, 5 channels for C3510), the wavelength of each channel is 400 - 820nm.
1 detection channels for Chromogenic Assay Method, the wavelength of each channel is
400 - 410nm(suitable for C3510,C3200).
2.3.2 Normal operating conditions
 Power requirements: rated voltage: AC100V-240V, frequency: 50Hz/60Hz;
 Ambient temperature: +10℃～+30℃;
 Relative humidity: ≤ 70%;
 Atmospheric pressure: 86kPa～106kPa;
 It shall not be used in the place with possible wave interference, dust and acid volatile gas;
 Avoid direct radiation from strong light.
 Sound level: ＜80dBA
2.3.3 Preheat time
Startup preheat time, i.e., the time from startup to the displayed temperature of the detection
part and the sample incubation position reaches 37℃±1.0℃ shall be less than 30 minutes.
2.3.4 Temperature control
 The temperature of the detection part and the sample incubation position shall be
controlled within 37.0℃±1.0℃.
 The temperature of the reagent cooling position shall be controlled at or under 16℃.
2.3.5 Test items and report units
 Test items: Including normal inspection and analysis items in coagulation and
anticoagulation, fibrinolytic and antifibrinolytic, as well as blood coagulation factor
categories clinically, like the determination of prothrombin time (PT), activated partial
thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-dimer, fibrinogen
degradation product (FDP), and antithrombin III (AT-III)(suitable for C3510,C3200).
 Report units: PT, APTT and TT: second (s), of which, International Normalized Ratio
(INR) also shall be reported for the determination result of PT; FIB: g/L or mg/d L;
D-Dimer: μg/L, ng/mL, mg/dL or μg/mL; FDP: μg/L, ng/mL, mg/dL or μg/mL; AT-III: %.
2.3.6 Channel consistency
For double-magnetic path magnetic bead, Immuno-turbidimetric method, and Chromogenic
Assay Method(only for C3510,C3200), the channel consistency shall be ≤ 5%.
2.3.7 Carryover rate
 Carryover rate of sample concentration: that of FIB for double-magnetic path magnetic
bead, D-Dimer in Immuno-Turbidimetric Assay Method and AT-III in Chromogenic Assay
Method methods shall be ≤ 10%.
 Carryover rate among reagents: dual bead magnetic method: that from FIB or TT to PT or
7
APTT shall be ≤10%. Immuno-TurbidimetricMethod: that from D-Dimer to FDP shall be

≤10%.
2.3.8 Test speed
The number tested within 1 hour for single item of D-Dimer and FDP in Immuno-turbidimetric
method shall be no less than 20.The number tested within 1 hour for single item of PT in dual
bead magnetic method shall be no less than 100.
2.3.9 Measurement repeatability
The measurement repeatability of the analyzer shall meet the requirements in Table 1.
Table 1 Requirements on the Measurement Repeatability of different Coagulation Test Items
CV
Item Name
Normal sample Abnormal sample
PT ≤3.0% ≤8.0%
APTT ≤4.0% ≤8.0%
FIB ≤8.0% ≤15.0%
TT ≤10.0% ≤15.0%
D-Dimer
≤10.0% ≤10.0%
(Immuno-Turbidimetric Method)
FDP
≤10.0% ≤10.0%
(Immuno-Turbidimetric Method)
AT-III
≤10.0% ≤15.0%
(Chromogenic Assay Method)
Note: Abnormal sample refers to the ones with the test results no less than twice of the
normal reference range of the device (excluding AT-III). The normal reference range of
AT-III is 80% - 120%, and the ones below 80% and over 120% are abnormal samples.
2.3.10 Measurement accuracy
 The relative bias of the coagulating property FIB measured is no more than ±10.0%.
 The relative bias of the fibrinolytic property D-Dimer and FDP as well as anticoagulation
property AT-III measured is no greater than ±10.0%.
2.3.11 Linearity
 FIB is measured for coagulating property. When FIB is within the linearity range of [0.7,
9.0] g/L, linear correlation coefficient is γ≥0.990.
 D-Dimer and FDP are measured for fibrinolytic property. When D-Dimer is within the
linearity range of [0.2, 20.0] μg/ml, and FDP is within the linearity range of [0.5, 80.0]
μg/ml, linear correlation coefficient is γ≥0.990.
 AT-III is measured for anticoagulation property. When AT-III is within the linearity range
of [5, 140] %, linear correlation coefficient is γ≥0.990. (suitable for C3510,C3200)
2.3.12 Continuous operating time

Continuous operating time shall be no less than 24h.
8
2.3.13 Basic functions

The analyzer has the following functions:
a) Power-on self-test, display function menu and enter the status ready for test;
b) The preheat time of the sample and the sample + reagent can be set within the range of 0s -
9,999s based on specific test items;
c) When the test item and reagent are selected, and the test is started, automatic sample
dispensing and automatic cleaning device, optical and double-magnetic path magnetic bead
detectors are able to complete sample dispensing, detection and cleaning automatically;
d) The built-in barcode scanner is able to scan the barcode information of the sample and the
reagent automatically; (suitable for C3510)
e) Reagent and consumables management device is able to receive the reagent and
consumables (the steel bead in the sample cuvette) quantity information in the ID card to
facilitate counting of the reagent consumed by the device and the consumables;
f) A test report can be generated after the test, and the test results can be printed as per the
format set by the user after connecting with the printer;
g) It can be connected with the computer for operation and data transmission.
2.3.14 Appearance
 The appearance shall be clean and free of defects such as scratch and burr.
 The graphs, symbols and words on the panel shall be correct, legible and uniform.
 Fasteners shall be reliably connected without looseness.
 Moving components shall be stable, free of jamming, sudden jumping and obvious lost
motion.
2.4 Safety Category

2.4.1 Electrical Safety
Level of transient overvoltage: Category II.
Rated pollution degree: 2
2.4.2 Electromagnetic Compatibility
Warning
a) This IVD medical equipment complies with the emission and immunity requirements described
in IEC 61326-1:2012 / EN 61326-1:2013 and IEC 61326-2-6:2012 / EN 61326-2-6:2013.
b) The intended use environments of this IVD medical equipment includes typical healthcare
environments (hospitals, clinics, doctor‘s offices), this equipment has been designed and tested to
CISPR 11 Class A. In a domestic environment it may cause radio interference, in which case, you
may need to take measures to mitigate the interference.
c) Advise that the electromagnetic environment should be evaluated prior to operation of the device.
d) Do not use this device in close proximity to sources of strong electromagnetic radiation (e.g.
unshielded intentional RF sources), as these can interfere with the proper operation.
9
Attention
▪ It is the manufacturer‘s responsibility to provide equipment electromagnetic

compatibility information to the customer or user.
▪ It is the user‘s responsibility to ensure that a compatible electromagnetic environment
for the equipment can be maintained in order that the device will perform as intended.
10
Chapter 3 Software System

3.1 General
This chapter is applicable to C3100, C3510 and C3200. The software includes host
software and PC operating software. The host software runs on the CPU module inside the
instrument, while the operating software runs on the Windows system. The host software
controls operation of the instrument and uploads the measurement results to the PC; the PC
software creates a list of experiment results and also fulfills experiment control, calibration,
quality control, medical record management and maintenance.
3.2 Update of host software
3.2.1 Preparation for update
1.Create an empty folder to contain the update files. For example, C:\Users\LY
\Desktop\update files.
2. Unzip the following technical files into the directory. The directory setting is shown in
Figure 3-1.
Figure 3-1 Unzipping path for technical files

3.2.2 Software interface
The interface of the online UpdateTool is shown in Figure 3-2.
11
Figure 3-2 Online update tool interface

Note: If the software is unable to run, you need to install dotNetFx40_FμLl_x86_x64.exe.
3.2.3 Operation procedure
1. Software Type can select C3510, C3100 or C3200.
2. Select―update‖ in ―Operation Type‖ drop-down list, besides user can select update
type with ―MergeUpdate‖ or ―Cover Update‖. Merge update will add to previous
configuration files, and cover update will replace previous configuration files; Select
―down‖ for log download, ―Downlog‖ for host log download, ―DownFolder‖ for
instrument working folders download.
3. Set File Path as the folder to contain the update files.
4. Initiate the instrument and coagulation analyzer control software and execute startup
sequence of the instrument (make sure the instrument is initiated properly).
5. Click the ―Start‖ button on the update tool interface to start update. Note: if it prompts
―Net Communicate Error!‖ when updating, first check the network setting. If it is still
abnormal, disable the local connection and then initiate the instrument.
6. Power supply shall not be disconnected during update, otherwise the board will be
irrecoverable.
7. If ―Update Successful, Restart the Instrument!‖ is prompted, restart the instrument.
Remark: difference between Merge update and Cover update:

 Both of merge update and cover update aim to upgrade instrument configuration files.
 Merge update aims to merge both of old version and new version configuration files when
upgrading. Cover update aims to use new version configuration to cover old version
configuration files.
12
 Merge update is pre-set of default upgrade option.

 When the configuration files were destroyed, or some configuration can‘t be replaced,
engineer should choose cover update. Cover update will conduct to data lose, i.e.
coordinate files lose, calibration parameter lose etc., maintenance engineer need to do
coordinate debugging again after complete cover update.
3.3 PC software installation and update

The operation procedure is shown in the operation manual.
3.4 Setting of Connection between PC and host
1. Step 1: access the network and sharing center
Use left mouse button to click the computer icon at the bottom right corner and then
click ―Open network and sharing center‖.
Figure 3-3 Access network and sharing center

2. Step 2: initiate network connection
Use left mouse button to click ―Change adapter setting‖
Figure 3-4 Interface for changing adapter setting

3. Step 3: select local connection
Use right mouse button to click ―Local Area Connection‖ and then select ―Properties‖
13
Figure 3-5 Set local connection

4. Select the IP address to be changed
Use left mouse button to double click ―Internet protocol version 4 (TCP/IPv4)‖
Figure 3-6 Interface for changing IP address

5. Set the IP add changed
Input the information for setting the network IP address and subnet mask.
Then click ―OK‖ to save the set network information.
3.5 LIS communication setting
The operation procedure is shown in the operation manual.
3.6 Debugging
Path: access ―Service‖→ ―Debug‖
14
Figure 3-7 Software basic parameters debugging interface

3.6.1 Probe coordinates
1. Double-probe parallel adjustment: power off the instrument, place the rinse tank
positioning tool at the rinse tank; move double probes to the rinse tank; adjust the
double probes to align the point to the positioning hole on the tool.
a) Rinse hole coordinates
i. Place the rinse tank positioning tool at the rinse tank.
ii. Click the ‗CAL‘ button relevant to the rinse hole.
iii. Command the X, Y, Z1 and Z2 motors to operate; move the sample probe to
the rinse hole to align the point to the hole on the tool; the coordinates of
point Z are consistent with that of hole bottom.
iv. Click ―Move in position‖ and the coordinates will be displayed in the
coordinate box.
Note: The probe point is movable and it may still keep moving down after
contacting the tool, thus the coordinates may be inaccurate. The correct
method to adjust Z coordinates: command Z motor to move down until the
probe point no longer moves. Then set the step range to be “1”. Command Z
motor to move up step by step until the probe moves up. Now the bottom is
at correct coordinates.
b) Tube holder (sample probe) coordinates
i. Place the tube holder positioning tool at the center of the A10 test
tube(suitable for C3510,C3200), or at the center of the A1 test tube(suitable
for C3100).
ii. Click the ‗CAL‘ button relevant to the tube holder (sample position).
iii. Command the X, Y and Z2 motors to operate; move the sample probe to the
center of the A10(C3510,C3200)/A1(C3100) test tube to align the point to
the positioning hole on the tool; the coordinates of point Z are consistent
with that of the tool plane.
iv. Click ―Move in position‖ and the coordinates will be displayed in the
coordinate box.
c) Preheating area coordinates
i. Place the preheating area positioning tool at the measuring hole No. 4.
ii. Click the ‗CAL‘ button relevant to the preheating area (reagent probe).
Command the X, Y and Z1 motors to operate; move the reagent probe to the
measuring hole No. 4 to align the point to the positioning hole on the tool;
the coordinates of point Z are consistent with that of the tool plane. Click
―Move in position‖ and the coordinates will be displayed in the coordinate
box.
iii. Click the ‗CAL‘ button relevant to the preheating area (sample probe).
Command the X, Y and Z2 motors to operate; move the sample probe to the
measuring hole No. 4 to align the point to the positioning hole on the tool;
the coordinates of point Z are consistent with that of the tool plane. Click
―Move in position‖ and the coordinates will be displayed in the coordinate
box.
15
3.6.2 Catcher coordinates

1. Click the ‗CAL‘ button relevant to dX. Command CX motor to operate and align the
cup feeder to the cup slot. Make sure the cup feeder positioning tool 1 can
successfully move into the cup feeder. The coordinates will be displayed in the
coordinate box. Click ―Enter‖ to confirm the parameters in the coordinate box.
2. Click the ‗CAL‘ button relevant the of X. Command CX motor to operate and align
the cup feeder to the preheating channel. Make sure the cup feeder positioning tool 2
can successfully move into the cup feeder and preheating channel. Click ―Move in
position‖ and the coordinates will be displayed in the coordinate box.
3. Install the catcher YZ positioning tool at the catcher.
4. Click the ‗CAL‘ button relevant to the Y and Z.
5. Command CY and CZ motors to operate. Move the catcher to the measuring hole No.
4 to align the tool the test channel and make sure the tool can successfully fit in. The
upper surface of the tool is level with the table top. Click ―Move in position‖ and the
coordinates will be displayed in the coordinate box.
3.6.3 Diluent position Z offset adjustment
Diluent:
a) Place an empty diluent vial at any diluent position.
b) Click the ‗CAL‘ button relevant to the diluent Z offset.
c) Command the motor to move the sample probe to the center of the empty diluent
vial until it reaches the vial bottom.
d) The probe will automatically reset and the coordinates will be automatically
calculated and will be displayed in the coordinate box relevant to ‗Diluent‘.
3.6.4 Sample tube Z offset adjustment
1. Short tube:
a) Place the short tube adapter and bullet centrifugal tube into the tube holder.
b) Click the ‗CAL‘ button relevant to the short tube Z offset.
a) Command the motor to move the sample probe to the center of the short tube
until it reaches the tube bottom.
b) The probe will automatically reset and the coordinates will be automatically
calculated and will be displayed in the coordinate box relevant to ‗Short tube‘.
2. Long tube:
a) Place the long tube into the tube holder and move it inside the instrument.
b) Click the ‗CAL‘ button relevant to the long tube Z offset.
c) Command the motor to move the sample probe to the center of the long tube
until it reaches the tube bottom.
d) The probe will automatically reset and the coordinates will be automatically
calculated and will be displayed in the coordinate box relevant to ‗Long tube‘.
3.6.5 Reagent tube Z offset adjustment
1. Make sure ―All‖ is selected in the drop-down box.
1. Place an empty reagent vial at position 1.
16
2. Click ‗CAL‘ button.

