Radiation Processing Industry - The Early Year

November 2022
1 Radiation Processing Industry: The Early Years

List of Abbreviations
AAMI Association for the Advancement of Medical Instrumentation

AECL Atomic Energy of Canada Ltd.
CEA Commissariat à l’Energie Atomique (France)
CPD Commercial Products Division
FAO Food and Agricultural Organisation of the United Nations
FDA Food and Drug Administration (USA)
ICGFI International Consultative Group on Food Irradiation
ICT Insulated Core Transformer
IFFIT International Facility for Food Irradiation Technology
IFIP International Project in the Field of Food Irradiation
IAEA International Atomic Energy Agency
iia International Irradiation Association
IMRP International Meeting on Radiation Processing
ISO International Organisation for Standardisation
MCi Million curies
MIT Massachusetts Institute of Technology
UK AEA United Kingdom Atomic Energy Authority
WHO World Health Organisation
November 2022
International Irradiation Association
Cover Photo: John Masefield (right) at the control console of the potato irradiator
Photo Credit: Getty Images - BET:516571460
Table of Contents
1 List of Abbreviations
5 In Tribute to John Masefield
7 Introduction
8 Fathers of The Radiation Processing Industry
8 John Masefield (1933-2022)
10 Roy Errington (1915-1996)
11 Arthur Charlesby (1915-1996)
12 Charles Artandi (1917-1980)
13 Paul Cooke (1924-2020)
14 Marsh Cleland (1926-2019)
15 Pierre Vidal (1910-2002)
16 Sam Nablo (1930 -2018)
17 Early Production of Cobalt-60
20 The First Commercial Gamma Irradiators
20 The Ethicon Irradiator
21 The First Multipurpose Gamma Irradiators
23 The First Industrial Accelerators
24 The First In-House Industrial Accelerators
25 The First Contract Service Accelerators
26 Development of Applications
31 Medical Device Sterilisation
34 Food Irradiation
39 Cultural Heritage Preservation
43 Annex 1: List of IMRP Laureates
45 Annex 2: The First International Meeting on
Radiation Processing (1976)
48 References
In Tribute to John Masefield
This document is published by the International Irradiation Association on the occasion of
the 20th International Meeting on Radiation Processing and in tribute to John Masefield, a
pioneer of the radiation processing industry who chaired the Association during the first
two decades of its existence.
It seemed opportune to try to narrate in a single document the developments that took
place in a period going approximately from 1950 to 1980 because this is when radiation
processing became more than a research theme and transformed into an industry.
It did not happen all in one place or over a short period of time. Rather, during these
booming years, there was a flurry of ideas to domesticate a new form of energy for
peaceful purposes. These ideas and attempts to implement them frequently appeared
simultaneously in different countries.
Yves Henon is the principal author of this document. Yves joined the irradiation community
in 1980, at the end of the period being covered, first working in a research centre, then
managing irradiation plants before becoming a consultant for the IAEA and the iia. He is
therefore well placed to reflect on the evolution of our industry.
The focus on North America and Europe is perhaps exaggerated. We are aware that
important developments have also occurred elsewhere, for example in Japan. The time
and resources available to write this document combined with the difficulty in finding
or accessing certain historical sources of information have imposed limits to this work.
Perhaps it will be taken up, improved, and expanded by others. In the meantime, it is
hoped that readers will find these stories useful.
We would like to thank the following people for their help and contribution:
Laurent Cortella, Nucleart, France Sophie Rouif, Ionisos, France

Xavier Coqueret, France Alan Tallentire, United Kingdom
Pierre Dardenne, Belgium Christian de Tassigny, France
Olgun Güven, Turkey Mark Thomas, STERIS AST, USA
Byron Lambert, Abbott Laboratories, USA Piotr Ulanski, Lodz University
Janusz Rosiak, Lodz University of Technology, Poland
of Technology, Poland Richard Wiens, Nordion, Canada
Paul Wynne
Chairman, International Irradiation Association

Introduction
Though largely unknown to most people, the radiation processing industry is now a well-
established and global industry. Its history can arbitrarily be divided into two periods.
The first one spans from the early 1950s to the late 1970s. It is an age of pioneers. Most
of them were engineers who became businessmen, and they would frequently exchange
with scientists during meetings and conferences. Passionate advocates of their technology
and its applications, to the point of sometimes lacking objectivity, they had to overcome
scepticism and constantly repeat that no, irradiated products are not radioactive. They
spoke in megarads, a now ancient dose unit. Even the expression ‘radiation processing’
was rarely used in discussions, books and articles. The 1971 Yearbook on Science and
Technology (McGraw Hill) speaks of ‘process radiation’. By its title, the First International
Meeting on Radiation Processing in 1976 greatly contributed to consecrating and
propagating the use of this name which adequately describes the process.
The second period began in the 1980s which marked the beginnings of a new era with
rapid international expansion, this was followed in the early 2000s, by numerous mergers
and acquisitions from which several global players emerged. We now speak in kilograys
and validate rather than commission.
The principal actors and witnesses of the earlier period have now passed away. I was
fortunate to have met many of them while they were still active. When the project of
writing this brief history of the early years of the radiation processing industry was formed
in 2021, it was realised that it was already too late to collect the memories and archives
of those who built our industry. Many of the documents covering the period from 1950 to
1970 have become difficult to access.
Imperfect as it is, this short history is intended as a testimony of and a tribute to the work
that our predecessors had to accomplish to bridge the gap between science and industry.
Yves Hénon
Director, International Irradiation Association

Fathers of the Radiation
Processing Industry
Picking people and naming them Fathers of the Radiation Processing
Industry could be tainted with arbitrariness. But there is some sort of ‘‘Who’s
Who’’ in the field of radiation processing, which is the list of IMRP Laureates
(Annex 1). All but one of those appearing hereafter (Roy Errington who retired
in 1974) received the IMRP Laureate Award, which is bestowed to those whose
contributions have significantly advanced the field of radiation processing
since the second IMRP in 1978.
They must be remembered: they left all who are now active in the radiation
processing industry the duty to administer their legacy.
A tribute to
John Masefield (1933-2022)
IMRP Laureate 1984
John Masefield, Chairman of the International

Irradiation Association for fifteen years,
was passionate about this work and used
all his skills and charisma to advance the
applications of irradiation for nearly 60 years.
John also served on the Board of Directors
of the Association for the Advancement of
Medical Instrumentation (AAMI) and was
Co-Chairman of the International Standards
Committee (ISO) that ultimately developed
the worldwide standards for the radiation
sterilisation of medical products (accepted as
ISO 11137). In 2003, he received the Kilmer
Memorial Award for International Leadership
in Advancing the Science and Practice of
Radiation Sterilisation.

