MCQ FOR PHARMACEUTICAL ANALYSIS-I (BP102T)

1. _________ is used as primary standard for standardization of NaOH.

A. Sodium carbonate B. Sodium bicarbonate
C. Sodium chloride D. Potassium dichromate

2. Phenolphthalein has a pH range of

A. 6.8 – 8.4 B. 1.2 – 2.8 C. 8.3 – 11.0 D. 4.2 – 6.3

3. Errors arise due to the individual analyst is responsible for them

A. Method error B. Instrumental error
C. Personal error D. Random error

4. Solution of known concentration is called

A. Standard solution B. Concentration
C. Solution D. Concentrated solution

5. Acid is a substance which dissociates in water to produce hydrogen ions

A. Arrhenius theory B. Lewis theory
C. Bronsted theory D. Lowry theory

6. The colour change is due to ionisation of the acid base indicators

A. Ostwald theory B. Chromophore theory
C. Quinonoid theory D. Resonance theory

7. Substance that can be reversibly oxidized or reduced, having different

distinct colour in the individual oxidized and reduced forms
A. Redox indicators B. Redox potential
C. Redox number D. Redox state

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8. 20 gm NaOH in 500 ml =
A. 0.1 N B. 1 N C. 0.5 M D. 0.05 N

9. In oxidation reduction change in __________ of reacting element takes place.

A. Volume B. pH C. Absorbance D. Valency

10. __________ is not an amphiprotic solvent.

A. Water B. Alcohol C. Acetic acid D. None

11. __________ is not type of co-precipitation

A. Surface adsorption B. Occlusion
C. Crystallization D. Mechanical entrapment

12. Oxidation-Reduction titration is also known as

A. Complexometric titration B. Gravimetric titration
C. Redox titration D. Gasometric titration

13. Potentiometry is type of ________ method.

A. Qualitative B. Chromatographic C. Classical D. Electro-chemical

14. ________ is chelating agent

A. Salicylic acid B. EDTA C. Benzoic acid D. Glycerol

15. __________ used as titrant in non-aqueous titration.

A. EDTA B. Perchloric acid C. Sodium nitrite D. Silver nitrite

16. Conductometry used for the measurement of

A. Conductivity B. Potential C. Temperature D. Concentration

17. Standardization of Iodine is carried out using ________________

A. Sodium thiosulphate B. Oxalic acid C. Perchloric acid D. None of these

18. The degree of agreement between measured value and accepted true
value is _____________
A. Precision B. Accuracy C. Range D. Average deviation

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19. Behavior of indicator is explained by ___________ theory.
A. Chromospheres B. Ionic C. Color D. Resonance

20. pH is defined as
A. –log [OH–] B. –log [H+] C. pH + pOH D. log pOH

21. The titration carries out between KCl and AgNO3 is termed
as_________titration.
A. Oxidation-Reduction B. Precipitation
C. Acid-Base D. None of these

22. 8.5 ml HCl in 1 litre = __________________

A. 0.1 M B. 0.1 N C. Both A and B D. 0.5 M

23. The number of gm-equivalent of the solute per liter of solution is known as
A. Normality B. Molarity C. Molality D. Mole fraction

24. The number of gm-mole of the solute per liter of solution is known as
A. Normality B. Molarity C. Molality D. Mole fraction

25. The number of gm-mole of the solute per kg of solution is known as

A. Normality B. Molarity C. Molality D. Mole fraction

26. The ratio of number of gm-mole of a component to total number of gm-

mole in mixture or solution is known as
A. Normality B. Molarity C. Molality D. Mole fraction

27. The number of gms of solute per 100 ml of solvent is known as

A. Normality B. % weight by volume C. Molality D. Mole fraction

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28. The chemical reagent from which solution of required concentration can
be prepared is
A. Secondary standard B. Dilute solution
C. Concentrated solution D. Primary standard

29. In strong acid – strong base titration, the pH of mixture at initial stage is
find out by formula
A. PH=-log[H+] B. [H+]=NaVa-NbVb/(Va + Vb)
C. POH = -log[OH-l D. [OH-] = NbVb – NaVa/ (Va+ Vb)