3. Command the motor to move the reagent probe to the center of the empty reagent vial
until it reaches the vial bottom.
2. The probe will automatically reset and the coordinates will be displayed in the
coordinate box relevant to Z1-Z24(C3510,C3200), the coordinates will be displayed
in the coordinate box relevant to Z1-Z10(C3100).
3.6.6 Coordinate compensation
1. Catcher: click the ‗Compens‘ button. Position the motor as prompted. The
compensation value will be displayed in the relevant coordinate box.
2. Sample feeder and preheating area: click the ‗Compens‘ button. Position the motor as
prompted. The compensation value will be displayed in the relevant coordinate box.
3. Sample feeder and sample area: click the ‗Compens‘ button. Position the motor as
prompted. The compensation value will be displayed in the relevant coordinate box.
3.6.7 Channel debugging by magnetic bead method
1. Air calibration test: single click ―Air calibration‖ and the instrument will
automatically execute calibration and record calibration data. This value shall be less
than 30.
2. Medium calibration test: add 150μL of clean water into the Cuvette (with steel ball).
Place the cup into the test channel and observe oscillation of the steel ball. Click
―Medium calibration‖ and the instrument will automatically execute calibration and
record the data. This value shall be greater than 100 and less than 1023 shall be ≥10
times of the air calibration value of the channel.
3.6.8 Optical channel setting
Click ―Auto CAL‖ to automatically calibrate the gain and luminous flux of the optical
channel.
3.7 Debugging setting
Path: access ―Service‖→ ―DebugSetup‖
Figure 3-8 Temperature control debugging interface
17
1. Probe: insert the thermometer into the preheating hole No. 1 in the preheating area to
measure the actual temperature. When the temperature stabilizes, input the actual
temperature at the temperature measurement point. Wait at least 5 minutes after the
alteration.
2. Cold batch: enter 16 at ―Temp. Target‖ and click ―Enter‖. Measure the actual
temperature with the thermometer. When the temperature stabilizes, input the actual
temperature at the temperature measurement point. Wait at least 5 minutes after the
alteration.
3. Reagent probe: click ―Rgt Prb Temp. Test‖. Place the empty cup as prompted and the
instrument will automatically discharge the liquid into the cup. Measure the
temperature of the liquid in the cup. When the temperature stabilizes, input the actual
temperature at the temperature measurement point. Wait at least 1 minute after the
alteration.
4. After the three values of ―Temp. Real‖ have been input, click to same them. Do not
click too early or click any more time, otherwise the temperature will be wrong.
5. Wait 5 minutes.
6. Repeat steps 1 to 3 and check whether the three temperature values are within target
temperature +/-0.5. If they are, exit the interface without saving them; if one of them
is not within the range, input all three measured temperature values and same them.
7. Repeat step 6 until all three temperature values are within target temperature +/-0.5.
3.8 Maintenance
Path: access ―Service‖→ ―Maintain‖
Figure 3-9Maintenance interface

Connect the cleanser bucket and waste fluid bucket. Click ―Pipe refill‖. Click ―Examine liq.
flow‖. Now the instrument tube has water flowing. The sample probe must be out of water
first and the water must flow smooth and straight.
3.9 Self-test
Path: access ―Service‖→ ―Self-test‖
18
Figure 3-10 Self-test interface

1. Motor positioning: click "Motor Pos.". The sample probe shall point to the positions
in the sample area and the diluent position, emergency position, probe washing
position, preheating position and test position; the reagent probe shall point to the
positions in the reagent area and the probe washing position, preheating position and
test position; the catcher shall point to the preheating position, test position and cup
channel.
2. Liquid level test: click ―Liq. Level Check‖ and use water to test the sensitivity. In 5
consecutive tests, the maximum offset of the step difference between the liquid levels
is less than 3. Both the sample probe and reagent probe must be tested.
Figure 3-11 Liquid level test

3. Catcher test: click ―Run self-test‖ and the catcher opens and closes once.
4. Solenoid valve test: click buttons 1~6 and open and close the valves individually.
Then you can hear the sound of the solenoid valve opening.
5. Tube seam test: click ―Pipe tightness‖. Observe the tube connections and make sure
19
they have no water leakage. Before tube seal test, make sure the tube has been
perfused and the tube is full of cleanser.
6. Cup holder test: click ―Start‖ to start catcher test. Place the cup into the cup channel.
The catcher grabs the Cuvette and places it in channel 1. Then the catcher grabs the
other cups and places them the relevant channels. During the test, make sure the
catcher grabs and places the cups smoothly with no jamming. Continue the test for 10
minutes.
7. Execute the time sequences: fill in ―Sequence No.‖, single click ―Run‖, instrument
executes corresponding time sequence action.
3.10 Calibration
Path: access ―Service‖→ ―Adjust‖
Figure 3-12 Calibration interface

The purpose of calibration is to ensure the values measured by the instrument are
consistent with our standard instrument, so that the various instruments at the client
perform with measurement consistency and the instruments can pass the external quality
assessment.
Recommended timing for value calibration at the client:
a) After the reagent is replaced with a new reagent or a reagent from a different
manufacturer;
b) When the quality control result exceeds the range of target value ±10%;
c) Before external quality assessment.
In the calibration interface, proceed with the following calibration procedure:
1. Check APTT, TT and TT and enter the target values corresponding to ―normal‖
and ―abnormal‖:
20
Figure 3-13 Calibration step 1

2. Place normal and abnormal quality control results in proper positions as
prompted:

3. Click ―Start‖. After the test, the result and calibration coefficient will be
displayed:

4. Click ―Save‖;
5. Put the calibration coefficient into the test record.
Note 1: The quality control sample must be used in 2 hours after redissolution
and the reagent must be from a vial opened in the day, otherwise the calibration
effect will be compromised.
Note 2: For TT, the discrimination between norm and abnormal quality control
samples is not significant and the software may display ―TT calibration
coefficient invalid‖. Now do nothing and just click ―Save‖.
Note 3: If the software displays ―APTT or PT calibration coefficient invalid‖,
that means the instrument has trouble and needs to be repaired.
21
Chapter 4 Operating Principles

The methodology supported by C3100/C3510/C3200 and the corresponding test items are shown in
Table 4–1.
Table 4-1 The methodology supported by the instrument models and the test items
Methodology Test item Supporting model
Dual bead magnetic
PT, TT, APTT, FIB C3100, C3510,C3200
method
Immuno-turbidimetric
DD, FDP C3100, C3510,C3200
method
Chromogenic
AT-III C3510,C3200
substrate method
4.1 Dual bead magnetic method

Auto coagulation analyzer operates with the Dual bead magnetic method. On both sides of
the Cuvette, there is one set of drive coil which generates constant alternating
electromagnetic field, to keep the specially made demagnetized steel ball oscillate with
equal amplitude. After addition of the coagulation activator, more fibrous protein is
generated and the viscosity of the blood plasma increases, so the oscillation amplitude of
the steel ball gradually decreases. The measuring coil on the other side detects the motion
change of the steel ball, thus the instrument can determine the coagulation time based on
the attenuation of the oscillation amplitude. The test principle is shown in Figure 4-1.
Advantage of Dual bead magnetic method:
■ Free from the effects of hemolysis, jaundice and hyperlipidemia
■ Preclude the background interference of turbid samples
Figure 4-1 schematic diagram of double magnetic circuit bead method
4.2 Immuno-turbidimetric method

In Immuno-turbidimetric method, we determine the concentration of the substance under
test based on the absorbancy change of the sample during the reaction. Light path in
straight line: the light ray from the light source is processed to become parallel rays. The
light ray goes through the sample and irradiates onto the photodiode where the light
changes into electrical signal and is magnified and processed at the monitor. The light path
is shown in Figure 4–2.
22
Transmission circuit
Sample
LED
Receiving
发
P
circuit
发
D
发
Figure 4-2 Light path diagram for Immuno-turbidimetric method

Take DD measurement as example to explain the reaction process of
Immuno-turbidimetric method: first add the diluted DD sample into the Cuvette and start
incubation. After incubation, move the Cuvette to the center of the test light path and add
the triggering reagent. The triggering reagent is the DD antibody containing latex particle.
The DD antibody and D dipolymer will have antibody-antigen reaction. As the reaction
progresses, the latex particles will concentrate in the sample, resulting in gradual decrease
of luminous flux of the solution. The DD concentration of the sample can be determined by
measuring the change rate of luminous flux.
4.3 Chromogenic substrate method
In chromogenic substrate method, we deduce the content and activity of the test sample by
measuring the absorbancy change of the chromogenic substrate. In the test channel, the
LED with central wavelength of 405nm is the light source. The detector and the light
source are aligned, with the light path basically the same as in the Immuno-turbidimetric
method.
The principle for coagulation analyzer to determine thrombus and hemostasis parameters
by using chromogenic substrate: we synthesize one amino acid sequence that is similar to
natural blood coagulation factors and that has small peptides at particular acting sites. We
can connect the hydrolysable chromogenic chemical gene to the amino acid at the acting
sites. As for the test, the coagulation factor has proteolytic enzyme activity. It has effects
on both natural protein chain and synthetic peptide chain substrate, thus releasing
chromogenic genes to color the solution. The color intensity is proportionate to the
coagulation factor activity, thus precise quantification can be done. Now there are dozens
of synthetic polypeptide substrates, while the mostly commonly used one is
paranitroaniline (PNA) which is in yellow and is detected by 405mm wave length.
During AT-III activity measurement, first add over dose of thrombin into the sample to
form 1:1 compound with the AT-III in the blood plasma. After a period of incubation, add
thrombin substrate S-2238 (H-D-Phe-Pip-Arg-PNA·2Hcl) into the reactant to release the
chromogenic group PNA. The chromogenic reaction intensity is positively correlated with
the volume of the remaining thrombin and is negatively correlated with the AT-III activity.
We use the optical system to observe change rate of 405nm light absorbancy by the
reactant, so as to deduce the activity of AT-III.
23
Chapter 5 Hydraulic System

5.1 Blood consumption
Table 5-1 Sample consumption
Items PT APTT TT FIB DD FDP AT-III
Sample volume μL 50 50 75 10 60 25 3
5.2 Incubation and measurement time

Table 5-2 Incubation and measurement time
Channel PT APTT TT FIB DD FDP AT-III
Incubation
180s 300s 180s 180s 150s 180s 180s
duration
5.3 Hydraulic system temperature control

Table 5-3 Hydraulic system temperature control
Items Reagent probe Incubation position Reagent position Model
Target temperature ℃ 37 37 16 C3510,C3200，C3100
5.4 Reagent consumption

Table 5-4 Reagent consumption
Buffer solution μL Hybrid reagent μL Triggering reagent μL
PT / / 100
APTT / 50 50
TT / / 75
FIB 90 / 50
DD 60 40 150
FDP 25 100 100
AT-Ⅲ 40 180 35
5.5 Description and functions of hydraulic system elements

This section briefly describes the elements and functions of the hydraulic system. The
symbols are indicated on the hydraulic system diagram.
Self-made valve
■ Symbols:
Two-way self-made valve Three-way self-made valve
24
■ Appearances:
Two-way self-made valve Three-way self-made valve
■ Functions:
Two-way valve: connect and disconnect the circuit. If the solenoid valve is not
powered, the tubes at the inlet and outlet are disconnected; if the solenoid is powered,
both the input and output ends are connected.
Three-way valve: switch between circuits. If the solenoid valve is not powered, the
common end and normally open end are connected; if the solenoid valve is powered,
the common end and normally closed end are connected.
■ Note: The operating pressure of the self-made valve is DC 12V and its maximum
permissible pressure 200KPa. Its internal operating component is electromagnet and it
is reset by spring, thus it should not be powered for too long. If the solenoid valve is
powered, the ejector pin goes down; if the valve is not powered, the ejector pin resets.
If you touch the ejector pin with your hand, you can feel its position to determine
whether the solenoid is operating.
SMC valve
■ Symbols
Same as two-way self-made valve
■ Appearance
■ Function: it is same as two-way self-made valve. Compared with two-way self-made

valve, this valve is able to withstand a greater temperature change.
■ Note: Attention shall be paid to differentiate them when replacing them.
Injector
■ Symbol:
25
■ Appearance: none.
■ Function: 500ul/1ml injector is mostly used to absorb and release samples and reagent
and to wash things.
■ Precautions:
Probes
■ Symbols:
■ Appearance:
Figure 5-1 Probes for coagulation analyzer

■ Function: sample probe is used to absorb samples and add samples into Cuvettes;
reagent probe is used to absorb reagent from reagent position, add reagent into reaction
cups and heat reagent.
■ Note: Sample needs and reagent probes need to be regular rinsed and unchoked.
■ Remark: After-sales old probes instrument please refer to Service Manual 2.0.
5.6 Detailed description of hydraulic system
The difference between C3100 and C3510/C3200 hydraulic systems mainly lies in the
cleaning module and waste liquid discharge module. C3100 is washed by injection pump
and double probes, while C3510 is washed by diaphragm pump.
5.6.1 C3100 hydraulic system
C3100 hydraulic system diagram is shown below:
26
C5
Bus bar
SV2
C6
T4
SV3
C7
T5
C9 C8
C11 C10
C13 C12
SV1
C2 C3 C4
C1 T7-P2 T6-P1
T2 T3
C22
T1
SR1
C15 C14
Cleaning
fluid SPB RPB
bucket
T10 WC1
发 5L发 Rinse
tank
M
C19 C16 C17

C20 LP1 C18
C21
T11 T9
T8
T12
Waste
fluid
bottle
Figure 5-2 C3100 hydraulic system diagram

Operating process of the instrument:
Sample absorption:
1. Sample probe absorbs sample: switch SV1 to double probes, open SV3 and pull down
injection pump for certain distance.
2. Reagent probe absorbs sample: switch SV1 to double probes, open SV2 and pull
down injection pump for certain distance.
Fluid release:
1. Sample probe releases fluid: switch SV1 to double probes, open SV3 and pull up
2. Reagent probe releases fluid: switch SV1 to double probes, open SV2 and pull up
Rinsing: switch SV1 to cleanser, pull down injection pump for certain distance, switch
SV1 to double probes, open SV2/SV3 and injection pump move up for certain distance.
Injection pump can‘t absorb cleaner once to clean both of sample probe and reagent probe
simultaneously.
5.6.2 C3510/C3200 hydraulic system

C3510/C3200 hydraulic system diagram is shown below:
27
Busbar
SV3
SV1 C9 C15
C6 C7 C11 C13
LP1 T8 T10 T12
C2 C3 T7
C1
T2 T3 T5 T6
C4 C5
T4
C25
SR
T1
T23 Injector C16
C8 SV2 C10
C12 C14
T9 T11 T13
C18 C17
SV5
Sample Reagent
needle SPB RPB needle
发发发 WC
发 5L发 rinse
tank
T22 C20 C22 C19 C21
T20 T14
T15
M SV4
T16
C29 C28 C27 LP2
C26
T24 T21 T17
T19 T18
C24
T25 C23
发发发
发 5L发
Figure 5-3 C3510/C3200 hydraulic system diagram

Operating process of the instrument:
Sample absorption:
1. Sample probe absorbs sample: close SV3, open SV2 and pull down injection pump for
certain distance.
2. Reagent probe absorbs sample: close SV3, open SV1 and pull down injection pump
for certain distance.
Fluid release
1. Sample probe releases fluid: close SV3, open SV2 and pull up injection pump for
certain distance.
2. Reagent probe releases fluid: close SV3, open SV1 and pull up injection pump for
certain distance.
Rinsing: open SV3 and SV1/SV2, start diaphragm pump LP1, extend cleaning duration,
close LP1, close SV3 and SV1/SV2, keep SV5 open for an extended duration and then
close SV5.
28
Chapter 6 Hardware System