Born on July 17, 1933, in Codsall, England, John was educated in engineering and physics
in the UK before moving to Atomic Energy of Canada Ltd (AECL) in the 1950s [1]. He joined
the Commercial Products Department (CPD) of Atomic Energy of Canada in 1959. There
he was part of the team who designed and built the Ethicon gamma irradiator but also
the Mobile Demonstration Irradiator that went into action in October 1961, to prove to
the Canadian potato industry that irradiation was a reliable, safe, and simple tool able
to prevent potatoes from sprouting [2]. Soon after, John left AECL to create the first
commercial food irradiator.
He founded Irradiated Foods of Canada Ltd., a name changed to Newfield Products in
1964. The large irradiator leased to him by CPD started operation around September
1965 in Mont-Saint-Hilaire, Québec. John Masefield was the firm’s technical vice-president.
Unfortunately, the venture soon turned into a disaster. Newfield Products lost 350,000
Canadian dollars in its first year of operation. The loss was partly due to the worst rains
in 50 years that ruined the potato crop and a lost gamble on the future potato market.
Newfield Products went into receivership in November 1966.
He then met Herbert Lank, Chairman of Du Pont Canada who advised him to spend a
few years figuring out what went wrong and to develop a revised commercial irradiation
business plan that would work and, in the meanwhile, teach a course in irradiation.
John did so over several years at Montreal’s McGill University while doing consultancy
on irradiation through a company named Masefield Enterprises. Then various medical
manufacturers started switching from ethylene oxide sterilisation to irradiation. John
thought that the time was ripe to establish a chain of irradiation centres in the US to
which manufacturers could ship unsterilised products for treatment en route to market.
Having convinced a few investors, in 1972 he created Isomedix [3]. The first irradiation
centre in Parsipanny, NJ, was to be followed by many others in Chicago, Spartanburg (SC),
Columbus (MS), Puerto Rico, Toronto, etc. Under John’s leadership for 25 years, Isomedix
became one of the largest international providers of contract irradiation services and was
acquired by STERIS for 142 million USD in 1997. John continued to share his knowledge
and help grow STERIS’s industrial sterilisation offering by serving as an executive advisor
to the company for the next 25 years. When the International Irradiation Association
was formed in 2004, he appeared as its natural leader and served as Chairman until his
late eighties, never missing a Board meeting. He remained active promoting modern
approaches to sterilisation.

Roy Errington (1915-1996)
Born in 1915, to a farming family near Goderich in Ontario,
he studied at the University of Toronto [4]. Just before
earning a PhD in physics, he was enticed to join Research
Enterprises, a Toronto-based wartime manufacturing
company. In 1946, Errington was hired by Eldorado Mining
and Refining Ltd., initially to sell off a stock of radium, a
byproduct of uranium accumulated during the Second
World War when Canada was the chief supplier of uranium
for the allies. Radium was then injected into cancer
tumours to kill them.
When other radioisotopes including cobalt-60 became available in the late 1950s, as head
of the Eldorado’s Commercial Products Division (CPD), Errington was the driving force
behind the development of teletherapy machines, Gammacells and industrial irradiators
for food and medical products. He strongly believed that it was important to ‘use machines
to help sell isotopes and use isotopes to help sell machines’. This certainly proved true
with industrial irradiation. In 1963, Errington was made an AECL vice-president [2].
Errington’s hands-on ways, his entrepreneurial spirit - within a government owned
corporation - and his ability to take risks on unproven products, largely contributed to
what Nordion is today. Under Errington, sales at Nordion soared from 230,000 CAD in
1946 to 11 million CAD in 1974, the year he retired. Staff grew from 3 people to 570.
He was treated with the cancer treatment equipment he helped design. At his request,
he was given double the doses of radiation that anyone had received up to that point at
the Ottawa Civic Hospital. He was told it was enough radiation to kill both the cancer and
him as well. He lived out his final years virtually cancer-free in a retirement community in
Picton, Ontario. Errington died in 1996 at the age of 81, just a month before being guest
of honour at Nordion’s 50th anniversary celebration.

Arthur Charlesby (1915-1996)
IMRP Laureate 1980
Dr. Arthur Charlesby can be considered as the father

of radiation chemistry. He discovered electron beam
crosslinking of polyethylene in 1940 while working
at the Royal Academy in London. He was founder
and editor-in- chief editor-in-chief of the Journal of
Radiation Physics and Chemistry.
Arthur Charlesby was born in London in 1915 [5]. A
physicist by training, he was endowed with an acute
intellect reinforced by a remarkable practical and commercial flair. These talents bore
fruit in later life in an astonishing number of original papers and patents largely concerned
with the effect of high energy radiation on polymeric materials.
Charlesby was educated in London and Antwerp and graduated from the Imperial College
of Science in London. His early professional career was interrupted by the Second World
War, in which he served in the Royal Air Force in the vital field of operational analysis. This
work involved collaboration with the United States Air Force on the effectiveness of Allied
bombing.
Immediately after the war, Charlesby became responsible for the planning of air traffic
in post-war Europe and was involved as an adviser during the Berlin airlift of 1948-49. He
then joined the Atomic Energy Research Establishment (AERE) at Harwell working on the
effects of radiation on materials. After a period with Tube Investments (TI), heading a small
research laboratory at Hinxton Hall, Cambridge, he moved in 1957 to the Royal Military
College of Science at Shrivenham as Professor of Physics and Head of Department.
This inaugurated a particularly fertile period in original work when Charlesby’s enthusiasm
for fundamental research produced a plethora of scientific papers devoted to the effects
of radiation on polymers. His significant contribution to this field lay in the discovery
that a flexible polymer such as polyethylene could be cross-linked and rendered rigid by
exposure to high-energy radiation. The benefits also include the resulting insolubility and
non-melting at temperatures higher than fusion of the crystalline phase.
Many commercial applications would ensue with an extensive range of patents world-
wide. While it is certainly true to acknowledge the strong commercial thrust of these
radiation studies, till the end of his life, Charlesby remained keenly interested in problems
of theoretical physics, notably in relativity theory [6].
Dr. Charlesby died in 1996 at the age of 81 in Swindon, Wiltshire.

Charles Artandi (1917-1980)
IMRP Laureate 1978
In 1978 Charles Artandi was named the “Father of Irradiation Sterilisation.” The Ethicon
irradiation plant which he established in New Jersey by 1960 became the Mecca for people
with an interest in radiation sterilisation from all over the world.
Born in Hungary where he achieved his PhD in the Royal Hungarian University of
Budapest, Charles Artandi first joined Johnson & Johnson in Australia, prior to his transfer
to its Ethicon subsidiary in 1953 [7]. He was assigned the task of developing reliable
sterilisation techniques. Having decided to focus on irradiation, Charles and his team
produced foundation work on the effects of radiation on one hundred different types of
microorganisms, suture materials, and a great variety of packaging materials. The value
of 25 kGy as a minimum sterilising dose originates from a study that he and Walton Van
Winkle performed in 1959 [8].
In 1976, Artandi was with C.W. Bruch (US FDA) behind the creation of a North American
Working Group, under the auspices of the Association for the Advancement of Medical
Instrumentation (AAMI) to develop guidelines for controlling the sterilisation of medical
devices by radiation. This included the development of satisfactory methods for
determining the approximate dose of radiation required to sterilise devices.
Vice President of Research and Development of Ethicon, Inc., Charles Artandi was
awarded the Johnson Medal for Research and Development in 1978 —the highest honour
the company offers—for his leadership in the development of irradiation technology. In
the same year he received the American Nuclear Society’s Radiation Industry Award for
his pioneering achievements. He received posthumously the Atomic Energy of Canada
Pioneer Award for his achievements in the field of dosimetry, radiation sterilisation,
standards and methods.
Charles Artandi died during the preparation of the Second Kilmer Conference, held in
Washington DC in 1980. His colleagues on the organising committee wrote in the preamble
of the proceedings: There appears from time to time an individual whose particular gifts
enable him to exercise a profound and beneficent influence on his colleagues. Charles
Artandi was such a man. During his long career he became a recognized international
authority on industrial sterilisation and occupied many positions where his understanding
and willingness to help enabled him to contribute much of value [7].