30. In Standard solution which of the following is accurately known ,

A. Normality, strength or % of chemicals B. Volume
C. Pressure D. Temperature

31. The process of adding known concentration until it complete the reaction
with known volume is called as
A. Titrant B. Analysis C. Titration D. Titrend

32. In titration end point can be determined by change in colour by

A. Measuring cylinder B. Burette C. Instrument D. Indicator

33. The Quantity of chemical in each liter of solution is known as

A. Normality B. Strength C. Molecular Weight D. Equivalence Weight

34. Exactly required concentration can be prepared from chemical reagent is

called as
A. Primary standard B. Secondary standard
C. Both A & B D. None of this

35. An example of a primary standard substance is

A. FeS04 B. Na2C03 C. NH4OH D. NaOH

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36. A normal solution is one which contains
A. Gram molecular weight/L B. Gram equivalence weight/L
C. Gram formula weight/L D. Gram molecular weight/Kg

37. A buffer solution can be formed by dissolving equal moles of

A. HF and NaF B. HCl and NaOH
C. KBr and Na3P04 D. CH3COOH and NaCl

38. The conjugate acid of H2ASO4- is

A. H3O+ B. AS04+ C. H3ASO4 D. H2ASO4+

39. Which of the following indicators has a transition point closest to the
equivalence point for the titration of a weak acid by a strong base?
A. Orange IV B. Thymol blue C. Methyl orange D. Bromcresol green

40. A solution of known concentration is the definition of a

A. Buffer solution. B. Neutral solution.
C. Standard solution. D. Saturated solution.

41. Which of the following is the strongest Bronsted-Lowry base?

A. NH3 B. CO3 +2 C. HSO3 D. H2BO3

42. An Arrhenius acid is defined as a chemical species that

A. is a proton donor. B. is a proton acceptor.
C. Produces hydrogen ions in solution. D. Produces hydroxide ions in
solution.

43. Consider the following reaction: H3BO3 (aq) + HS- (aq) →H2BO3- (aq) + H2S
(aq) The order of Bronsted-Lowry acids and bases in this equation is
A. Acid, base, base, acid. B. Acid, base, acid, base.
C. Base, acid, acid, base. D. Base, acid, base, acid.

44. Which of the following indicators is yellow at a pH of 10.0?

A. Methyl red B. Phenol red C. Thymol blue D. Methyl violet

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45. Which of the following is a general property of bases?
A. Taste sour
B. Turns litmus red
C. Conduct electric current in solution
D. Concentration of H3O+ is greater than concentration of OH

46. The conjugate base of an acid is produced by

A. Adding a proton to the acid.
B. Adding an electron to the acid.
C. Removing a proton from the acid
D. Removing an electron from the acid

47. A buffer solution may contain equal moles of

A. Weak acid and strong base.
B. Strong acid and strong base.
C. Weak acid and its conjugate base.
D. Strong acid and its conjugate base.

48. Which of the following are general properties of bases in aqueous

solution?
A. Feel slippery and increase H3O+
B. Turn litmus red and accept a proton
C. Conduct electricity and turn littmus blue
D. Feel slippery and react with Au to produce H2

49. Pure sodium hydrogen phthalate is used to standardize a solution of NaOH

for acid-base titration. What term is used to describe the sodium hydrogen
phthalate?
A. Titrant base B. Standard buffer
C. Equivalent base D. Primary standard

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50. An Arrhenius base is defined as a compound that
A. Accepts OH- in solution. B. Releases OH-in solution.
C. Accepts protons in solution. D. Donates protons in solution.

51. A Bronsted-Lowry acid is defined as a substance that

A. releases H+ (aq) B. releases OH-(aq)
C. accepts proton in solution D. donates proton in solution

52. A basic solution can be defined as one in which

A. [H3O+] is not present B. [H3O+] is equal to [OH-]
C. [H3O+] is less than [OH:] D. [H3O+] is greater than [OH-]

53. A chemical indicator in solution consists of

A. A weak acid and its conjugate acid.
B. A weak acid and its conjugate base.
C. A strong acid and its conjugate acid.
D. A strong acid and its conjugate base.