6.1 General
The hardware logic system embodies the functions and external interfaces of the hardware
system and, based on the internal logical relationship, it consists of several components:
data, user interaction, control flow, power supply system, structure and interconnection.
scanner
Internet port adapter board
Z-direction motor
Main control board for reagent probe
Z-direction motor
for sample probe
Probe drive
Reset sensor for Z-direction
CPU motor of reagent probe
24V power
Module board Reset sensor for Z-direction
motor of sample probe
supply board
Power Heating wire of reagent
probe
switch
12V power Temperature small plate
Other
connection line
Whole unit supply board of reagent probe
grounding
CAN bus
Power supply Liquid level detection Anticollision sensor of
bus sample probe
board of sample probe
Anticollision sensor of
Cuvette exist detection
reagent probe
sensor
Liquid level signal of
Catcher electomagnet Liquid level detection sample probe
board of reagent probe Liquid level signal of
CZ motor reset sensor
reagent probe
SV4
Cuvette drive
CY motor reset sensor
RFID board
Cuvette intake motor
reset sensor
board Indicator LED
CY motor X-direction
motor of probe
Cuvette tray
motor Syringe motor
Cuvette
intake motor Y-direction
CZ motor motor of probe
Peristaltic
Optical receiving board pump motor
Reset sensor for Y-
Reagent position TEC direction motor of probe
Optical emission board Reset sensor for X-
Reagent position TEC direction motor of probe
Reset sensor for syringe
Reagent position fan
Fluid circuit
motor
Test Test Test Test
Reagent position fan Cleanser floater
strip strip strip strip
drive board
Temperature
Power supply board fan Waste fluid floater
Magnetic bead board Micro-switch for opening

Air duct fan
Mixing
control drive cover
motor board Temperature small plate of SV1

Mixing reagent position
motor SV2
Mixing Rack in place detection
motor board
SV3
Mixing
motor Three-way valve
Mixing
motor
Heating plate Waste liquid pump
Figure 6-1 Logic block diagram of hardware
6.2 Main control panel and CPU carrier plate

6.2.1 General
The main control panel and CPU carrier plate execute the time sequences, control the drive
boards, receive and process the data from the sensors, monitor the operating status of the
instrument and communicate with the PC.
29
Probe drive board

J4 J3
Power CA
supply N
J17 J2
CPU
module
Fluid circuit drive

Network
CA cable
Interface
N
J3
board
board J4 J1 J18
J5 Power J10Main control panel J11 Serial
J2
supply port line
J9 J13 Scanner
Power
supply
24V power
supply board
Figure 6-2 Main control panel and CPU module function diagram
6.2.2 Function
In terms of circuit and signal features, main control panel and CPU carrier plate consist of
3 modules: power module, digital circuit module and interface module.
6.2.3 Functions of power module
Input 24V, one circuit to probe drive board and one circuit to the other drive boards.
24V converted to 5V, to power hydraulic system drive board, probe drive board and
temperature controller.
24V converted to 5V, 5V converted to 3.3V, to power CPU carrier plate; 5V by CAN
connecting line to power probe panel, optical receiver, card reader and probe drive board.
6.2.4 Digital circuit module
CPU module interface: connect the CPU carrier plate. The CPU module is the core of the
digital system and is used for time sequence scheduling, data processing and hardware
system control.
SD card interface module: upload programs to CPU module and store data.
6.2.5 Structure diagram
The structure diagram for main control and CPU carrier plate PCBA is shown below:
30
Figure 6-3 Structure diagram for main control and CPU carrier plate PCBA(C3100)
Figure 6-4 Structure diagram for main control and CPU carrier plate PCBA(C3510,C3200)
31
6.2.6 Interface
Table 6-1 Definition of main control panel interface
Socket tag
Interface function
No.
2 CAN interfaces are equivalent and
J1, J2 CAN interface
interchangeable.
Connect with status indicate board(buzzer,LED,
J8 Status indicate board
only C3200)
J9 24V power input From power panel
To probe drive board and hydraulic system
J17, J10 24V and 5V output
drive board
Test tube barcode scanner interface in host
J13 Scanner interface
(only C3510)
J11 Serial port interface
J18 Communication interface between host and PC
6.2.7 Indicator lamp and test point
The functions of the indicator lamp are shown in Table 6–2.
Table 6-2 Indicator lamp on main control panel
Indicator
Function
lamp
D12 5V power supply indicator lamp. Normal state: lit
D14 5V power supply indicator lamp. Normal state: lit
D1 CPU status indicator lamp. Normal state: lit
D5 Network connection indicator lamp, lit if network connected
D6 Network connection indicator lamp, lit if no network connected
The test points on the board are shown in Table 6-3.
Table 6-3 Test points on main control panel
Test
Silk-screen marker Function description Remarks
point
TP1 TP1 3.3V power supply test point 3.3V
TP2 TP2 24V test point 24V
TP5 TP5 Digital grounding
6.2.8 Fault diagnosis and handling
The table below lists the common faults of the main control and CPU carrier plate and the
solutions to the faults, so that you may determine whether a fault of the whole instrument is
caused at a board or not. These solutions are only intended for the hardware and do not
cover hydraulic system, optics, reagent or software, for these issues are elaborated in the
relevant sections of this manual.
Before checking the fault of the main control and CPU carrier plate, check the
following:
1. If the fault is related to the power supply, check the output of the power panel;
2. Check whether the wires connected to the main control are loose, whether the
tag number matches the socket tag number on the main control panel, whether
the connection is secure and whether there is any breakage or rupture;
3. Check whether the board power supply input is correct and whether the
indicator lamp on the main control panel is in proper condition.
32
4. Restart the instrument to see if the fault is eliminated.

If the connections, input power supply and indicator lamp are all proper but the fault
remains after restart, analyze the fault as per the instructions in this table.
Warning
■ Wear antistatic gloves when inserting or pulling a board and graph the edge of the board.
■ When the probe of the multimeter or any other measuring instrument touches a test object, avoid touching
the adjacent component or electric wire, to protect the board from short circuit.
Table 6-4 Faults of main control and CPU carrier plate and the solutions
S/N Fault Cause Fault diagnosis
Link failed, It counts as the fault of the main control panel under the
fault still following conditions:
remains after Failure of circuit  First check whether the communication line is normal
1
restart of the or wire  D1 indicator lamp unlit
instrument and  24V normal, but D5 or D6 lamp unlit
software Failure of main control panel or SD card
6.3 Hydraulic system drive board

6.3.1 General
The hydraulic system drive board controls the X and Y motors, injectors, liquid waste
pump, sensor and solenoid valve.
liquid waste pump
Floater and limit
valve
Panel indicator
motor
switch
Solenoid
valve2
Injector
optocoupl
motor
Solenoid
1
X motor
Y motor
er
J8 J9J10 J13J11J14J16J17J15
CPU
module
Test
cup CA CA
N N
drive J3 Fluid circuit drive board J4
boar Main
Power J6 J5 Power
d supply
control
supply
panel
J24 J24
J25
Temperatur
e control
panel
Figure 6-5 Hydraulic system drive board function diagram
33
6.3.2 Structure
PCBA structure diagram is shown below:
Figure 6-6 Structure diagram for hydraulic system drive board PCBA
6.3.3 Interface
Table 6-5 Interfaces of hydraulic system drive board
Socket tag
Interface function
No.
J8 X motor
J9 Y motor
J10 Injector motor
J11 Liquid waste pump motor
J5 24V and 5V input From main control panel
J6 24V and 5V output To Cuvette drive board
J24 12V input Only C3510,C3200
Pin1~4:X sensor, Pin5~8:Y sensor, Pin9~12:
J13 Sensor connector
injection pump sensor
J14 Floater and limit switch connector Pin5-8: level indicator, Pin1-4: limit switch
J15 Sample position LED control Only C3100
J16 Solenoid valve interface 1
J17 Solenoid valve interface 2 Only C3510,C3200
J1 MCU debugging interface
J3 CAN interface 1
J4 CAN interface 2
interchangeable.
J23 CAN interface 3
J2 Environment temperature sensor interface C3200
34
6.3.4 Indicator lamp

Table 6-6 Indicator lamp for hydraulic system drive board
Indicator
Definition Function Identification
lamp
Normally, this LED lamp is lit. If it is unlit, the
Digital 5V power supply 5V power supply has trouble and the main
D7 VCC
indicator lamp elements on the drive control panel will not
work.
24V power supply indicator
D6 24V power supply has trouble and the motor
lamp
will not work.
Digital 3.3V power supply 3.3V power supply has trouble; if D6 lamp is lit
D9
indicator lamp while this lamp is unlit, the power supply chip is
damaged.
Normally, this LED lamp flickers. If the D9
D1 MCU indicator lamp lamp is lit while this lamp does not flicker
singlechip microcomputer has trouble.
Table 6-7 Faults of hydraulic system drive board and the solutions
S/N Fault Checking
A Opaque material can make the sensor switch between ―blocked‖ and
―unblocked‖ states. Check whether the sensor switches between
different electric levels (high level near 5V and low level near 0V). If it
does, the sensor and its connecting wire are both normal. If the sensor
shows no change when it is blocked or unblocked, it is possible that the
sensor surface has foreign matter, the sensor is damaged or its
connecting wire is broken. Remove the sensor, scrub its surface with
Fault of moving
clean tissue or cloth and then check whether the sensor shows change
1 mechanism (e.g. motor
when it is blocked. If it does not, replace the sensor. If the problem
and sensor)
remains after the sensor is replaced, replace the connecting wire of the
sensor.
B If the cause is not item 1, position the motor and observe the motion of
the motor. If the motor works, check whether the sensor is blocked by
the blocking piece when the motor works. If the motor does not work,
check whether the connecting wire of the motor is securely connected. If
connection is correct, the time sequence may be wrong.
Waste fluid bucket,
A Check whether the sensor connecting wire is loose;
cleanser bucket, glass
B Check whether the connectors for waste fluid bucket and cleanser
shield limit switch and
2 floater are securely connected;
door limit switch have
C Check whether the floater sensor moves up and down smoothly, for
false alarm or no
incorrect installation may disable the floater from moving.
alarm
6.4 Cuvette drive board

6.4.1 General
The Cuvette drive board controls CX, CY, CZ, Cuvette tray, relevant sensor and
electromagnet.
35
CA
Indicator D1 N
Card reader J23
lamp
CX motor J8
CY motor J9 CA Fluid
J11 N circuit
Test cup tray motor Test cup drive board J4
drive
CZ motor J10 J5 Power board
Optocoupler J13 supply
Electromagnet
J18 J6 J3
Reflective optocoupler
Power CA
supply N
Temperature control
panel
Figure 6-7 Cuvette drive board function diagram

6.4.2 Structure
Figure 6-8 Structure diagram for Cuvette drive board PCBA
36
6.4.3 Interface
Definitions of interfaces of Cuvette drive board
Table 6-8 Definitions of interfaces of Cuvette drive board
Socket tag
Interface function
No.
J8 CX motor
J9 CY motor
J10 CZ motor
J11 Cuvette tray motor
J5 24V and 5V input From hydraulic system drive board
J6 24V and 5V output To temperature controller
J24 12V input Only C3510
Pin1~4: CX sensor, Pin5~8: CY sensor,
J13 Sensor connector
Pin9~12: CZ sensor
J17 Solenoid valve interface Only C3510,C3200
J3 CAN interface 1
J4 CAN interface 2
interchangeable.
J23 CAN interface 3
J2 UART debugging interface
Table 6-9 Indicator lamps for Cuvette drive board
Indicator
lamp
Digital 5V power supply 5V power supply has trouble and the main
D7 VCC
indicator lamp elements on the drive control panel will not
work.
lamp
will not work.
D9
damaged.
Table 6-10 Faults of Cuvette drive board and the solutions
S/N Fault Checking
Fault of moving
and sensor)
sensor.
37
S/N Fault Checking

Waste fluid bucket,
false alarm or no
alarm
6.5 Probe drive board

6.5.1 General
The Cuvette drive board controls sample probe, reagent probe motor, reagent probe heating
and level gauge interface
Reagent needle
Reagent needle
Sample needle
Sample needle
optocoupler
optocoupler
motor
motor
Liquid level
J5 J6 J8 J10
J7 detector
J16
J9 Liquid level
Probe drive board J15 detector
Reagent needle
J14 heating
J4 J3
Power CA
Temperature
supply N plate
J17 J2
CPU module
Main control panel
Figure 6-9 Probe drive board function diagram
38
6.5.2 Structure
Figure 6-10 Structure diagram for probe drive board PCBA

6.5.3 Interface
Table 6-11 Interfaces of probe drive board
Socket tag
Interface function
No.
J5 Sample probe motor
J6 Reagent probe motor
J7 Sample probe sensor
J8 Reagent probe sensor
J9 Sample probe level gauge interface
J10 Reagent probe level gauge interface
J14 Reagent probe heating and temperature testing
J3 CAN interface
J15 Sample probe level gauge UART interface
J16 Reagent probe level gauge UART interface
J4 24V input
Table 6-12 Indicator lamp for probe drive board
Indicator
lamp
39
Indicator
lamp
Digital 12V power supply
D8 12V power supply has trouble and the level VCC
indicator lamp
gauge will not work.
lamp
will not work.
D9
damaged.
Table 6-13 Faults of probe drive board and the solutions
S/N Fault Checking
Fault of moving
and sensor)
sensor.
Waste fluid bucket,
false alarm or no
alarm
A Check whether the connecting wire is loose;
Reagent probe
B Check whether the pin 1 of J14 is 3.3V
temperature jumps
C Check whether the pin 4 of J14 is 24V
3 violently or very
D Restart the instrument and software to see if the temperature is normal
different from the
If the abovementioned problems are ruled out, the drive board may have
desired value
trouble
6.6 Temperature control drive board

6.6.1 General
The temperature control drive board controls the mixing motor rotation, preheating area
heating, cooling area cooling and test tube stand testing
40
Probe Optical Tube Serial

Fan 2 Fan 1
board board stand port
test debug
board ging
J9 J17 J24 J22 J16 J3

CETO RAC
CAN
GUANG FAN FAN UART
interface for U K 2 J1 Peltier
J 2
CA
other boards XUE 9 1
TEC TEC
N
5
1
CAN
J J2 Peltier
CA
interface for
N
2
other boards 4 1 2
Cooling
Temperature controller
12V input
TEM
area J2 12V
P2
temperatu J2 J2
output
0 power
12V
re 5 3
detection input
Power
input
HEA
24V and J1
6
T
5V input
8
M1 M2 M3 M4 M5
J11 J12 J13 J14 J15
12V output to
test cup drive
Mixing board and fluid
Mixing Mixing Mixing Mixing circuit drive
motor board
motor 1 motor 3 motor 4 motor 5
2
Figure 6-11 Temperature controller function diagram

6.6.2 Structure
41
Figure 6-12 Temperature controller PCBA structure diagram

6.6.3 Interface
Table 6-14 Interfaces of temperature control drive board
Socket tag
Interface function
No.
J11-J15 Mixing motor
J18 Preheating area heating and temperature testing
J23 12V power input
J25 12V power output
J19 Cooling area interface
J21 Cooling area interface Only C3510,C3200
J16 Cold batch fan interface
J22 Power supply and air duct fan interface Only C3510,C3200
J24 Test tube stand testing interface
J17 Optical receiver power supply interface
J9 Probe panel power supply interface
J4, J5 CAN communication interface
J20 Cooling area temperature testing interface
J6 24V input
42