Paul Cooke (1924-2020)
IMRP Laureate 1978
Paul Cook was born in Ridgewood, New Jersey, in 1924.

He developed an interest in chemistry at a young age,
advancing from a basement laboratory in his parents’
home to studying chemical engineering at MIT. In 1943,
he put his education on hold to enlist in the army. In the
Army Specialised Training Program, he studied mechanical
engineering for two terms at Stanford University. As a
lieutenant he joined the famed 10th Mountain Division
serving in combat in Italy toward the end of the Second World War. Upon completion of
his military service, he returned to MIT, completing his degree in 1947. In 1948 he joined
SRI International, an independent, not-for-profit research centre serving government and
industry [10].
In 1957, starting from a tiny building in Redwood City, Paul Cook founded Raytherm Wire
and Cable to take commercial advantage of the crosslinking effect of electron beam on
polyethylene for wire and cable insulation. Cook mortgaged his house to rent the very first
high-energy electron accelerator produced by General Electric, which was delivered in March
1957 [11]. Later that year, he formed Rayclad Tubes to produce heat shrinkable tubing. Both
companies were consolidated into the Raychem Corporation in 1960 and are now part of
Tyco Electronics.
Paul and his associates James B. Meikle, and Richard W. Muchmore helped move radiation
chemistry from an almost purely experimental niche in research labs into viable applications
in industrial processing . Among Raychem’s first products were a flame retardant irradiated
polyethylene insulated wire and heat shrink flame retardant polyethylene tubing. Raychem’s
early days were not easy. Soon after processes for commercial production had been scaled
up, the tube of the accelerator failed. Without radiation capacity for 11 weeks, Raychem
nearly went bankrupt by the time a new tube was finally installed and working.
With offices in more than 40 countries and thousands of employees, Paul served as CEO
of this Fortune 500 company until 1990. Raychem was acquired by Tyco International in
1999. At the time of the sale the company had reached sales exceeding 2 billion USD and
was operating in over 60 countries. Inspiring a new generation of innovators through his
leadership, Paul received many awards in his lifetime. In 1988, President Ronald Reagan
presented Paul with the National Medal of Technology for creating a worldwide chemically
based industry. He also received the Winthrop-Sears Medal from the Chemical Industry
Association and he was named to the San Francisco Bay area business Hall of Fame in 1999.
In this spirit of giving back, Paul was very active in his alma mater MIT, serving as chair of
the chemical department and becoming a member of the MIT corporation. He eventually
returned to SRI as a Director and served as Chairman from 1993 to 1998. Paul Cook loved new
technologies, innovators and doers. After retiring from Raychem he was involved in many
startups and new ventures. Until his death in December 2020, he remained as chairman of
his latest venture, Vox Frontera Inc., a voice recognition company.

Marsh Cleland (1926-2019)
IMRP Laureate 1992
Marshall R. Cleland was born in Vermillion, South Dakota

on February 9, 1926. The pursuit of his baccalaureate
was interrupted by service in the Army Air Corps during
World War II [12]. He obtained his B.A. in Physics from
the University of South Dakota and went on to earn his
doctorate in Nuclear Physics at Washington University in
St. Louis, Missouri, in 1951.
Following a year as a physicist at the National Bureau of
Standards then in Washington, DC, Marsh devoted his efforts to developing high power
accelerators. This led to his co-founding of Radiation Dynamics, Inc. in Westbury, New
York in 1958, of which he was first vice president and then chairman. He developed and
commercialised his innovative accelerator, the Dynamitron™. Hundreds of these high-
power accelerators have been installed across the world, mostly for the manufacture of
wires and cables, heat shrinkable products, tire components and other applications. He
spent the last years of his career with IBA Industrial, the Belgian company who acquired
RDI in 1999.
Marsh Cleland was awarded eighteen US patents and corresponding foreign issuances,
including the basic patent on his accelerator design. He published more than 200 papers
and chaired numerous sessions at radiation and accelerator conferences. He also was
a member of the American Nuclear Society, the American Physical Society, the New
York Academy of Sciences, ASTM International and the Council on Ionising Radiation
Measurements and Standards (CIRMS), of which he was a co-founder and its first
President.
At the eighth International Meeting on Radiation Processing held in Beijing in 1992,
Marsh was named an IMRP laureate. In 2004, he was named a Fellow of the American
Physical Society. In 2006, ASTM International conferred the Peter D. Hedgecock Award
on Marsh for his sustained and exceptional contributions to the development and use
of nuclear-related standards. In 2009, Marsh was awarded the CIRMS Caswell Award
for Distinguished Achievements in the Field of Ionising Radiation Measurements and
Standards. The Rad Journal honoured Dr. Cleland with its Gunderson Award in 2011 for
his lifetime contributions to Radiation Safety and Technology.

Pierre Vidal (1910-2002)
IMRP Laureate 1994
Pierre Vidal devoted a major part of his long life to the

irradiation industry. He was the first entrepreneur to offer
contract irradiation services on a commercial basis and the
founder of the first irradiation industry trade organisation.
Born in the region of Lyon and a great wine connoisseur,
Pierre Vidal started his professional activity after the
Second World War as manager of Entrepôts Frigorifiques
Lyonnais (EFL) owned by the Ministry of Agriculture. It was
a large complex combining frozen storage, fast-freezing capacity, packing stations, and
a disinfestation station for fruit and vegetables. After a stay in the United States, Pierre
Vidal was convinced that food irradiation was about to revolutionise food preservation.
In 1956 he founded the Centre Lyonnais des Applications Atomiques (CLAA) near
Lyon, the first private gamma irradiation company in the world, but he did not have an
irradiator yet. The French authorities delivered the licence in 1958 [13]. In 1961, the CLAA
became Conservatome (the atom that keeps) and the first irradiation unit started. The
cobalt-60 had been supplied by the French Atomic Energy Commission (CEA) who was a
shareholder.
To prove the benefits and the feasibility of food irradiation, Pierre Vidal is also at the
origin of IRMA, a mobile irradiator containing 175,000 Ci of cesium-137 built in 1963.
On the site of the first irradiator in Dagneux, near Lyon, two more larger and improved
units were built in 1962 and 1972. These facilities were the seeds of the French Groupe
Ionisos founded in 1993 and now present in several European countries. Over the
years, medical sterilisation and cross-linking of plastics became the core business of
Conservatome, but Pierre never stopped pleading the cause of food irradiation and never
lost faith in the future of this beneficial application.
Like many pioneers in a new industrial activity, Pierre had to tackle a myriad of problems,
often fighting against more regulatory requirements that he found unnecessary. This
convinced him that the growing irradiation industry needed to be organised to defend
its interests. In 1970, Pierre founded the ‘‘Association Internationale d’Irradiation
Industrielle’’ (AIII), of which he remained Chairman until he retired in 1998. At first,
members were mostly European irradiation facilities but later the AIII attracted members
from all over the world. To ensure that the interests of the irradiation industry would
be taken into consideration, Pierre Vidal participated in many meetings and irradiation-
related activities. He was a member of several different standardisation committees and
used every opportunity to support the harmonisation of standards and regulations [14].
The International Irradiation Association was born from AIII.