54. What do a chemical indicator and a buffer solution typically both contain?
A. A strong acid and its conjugate acid
B. A strong acid and its conjugate base
C. A weak acid and its conjugate acid.
D. A weak acid and its conjugate base.

55. When performing a titration experiment, the indicator must always have
A. distinct colour change at pH = 7.0.
B. The ability to change from colourless to pink,
C. A transition point that is close to the equivalence point.
D.An equivalence point that is close to the stoichiometric point.

56. Which of the following is not a good use for an acid-base titration curve?
A. to determine the concentration of the base
B. to select a suitable indicator for the titration
C. to determine whether the acid is strong or weak
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D. to select a suitable primary standard for the titration

57. Which of the following acids has the weakest conjugate base?
A. HIO3 B. HNO2 C. H3PO4 D.CH3COOH

58. Which of the followiing 1.0 M salt solutions will be acidic?

A. NaNO3 B.NaHCO3 C. NaHSO4 D. NaHPO4

59. The pH at which an indicator changes colour is known as its

A. Standard point. B. Transition point.
C. Equivalence point. D. Stoichiometric point.

60. A buffer solution can be prepared by dissolving equal moles of A.

A weak base and a strong base.
B. A weak acid and its conjugate base.
C. A strong base and its conjugate acid.
D. A strong acid and its conjugate base.

61. A Bronsted-Lowry acid is defined as a substance that

A. releases H+ B. releases OH (aq)
C. accepts a proton D. donates a proton

62. A chemical indicator in solution consists of

A. A weak acid and its conjugate acid.
B. A weak acid and its conjugate base.
C. A strong acid and its conjugate acid.
D. A strong acid and its conjugate base.

63. Which is the conjugate base of H2PO4-?

A. OH B. PO4 -3 C. HPO4-2 D. H3PO4

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64. What do a chemical indicator and a buffer solution typically both contain?
A. a strong acid and its conjugate acid
B. a strong add and its conjugate base
C. a weak add and its conjugate acid
D. a weak add and its conjugate base

65. Non aqueous titration is carried out for

A. Water insoluble drug B. Weakly acidic drug
C. Weakly basic drug D. All the above

66. Which one is aprotic solvent?

A. Chloroform B. Benzene C. Both D. None

67. Prototogenic solvent is

A. Sulphuric acid B. Hydrochloric acid C. Nitric acid D. All the above

68. Protophilic solvent is

A. Sodium hydroxide B. Lithium methoxide
C. Sodium methoxide D. All

69. Which one is useful in non aqueous titration?

A. Levelling solvent B. Differentiating solvent C. Both D. None

70. Water may interfere with non aqueous titration by

A. Acting as Strong acid than the weakly acidic drug
B. Acting as Strong base than the weakly basic drug
C. Both D. None

71. In the preparation of the 0.1 (N) perchloric acid amount of acetic
anhydride should be optimum. Why?
A. If added more quantity then amine drug may acetylate and causes
erroneous result
B. If added less quantity then water may interfere with the titration
C. Formation of acetyl perchlorate can cause explosion
D. All

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72. Perchloric acid can be standardized by using
A. Benzoic acid B. Oxalic acid
C. Potassium hydrogen phthalate D. Tartaric add

73. Which one is used as indicator for non aqueous titration?

A. Crystal violet B. Thymol blue C. Oracet blue B D. All

74. Potentiometric titration is used in nonaqueous titration, when

A. Colour of the solution is high
B. Colour of the solution is low
C. Both
D. None

75. Sodium Acetate, NaC2H302, is a water soluble salt that forms an aqueous
solution that is
A. Acidic B. Basic C. Neutral D. None