Table 6-15 Indicator lamp for temperature control drive board
Indicator
lamp
Digital 12V power supply 12V has trouble and the cooling system and fan
D7
indicator lamp will not work and the probe panel optical power
supply has trouble
lamp
will not work.
D26
damaged.
Table 6-16 Faults of temperature control drive board and the solutions
S/N Fault Checking
A If one mixing motor does not rotate, you need to check whether the 24V
power supply is normal and whether the motor connecting wire is
securely connected. If connection is sound, the mixing motor connecting
wire may be wrong. Now switch the multimeter to the conductivity
measurement mode. First check whether the pin 1 and pin 2 of motor
1 Mixing motor failure
connecting wire interface are conductive and then whether the pin 3 and
pin 4 are conductive. If any one of them is nonconductive, the coil
connection is wrong. Motors 1 and 2 use one coil and motors 3 and 4
use one coil, there should be conductivity between pins 1 and 2 and
between pins 3 and 4.
A Check whether 12V power supply is normal;
Cooling area is not B Check whether the cooling area connection is reversed, for reverse
2
cooling connection will make it heating;
C Check whether the temperature in the cooling area is correct.
Preheating area
B Check whether the pin 1 of J18 is 3.3V
temperature jumps
C Check whether the pin 4 of J18 is 24V
3 violently or very
D Restart the instrument and software to see if the temperature is normal
different from the
If the abovementioned problems are ruled out, the drive board may have
desired value
trouble
B Replace the test tube stand detector and check whether test tube stand
Test tube stand testing
4 testing is normal
error
C If the abovementioned problems are ruled out, the drive board may have
trouble
43
6.7 Optical receiver (suitable for C3510/C3200 model)

6.7.1 General
The optical receiver controls flickering of LED and uploading of received brightness AD
values
Optical receiver
Serial port
debuggin
J3
g
J4 J5 J1
CAN Temperatur
Optical
interfac e control
panel transmitter
e
Figure 6-13 C3510 optical receiver function diagram
Optical receiver
J2 JTAG
J4 J5 J1
CAN Temperature Optical

interface control panel transmitter
44
6.7.2 Structure
Figure 6-15 C3510 optical receiver PCBA structure diagram
45
6.7.3 Interface
Table 6-17 Interfaces of C3510 optical receiver
Socket tag
Interface function
No.
J1 Optical transmitter interface
J4 CAN interface
Interface between 12V and -9.5V power supply
J5
modules
J2 JTAG(C3200)

Table 6-18 Indicator lamps of C3510 optical receiver
Indicator
lamp
D9 Digital 9V power supply
9V power supply has trouble and the LED will VCC
(C3510) indicator lamp
not work.
5V power supply indicator Normally, this LED lamp is lit. If it is unlit, the
D6
lamp 5V power supply has trouble.
D7
damaged.

Table 6-19 Faults of C3510/C3200 optical receiver and the solutions
S/N Fault Checking
A When the LED flickers properly, if the luminous flux brightness value is
0 or the brightness difference value remains unchanged, the luminous
Luminous flux
flux is abnormal. One possible cause is that the power supply has
1 brightness value
trouble, so check whether the 9V and -9.5V power supply modules are
abnormal
normal; the other cause is that the optical receiver LED fails, so just
replace it.
6.8 Optical receiver (suitable for C3100 model)

6.8.1 General
The optical receiver controls flickering of LED and uploading of received brightness AD
values
46
Optical receiver
CAN LED
CAN Optical
interfac transmitter
e
6.8.2 PCBA structure

6.8.3 Interface
Table 6-20 Interfaces of C3100 optical receiver
Socket tag
Interface function
No.
LED Optical transmitter interface
CAN CAN interface
Table 6-21 Faults of C3100 optical receiver and the solutions
S/N Fault Checking
A When the LED flickers properly, if the luminous flux brightness value is
Luminous flux 0 or the brightness difference value remains unchanged, the luminous
1 brightness value flux is abnormal. One possible cause is that the power supply has
abnormal trouble, so check whether the 12V,5V power supply module is normal;
the other cause is that the optical receiver LED fails, so just replace it.
47
6.9 Optical transmitter (suitable for C3510/C3200 model)

6.9.1 General
Optical transmitter controls flickering LED
Optical transmitter
J1
Optical
receiver
Figure 6-19 C3510/C3200 optical transmitter function diagram
6.9.2 Structure
Figure 6-20 C3510 optical transmitter PCBA structure diagram
Figure 6-21 C3200 optical transmitter PCBA structure diagram
6.9.3 Interface
Table 6-22 Interfaces of C3510/C3200 optical transmitter
Socket tag
Interface function
No.
J1 Optical receiver interface
48

Table 6-23 Indicator lamps of C3510 optical transmitter
Indicator
Definition Function Model
lamp
D1, D3,
D5, D7, Green lamp For DD and FDP C3510
D9
D11 Purple lamp For AT-III C3510
D2、D3、
D4、D5、 Green lamp For DD and FDP C3200
D6
D1 Purple lamp For AT-III C3200
Table 6-24 Faults of C3510 optical transmitter and the solutions
S/N Fault Checking
A If the LED does not flicker properly, one possible cause is abnormal
power supply, so check whether the 12V,5V power supply is normal;
1 LED unlit
the second cause is bad connection; third cause is that the LED fails, so
just replace it.
6.10 Optical transmitter (suitable for C3100 model)

6.10.1 General
Optical transmitter controls flickering LED
Optical transmitter
J1
Optical
receiver
Figure 6-22 C3100 optical transmitter function diagram
49
6.10.2 Structure
Figure 6-23 C3100_optical transmitter PCBA structure diagram

6.10.3 Interface
Table 6-25 Interfaces of C3100 optical transmitter
Socket tag
Interface function
No.
J1 Optical receiver interface
Table 6-26 Indicator lamps of C3100 optical transmitter
Indicator
lamp
D2, D4,
Green lamp For DD and FDP
D7, D8
Table 6-27 Faults of optical transmitter and the solutions
S/N Fault Checking
If the LED does not flicker properly, one possible cause is abnormal power
1 LED unlit supply, so check whether the 9V power supply is normal; the second cause is
bad connection; third cause is that the LED fails, so just replace it.
6.11 Probe panel

6.11.1 General
The probe panel controls oscillation of steel ball, calculates the oscillation amplitude AD
value, uploads the coagulation time and measures the air calibration and medium
calibration values.
50
Probe panel
J4 J3 J5
CAN CAN Temperatur

interfac interfac e control
e e panel
Figure 6-24 Probe panel function diagram
6.11.2 Structure
Figure 6-25 Probe panel PCBA structure diagram

6.11.3 Interface
Table 6-28 Interfaces of probe panel
Socket tag
Interface function
No.
J5 12V and -9.5V power supply interfaces
J3, J4 CAN interface, connection for optical receiver
51

Table 6-29 Faults of probe panel and the solutions
S/N Fault Checking
A If the steel ball does not oscillate, there are two possible causes: first,
Steel ball does not the board sub-program is running and this is usually the result of quick
1
oscillate restart after shutdown, so shut down the instrument and restart it in after
30s; second, the 12V power supply is abnormal.
Probe air calibration
and medium
2 A Replace corresponding channel test strip.
calibration values too
low
6.12 Card reader

6.12.1 General
The card reader detects a card and reads/writes the card information.
Card reader
indicator
lamp
J1
J CAN
3 interface
Card reader
Figure 6-26 Card reader function diagram
52
6.12.2 Structure
Figure 6-27 Card reader PCBA structure diagram

6.12.3 Interface
Table 6-30 Interfaces of card reader
Socket tag
Interface function
No.
J1 Card reader indicator lamp
J3 CAN interface

Table 6-31 Faults of card reader and the solutions
S/N Fault Checking
Indicator lamp is not
lit when the card is A This is usually the result of improper card swiping distance, so adjust
1
placed on the card the value of the capacitor CX1 to set a proper card swiping distance
reader
6.13 Big heater

6.13.1 General
Big heater supplies current for the circuit board heating line to heat the sample testing area.
Use one temperature sensor to detect the heating temperature and give feedback, so as to
control the temperature.
53
Big heater
J1
Temperature
control panel
Figure 6-28 Big heater function diagram
6.13.2 Structure
Figure 6-29 Big heater PCBA structure diagram

6.13.3 Interface
Table 6-32 Interfaces of big heater
Socket tag
Interface function
No.
J1 24V input and temperature testing

Table 6-33 Faults of big heater and the solutions
S/N Fault Checking
The temperature of the A Check whether the connecting wire is loose;
sample testing area is B Check whether the power input of J1 is 24V;
1 not displayed or is C Restart the instrument and software to see if the temperature is normal
very different from the D If the abovementioned problems are ruled out, the big heater may have
desired value trouble
6.14 Interface board

6.14.1 General
The interface board communicates with the outside world through the RS232 serial port
and Ethernet interface.
54
Main control
panel
J1
PC unit J3 Interface board P1 PC unit
J2
Main control
panel
Figure 6-30 Interface function diagram
6.14.2 Structure
The PCBA structure is shown in Figure 6-27:
Figure 6-31 Interface board PCBA structure diagram

6.14.3 Interface
Table 6-34 Interfaces of interface board
Socket tag
Interface function
No.
J1 Communicate with main control panel RS232
J2 Communicate with main control panel Ethernet
J3 Communicate with PC Ethernet
Only matches the old version of C3100
P1 Communicate with PC RS232
software
Table 6-35 Faults of interface board and the solutions
S/N Fault Checking
A Check whether the main control panel connecting wire is loose;
B Restart the instrument and software to see if RS232 communication is
RS232 not
1 normal;
communicating
C If the abovementioned problems are ruled out, the interface board may
have trouble.
A Check whether the main control panel connecting wire is loose;
Ethernet not
2 B Restart the instrument and software to see if Ethernet communication is
communicating
normal;
55
S/N Fault Checking

C If the abovementioned problems are ruled out, the interface board may
have trouble.
6.15 Sample stand position detector (only suitable for C3510)

6.15.1 General
The sample stand position detector mainly gives the sample stand position detection
signals.
Sample stand position detector
J8
Temperature
control panel
Figure 6-32 Sample stand position detector function diagram

6.15.2 Structure
Figure 6-33 Sample stand position detector function diagram

6.15.3 Interface
Table 6-36 Interfaces of sample stand position detector
Socket tag
Interface function
No.
3.3V power input and sample stand signal
J8
detection
Table 6-37 Faults of sample position detector and the solutions
S/N Fault Checking
A Check whether the temperature controller connecting wire is loose;
B Restart the instrument and software to see if sample stand testing is
Sample stand not
1 normal;
detected
C If the abovementioned problems are ruled out, the sample stand position
detector may have trouble.
56
Chapter 7 Mechanical System

7.1 C3510 instrument composition
Front view of the instrument is shown in Figure 7-1.
Figure 7-1 Instrument front view

S/N Description S/N Description
1 Upper cover plate 4 Front cover plate
2 Right door 5 Test tube stand
3 Transparent shield 6 Left door
The instrument front has upper cover plate, right door, transparent shield, front cover plate,
test tube stand and left door. Open the right door to replace Cuvette tray, pull out the test
tube stand to add or replace the sample and open the transparent shield to add or replace
the reagent.
Rear view of the instrument is shown in Figure 7-2.
1
1
Figure 7-2 Instrument rear view
57

1 Rear cover plate
The rear of the instrument is the rear cover plate.
Left side view of the instrument is shown in Figure 7-3.
5
1
1
1 6
1
2
1
7
3 1
8
4 1
9
1
Figure 7-3 Instrument left side view

1 Left door 6 Power connection terminal
2 RS232 interface 7 Serial port
3 Waste fluid testing port 8 Cleanser testing port
4 Waste fluid tube connector 9 Cleanser tube connector
5 Power switch
The left side of the instrument has power switch, power supply, data interface, external
tube connector and liquid level detector connection terminal.
7.2 C3510 layout
Front components of the instrument are shown in Figure 7-4.
58
1
1
2 12
1
11
10
3 4 5 6 7 8 9
1 1 1 1 1 1 1
Figure 7-4 Front panel of the instrument

1 Double-probe travel assembly 7 Sample test area
2 Diluent carrying area 8 Cup holder
3 Sample carrying area 9 Waste cup carrying area
4 Emergency carrying area 10 Cuvette tray
5 Reagent carrying area 11 Cup transport
6 Probe cleaning area 12 Tape collector
The front of the instrument has the sample and reagent carrying area, sample testing
module, cup holder and cup transport, to test the entire sample.
Left side components of the instrument are shown in Figure 7-5.
59
1
1
Figure 7-5 Instrument left side view

1 Fluid valve
The left side of the instrument has pump and fluid valve.
The rear components of the instrument are shown in Figure 7-6.
1
1
2
1

1 Board integration module 2 Power module
The instrument rear has board module and power module.
60
7.3 C3100 instrument composition

The instrument appearance is shown in Figures 7-7, 7-8 and 7-9.
The instrument consists of the casing and the functional components including socket,
pump stand, drawer, double-probe travel assembly, cup feeder, cup holder travel
mechanism and testing unit. The instrument is connected to external cleanser and it also
has internal probe cleanser, reagents and samples.
Figure 7-7 Instrument front view
Figure 7-8 Instrument side view
61

List of instrument appearance introductions
1 Left door 4 Top cover plate
2 Right door 5 Front shield
3 Rear cover plate 6 Front door
The exterior of the instrument consists of the white doors and the dark brown front shield.
According to the front view in Figure 7-1, the front has the product LOGO and card reader
indicator lamp. The dark brown front shield can be easily opened to check the operation
status of the instrument. If you pull out the spring plunger, you can easily open the front
door to replace the reagent and sample in the drawer; according to Figure 7-8, the side of
the instrument has the card reader assembly which includes the power switch, power
interface, data line and network cable ports and probe cleanser and waste fluid ports;
according to Figure 7-9, the rear of the instrument has one metal cover plate which has
dustproof heat dissipation holes to protect the interior from dust and help cool the circuit
board.
7.4 C3100 layout
Figure 7-10 Left side view of the instrument (open the left door)
List of instrument left side introductions
62
1 Socket assembly 2 Pump stand assembly

Open the left door of the instrument to see the interior structure as shown in Figure 7-10.
The left-side board accommodates the socket assembly and pump stand assembly. The
socket assembly accommodates the power supply, data interface and network interface and
it also accommodates the probe cleanser and waste fluid ports; the pump stand assembly
accommodates the plunger pump, peristaltic pump and various valves, to drive and control
the hydraulic system components.
Figure 7-11 Center view of the instrument (open the shield plate and the front panel)
List of instrument center introductions
Double-probe travel
1 3 Testing unit
assembly
Cup holder travel
2 4 Drawer
mechanism
Open the dark brown front shield and front door of to see the interior structure as shown in
Figure 7-11. According to this picture, the bottom plate of the instrument accommodates
the drawer and testing unit; the right-side board accommodates the cup holder travel
mechanism and cup feeder; the double-probe travel assembly can move and it
accommodates the reagent probe and sample probe.
63
Figure 7-12 Right side view of the instrument (open the right door)
List of instrument right side introductions
1 Cuvette tray 2 Cup feeder
Open the right door of the instrument to see the interior structure as shown in Figure 7-12.
According to this picture, the right-side board accommodates the cuvette tray and cup
feeder.
Figure 7-13 Rear view of the instrument (open the rear cover plate)
64
List of instrument rear introductions