Sam Nablo (1930 -2018)
IMRP Laureate 1989
An inventor and an entrepreneur, Samuel Nablo was born

in Dunnville, Ontario, and attended McMaster University
in Hamilton, Ontario, earning his B.Sc., M.Sc., and Ph.D.
degrees in Physics. During this time, he met his wife Ruth
with whom he would spend 62 years [15].
Sam was a principal in the founding of two high technology
companies: MedPak Inc. and Electron Processing Systems,
Inc. In 1972, Sam was the co-founder of Energy Sciences
Inc., where he helped develop a family of electron processors for industrial use.
Energy Sciences Inc. pioneered the low voltage EB market. ESI received the first U.S. patent
for the Electrocurtain Lab Unit. Progressively, suppliers developed new EB compatible
coatings and inks. In 1985, ESI introduced the first industrial in-line EB steriliser.
Today, Energy Sciences Inc. (ESI) is the world leader in low energy (up to 300kV)
Electron Beam (EB) systems used among others in flexible packaging and folding carton
packaging to cure inks, coatings and laminating adhesives. The success of the multicolour
lithographic printing of web using single station electron curing opened a large market.
With his inquisitive mind and enthusiastic spirit, Sam made fast friends. He died in 2018
at the age of 87.
The recent Team Nablo project, named in his memory and operated by Pacific Northwest
National Laboratories (PNNL), explores material compatibility for radiation sterilisation
using the three types of ionising radiation.

Early Production of Cobalt-60
In 1953 President Eisenhower gave a major boost to the development of research and
applications of radioisotopes by launching the Atoms for Peace initiative. During the
decade that followed the Second World War, nuclear research organisations in the
USA, Canada, UK, France, Denmark, and USSR developed various types of small-scale
irradiators, most often using spent fuel as a source of gamma rays. It rapidly appeared that
cobalt-60 would be the radioisotope of choice to produce gamma radiation. Caesium-137
was to be used in hospital and laboratory irradiators only. Various programs currently
aim at replacing them by non radioisotopic sources. The use of cesium-137 in industrial
irradiators has been very limited and completely ceased after a source leak that occurred
in Decatur, Georgia in 1988 [16].
Cobalt-60 was first offered for sale in 1949 by Eldorado, a business established as a
gold mining company by brothers Charles and Gilbert Labine in 1926. In the 1930s the
company mined radium and then uranium that would become critical during the Second
World War. The company was nationalised into a Crown corporation in 1943 [2].
A collaboration between British and Canadian nuclear scientists led to the establishment
of the National Research Experimental, or NRX under the National Research Council
(NRC). Located in Chalk River (Ontario, Canada), the NRX was the most powerful research
reactor of its time. One of its characteristics was the high number of free neutrons that
it generated. Cobalt-60 was one of many isotopes that NRX could produce. Nuclear
scientists were predicting immediate practical applications in medicine and industry. As
the only marketer of radioactive products in Canada, Eldorado appeared as the natural
vehicle to sell the isotopes produced in NRX. In 1949 Eldorado got from NRC exclusive
rights to distribute cobalt-60 from Chalk River to commercial and industry users. The
agreement was later extended to other users and by 1951 all orders for isotopes would
go through Eldorado. The person in charge of sales, Roy Errington, decided that the
company needed a catalogue for the new line of products and the department became
Eldorado’s Commercial Products Division (CPD). Errington hired salesmen with a scientific
or engineering background.
In 1952, the government of Canada created Atomic Energy of Canada Limited (AECL) to
promote the peaceful use of nuclear energy, take over the Chalk River operation from
the NRC, and build a second reactor on the same site. That same year AECL took over
Eldorado’s CPD.
The radium-bombs in use for teletherapy since the 1930s had to be very close to the
body surface and the beta radiation would dose skin and surrounding healthy tissue.
To produce higher energies, various electric machines were installed but they were
expensive, bulky and difficult to maintain and operate. Cobalt-60 appeared as a better
alternative. In 1947, Mayneord and Cipriani [17] had determined the energies of the
two gamma photons emitted by cobalt-60. These and its half-life made cobalt-60 a very
suitable candidate for use in radiotherapy. A stronger, cleaner, and simpler teletherapy
source than radium, cobalt-60 was also much cheaper. In mid-1951 the first Eldorado A

Beam-Therapy Unit (BTU) loaded with one thousand curies of cobalt-60 was ready and
installed at the Victoria Hospital in London (Ontario). Many units were sold since cobalt-60
teletherapy was revolutionising radiation oncology and naturally competition appeared,
often using Canadian cobalt-60 sold by CPD.
After the new Chalk River reactor NRU started operating, the cobalt-60 supply could
better face the market growth. CPD had humble beginnings; the main offices were in
the basement of a building and extra office space had to be leased nearby. The source
loading for the teletherapy machines were taking place in two rented garages isolated
from any inhabited structure.
In July 1947, the new reactor NRX achieved criticality and more cobalt-60 became available,
but like for the NRU, serious fuel channel cooling accidents temporarily disrupted supply.
These accidents created early challenges to the fledgling program’s credibility but with
them came hard but important nuclear safety lessons [18].
Errington’s idea to ‘package’ cobalt-60 in devices went on with the Gammacell, a self-
shielded irradiator that for decades would become a standard equipment of laboratories
and hospitals that needed a small gamma irradiation capacity. The prototype of the
Gammacell-220 was presented at the Atom Fair in New York in 1957. The salesmen
amused spectators by showing that the colour of drinking glasses and eyeglasses could
be changed. This was another device having the virtue of requiring replenishments but
not as much cobalt-60 as large irradiators that would treat food or sterilise medical
devices on a commercial scale. And indeed, the output from the NRX and the NRU would
not be enough to meet demand for industrial irradiators, even if they used Low Specific
Activity (LSA) cobalt-60 as opposed to High Specific Activity (HSA) in teletherapy units. The
first large irradiator designed and built in 1964 by CPD for Ethicon Inc. in Sommerville,
New Jersey would require 750,000 curies of cobalt-60. The mother company, Johnson &
Johnson would soon want irradiators for their other subsidiaries. In 1967, the German
medical manufacturer Willy Rusch near Stuttgart ordered a 1.5 MCi irradiator, the biggest
at the time.
It happens that Canada had chosen to develop a heavy water moderated reactor
which became known as CANDU (standing for Canada Deuterium Uranium) to produce
electricity. As the result of a collaboration between AECL and the Hydro-Electric Power
Commission of Ontario, the predecessor to Ontario Hydro (which was later reorganised
into five components, including the still-existing Ontario Power Generation), the Nuclear
Power Demonstration (NPD) reactor built by Canadian General Electric (CGE) commenced
operation in 1962, supplying 20 MW of electricity to the Hydro system [19]. NPD was
followed by the ten-fold larger prototype, Douglas Point, which commenced operation
in 1967. Located at what later was to become Ontario Hydro’s Bruce Nuclear Power
Development site on Lake Huron, Douglas Point, together with NPD, established the
technological base necessary for the larger commercial CANDU units to follow in the
1970s and 1980s at Pickering, Bruce and Darlington stations.