76. All the compounds given can be assayed by NAT except

A. Piperazine citrate B. Diethylcarbamazine
C. Niclosamide D. Metrifonate

77. Example for amphiprotic solvent

A. Methanol B. Glacial acetic add C. Water D. All of the above

78. Nature of amphiprotic solvent P) Acts as a base in strong acidic

environment Q) Acts as a acid in strong basic environment R) Acts as a base
in weak basic environment S) Neutral in nature
A. P,R B. P,S C. Q,R D. P,Q

79. Principle involved in non aqueous titration of weakly basic drug

A. Proton donation from acetic acid to drug
B. Proton donation from onium ion to acetic acid
C. Proton donation from perchloric acid to acetic acid
D. All of the above

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80. AgCl has to be filtered off before titration using
A. Modified Volhard’s method B. Mohr’s method
C. Fajan’s method D. None of the above

81. The adsorption indicator in Fajan’s method has to be;

A. Of the same charge as titrant B. Of the opposite charge as titrant
C. Has no charge. D. None of above

82. Titrations based on the use of silver nitrate are called

A. Argentometric B. Complexometric
C. Amperometric D. Conductometric

83. Adsorption indicators are used in

A. Fajan’s method B. Mohr’s method C. Volhard’s method D. All

84. Which method follows the principle of formation of coloured precipitate

at the end point?
A. Fajan’s method B. Volhard’s method
C. Modified Volhard’s metlrod D. All

85. In Which method, ferric ammonium sulphate is used as an indicator?

A. Fajan s method B. Mohr’s method C. Volhard’s method D. None

86. Potassium chromate (K2CrO4) is used as an indicator in

A. Mohr’s method B. Volhard’s method C. Fajan’s method D. None

87. Which of the following is an example of adsorption indicators?

A. Eosin B. Phenolphthalein C. Methyl red D. Ninhydrin

88. Which method is used in water analysis

A. Fajan’s method B. Mohr’s method C. Volhard’s method D. None

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 89. EDTA has_____binding sites and therefore it is also called as multidentate
ligand.
A. Six B. Five C. Four D. Seven

90. _______agent forms the complex with the metal ions that are not required
in the estimation
A. Masking B. Demasking C. Both D. None

91. The endpoint for an EDTA titration is usually found by using a indicator
A. Metallochromic B. Redox C. Acid base D. All

92. Which one is polydentale

A. Ethylene diamine B. EDTA C. Both D. None

93. Which one is sequestering agent?

A. Salicylaldoxime B. 8-hydroxy quinolilne C. EDTA D. All

94. The complexometric titration where EDTA is used carried out at basic pH.
Why?
A. For the stability of complex formed B. Reaction rate is optimum in basic pH
C. There is less number of side reaction D. All

95. Which is used as masking agent for lead in complexometrric titration?

A. Sod. Sulphide B. Oxalate C. Thiocetanaide D. All

96. Dimercaprol is used as complexing agent for complexion of

A. Mercury B. Arsenic C. Lead D. All

97. Indicator used in complexometric titration is

A. Erichrome black T B. E- Xylenolorange C. Mordant black II D. All

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98. Name the assay method for the drug calcium gluconate
A. Non aq titration B. Acid base titaration
C. Complexometric D. lodometric

99. Number of rings observed in the tetravalent ion EDTA complex

A. 4 B. 5 C. 6 D. 3

100. Following are properties of good precipitate except:

A. Easily filtered and washed free of contamination.
B. Significant loss of the analyte occurs during filtration and washing.
C. Unreactive with constituents of the atmosphere.
D. both a and b

101. In ____________, analyte is separated from a solution of the sample as a

precipitate and is converted into a compound of known composition
A. Volatilization gravimetry B. Precipitation gravimetry
C. Electrogravimetry D. Precipitation point

102. ___________is the weight of analyte per unit weight of the precipitate.
A. Gravimetric factor B. Precipitation factor
C. Electrogravimetry factor D. None of the above