Hydraulic system drive
1 5 Power shielding case
board
24V/6A power board
2 Cuvette drive board 6
PCBA
3 Main control panel 7 12V power board PCBA
Temperature control drive
4 Trunking 8
board PCBA
Open the rear cover plate of the instrument to see the electric circuit components which
include drive board PCBAs, connecting circuit, trunking and fixing plate. The cuvette drive
board controls the catcher; the hydraulic system drive board controls the pump and valve;
the main control panel accommodates the CPU which controls the entire system. Open the
power shielding case to see the temperature control drive board and power board. The
temperature control drive board controls the temperature of the system components
including testing unit, double probes, cold batch, Peltier board and fan; the 12V and 24V
power boards supply stable voltage for the operating units.
Figure 7-14 Instrument interior structure layout (open the front shield and top cover plate)
Instrument center layout
1 Rinse tank 4 Testing unit
Double-probe travel
2 Cup feeder 5
assembly
Cup holder travel
3 6 Drawer
mechanism
Open the front shield and top cover plate to see the interior structure as shown in Figure
7-14. To the left is the drawer and to the right are the testing unit and cup holder travel
65
mechanism. Above the cup feeder and rinse tank is the double-probe travel assembly.
Above the drawer are the sample area and reagent area. When the instrument is operating,
the card reader is above the right door.
66
Chapter 8 Assembly Replacement

8.1 C3510 double-probe travel assembly
The double-probe travel assembly is where the samples and reagents are extracted and
added and it can move in X, Y and Z directions.
■ Tools
One set of socket head wrenches
Cross screwdriver
■ Steps
1. Unscrew the three M4×20 cross recessed pan head screws and remove the rear
cover plate. See Figure 8-1.
2. Open the transparent shield and move the double-probe assembly to the proper
position at the left side.
3. Unscrew the four M4×12 socket head cap screws and loosen the X toothed belt
seat a. See Figure 8-2.
4. Open the left door; unscrew the nine M4×10 cross recessed pan head screws and
remove the left door. See Figure 8-3.
5. Pull out the connecting wire of the double-probe assembly and unscrew the
double-probe connecting tube.
6. Unscrew the six M4×8 socket head cap screws, two M5×12 socket head cap
screws and remove the two X fixing sleeves b. See Figure 8-4.
7. Open the right door and unscrew the two M5×12 socket head cap screws. See
Figure 8-4.
8. Extract the X optical axis from the left side to remove the entire double-probe
assembly.
Figure 8-1 Removal of rear cover plate
67
Figure 8-2 Removal of left door assembly
10
Figure 8-3 Removal of left and right X fixing sleeves b
68
11
Figure 8-4 Position of double-probe travel assembly

Table 8-1 List of exterior cover parts
S/N Description FRU code S/N Description FRU code
M4×10 cross
1 Rear cover plate 042-013639-00 7 recessed pan head
screw
M4×20 cross recessed pan M5×12 socket head
2 8
head screw cap screw
3 X toothed belt seat a 041-009581-00 9 X fixing sleeve b 041-009538-00
M4×12 socket head cap M4×8 socket head
4 10
screw cap screw
Double-probe travel
5 Left door 043-004377-00 11 115-028407-00
assembly
6 Left door 115-023019-00
■ Confirmation
1. Before removing the double-probe travel assembly, all the lines connected to it
are disconnected;
2. Before removing this assembly, keep the reagent probe and sample probe
protected (they can be removed first as shown in Sections 8.3 and 8.4);
3. When removing the double-probe assembly, protect the X optical axis from
collision.
■ Exploded view for double-probe assembly
69
Figure 8-5 Exploded view for double-probe travel assembly

Table 8-2 List of parts of double-probe assembly
M6×20 socket head cap
1 21 Y sensor mask 042-013618-00
screw
2 Y optical axis 032-000401-00 22 Y axis support 041-018300-00
M3×10 socket head cap M4×10 cross recessed
3 23
screw countersunk head screw
4 Y belt pressing plate 041-018301-00 24 X guide line stand 041-009613-00
5 Y belt fixed seat 041-018302-00 25
screw
6 26 Sensor SG-214B 111021
screw
M4×10 cross recessed M3×6 cross recessed pan
7 27
countersunk head screw head screw
8 Y belt wheel pressing plate 041-018311-00 28 X sliding rack 041-018297-00
Deep groove ball bearing X linear bearing
9 032-000294-00 29 032-000296-00
5X11X3/618/5 LM13UU/Φ23*Φ13*32L
10 Belt wheel MXL037-5 041-012916-00 30 X sliding rack baffle 041-009612-00
M3×3 socket head cap M4×8 socket head cap
11 31
jackscrew screw
X sliding rack spacer
12 Belt wheel spindle 041-018317-00 32 043-003729-00
bush
70

13 Y front holder 041-018299-00 33 Y motor frame 041-009609-00
14 34 Y motor frame plate 041-018298-00
screw
Stepping motor
15 Joint P-200N 0040-10-32305 35 024-000537-00
17PM-K049B
Synchronous toothed belt
16 Joint nut 041-015817-00 36 031-000274-00
Y
17 Joint P-208 0040-10-32304 37 Z head assembly
18 38 XY tension spring 033-000281-00
screw
19 Y guide line stand a 042-013623-00
20
screw
Figure 8-6 Exploded view for Z head assembly

Table 8-3 List of parts of Z head assembly
1 Z motor board a 041-018310-00 18
screw
Flanged elongated linear
Stepping motor
2 117085 19 bearing 032-000399-00
42BYGH023-P31
LMH10 LUU
M3×8 socket head cap Flanged linear bearing
3 20 032-000398-00
screw LMH10UU
M3×8 cross recessed pan
4 Z coupler pin 041-009589-00 21
head screw
5 Probe drive board 051-001942-00 22 Z-type nut 041-018303-00
6 Z board fixing plate a 042-013617-00 23 Z fixed seat, left 041-018312-00
7 Z board shield, a 042-013624-00 24 Z sensor mask, left 042-013620-00
8 M3×6 socket head cap 25 Guide rail spacing board 041-018316-00
71

screw
9 26
screw screw
Reagent probe mounting Sample probe mounting
10 041-018315-00 27 041-018314-00
plate plate
Level gauge shield, right
11 Copper pillar M3×8 28 042-013622-00
and left
12 C3510 level gauge 115-027923-00 29 Y sliding rack a 041-018309-00
13 Level gauge shield, right 042-013622-00 30 Sensor SG-214B 111021
14 31 Z screw rod 041-009590-00
head screw
Linear guide rail
15 032-000400-00 32 Z coupler clamp 042-010272-00
MGN9H1R135Z1HM
16 Z sensor mask, right 042-013619-00 33 Z coupler 049-000625-00
17 Z fixed seat, right 041-018313-00
8.2 C3100 double-probe travel assembly

The double-probe travel assembly is where the samples and reagents are extracted and
added and it can move in X, Y and Z directions.
■ Tools
Cross screwdriver
Scissors
■ Steps
1. Unscrew the three M4×10 cross recessed pan head screws and remove the rear
cover plate. See Figure 8-7.
2. Unscrew the three M3×6 cross recessed pan head screws and remove the PCBA
fixing plate 1. See Figure 8-8.
3. Unscrew the four M4×12 socket head cap screws, loosen the X toothed belt seat a,
unscrew one M4×12 cross recessed countersunk head screws and loosen the X
drag chain. See Figure 8-9.
4. Unscrew the two M3×8 cross recessed pan head screws and remove the left door.
See Figure 8-9.
5. Pull out the connecting wire of the double-probe assembly and unscrew the
double-probe connecting tube.
6. Unscrew the seven M4×8 socket head cap screws, two M5×12 socket head cap
screws and remove the X fixing sleeves a and b. See Figure 8-9.
7. Open the right door and unscrew the two M5×12 socket head cap screws. See
Figure 8-9.
8. Extract the X optical axis from the left side to remove the entire double-probe
assembly.
72
Figure 8-7 Removal of rear cover plate
Figure 8-8 Removal of PCBA fixing plate
1
0
11
12
13
Figure 8-9 Removal of left and right X fixing sleeves a and b
73
14
Figure 8-10 Position of double-probe travel assembly

Table 8-4 List of exterior parts
1 8 X toothed belt seat a 041-009581-00
head screw
M4×12 cross recessed
2 Rear shield 042-011147-00 9
countersunk head screw
M3×6 cross recessed pan M4×8 socket head cap
3 10
head screw screw
4 PCBA fixing plate 1 042-012550-00 11 X fixing sleeve a 041-009537-00
5 Left door 043-004371-00 12
screw
6 13 X fixing sleeve b 041-009538-00
head screw
M4×12 socket head cap Double-probe travel
7 14 115-026597-00
screw assembly
■ Confirmation
1. Before removing the double-probe travel assembly, all the lines connected to it
are disconnected;
2. Before removing this assembly, keep the reagent probe and sample probe
protected (they can be removed first as shown in Section 8.5 ―Sample probe
module‖ and Section 8.6 ―Reagent probe module‖);
3. When removing the double-probe assembly, protect the X optical axis from
collision.
■ Exploded view for double-probe assembly
74
Figure 8-11 Exploded view for double-probe travel assembly

Table 8-5 List of parts of double-probe travel assembly
1 Z head assembly 16 Y axis support pad 041-016660-00
Y axis drag chain
2 Y axis guiding shaft 041-012522-00 17 041-012521-00
mounting plate
3 XY tension spring 033-000281-00 18
screw
4 19 Sensor SG-214B 111021
screw
Synchronous toothed belt M3×6 cross recessed pan
5 031-000274-00 20
Y head screw
6 X sliding rack 041-009611-00 21 Y sensor stand 041-009616-00
Stepping motor M3×10 socket head cap
7 024-000537-00 22
17PM-K049B screw
8 Y motor frame 041-009609-00 23 Y motor frame plate 041-009610-00
9 24
screw screw
10 Belt wheel MXL037-5 041-012916-00 25 X guide line stand 041-009613-00
M3×3 socket head cap M4×10 cross recessed
11 26
jackscrew countersunk head screw
12 X sliding rack spacer bush 043-003729-00 27 Y front 043-003728-00
X linear bearing Deep groove ball bearing
13 032-000296-00 28 032-000294-00
LM13UU/Φ23*Φ13*32L 5X11X3/618/5
14 X sliding rack baffle 041-009612-00 29 Belt wheel spindle 041-012919-00
15 30 XY belt wheel plate 041-009580-00
screw
75
Figure 8-12 Exploded view for Z head assembly

Table 8-6 List of parts of Z head assembly
Stepping motor
1 117085 24 Y belt binder 041-009614-00
42BYGH023-P31
2 Z motor board 042-010273-00 25 Y sliding rack 043-004243-00
M4×8 socket head cap Reagent probe module
3 26 115-028469-00
screw FRU
M3×10 socket head cap Sample probe module
4 27 115-028470-00
screw FRU
Outer tube of reagent
5 Z coupler clamp 042-010272-00 28 041-012526-00
probe
6 Z coupler 049-000625-00 29 Heating rod assembly 041-012525-00
Outer tube of reagent
7 Z axis nut clamp 041-009586-00 30 041-012526-00
probe
8 Z coupler pin 041-009589-00 31 Z tube upper end b 043-004541-00
9 Z sensor mask (right) 042-011444-00 32 Z motor frame 041-009587-00
10 33 Z tube upper end 043-003721-00
screw
11 Temperature plate 1210123 34 Y guide line stand 041-009591-00
12 Z-type nut 043-003708-00 35 Y sensor blocking piece 042-010279-00
13 Z-type nut seat 043-003709-00 36 Joint nut 041-015817-00
76

14 Z screw rod 041-009590-00 37 Joint P-200N 0040-10-32305
15 Y sliding rack spacer bush 043-003712-00 38 Joint P-208 0040-10-32304
16 Y sliding rack bearing 032-000297-00 39 Sensor SG-214B 111021
17 D15 hole retainer ring 40 Z bearing 041-009588-00
18 Z sensor mask, C2A 042-010271-00 41
head screw
19 42 Z circuit board rack 043-003710-00
head screw
20 Level gauge (Precil) 115-022354-00 43 PCBA fixing plate 3 042-012552-00
21 Level gauge right shield 042-010771-00 44 Probe drive board PCBA 051-001643-00
22 Copper pillar M3×8 45 Z hold shield, upper 043-003716-00
23 Level gauge left shield 042-010770-00
8.3 C3510 sample probe assembly

The sample probe assembly is installed at the double-probe travel assembly and is used to
extract and release samples. The probes can also measure liquid level and prevent collision
in the vertical direction.
■ Tools
Straight screwdriver
■ Steps
1. Open the transparent shield;
2. Unscrew the joint P-208 and joint nut, remove the joint P-200N and disconnect
the tube connection. See Figure 8-13;
3. Unscrew the three M3×6 cross recessed pan head screws and remove the level
gauge left shield;
4. Unscrew the two M3×6 cross recessed pan head screws, as shown in Figure 8-14;
5. Unscrew the two M3×10 socket head cap screws and remove the sample probe
assembly. See Figure 8-15.
■ Confirmation
1. Loosen the cable tie before removing the level gauge left shield.
77
Figure 8-13 Sample probe removal diagram 1

Table 8-7 List of exterior parts of sample probe
1 Joint P-208 0040-10-32304 4 Level gauge shield, left 042-013621-00
2 Joint P-200N 0040-10-32305 5
screw
3
head screw
78
■ Exploded view for sample probe assembly
Figure 8-16 Exploded view for sample probe
Table 8-8 List of parts of sample probe

1 Locking joint 041-016653-00 5 Anticollision spring 033-000496-00
2 Tube pad 041-016657-00 6
screw
Sample probe mounting
3 Anticollision screw 041-018304-00 7 041-018306-00
seat
4 Sample probe adjuster 041-018305-00 8 Sample probe module
8.4 C3100 sample probe module

The sample probe assembly is installed at the double-probe travel assembly and is used to
extract and release samples. The probes can also measure liquid level and prevent collision
in the vertical direction.
■ Tools
79
■ Steps
gauge left shield;
4. Unscrew the two M3×6 cross recessed pan head screws. See Figure 8-18.
5. Unscrew the two M3×10 socket head cap screws and remove the sample probe
assembly. See Figure 8-19
■ Confirmation
1. Loosen the cable tie before removing the level gauge left shield.
80
Table 8-9 List of exterior parts of sample probe

1 Joint P-208 0040-10-32304 4 Level gauge left shield 042-010770-00
Sample probe module
2 Joint P-200N 0040-10-32305 5 115-028470-00
FRU
3
head screw
8.5 C3510 reagent probe assembly

The reagent probe assembly is installed at the double-probe travel assembly and is used to
extract and release reagents. The probes can also measure liquid level, fulfill heating and
prevent collision in the vertical direction.
■ Tools
■ Steps
gauge right shield;
5. Unscrew the two M3×10 socket head cap screws and remove the reagent probe
■ Confirmation
1. Loosen the cable tie before removing the level gauge right shield.
81
Figure 8-20 Reagent probe removal diagram 1
82
Table 8-10 List of exterior parts of reagent probe

1 4 Level gauge shield, right 042-013622-00
head screw
2 Joint P-208 0040-10-32304 5
screw
3 Joint P-200N 0040-10-32305 6 Reagent probe module
■ Exploded view for reagent probe assembly
Figure 8-23 Exploded view for reagent probe
83
Table 8-11 List of parts of reagent probe