CPD asked Hydro to consider producing cobalt-60 in their power reactors by putting
cobalt-59 into the control rods. Hydro agreed after having determined that this would not
alter the performance of the reactors. The shape of the LSA sources used for industrial
irradiation would differ from HSA sources and they would have to be removed during
regular maintenance shutdowns every 18 to 36 months. A mutually beneficial agreement
was signed by which CPD would establish its place as leading supplier of cobalt-60 and
Hydro would get extra revenue from a by-product of CANDU operation. However, Hydro
demanded that any cobalt-60 they were asked to produce would be paid. At Chalk River,
CPD would not have to pay for any cobalt-60 that it did not use. Forecasting demand
years ahead on a new market would become a critical exercise for CPD. AECL and Hydro
subsequently developed the capability for producing large quantities of Cobalt-60 in
several of Hydro’s CANDU units.
AECL reorganised its operation in 1978 and CPD became the Radiation Chemical Company
(RCC). In 1988, the company reincarnated as the privatised Nordion International Inc.
In 1960, CPD celebrated the shipping of its one millionth curie. Around 2010, Nordion
passed the one billion curies mark. Canada’s current share of the world Cobalt-60 market
is estimated at about 80%.
As applications of irradiation developed and demand increased, cobalt-60 production
technology was developed in Russia and India. Cobalt-60 was first produced by MAYAK
p.a. in Russia in 1963 and was later expanded into the Leningrad Nuclear Power Plants.
Indian production of Cobalt-60 started in the mid-1970’s following intense investment
and development of the country’s nuclear, isotope production and radioactive source
production infrastructure and capabilities. In 1985, Argentina started production at the
Embalse reactor.

The First Commercial Gamma Irradiators
The first in-house gamma irradiators
The world’s first commercial gamma irradiation plant was constructed at Dandenong,
Victoria, for the company Gamma Sterilisation Pty Ltd. in 1959. It had an initial load
of 150,000 curies of cobalt-60 and was designed to irradiate goat hair bales exported
to the UK parent company Westminster Carpets to manufacture carpets. There was a
concern that the deadly bacteria anthrax could be present in the wool, and irradiation
was a good safety measure, the same as used many years later for government mail in
the United States. The advent of synthetic materials put a stop to the import of goat hair
to manufacture carpets and consequently irradiation was no longer needed. The plant
continued operating as a general-purpose irradiator, sterilising various medical products
and biological tissues on a contract basis until 1976. It was then declared obsolete and
dismantled, the cobalt-60 being sold and transferred to the Australian Atomic Energy
Commission. It had also suffered from competition. In 1971, an AECL JS6500 radiation
plant was installed — also at Dandenong — for Tasman Vaccine Laboratory (Australia)
Pty Ltd., a subsidiary of Tasman Vaccine Laboratory (New Zealand) Pty Ltd. These com-
panies were acquired in 1976 by I.C.I. (New Zealand). Contract sterilisation was the main
business with a small part of the capacity being used for the company’s own products,
mainly dressings. In 1972, Johnson & Johnson (Australia) Pty Ltd. built the third Aus-
tralian industrial radiation plant in Botany (New South Wales), also an AECL JS6500, to
sterilise their own products only [20].
The Ethicon Irradiator

In 1961, Ethicon Inc., of Ralway, New Jersey, a US subsidiary of Johnson & Johnson had
decided to acquire a gamma irradiator to sterilise sutures and other single-use medical
items. Two potential suppliers were invited to bid: the Canadian AECL CPD and a British
firm, HS Marsh Ltd., which had an arrangement with the UK Atomic Energy Agency. The
CPD got the deal [2]. The facility was built in Sommerville, New Jersey, in 1964. That same
year Johnson & Johnson’s Ethicon
Division also constructed gamma
irradiators in San Angelo, Texas and
Peterborough, Ontario.
Johnson & Johnson built two more in-
house irradiators in Texas (San Angelo)
and in England (Slough) before 1965.
An irradiator dedicated to the
production of wood-plastic flooring
was also built in the United States at
about the same time.
adiator [21]
Figure: The Ethicon irr

The first multipurpose gamma irradiators
In early 1960, the first semi-industrial gamma irradiator built and operated by a private
company specifically for the purpose of offering commercial irradiation services to
third parties started in Dagneux, near Lyon, France. The owner, Pierre Vidal, believed
that preservation of food by irradiation was just around the corner so he named the
company Conservatome. He had to fight hard to get the funding (CEA and Michelin had a
participation), to get the licence (first powerful radioactive sources outside a military zone
or nuclear research centres), and to get cobalt-60, a rare and expensive material in the
late 1950s. The first sources came from Oak
Ridge (3,000 then 40,000 curies) [22].
That same year 1960, the world’s first large
gamma irradiator facility was commissioned
at the Research Laboratory of the UK Atomic
Energy Authority in Wantage. Intended as a
pilot plant, the facility consisted of two gamma
units, one continuous type, and the other of
a batch type. Both would store the cobalt
60 sources in water pools. The total source
loading reached half a million curies by 1970.
The continuous plant, known as the Package
Irradiation Plant, incorporated automatic
conveying of standard packages to the
irradiation room. Initially it was able to process Figure: The first irr
adiator of Conserva
tome
5 to 6 m3 of products per day at 25 kGy.
Picture: The irradiators hall at Wantage [24]

A wide variety of industrial firms were able to carry out large scale market trials on their
products. It was not long before two private companies decided to enter the business of
irradiation for third parties. In 1967, Irradiated Products Ltd (IPL) was set up and managed
by two ex-scientists from the UK Atomic Energy Authority. The company was owned by
London Rubber, a manufacturer of latex gloves. The UKAEA Wantage facilities were
leased to IPL from 1970 to 1972 before being demolished in 1973. In 1969, H.S. Marsh
Ltd designed and constructed a plant for Gamma Radiation Services Ltd (GRS). IPL and
GRS merged to form Isotron in 1983. Two years later Isotron became the first irradiation
company to be floated on a stock exchange. Isotron acquired Gammaster in 2001 and
was acquired by Synergy Health plc in 2007.
By 1970, there were two dozen large gamma irradiators sterilising medical devices and
most of them were in Europe.
The First Large Gamma Irradiators
Location Operator Designer Capacity (MCi) Since
Argentina – Ezeiza CNEA CNEA 1 1970
Australia – Dandenong Gamma Sterilization Pty AERE Harwell 2 1960
Denmark – Roskilde Nunc A/S AECL 1 1969
France - Dagneux Conservatome D1 CLAA 1 1960
France - Dagneux Conservatome D2 Conservatome 1 1968
France - Dagneux Conservatome D3 Conservatome 1 1973
Germany – Hamburg Ethicon GmbH Marsh 0.75 1966
Germany – Melsungen B.Braun Co. Sulzer Brothers 0.6 1966
Germany - Rommelshausen Firma Willy Rüsch AECL 1.5 1968
East Germany – Rossendorf Zentralinst für Kernforschung Own design 0.5 1967
Italy - Bologna ICO SpA Marsh 0.5 1967
Japan – Tochigi Japan RI Irradiation Service 0.5 1970