103. Digestion of precipitate also known as

A. Ageing B. Gravimetric factor
C. Co – precipitation D. Ostwald ripening

104. SI unit of conductance is

A. Mho B. Seimens C. Volt D. None of the above

105. Current used for measured of conductance is

A. A.C B. D.C C. Both A and B D. None of these

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106. Hydrogen and Hydroxyl ions are potent_____
A. Conductivity B. Molar conductance
C. Conductance Enhancers D. None of the above

107. _______is the product of specific conductance and volume of electrolyte

A. Conductivity B. Molar conductance
C. Conductance Enhancers D. None of the above

108. _____is the conductance offered by 1 cm^ of an electrolytic solution

A. Molar conductjince B. Conductance Enhancers
C. Specific conductance D. Specific Resistance

109. Potentiometry is an_____method of analysis

A. Spectroscopic B. Electrometric C. Analytical D. None of the above

110. Example for reference electrode except

A. Antimony electrode B. Silver-silver electrode
C. Calomel electrode D. None of the above

111. The indicator used in estimation of hardness of water by potentiometiy

A. PH B. PM C. Both a and b D. None of the above

112. Which of the following two are used reference electrodes in

polentiometry? P) Glass membrane Q) Hg-calomel R) Ag-silver chloride S) Ion
selective
A)P,Q B)P,S C)Q,R D)P,R

113. __________electrode is employed as a secondary reference electrode

A. Hydrogen electrode B. Droping Mercury Electrode
C. Calomel electrode D. None of the above

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114. Each electrochemical cell is composed of
A. Two half cells B. Half cells C. Both A and B D. None of the above

115. An electrode, whose electrode potential is well known and stable is a

A. Indicator electrode B. Reference electrode
C. Both A and B D. None of the above

116. In polarography, when limiting current is achieved, one of the following

process takes place. Choose that.
A-The rate of electron transfer just matches the rate of mass transfer
B. The rate of electron transfer is slower than the rate of mass transfer
C. The rate of electron transfer becomes independent of the rate of mass
transfer
D. The rate of electron transfer far exceeds the rate of mass transfer

117. Which of the following is used as indicator electrode in polarography?

A. Glass B. Dropping mercury C. Platinum D. Silver

118. For Qualitative analysis by polarography, characteristic parameter used

is
A, Diffusion current B. Half wave potential
C. Voltage D. None of the above

119. Limiting current is sum of diffusion current and

A. Residual current B. Faradic current
C. Migration current D .Additional current Ans.B

120. Gradual rising in current in polarography is called

A. Weak current B. Higher current
C. Migration Currerrt D.Residual current

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121. Reason for generation of migration current in polarogram is
A. Migration and diffusion of charged particles
B. Migration of charged particles
C. Diffusion of charged particle
D. None of the above

122. The D and L isomeric forms can be distinguished by

A. Polarimetry B. Refractometry C. Potentiometry D. Conductometry

123. Sodium vapor lamp used in Polar meter emit light of wavelength (in
Angstrom)
A. 5890 & 5896 B. 4368 & 4916 C. 5770 & 5791 D.5461 & 4368

124. Oxidation involves

A. loss of hydrogen B. loss of oxygen C. gain in hydrogen D. gain in
electrons

125. In a reaction between CuSO4(aq) and Zi(aq)

A. Zinc experiences an increase in the oxidation state
B. undergoes oxidation
C. Zinc undergoes oxidation
D. all of these

126. Oxidizing agents

A. are mostly non-metals B. are mostly metals
C. decrease in oxidation state D. are mostly transition metals

127. Upon oxidation of acidified potassium manganate (VII), the purple color
of Manganese
A. stays B. changes to pink C. becomes colorless D. becomes blue

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128. Hydrogen acts as a reducing agent,
A. by taking oxygen B. by giving electron
C. by taking hydrogen D. Both A and B

129. Reduction involves

A. loss of oxygen B. gain in hydrogen C gain in oxygen D. loss of electrons

130. Oxidizing agents does not include

A. potassium iodide B. potassium manganate
C. potassium dichromate D. bromine solutions

131. Hydrogen electrode can be used as

A. Indicator electrode B. Reference electrode
C. Secondary reference electrode D. Both A and b

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