2 Tube pad 041-016657-00 6
screw
Reagent probe mounting
seat
4 Reagent probe adjuster 041-018307-00 8 Reagent probe module
8.6 C3100 reagent probe module

The reagent probe assembly is installed at the double-probe travel assembly and is used to
extract and release reagents. The probes can also measure liquid level, fulfill heating and
prevent collision in the vertical direction.
■ Tools
■ Steps
gauge right shield;
5. Unscrew the two M3×10 socket head cap screws and remove the reagent probe
■ Confirmation
1. Loosen the cable tie before removing the level gauge right shield.
84
85
Table 8-12 List of exterior parts of reagent probe

1 Joint P-208 0040-10-32304 4 Level gauge right shield 042-010771-00
Reagent probe module
2 Joint P-200N 0040-10-32305 5 115-028469-00
FRU
3
head screw
■ Exploded view for reagent probe assembly
Figure 8-27 Exploded view for reagent probe
86
Table 8-13 List of parts of reagent probe

2 Tube pad 041-016657-00 6
screw
Reagent probe mounting
seat
4 Reagent probe adjuster 041-018307-00 8 Reagent probe module
8.7 C3510/C3200 testing base parts

The testing base assembly is used for sample preheating and reaction and testing of
reagents and samples.
8.7.1 Optical assembly
■ Tools
Cross screwdriver
■ Steps
1. Remove the cuvette tray, unscrew the three M3×8 cross recessed countersunk
head screw and take out the pressing plate from the rear (Figure 8-28).
Figure 8-28 Pressing plate removal diagram

2. Unscrew the three M4×20 hexagon socket cap screws and pull out the support pin
(see Figure 8-28).
3. Unscrew the two M4×12 hexagon socket cap screws and take out the right-side board
baffle (see Figure 8-29).
87
Figure 8-29 Right-side board baffle removal diagram

4. Reach a hand into the opening of the right-side board baffle to pull out all the wires
connected to the optical board (see Figure 8-30).
Figure 8-30 Optical testing board wire harness connection

5. Unscrew the ten M3×10 combination screws and remove the testing base cover plate
(see Figure 8-31).
88
Figure 8-31 Testing base cover plate removal diagram

6. Unscrew the four M4×10 hexagon socket cap screws and pull out the optical assembly
upward (see Figure 8-32). Keep protecting the socket and elements on the optical
board (see Figure 8-32).
安装定位
基准边
Figure 8-32 Optical assembly removal diagram
Table 8-14 List of parts of testing base

Testing base cover
1 Cover plate \ 4 \
plate
2 Optical support pin \ 5 Optical assembly 115-028420-00
3 Right-side board baffle \ 6 Testing base \
89
■ Confirmation
1. When installing the optical assembly, fit the two reference edges tightly to the
testing edges as shown in Figure 8-32 and then unscrew the four M4×10 hexagon
socket cap screws;
2. Check the parts and make sure they are placed and fixed in right positions;
3. Check whether the signal lines are correctly connected;
4. Start the instrument to check whether the optical assembly works properly.
8.7.2 Test strip
■ Tools
■ Steps
1. Unscrew the ten M3×10 combination screws and remove the testing base cover
plate (see Figure 8-33).
2. Pull out the test strip upward (see Figure 8-33).
Figure 8-33 Test strip assembly removal diagram
Table 8-15 List of parts of test strip

1 Test strip 045-001191-00
■ Confirmation
2. Check whether the test strip board is securely connected;
3. Start the instrument to check whether the test strip assembly works properly.
90
8.7.3 Magnetic bead board

■ Tools
■ Steps
1. Take out the waste cuvette box.
2. Reach a hand into the opening of the waste cuvette box to unscrew the four
M3×10 hexagon socket cap screws and pull out the magnetic bead board
downward (see Figure 8-34).
1 Magnetic bead board 051-001887-00 2 Screw M3×10 \
■ Confirmation
2. Check whether the magnetic bead board and test strip are connected and fixed
correctly;
3. Start the instrument to check whether the magnetic bead board assembly works
properly.
Figure 8-34 Magnetic bead board removal diagram
8.8 C3100 testing base parts

8.8.1 Optical assembly
■ Tools
Cross screwdriver
■ Steps
1. Pull out the drawer, unscrew the ten M3×10 combination screws and pull out the
soaker shield forward (see Figure 8-35).
2. Pull out the testing base cover plate upward (see Figure 8-35).
91
Figure 8-35 Testing base cover plate removal diagram

3. Reach a hand into the opening of the right-side board baffle to pull out all the wires
connected to the optical board (see Figure 8-36).
Figure 8-36 Optical testing board wire harness connection

4. Unscrew the three M3×10 combination screws and pull out the optical assembly
upward (see Figure 8-37). Keep protecting the socket and elements on the optical
board.
92
Figure 8-37 Optical assembly removal diagram
Table 8-16 List of parts of testing base

Testing base cover
1 Soaker shield \ 3 \
plate
M3×10 combination
2 \ 4 Optical assembly 115-026600-00
screw
■ Confirmation
1. Check whether the parts are placed and fixed in right positions;
2. Check whether the signal lines are correctly connected;
3. Start the instrument to check whether the optical assembly works properly.
8.8.2 Test strip assembly

■ Tools
■ Steps
1. Pull out the drawer, unscrew the ten M3×10 combination screws, pull out the
soaker shield forward and pull out the testing base cover plate upward (see Figure
8-38).
2. Pull out the test strip upward (see Figure 8-38).
93
Figure 8-38 Test strip assembly removal diagram
Table 8-17 List of parts of test strip

1 Test strip 045-001191-00
■ Confirmation
2. Check whether the test strip board is securely connected;
3. Start the instrument to check whether the test strip assembly works properly.
8.8.3 Magnetic bead board
■ Tools
■ Steps
1. Open the right door, pull out the drawer and take out the waste cuvette box.
2. Reach a hand into the right-side opening to unscrew the four M3×10 hexagon
socket cap screws and pull out the magnetic bead board downward (see Figure
8-39).
Table 8-18 List of parts of magnetic bead board
1 Magnetic bead board 051-001887-00 2 Screw M3×10 \
■ Confirmation
2. Check whether the magnetic bead board and test strip are connected and fixed
correctly;
3. Start the instrument to check whether the magnetic bead board assembly works
properly.
94
Figure 8-39 Magnetic bead board removal diagram
8.9 Cup holder travel mechanism

8.9.1 Sensor catcher assembly
■ Tools
Cross screwdriver
■ Steps
1. Open the transparent shield, unscrew the two M3×8 cross recessed screws and
take out the ZY shield (see Figure 8-40).
Figure 8-40 ZY shield removal diagram

2. Pull out the connecting line of the catcher, unscrew the two M3X16 cross recessed
screws and take out the sensor catcher assembly (see Figure 8-41).
95
Figure 8-41 Sensor catcher assembly removal diagram
Table 8-19 List of parts of cup holder travel mechanism

Sensor catcher
1 ZY shield \ 2 045-001738-00
assembly
M3×16 cross recessed
3 \
screws
■ Confirmation
2. Check whether the left and right parts of the catcher are aligned with the Cuvette
holes on the testing base;
3. Check whether the wire harness of the catcher is connected correctly;
4. Start the instrument to check whether the sensor catcher assembly works
properly.
8.9.2 Reflective sensor
■ Tools
Cross screwdriver
■ Steps
Open the transparent shield, unscrew the two M3×8 cross recessed screws and take out
the ZY shield (see Figure 8-42).
Pull out the connecting wire harness of the reflective sensor (see Figure 8-42).
Pull the sensor catcher assembly upward to the highest position, unscrew the M3×12
cross recessed screws and pull out the reflective sensor forward (see Figure 8-42).
96
1
2
Figure 8-42 Reflective sensor removal diagram
Table 8-20 List of parts of reflective sensor

M3×16 cross
1 Reflective sensor P01120-001 2 \
recessed screws
■ Confirmation
2. Check whether the wire harness of the reflective sensor is connected correctly;
3. Start the instrument to check whether the reflective sensor works properly.
8.10 Tape releaser assembly

Tape releaser and tape collector together deliver Cuvettes.
■ Tools
■ Steps
1. Open the right door, revolve the tape releaser pressing plate counterclockwise by
90 degrees, take out the Cuvette tray and place it on the table carefully (see
Figure 8-43).
97
Figure 8-43 Cuvette tray removal diagram

2. Unscrew the four M4×8 hexagon socket cap screws and pull out the tape releaser (see
Figure 8-41).
Figure 8-44 Tape releaser assembly removal diagram

Table 8-21 List of parts of tape releaser assembly
1 Cuvette tray \ 3 M4×8 screw \
Tape releaser pressing
2 \ 4 Tape releaser 115-023024-00
plate
■ Confirmation
2. Start the instrument to check whether the tape releaser assembly works properly.
8.11 Tape collector assembly

Tape collector and tape releaser together deliver Cuvettes.
■ Tools
■ Steps
98
1. Open the right door, open the cuvette cover plate upward, revolve the tape
collector pressing plate outward by 90 degrees, take out the cuvette tray drive
wheel and place it on the table (see Figure 8-45).
2. Unscrew the three M4×12 hexagon socket cap screws and pull out the tape
collector outward (see Figure 8-45).
Figure 8-45 Tape collector assembly removal diagram
Table 8-22 List of parts of tape collector assembly

1 Tape collector \ 4 Cuvette tray belt \
Tape collector pressing
2 \ 5 Cuvette cover plate \
plate
Cuvette tray drive
3 \
wheel
■ Confirmation
2. After installing the cuvette tray drive wheel, revolve the cuvette tray
counterclockwise to tighten the belt.
Start the instrument to check whether the tape collector assembly works properly.
99
8.12 C3510/C3200 left-side pump stand assembly
Figure 8-46 Hydraulic system assembly diagram
Table 8-23 List of parts of left-side pump

1 Left-side pump 6 Peristaltic pump
2 500μL injector 7 Anti-vibration pad
3 Peristaltic pump support 8 Diaphragm pump
4 Bus bar assembly 9 Three-way miniature solenoid valve (short wire)
5 Self-made valve support 10 Two-way miniature solenoid valve (short wire)
100
8.13 C3100 left-side pump stand assembly diagram
Figure 8-47 Hydraulic system assembly diagram
Table 8-24 List of parts of hydraulic system

1 Bus bar assembly 4 Peristaltic pump
2 Peristaltic pump support 5 Left-side pump
3 (ceramic) integrated injector
8.14 C3510/C3200 injector assembly

■ Tools
1 set of socket head wrenches
■ Replacement steps
Note: the instrument has one 500μL injector which is fixed on the left-side pump
stand.
1. Open the left door
2. Pull out all the rubber tubes connected to the injector;
3. The injector must be removed as a whole. Use the socket head wrench to remove
the four M4 socket head cap screws of the injector and disconnect the motor wire
from the sensor wire. See Figure 8-48.
4. The transmission part of the injector can be replaced individually.
101
Figure 8-48 Injector assembly removal diagram
Table 8-25 List of parts of injector

1 500μL injector \ 3 M4 socket head cap screw \
2 KS330 \ 4 KS330 \
■ Confirmation
1. After replacing the injector, connect the rubber tubes and wires correctly.
2. Start the instrument and it will Run self-testing. Check whether the injector works
properly.
8.15 Peristaltic pump assembly
■ Tools
1 set of socket head wrenches
■ Steps
1. Open the left door.
2. Pull out all the rubber tubes and wires connected to the peristaltic pump, use a
socket head wrench to remove the three M4 socket head cap screws of the
peristaltic pump and disconnect the motor connecting wires. See Figure 8-49.
102
Figure 8-49 Peristaltic pump removal diagram
Table 8-26 List of installation parts of peristaltic pump

M4 socket head cap
1 HSR4330 \ 3 \
screw
2 Peristaltic pump \ 4
■ Confirmation
1. After replacing the peristaltic pump, connect the rubber tubes and wire correctly.
2. Start the instrument and it will Run self-testing. Check whether the peristaltic
pump works properly.
■ Exploded view for the assembly
Figure 8-50 Exploded view for peristaltic pump

Table 8-27 List of parts of peristaltic pump
1 Pump stand 5 Pump impeller
2 Pump shaft block 6 42BYGH023-P01
3 Blind rivet 7 Tension spring
4 Pump clamp 8 Joint, white nylon reducer
8.16 C3510/C3200 solenoid valve and diaphragm pump

■ Tools
Cross screwdriver, 1 set of socket head wrenches
■ Steps
2. Pull out all the rubber tubes and wires connected to the solenoid valve, use a cross
103
screwdriver to remove the two M2.5 screws fixing the solenoid valve and then
disconnect the connecting wire of the solenoid valve. See Figure 8-51.
3. Pull out all the rubber tubes and wires connected to the diaphragm pump, use a
cross screwdriver to remove the two M3 screws fixing the solenoid valve and
then disconnect the connecting wire of the diaphragm pump. See Figure 8-51.
Figure 8-51 Solenoid valve and diaphragm pump removal diagram
Table 8-28 List of parts of solenoid valve and diaphragm pump

Self-made valve Cross recessed pan
1 \ 5 \
support head screws M3
Three-way
miniature
2 \ 6 Diaphragm pump \
solenoid valve
(short wire)
Two-way
miniature
3 \ 7 Anti-vibration pad \
solenoid valve
(short wire)
Cross recessed
M4 socket head cap
4 pan head screws \ 8 \
screw
M2.5
■ Confirmation
1. After replacing the solenoid valve and diaphragm pump, connect the wires and
rubber tubes.
2. Start the instrument and it will Run self-testing. Check whether the solenoid valve
and diaphragm pump works properly.
104
8.17 C3510/C3200 Bus bar assembly

■ Tools
Cross screwdriver
■ Steps
2. Pull out the rubber tubes and wires connected to the bus bar and use a socket head
wrench to remove the two M4 screws fixing the bus bar, to remove the bus bar
Figure 8-52 Bus bar removal diagram
Table 8-29 List of parts of bus bar

Enlarged bus
1 \ 3
bar
socket head cap
2 \ 4
screw M4
■ Confirmation
1. After replacing the bus bar, connect the wires and rubber tubes.
105
Figure 8-53 Exploded view for bus bar

1 Enlarged bus bar 5 Joint P-200N
2 Bus bar locating pin 6 Joint P-208
3 Solenoid valve for bottom tube 7 Bus bar pad
4 Enlarged bus bar mounting rack 8 Joint, white nylon plug-in joint
8.18 C3100 bus bar assembly

■ Tools
Cross screwdriver
■ Steps
1. Open the left-side internal shield plate.
2. Pull out the rubber tubes and wires connected to the bus bar and use a socket head
wrench to remove the two M4 screws fixing the bus bar, to remove the bus bar
Figure 8-54 Bus bar removal diagram

106

Enlarged bus
1 \ 3
bar
socket head cap
2 \ 4
screw M4
■ Confirmation
1. After replacing the bus bar, connect the wires and rubber tubes.
Figure 8-55 Exploded view for bus bar

1 Bus bar 6 Joint, white nylon plug-in joint
2 Bus bar locating pin 7 Joint, white nylon plug screw
Two-position two-way solenoid valve
3 8 Bus bar mounting rack
for base plate tube
Two-position three-way solenoid valve
4 9 Joint P-200N
for base plate tube
5 Joint P-208 10 Bus bar pad
8.19 C3510 reagent assembly