Netherlands – Ede Gammaster AECL 1 1970
New Zealand – Upper Hut Tasman Vaccine Lab. AECL 1 1966
Sweden – Skärhamn Radona Irradiation AB Marsh 1 1968
UK – Wantage Irradiated Products Ltd (PIP I) Rubery Owen 0.7 1960
UK – Slough Johnson’s Ethical Plastics Marsh 0.75 1962
UK – Reading Gillette Industries Ltd Marsh 0.75 1964
UK – Wantage Irradiated Products Ltd (PIP II) UKAEA 0.7 1965
UK – Reading Gamma Radiation Services Ltd Marsh 1 1970
USA – Sommerville, NJ Ethicon Inc. AECL 1964
USA - San Angelo, TX Ethicon Inc. AECL 1964
USA - North Canaan, CN Becton Dickinson AECL 1 1970
Table extracted from Table II in [25]

The First Industrial Accelerators
During the first half of the 20th century there was a lot of interest in accelerators, and
various machines were invented for laboratory use. By the 1940s, three acceleration
mechanisms had been demonstrated: DC acceleration, resonant acceleration and
the betatron mechanism [26]. After the Second World War the challenge was to build
machines for industrial use.
The first industrial high current electron accelerator was developed by a protégé of
William Coolidge at the General Electric Company (GE), Willem Westendorp [27]. Patented
in 1940, it is a resonant transformer system, which increases voltages from 200 to as high
as 44,000,000 in a series of low frequency “pushes” from carefully tuned coils [28].
While intended to be a high voltage source for X-rays, the GE resonant transformer was
adopted for industrial use, for example at Raychem in 1957 [27].
Robert Van de Graaff (1901-1967) is the American physicist who invented the accelerator
named after him, a type of high-voltage electrostatic generator. The device found
widespread use in atomic research, medicine, and industry. Van de Graaff had developed
his interest in atom physics while attending the lectures of Marie Curie at the Sorbonne
in Paris in 1924 [29]. Back in the United States he conceived the idea of a high voltage
generator for X-rays and spent years developing it with his colleague John Trump at the
Massachusetts Institute of Technology (MIT). In 1946, Van de Graaff and Trump co-founded
the High Voltage Engineering Corporation (HVEC) [29]. They designed an insulating core
transformer (ICT) accelerator for which a patent was issued in 1965. The machine was
improved for industrial use by Roy Emanuelson, an HVEC engineer. For decades now, ICTs
in the 300 keV to 2.5 MeV range have been widely used for crosslinking.
John Cockcroft and Ernest Walton were the first to split the atom in Cambridge, UK, in
1932. For that they had
designed a generator, or
multiplier, which was an
electric circuit generating
a high DC voltage from a
low-voltage AC or pulsing
DC input. This machine
design remains the basis
for many high-current, mid-
energy electron accelerators
currently used in industry
[27].
In 1956, Marshal Cleland
at Washington University
invented a variation of the ne® one of
p looking at a roll of Irrathe
Picture: Willem Westendor
Cockcroft-Walton accelerator the very first irradiated pol
ymers [28].
that he called Dynamitron® in

which voltage is induced in semi-circular corona rings attached to each end of the diode
rectifier tubes. The accelerator stack is inside a tank of pressurised sulphur hexafluoride
gas for insulation [30]. The advantage of this design is that it can produce higher beam
currents than the Cockcroft-Walton design, up to hundreds of milliamperes. Having been
rejected by HVEC in attempting to licence his technology, Cleland followed the advice
of Arthur Holly Compton, then Chancellor of Washington University in St. Louis, and
went to the New York City area to obtain venture capital. There, along with a graduate
school classmate, Kennard Morganstern (IMRP Laureate 1985), they founded Radiation
Dynamics, Incorporated (RDI) in 1958 [31]. More than 200 Dynamitrons® were sold by RDI,
now belonging to IBA.
The Swedish physicist Gustaf Ising (1884-1960) proposed the concept of radiofrequency
(RF) linear accelerators (Linacs) and the Norwegian physicist Rolf Wideröe (1902-
1996) constructed one in the 1920s. The method was resonating particles with a radio
frequency electric field to add energy to each traversal of the field. At Stanford University,
two brothers, Russell and Sigurd Varian, worked to develop a source of strong microwave
signals to improve air navigation and warn of potential Nazi bombing raids. On August 30,
1937, they presented the klystron, a high-frequency amplifier for generating microwaves
[32]. This invention made it possible to increase the power levels of Linacs. The two
brothers could reach energies of 10 MeV with average beam current of 1 to 2 mA. Linacs
are now commonly used for the sterilisation of medical devices.
Sam Nablo developed a low-voltage accelerator (≤300 kV) based on the ideas of an Energy
Sciences Incorporated (ESI) engineer, Bertram Quintal, that relies on self-shielding of the
accelerator and under-beam conveyance with lead (or steel) to protect the personnel
from X-rays emissions.
A technique of using parallel segmented filaments for low-energy accelerators was
developed by Sherman Farrell in 1975, which was adopted by RPC Industries, now PCT
Engineered Systems [27].
The most recent type of high-energy accelerators is also one of the most original. The
Rhodotron, where electrons are accelerated in a flower-shape recirculating pattern
was the idea of J. Pottier and his team at the Saclay Nuclear Research Centre of the
French Atomic Energy Commission (CEA) near Paris in the 1980s. The CEA did not wish
to commercialise the machine. Ion Beam Applications SA (IBA), initially a spin-off of the
research centre for cyclotrons of the Catholic University of Louvain (Belgium) obtained an
exclusive licence in 1989. There was still considerable work to be done. Yves Jongen (IMRP
Laureate 2003) and Michel Abs developed a 10 MeV, 100 kW prototype that successfully
completed the beam tests at the end of 1994. Three machines were sold in 1995. [33]
These machines may soon open the era of X-rays for industry.
The First In-House Industrial Accelerators

In the 1950s, low-energy or medium-energy electrons were the only option for those
who wanted to use irradiation for their products. Cobalt-60 was scarce and expensive.
The German company Gewurzmüller acquired a van de Graaf machine for the microbial
decontamination of their spices but could not use it for long because of a sudden ban on
food irradiation [34].