The reagent assembly carries reagents, mixes reagents, cools reagents and carries
emergency samples.
■ Tools
Cross screwdriver
107
■ Steps
1. Open the left door ○
2 ; unscrew the nine M4×10 cross recessed pan head screws ○
3
and remove the left door ○1 . See Figure 8-56.
Figure-56 Left door removal diagram

2. Take out the sample drawer ○ 4 , open the right door, unscrew the two M6×16 socket
head cap screws ○ 6 and remove the front panel ○ 5 ; take out the four white plastic
waterproof pads ○ 7 , unscrew the four M4×12 cross recessed pan head screws ○ 8
below the waterproof pad, raise the reagent assembly ○ 9 and pull out the connecting
cable plug. See Figure 8-57.
Figure 8-57 Reagent assembly removal diagram
108
Table 8-33 List of parts of reagent assembly

M6X16 hexagon socket cap
1 Left door 115-023019-00 6
screws
2 Left door 043-004377-00 7 Waterproof pad 041-018085-00
M4×10 cross recessed M4×12 cross recessed pan
3 8
pan head screw head screw
4 Sample drawer 115-028410-00 9 Reagent assembly 115-028208-00
5 Front panel 115-028411-00
8.20 C3510 exploded view for reagent assembly
Figure 8-58 Exploded view for reagent assembly
Table 8-34 List of parts of reagent assembly

S/N Description FRU code Quantity S/N Description FRU code Quantity
M4×12 cross
1 Cooling fin 041-018358-00 2 14 recessed pan 3
head screws
CoolerMaster -A73 Moistureproof
2 024-000552-00 2 15 041-013004-00 2
cooling fan cotton
3 Fan connector 043-004890-00 2 16 Wind screen 042-013543-00 1
Thermal
4 Compression screw 041-013534-00 8 17 041-018088-00 3
insulating pad
Reagent stand
5 Cold batch spring 219493 8 18 041-018091-00 1
silk-screen
Cooling
Thermal insulating element/C2A
6 041-013535-00 8 19 112033 2
pad (Peltier
board)
M2X5 cross Cold batch
7 10 20 041-018359-00 1
recessed pan head seat
109
S/N Description FRU code Quantity S/N Description FRU code Quantity
screws
Motor Mixing motor
8 117079 5 21 041-018081-00 5
15BY20L03-07 pad
Thermal
insulation
9 Motor frame 041-018080-00 5 22 041-018082-00 1
cotton for
motor
Thermal
insulation
10 Magnetic cavity 043-003740-00 5 23 041-018083-00 1
cotton 1 for
motor
Thermal
11 Magnet 5*5*3 034-000324-00 10 24 insulation 041-018084-00 1
cotton
M3×8 cross
Temperature
12 recessed pan head 11 25 1210123 1
plate
screws
M3×10 cross
13 Drain tube 041-013533-00 3 26 recessed pan 5
head screws
110
Chapter 9 Fault Codes

9.1 Introduction
The fault codes explained in this chapter are applicable to C3510 and C3100 models. In
case of a fault, click ―Prompt‖ on the status bar to pop up the prompt. See the picture. The
number in the circle is the number of faults and the number at the head of the fault
character is the serial number of the fault.
Figure 9-1 Fault pop-up area
9.2 List of faults

Definition of fault level:
S=Fatal, must reset instrument and software.
A=Serious, lead to instrument out of work and software block, user must participate in eliminating faults.
B=Urgent, lead to part of functions out of work,and user can participate in eliminating faults.
C=Not urgent,do not affect normal operation, and user can not participate in eliminating faults.
Table 9-1 List of faults
Fault
Message (description) Scenario Level Solution Parameter interpretation
No.
1 Drawer not in position Any A Push drawer in position ---
Protective cover not Close the protective
2 Any A ---
closed cover
1 Replace the
Cuvette tray
2 Tighten the
Experiment A Cuvette belt and ---
skip the vacancy
Unable to grab new 3. Click to eliminate
5
cup fault.
1 Replace the
Cuvette tray
Startup C 2 Tighten the
Cuvette belt and
skip the vacancy
Startup,
experiment C
completion
Empty the waste fluid
6 Waste fluid bottle full Experiment B ---
bottle
Experiment
preparation, A
shutdown
Startup,
experiment C
completion
After suspend,fill
7 Cleaning bottle empty Experiment B ---
cleanser
Experiment
preparation, A
shutdown
1. Reagent tube tag No.
9 Reagent shortage Experiment B Add reagent
2. -1
111
Fault
No.
3. Item No. of the
current experiment
1. Diluent tube tag No.
2. -1
10 Diluent shortage Experiment B Add diluent
3. Item No. of the
current experiment
1. Channel No.
2. Tube tag No. of the
Catcher cup capture
11 Experiment C Check the catcher current experiment
fault
3. Item No. of the
current experiment
Startup, 1. Channel No.
C
shutdown 2. Tube tag No. of the
current experiment
Catcher cup placement Experiment 3. Item No. of the
12 Check the catcher
fault preparation, current experiment
A
catcher test, 4. If it is not an
experiment experiment, all three
parameters are -1
Experiment,
1. Probe cleanser tube
test C
Probe cleanser tag No.
13 completion Add Probe cleanser
shortage
1: Probe cleanser tube
Shutdown A
tag No. 2, 3: -1
2. Reserved
Experiment C current experiment
4. Item No. of the
21 Blood plasma shortage Blood plasma shortage
current experiment
1. Reserved
Calibrate
A 2. Tube tag No. of the
pre-dilution
current experiment
Serious fault, please
shut down the
Z1 motor unable to instrument immediately
22 Any S ---
reset and contact the
customer service
personnel
shut down the
Z2 motor unable to instrument immediately
23 Any S ---
customer service
personnel
1Remove all foreign
matter in the preheating
area and restart the
25 Optical channel fault Startup C ---
instrument
2Contact the customer
service
shut down the
X motor unable to instrument immediately
26 Any S ---
customer service
personnel
27 Y motor unable to Any S Serious fault, please ---
112
Fault
No.
reset shut down the
instrument immediately
and contact the
customer service
personnel
Try to manually
eliminate the fault and
then click
‗Troubleshooting‘, or
CX motor unable to
28 Any A shut down the ---
reset
and contact the
customer service
personnel
Try to manually
then click
CY motor unable to
reset
and contact the
customer service
personnel
Try to manually
then click
CZ motor unable to
reset
and contact the
customer service
personnel
1. Reserved
Remove the dropped
31 Catcher cup drop fault Experiment A current experiment
cup
3. Item No. of the
current experiment
It is impossible to
conduct new optical
No optical channel experiment. Please
32 ---
available complete the current
experiment and restart
the instrument.
It is impossible to
conduct new magnetic
No magnetic bead bead experiment.
33 1.
channel available B Please complete the
Experiment
current experiment and
restart the instrument.
It is impossible to
conduct new optical
No optical preheating experiment. Please
34 1.
channel available complete the current
the instrument.
No magnetic bead It is impossible to
35 1.
preheating channel conduct new magnetic
113
Fault
No.
available bead experiment.
Please complete the
Check the channel for
Experiment
36 Channel fault foreign matter and ---
preparation
clean it if any
shut down the
P1 motor unable to instrument immediately
37 Any A ---
customer service
personnel
Replace the cleanser
Cleanser nearly
38 Experiment S bucket and click ―Fault ---
depleted
removed‖
Diluent shortage
Calibrate
39 during pre-dilution C Add diluent Diluent tube tag No.
pre-dilution
calibration
1. Reserved
Insert the test tube in
Test tube holder not in 2. Test tube holder No.
40 Experiment A the proper position
position of the current
upon new experiment
experiment
1Remove all foreign
matter in the preheating
Immuno-turbidimetry area and restart the
41 Startup A ---
channel fault instrument
service
1Remove all foreign
matter in the
Chromogenic
preheating area and
42 substrate method Startup C ---
restart the instrument
channel fault
service
It is impossible to
conduct new
No immuno-turbidimetry
43 immuno-turbidimetry Experiment C experiment. Please ---
channel available complete the current
the instrument.
It is impossible to
conduct new
No chromogenic chromogenic substrate
44 substrate method Experiment B method experiment. ---
channel available Please complete the
It is impossible to
conduct new
No
immuno-turbidimetry
immuno-turbidimetry
45 Experiment B experiment. Please ---
preheating channel
complete the current
available
the instrument.
46 No chromogenic Experiment B It is impossible to ---
114
Fault
No.
substrate method conduct new
preheating channel chromogenic substrate
available method experiment.
Please complete the
1 Restart t he
Card reader unable to instrument
47 Startup B ---
connect 2 Contact the
customer service
1 Restart the host 30
seconds after
Magnetic bead
power-off of the
48 measuring meter Startup C ---
host
unable to connect
2 Contact the
customer service
1 Restart the host 30
seconds after
Optical receiver power-off of the
49 Startup S ---
unable to connect host
2 Contact the
customer service
1 Try to clean up
pre-heating area
Part of optical manually and
50 channels need Startup C restart the
calibration instrument.
2 Contact the
customer service
1 Try to clean up Adjust of optic
pre-heating area transmission gain，calibrate
Part of
manually and optical channels
Immuno-Turbidimetric
51 Startup C restart the automatically.
method channels need
instrument.
calibration
2 Contact the
customer service
Please add probe 1.probe cleanser tube
cleanser position
52 Lack of probe cleanser Experiment C immediately ， New software: may
otherwise new test without parameter
will not start.
Liquid level 1.=1sample liquid board
board(No.)reset =2 reagent liquid board
failure, click ―fault =3 both failure
handling‖ then
Liquid level board device will try to New software：
53 Experiment A
reset failure reset again, if still 1.No. of PCBA
failure, please
reset instrument or
contact the
customer service
Rack be pushed too Pull out and put in
54 Any B
quickly slowly
Startup / Clean up cuvette
55 Cuvette box is full A
Experiment box
56 XXX lack of reagent Experiment B Add reagent
115
9.3 Common faults and the solutions

9.3.1 Startup impossible
1. Possible causes:
a) Power line fails.
b) Power switch fails.
c) Protective tube is burnt.
d) Power board is damaged.
e) Network setting is incorrect.
2. Solutions to the fault:
a) Check whether the power input of the instrument is proper.
b) Check whether the power switch and wiring of the instrument are proper.
Replace any failing element.
c) Check whether the power board output of the instrument is proper. Replace the
power board if it fails.
d) Reset the IP and subnet mask of the network card.
9.3.2 Self checking abnormal upon startup
1. Possible causes:
a) CAN communication abnormal.
b) Board fails.
c) Motor motion abnormal
d) Sensor testing fault
a) Check whether the board nodes of the instrument are proper. Use the tool
software to read the nodes and check whether any of them is missing.
b) Check whether the connection between the boards of the instrument is proper.
c) Check whether the motor works proper and whether it is jammed.
d) Check whether the sensor and blocking piece of the instrument are proper.
9.3.3 Heating abnormal in preheating area
1. Possible causes:
a) The indicated temperature is too different from the actual temperature.
b) The heater is damaged and heating is impossible.
c) Probe temperature controller is damaged.
a) Calibrate the indicated temperature and actual temperature and reset the actual
temperature value.
b) Replace the thermometer.
c) Replace the heater.
116
d) Replace the probe temperature controller.

9.3.4 Abnormal heating of reagent probe
1. Possible causes:
a) The indicated temperature is too different from the actual temperature.
b) The heating wire of the reagent probe heating rod is broken.
c) Reagent probe temperature controller is damaged.
a) Calibrate the indicated temperature and actual temperature and reset the actual
temperature value.
b) Replace the thermometer.
c) Replace the reagent probe heating rod.
d) Replace the reagent probe temperature controller.
9.3.5 Cooling anomaly in cold batch
1. Possible causes:
a) Set target temperature is too high or too low.
b) Cold batch Peltier board DC12V input power fails.
c) Cold batch temperature controller fails.
d) Cooling element fails.
e) Exhaust fan fails.
a) Reset the cold batch target temperature by the software.
b) Replace the failing power board and connect the wire correctly.
c) Replace the failing temperature controller.
d) Replace the Peltier board.
e) Replace the exhaust fan and connect the wire correctly.
9.3.6 Waste fluid discharge anomaly
1. Possible causes:
a) The waste fluid discharge port of the rinse tank is clogged.
b) The rubber tube from rinse tank to peristaltic pump inlet, from peristaltic pump
outlet to socket waste fluid joint or from socket waste fluid joint to waste fluid
bottle is clogged or bent.
c) Peristaltic pump does not rotate.
d) Peristaltic pump tube is rupture or the tube is not pressed tight when the pump
rotates.
a) Clean the foreign matter in the rinse tank.
b) Check the tube connections.
c) Check the peristaltic pump.
117
d) Replace the ruptured peristaltic pump tube.

9.3.7 Injection effluent anomaly
1. Possible causes:
a) Exterior cleanser is in shortage.
b) The tube from the cleanser to the socket is ruptured or is not securely connected.
c) In the instrument, the tube from the socket cleanser joint to solenoid valve, from
solenoid valve to injector, from solenoid valve to double-probe is not tightly
sealed or is ruptured or leaking.
d) Solenoid valve connection is abnormal or solenoid valve is damaged.
e) Sample probe or reagent probe is clogged.
f) The tube from the solenoid valve to the injector is disconnected.
g) Injector is leaking or jammed.
a) Replenish cleanser timely.
b) Check the exterior tube connections.
c) Check the interior joints and tube connections.
d) Check whether the solenoid valve wire is proper.
e) Replace the failing solenoid valve.
f) Use a tool to unclog the sample probe and reagent probe.
g) Replace the failing injector.
9.3.8 Liquid level detection anomaly
1. Possible causes:
a) Instrument ground wire is in poor condition or there is great interference.
b) Liquid level measurement wiring fails.
c) The set liquid level measurement sensitivity parameter is improper.
d) Level gauge fails.
e) Tube sealing is in poor condition or the probes are leaking.
a) Check the power input of the instrument.
b) Check the instrument wire connection.
c) Replace the failing board.
d) Reconnect the tube.
9.3.9 Inability to grab new cup
1. Possible causes:
a) Cuvette absent in Cuvette tray or cup feeder channel
b) Cup jammed in cup feeder channel or slot
c) Cuvette is damaged and impossible to capture.
118
d) The set coordinates for cup feeding and cup capture are incorrect.
e) The set coordinates for the cup capture position are incorrect.
f) Grabber capture fault fails.
a) Add or replace Cuvettes and pull in the turnplate belt.
b) Clean the damaged Cuvettes in the cup feeder channel or slot.
c) Adjust the coordinates of the cup feeder channel and grabber.
d) Replace the grabber.
9.3.10 Grabber capture fault
1. Possible causes:
a) The set coordinates for the cup capture position are incorrect.
b) The grabber is worn and is impossible to open.
c) Grabber spring is damaged.
d) Grabber sensor fails.
e) Cuvette is damaged.
a) Adjust the coordinates of the grabber.
b) Replace the grabber.
c) Remove the damaged Cuvettes.
9.3.11 Grabber release fault
1. Possible causes:
a) The set coordinates for the cup capture position are incorrect.
b) The grabber is worn and is impossible to open.
c) Grabber spring is damaged.
d) Grabber magnet fails.
e) Grabber sensor fails.
f) Grabber magnet input voltage fails.
g) There is foreign matter in the Cuvette channel.
a) Adjust the coordinates of the grabber.
b) Replace the grabber.
c) Check the magnet power supply line.
d) Remove the foreign matter in the Cuvette channel.
9.3.12 Card reading anomaly
1. Possible causes:
a) Card is incorrect, invalid or outdated.
119
b) Card is not placed properly upon card reading.

c) Card reader fails.
a) Use correct card and place it correctly.
b) Replace the card reader.
9.3.13 Optical channel anomaly
1. Possible causes:
a) There is foreign matter in the optical channel.
b) Optical board is damaged.
a) Clean the optical channel.
b) Replace the optical board.
9.3.14 Steel ball jumping out of the instrument
1. Possible causes:
a) Reagent probe or sample probe is in wrong position, which is the result of the
probe colliding with a cup during fluid release.
b) Capture position is incorrect, resulting in the fault.
a) Adjust the coordinates of the probe preheating area and adjust the positions of
the double probes.
b) Adjust the coordinates of the grabber.
9.3.15 Instrument values anomaly
1. Possible causes:
a) Heating of preheating area, heating of reagent probe or cooling cold batch fails.
b) Instrument setting is incorrect or the probe is jammed.
c) Level gauge does not work and it is impossible to extract sample or prick
erythrocyte.
d) Magnetic bead tester fails.
a) Find the fault of heating or cooling.
b) Inject fluid the through the tube, observe the water columns in the double probes
and find the hydraulic system fault.
c) Perform Liquid level check and find the fault of level gauge.
d) Redo air calibration and medium calibration for the magnetic bead test channel.
Replace the test strip or probe panel if the ratio is less than 10.
9.3.16 No steel ball or timeout anomaly
1. Possible causes:
a) No steel ball in Cuvette
120
b) Sample shortage
c) Reagent in shortage or outdated
d) Instrument setting is incorrect or the probe is jammed.
e) Level gauge does not work.
f) Magnetic bead tester fails.
a) Redo the experiment.
b) Replenish the sample.
c) Replenish or replace the reagent.
d) In the case of inaccurate setting, replace the relevant element. If a probe is
jammed, execute the immersion procedure or use a tool to unclog the probe. The
methods are shown in Section 10.2.3.
e) Perform Liquid level check and find the fault of level gauge.
f) Redo air calibration and medium calibration for the magnetic bead test channel.
Replace the test strip or probe panel if the ratio is less than 10.
121
122
Chapter 10 Active Maintenance

This chapter elaborates the content and frequency of auto coagulation analyzer maintenance and the
parts to be regularly replaced.
Attention
 Only use Precil specified cuvette, cleaning and reagents.

 Do not mix the new container of reagent with the residue in the replaced container to
ensure accurate measurement.
 Do not reuse the one-off products.
Caution
 Performing unauthorized maintenance procedures can damage your analyzer. Do not

perform maintenance procedures that are not described in this chapter.
 In case of problems not specified in this manual, contact Precil customer service
department or your local distributor for assistance.
 Only Precil –supplied parts can be used for maintenance. For any questions, contact
Precil customer service department or your local distributor.
 Exercise caution to avoid contact with the sharp sample probe when performing
maintenance.
▪ Precil does not claim the validity of the listed chemicals in infection control. For effective
control of infection, please consult the Infection Prevention Department of the hospital or
the epidemic professionals.
Warning
▪ Do not use any decontamination or cleanser which could cause a HAZARD as a result of a
reaction with parts of the equipment or with material contained in it. If there is any doubt
about the compatibility of the decontamination or cleanser with parts of the equipment or
with material contained in it, please contact our customer service department or the local
distributor.
• If you accidentally spill hazardous material (for example, reagents) on the instrument,
clean and sterilize the instrument with specified disinfectant. Wear proper personal
protective equipment (e.g. gloves, lab coat, etc.) and follow safe laboratory procedures
when handling them and the contacted areas in the laboratory.
123
Caution
▪ The user shall perform daily cleaning and sterilization to the cover of the analyzer. Use
the specified materials to sterilize the equipment only. For any damage to the instrument
or other accidents caused by using materials other than specified, Precil will not provide
any warranty.
▪ The cleaning may damage the system to some extent. It is recommended to perform the
cleaning only when necessary according to your laboratory protocol.
10.1 Tools and consumables

 Tools
Table 10-1 List of tools
S/N Tool name Quantity Remarks
1 Cross screwdriver 1 Nr.
2 Straight screwdriver 1 Nr.
3 Socket head wrench 1 set
4 Diagonal pliers 1 Nr.
5 Tweezers 1 Nr.
6 Blade 1
7 Acupuncture needle 1
 Consumables
Table 10-2 List of consumables
S/N Tool name Quantity Remarks
1 Gloves 2-3 Nr.
2 Tissue 1 roll
3 Cable tie 8 Nr.
4 Cotton swab 1 pack
5 Cleaning cloth 3 pcs.
6 Lubricating grease 1 tin
7 Ionized water 1 bottle
8 1ml injector 1 Nr. C3100
8 500μL injector 1 Nr. C3510/C3200
Test repeatability and carried
9 Normal quality control 4 Nr.
contamination
Test repeatability and carried
10 Abnormal quality control 4 Nr.
contamination
10.2 Maintenance plan

10.2.1 Maintenance frequency
Maintenance includes daily maintenance, weekly maintenance, monthly maintenance,
unscheduled maintenance and yearly maintenance, where daily maintenance, weekly
maintenance and monthly maintenance can be done by the customers themselves.
10.2.2 Maintenance tasks
a) Daily maintenance:
Check/clean sample/reagent probe;
124
Check cleanser/waste fluid connections;

Check printer/printing paper.
b) Weekly maintenance:
Clean exterior of sample probe;
Clean exterior of reagent probe;
Clean the instrument;
Clean the Cuvette tray.
c) Monthly maintenance:
Check rinse tank;
Check waste fluid floater.
d) Yearly maintenance:
Lubricate the moving parts.
Check crystallization in solenoid valve
e) Unscheduled maintenance:
Clean sample probe;
Clean reagent probe;
Replace sample probe;
Replace reagent probe;
Note:
1) During cleaning, wear protective gloves. After cleaning, wash your hands with
detergent or disinfectant.
Warning
 The sample probe and reagent probe have sharp tips that may be contaminated by a
blood sample, quality control material, or calibrator and become biologically infectious.
Therefore, do not touch the probes.
 Wear rubber gloves when disposing waste liquid. Use a disinfectant to clean your
hands after the operation.
 Dispose waste liquid in compliance with your local medical waste and infectious
waste disposal regulations.
125
 Checklist of maintenance points

Hospital: Department: Department head: Instrument model: Serial number: Department tel.:
Frequency Maintenance task January February March April May June July August September October November December
Clean reagent probe
Unscheduled Clean sample probe
maintenance Replace sample probe
Replace reagent probe
Monthly Check waste fluid tank floater
maintenance Check rinse tank
Check crystallization in solenoid
Yearly
valve
maintenance
Lubricate the moving parts
10.2.3 Steps
Warning
▪ Please cautiously protect yourself from injury by the probes.
Attention
▪ Maintenance can only be performed by trained examination specialists or trained doctor,

nurse or laboratorian.
126
▪ Wear gloves and work clothes during operation.

▪ Do not discard the cleaning materials randomly, but dispose of them in accordance with
the applicable regulations
■ Daily maintenance
Tools and
Items Maintenance tasks Steps Remarks
consumables
(1) Click the ―Maintenance‖ button to access the menu
and select the ―Observe water column in double
probes‖ button.
(2) Observe the effluent from the sample/reagent probe. Cleaning
Check whether the water from the interior of the cloth
Check/clean ● Clean sample probe Deionized
sample/reagent probe is continuous, whether the
sample/reagent probe ● Clean reagent probe water
water flow direction is consistent with the
Acupuncture
sample/reagent probe and whether water flow rate is needle
normal.
If anything is abnormal, clean the sample probe. The
methods are shown in ―Unscheduled maintenance‖.
(1) Check whether the clean fluid and waste fluid tubes
● Check cleanser connections of the coagulation analyzer are correctly connected
Check cleanser/waste
● Check waste fluid to the indicator on the panel; /
fluid connections
connections (2) Make sure the fluid tubes are unblocked, unbent,
undistorted and not leaking.
In every day, check the printer power indicator lamp and
Check printer/printing ● Printer/printing paper
make sure the indicator lamp is correct and the printer
paper
has ample paper.
■ Weekly maintenance
127
Tools and
consumables
(1) Make sure the instrument power supply is
severed;
(2) Raise the sample probe and reagent probe to the
highest point;
(3) Pull the probe to the end of the guide rail; Do not waggle
● Clean exterior of sample
Clean exterior of sample (4) Use a piece of cloth soaked with deionized the sample/reagent
probe Gauze
probe/reagent probe; water to scrub the exterior of the sample probe probe during
● Clean exterior of reagent Deionized water
and reagent probe, particularly the probe point, cleaning, so as to
probe
until the exterior of the probes is smooth and avoid coordinate
stainless; offset.
(5) After the cleaning, close the cover plate and
connect the power supply. The instrument will
automatically reset.
(1) Make sure the instrument power supply is
● Clean test tube holder
severed;
Clean the instrument ● Clean reagent panel
(2) Use clean gauze to scrub the panel. If necessary, Gauze
● Clean reaction panel
dip small amount of clean water or disinfectant
on the gauze before scrubbing.
● Clean debris in Cuvette
Clean debris in Cuvette tray Cleaning cloth
tray (1) Use rag to clean the debris in the Cuvette tray
■ Monthly maintenance
Tools and
consumables
Check the rinse tank for foreign matter and clean any foreign Attention: wear gloves in
Check rinse tank ● Clean rinse tank Tweezers, gauze
matter with a proper tool, to prevent clogging in the tubes. this work
Attention:
When cleaning the floater
(1) If waste fluid bucket is in use, open the bucket cover and in waste fluid bucket, the
● Check the floater
check the waste fluid floater for contaminant. Keep the Disinfectant instrument must be shut
Check waste fluid floater in waste fluid
float soaked in liquid disinfectant for over 10 minutes to down, so as to prevent
bucket
clean it. waste fluid discharge
caused by dormant mode
of the instrument.
128
■ Yearly maintenance
Tools and
consumables
(1) Check the X optical axis, Y optical axis, Z screw rod
and linear guide rail in the double-probe travel
assembly of the instrument and lubricate them with
small amount of lubricating grease.
Lubricating
Lubricate the moving (2) Check the Y linear guide rail and Z linear guide rail
● Check the moving parts grease
parts in the catcher travel mechanism and lubricate them
with small amount of lubricating grease.
(3) Check the linear guide rail in the horizontal cup
feeder assembly and lubricate it.
(4) Check the screw rod in the injector and lubricate it.
Check crystallization in Check crystallization in solenoid Check wheather there are crystallization in solenoid valve,
Gauze
solenoid valve valve use gauze to clean
■ Unscheduled maintenance
Tools and
consumables
Attention! Please
(1) If the water at the probe point is abnormal, use an cautiously protect yourself
Clean sample Acupuncture
● Clean sample/reagent probe acupuncture probe to pierce through the probe point from injury by the probes.
probe/reagent probe probe
and clean the foreign matter in the syringe. Please do not damage the
sample/reagent probe.
(1) If the sample probe/reagent probe is damaged or
Replace sample
● Sample probe/reagent probe bent, please the customer service to replace it.
probe/reagent probe
129
10.3 Status checking

Check whether the instrument is in normal state. Perform the status checking listed in the
table below during every visit:
10.4 Regular replacement
During the visit, replace the parts based on their service life. The instrument statistics
screen shows the vulnerable parts and their service life.
Table 10-1 List of vulnerable parts
Service
S/N Description FRU code Position Remarks
life
1
2
130
Chapter 11 Attached Lists

11.1 FRU list
11.1.1 List of spare parts for board maintenance
11.1.2 List of spare parts for valve maintenance
11.1.3 List of spare parts for rubber tube and joint maintenance
11.1.4 List of spare parts for component maintenance
11.1.5 List of spare parts for wires maintenance
11.2 Information on hydraulic system diagram
11.2.1 Table of rubber tube models
11.2.2 Table of joints
11.2.3 Table of other materials
11.2.4 Table of valves
The valve codes on the hydraulic system diagrams and the corresponding valve models are
listed in the tables below:
C3510/C3200
Graphical
S/N FRU code Material description
expression
1 SV1 082-001906-00 Two-position two-way solenoid valve
3 SV3 801-3201-00002-00 Two-way miniature solenoid valve (short wire)
4 SV4 801-3201-00003-00 Three-way miniature solenoid valve (short wire)
5 SV5 801-3201-00002-00 Two-way miniature solenoid valve (short wire)
6 LP1 0040-10-32344 Diaphragm pump
7 LP2 115-021018-00 Peristaltic pump
C3100
Graphical
S/N FRU code Material description
expression
1 SV1 082-001646-00 Two-position three-way solenoid valve
4 LP1 115-021018-00 Peristaltic pump
131

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AUTO COAGULATION ANALYZER

After-sales Service Department

Version Content of revision Person Time of revision

1.0 Service Manual Rev. 1 Wang Haoyu 2015.10.19

Revise service manual according to current instrument

CHAPTER 8 ASSEMBLY REPLACEMENT ....................................................................................................... 67

Chapter 1 Manual Overview

1.1 Scope of application

Read the attached document

Alert of high temperature

Only for in vitro diagnosis

On (power: connection to the mains)

Off (power: disconnection to the mains)

The following definition of the WEEE label applies to

Chapter 2 Product Specification

Figure 2-1 N-G voltage test method

2.3 Technical Parameters

APTT shall be ≤10%. Immuno-TurbidimetricMethod: that from D-Dimer to FDP shall be

2.3.12 Continuous operating time

2.3.13 Basic functions

2.4 Safety Category

▪ It is the manufacturer‘s responsibility to provide equipment electromagnetic

Chapter 3 Software System

Figure 3-1 Unzipping path for technical files

The interface of the online UpdateTool is shown in Figure 3-2.

Figure 3-2 Online update tool interface

Remark: difference between Merge update and Cover update:

 Merge update is pre-set of default upgrade option.

3.3 PC software installation and update

Figure 3-3 Access network and sharing center

Figure 3-4 Interface for changing adapter setting

Figure 3-5 Set local connection

Figure 3-6 Interface for changing IP address

Figure 3-7 Software basic parameters debugging interface

3.6.2 Catcher coordinates

2. Click ‗CAL‘ button.

Figure 3-8 Temperature control debugging interface

Figure 3-9Maintenance interface

Figure 3-10 Self-test interface

Figure 3-11 Liquid level test

Figure 3-12 Calibration interface

Figure 3-13 Calibration step 1

Figure 3-14 Calibration step 2

Figure 3-15 Calibration step 3

Chapter 4 Operating Principles

4.1 Dual bead magnetic method

Figure 4-1 schematic diagram of double magnetic circuit bead method

4.2 Immuno-turbidimetric method

Figure 4-2 Light path diagram for Immuno-turbidimetric method

Chapter 5 Hydraulic System

5.2 Incubation and measurement time

5.3 Hydraulic system temperature control

5.4 Reagent consumption

5.5 Description and functions of hydraulic system elements

■ Function: it is same as two-way self-made valve. Compared with two-way self-made

Figure 5-1 Probes for coagulation analyzer

C19 C16 C17

Figure 5-2 C3100 hydraulic system diagram

5.6.2 C3510/C3200 hydraulic system