In 1957, Ethicon in Sommerville, New Jersey, bought a 2 MeV-5 kW microwave linear
electron accelerator made by High Voltage Engineering Corporation to sterilise sutures.
The limited penetration of the beam and the reliability of the machine being insufficient,
the company switched to gamma irradiation in 1960.
With the chemical industry realising the industrial potential of irradiation for polyethylene
cross-linking, companies like the General Electric Company, Raychem and Cryovac
purchased electron accelerators. As is still the case today, information on the number
and characteristics of machines is hard to come by, as this is a sector where secrecy is
important to maintain commercial advantage.
The first contract service accelerators

In the autumn of 1960, the Danish Atomic Energy Authority started operating a 10 MeV
Linac Model V 77700 from Varian Associates (Palo Alto, California) in their Risø research
establishment. The machine produced a stable beam with an average power of 5 kW.
The conveyor speed could vary from 0.2 to 600 mm/s. First used for research only, the
accelerator started providing sterilisation services to medical device manufacturers
in 1961.
The first private company created to offer electron beam processing services was CARIC
- SRTI (Société de Recherche et Technique Industrielle) in Corbeville near Paris in 1967
[35] with Pierre Icre as its manager. The facility was equipped with a 6 MeV, 7 kW linac
named Circe 10 manufactured by a subsidiary of Thomson, CGR-MeV, whose Director,
Theo Sadat (IMRP Laureate 2006), was a staunch advocate of accelerators. After having
built another service facility in the Champagne region in the 1980s, CARIC was acquired
by Ionisos.

Development of Applications
Enhancement of Polymer Properties
The importance of radiation processing to enhance the properties of polymers is often
overlooked, though it is by far the main industrial application of irradiation. If these
commercial applications receive little publicity, it is because their development and even
their use have mostly taken place in secret due to the economic stakes in a competitive
environment.
When nuclear fission reactors provided relatively inexpensive, powerful gamma radiation
sources after the Second World War, the creativity of chemists was stimulated. The fact
that ionizing radiation brings energy to a system and can modify it without residues was
of great interest to the chemical industry. When it became practical to use irradiation
outside laboratories, various attempts were made to synthetise chemicals or improve
catalysts with the help of irradiation. Fortunately, the idea of turning nuclear reactors
into chemical plants where radiation would assist chemical processes did not go too far.
Irradiation of abundant bulk material such as natural gas, coal, oil, or rubber did not
prove successful [36]. Using irradiation for chain chlorination of molecular compounds
was abandoned because it was too difficult. The Brookhaven National Laboratory and
the Takasaki Radiation Chemistry Research Laboratory developed a process to induce
polymerisation of ethylene at high pressure by gamma radiation but this was not
commercially applied [37]. In 1963, the Dow Chemical Company went as far as starting
the commercial production of ethyl bromide in Midland, Michigan by inducing the
addition of hydrogen bromide to ethylene with a source of 1,800 curies of cobalt-60 in an
underground tank. [38].
A related application is the treatment of flue gases, where the energy from radiation is
absorbed by nitrogen, oxygen and water to form active chemical species that will oxidise
sulphur dioxide and nitrogen oxides, which are toxic gases emitted by coal and oil-fire
boilers in power plants. For many years, Prof. Andrzej Chmieliewski (IMRP Laureate 2013)
has advocated this application, now categorised as an environmental application of
irradiation. The concept to remove sulphur dioxides and nitrogen oxides using electron
beams was first suggested and investigated by the joint research of the Japan Atomic
Energy Research Institute (JAERI) and the US Ebara Corporation. The first plants were
constructed in the 1970s by Ebara, included one for the Nippon Steel Corporation, which
successfully treated iron ore sintering exhaust gas using two electron accelerators. A few
more installations were built in Germany, China and Poland.
Due to the non-specific nature of many radiation-induced reactions and the relatively
high cost of ionizing radiation as an energy source, the applications in industrial
chemistry failed for safety, technical or economic reasons. It soon appeared that, as the
specific energy requirements for radiation-chemical determines the required absorbed
dose, higher molecular weights would be provide more favorable opportunities [39].
Modification of polymers eventually became the main application of irradiation, certainly
not as the result of an evidence, but rather from multiple observations, trials and errors.

The design and contruction of nuclear reactors was a main driver to better understanding
the effects of irradiation on materials such as polymeric materials given that they could
impact the safety, operation and longevity of equipment.
Davidson and Geib reported in 1948 that the molecular weight of natural rubber
bombarded in the Oak Ridge atomic pile increased [40]. In 1950, Dole reported that
polyethylene crosslinks under irradiation while presenting the M.Sc. thesis of D. G. Rose
on the Effect of Radiation on Colloidal and High Polymer Substances at a Symposium
of the US Army Chemical Center. The first scientific article on the topic, Cross-linking of
polythene by pile radiation was published by Charlesby in the Proceedings of the Royal
Society in November 1952 (volume 215, issue 1121). It is an extensive study conducted in
the UK Atomic Energy Authority atomic pile at Harwell [39].
Irradiation could thus be envisaged as a physical method to produce crosslinking in
polyethylene and in other long-chain polymers under accurately controllable conditions,
without the incorporation of other chemical compounds and without heat treatment.
Commercial applications rapidly followed, using the accelerators available at the time,
generating what would become a multi-billion-dollar business.
In January 1957, Paul Cook founded Raytherm Wire and Cable and crosslinked by
irradiation the polyethylene for wire and cable insulation. Later that year, he formed
Rayclad Tubes to produce polyethylene heat shrinkable tubing. These businesses
were consolidated into the Raychem Corporation in 1960, which became part of Tyco
Electronics. In 1961, industrial irradiation of wires and cables also started in Japan.
In 1956, Bill Baird from the Cryovac Division of what was to become W. R. Grace - and is
now part of Standard Industries - visited Paul Cook to also use radiation crosslinking for
producing heat shrinkable materials. The Cryovac® Type L plastic shrink films and bags to
protect meats and poultry, was marketed by Grace in 1960. While Raychem has long been
acknowledged to have more installed kilowatts of electron beam power than any firm,
Cryovac would have more accelerators (ICTs and Dynamitrons) in their manufacturing
operations.
The 1960s would see a diversification of new applications to polymers, starting with
coatings. Bill Burlant at the Ford Motor Company used electrons of a few hundred keV
to cure automotive coatings using cable connected scanned beam accelerator produced
by RDI. Daniel Carlick, Technical Director of Sun Chemical, a leading ink manufacturer,
developed the use of electron beam in curing printing inks. Substantial businesses have
evolved based on providing the raw materials, monomers, and oligomers, used in EB
curable inks, coatings and adhesives, and formulated systems [27].
In Japan, manufacturers of radial tires started using electron beam to partially crosslink
plies that would be molded and cured into the final tire. The advantage is the capability
to better position tire cords and hold them in place in the final molding process. In 1966,
P.A. King was the first to crosslink polyethylene oxide to produce hydrogels which would
find application in the production of dressings that create a moist healing environment
and are painless to change. Hydrogel dressings produced by radiation technology were
later developed by Prof. Janusz Rosiak from the Institute of Applied Radiation Chemistry,
Lodz University of Technology, Poland.

One of the applications of radiation polymerization was the production of flooring resistant
to humidity, wear and abrasion. Red oak impregnated with a methyl metacrylate was the
common recipe to produce wood plastics. In 1976, there were 3 gamma facilities producing
wood acrylics in the USA: Applied Radiant Energy in Virginia, Radiation Technology in the
state of New York, and Arco Chemical in Pensylvania [41]. The development of closed cell
polyethylene foams used for padding in cars or to make gym rugs emerged in the 1970s.
If radiation processes and products were developed almost exclusively by private
companies, the role of academia in the development of polymers irradiation cannot
be understated. If Arthur Charlesby is rightly considered as the founding father of
radiation chemistry applied to polymers, several others had a major contribution in the
advancement of this science.

Joseph Silverman (1922-2019)
IMRP Laureate 1987
Joseph Silverman was one of the creators of radiation chemistry

and the processing of polymers, and one of the most distinguished
radiation chemists in the world.
A professor in the Department of Materials Science and Engineering at the University
of Maryland, Joseph Silverman had a long and distinguished career. He had earned his
Ph.D. in Physical Chemistry from Columbia University in 1951. He served eight years in
industry, and a year as an associate professor at Stony Brook University before he was
recruited in 1960 to help launch the University of Maryland’s nuclear program as part of
the Department of Chemical Engineering. An expert in the interaction of ionizing radiation
with polymers, Silverman built much of the nuclear program from the ground up, including
the University’s first radiation facilities and supporting laboratories, and the program’s
first curriculum. Dr. Silverman published hundreds of papers on radiation chemistry
and radiation engineering, radiation-induced polymerization, radiation modification of
polymers, pulse radiolysis, and nuclear engineering. During his tenure, he directed more
than 40 Ph.D. dissertations, and tens of M.Sc. theses. He received a Lifetime Achievement
Award for his fundamental and applied work in radiation physics and chemistry at the
9th International Symposium on Ionizing Radiation and Polymers in 2010 [42]. Professor
Silverman was always kind, thoughtful and considerate. He died in November2019 at the
age of 97.
Vivian Stannett (1917-2002)

IMRP Laureate 1984
Vivian Stannett was a prominent polymer scientist and engineer

who used radiation to develop flame-resistant textiles, plastic
bottles that prevent soft drinks from going flat, and super-
absorbent paper towels and diapers. He researched chemical
modifications of cellulose and investigated the application of
polymers to textiles, pulp, and paper.
Born and raised in England, Vivian Stannett moved to the United States after World War
II and received his Ph.D. in physical chemistry in 1947. In 1950, Vivian became a research
associate at what is now the Carnegie Mellon University in Pittsburgh before becoming a
professor at the College of Forestry in Syracuse, New York. In 1958, during a sabbatical,
he partnered with Professors Adolphe Chapiro and Michel Magat at the University of
Paris who worked in the field radiation grafting and radiation chemistry of polymers. In
1961, Stannett was appointed to associate director of the Camille-Dreyfus Laboratory for
Polymer Research and then became a professor at Duke University and North Carolina
State University.
Vivian Stannett published over 400 papers and reviews on polymer science and technology
and received many distinctions [43].

Adolphe Chapiro
Adolphe Chapiro was born in 1924 in Moscow, in the
former USSR. He arrived in France in 1933 and received his
Ph.D. in chemistry at the University of Paris in 1950. Most
of his long career was spent at the Centre National de la
Recherche Scientifique (CNRS) near Paris. His contributions
to the advancement of radiation-initiated polymerization and
radiation grafting were major.
In 1949 Dr Chapiro published his first article on polymerization by gamma radiation [44].
His first paper on polyethylene grafting appeared in a publication in 1958 [45]. In 1962,
Chapiro published Radiation Chemistry of Polymeric Systems (Interscience, New York),
one of the earliest books on the topic.
A great collector of watches, Adolphe Chapiro also wrote an authoritative book on ancient
watches: La Montre Française du XVIè Siècle Jusqu’à 1900 (Editions de l’Amateur, 1991).

Medical Device Sterilisation
It is no coincidence that radiation sterilisation – like ethylene oxide sterilisation – emerged
in the 1950s. Inexpensive plastics were becoming available, opening the way to a revolution
in healthcare; disposable medical devices started to replace resterilisable items. Besides
reducing infection risk, single use devices were also lifting the heavy burden of cleaning,
maintenance, and sterilisation off the backs of hospital personnel.
The first commercially sterilised product was an eye ointment, but the first medical
devices commercially radio sterilised from 1956 were sutures manufactured by Ethicon
Inc. in the USA. Heat sterilisation was not satisfactory for sutures: it adversely affected
product quality and restricted the choice of packaging material [46]. Irradiation took
place in Sommerville, New Jersey, first by electron beam and a few years later by gamma
radiation.
The new sterilisation method had been developed by Charles Artandi and his team who
produced major studies on the effects of radiation on a wide range of microorganisms
found on medical devices, on suture materials and a great variety of packaging materials.
Artandi also completed biological safety tests and clinical studies. He could eliminate the
use of glass tubes for sterilisation and use more convenient and less expensive packaging
materials instead, like aluminium foil and various laminates.
From the study of over 150 different species of microorganisms, Artandi and Van Winkle
concluded that a dose of 25 kGy (2.5 Mrad) was 40% above the minimum required to
kill the most resistant microorganisms [8]. This dose of 25 kGy remained the universally
accepted sterilisation dose for decades, except for a few countries. The Scandinavian
public health authorities recommended a minimum dose of radiation of 35 kGy for a
bioburden below 50 per item, 45 kGy between 50 and 500, and 50 kGy between 500 and
5,000 [25].
The UK was a pioneer and early adopter of radiation sterilisation. As early as 1952,
experiments were carried out by J.O Dawson and A. Charlesby on the sterilisation of
sutures [24]. Accompanying the birth of a business for pre-packed sterile single use
medical devices, significant quantities were sterilised at the UKAEA Wantage facility where
extensive studies had been carried out. In 1961, Darmandy et al. confirmed the suitability
of 25 kGy as a sterilising dose and suggested the use of Bacillus pumilus E601 as a test
organism for the efficacy of the treatment [47].
In 1963, the team published a book entitled Massive Radiation Techniques, a collaborative
work edited by S. Jefferson, which, according to the UK Panel, remained the textbook for
all those interested in the topic.
The first international conference on the radiation sterilisation of medical supplies was
held at Risø, Denmark in 1964 with participation from 14 countries. With the aim of
establishing international rules for the application of ionising radiation for sterilisation
of medical products, the IAEA proposed a Recommended Code of Practice for Radiation
Sterilisation of Medical Products at an international symposium in Budapest in 1967.

Many countries recognized the usefulness of the Code and adopted parts of it into
their regulations governing sterility control. The IAEA published a Manual on Radiation
Sterilisation of Medical and Biological Materials, which along with training courses
organised in Mumbai (1969) and Buenos Aires (1971) contributed to the dissemination
of the technology.
Before ISO 11137 standards became a universal reference for the validation and routine
control of radiation sterilisation, there were many debates which appear irrelevant today.
In the 20th century, they required long battles in some countries.
• Transiting from the concept of absolute sterility to sterility assurance level. It is in

Scandinavia that the concept of safety margin – a numerically defined probability
of non-sterility was first introduced in national regulations [48]. The concept of
Sterility Assurance Level (SAL) was refined later. This was uncomfortable for those
who preferred a ‘clear’ answer as to whether a product is sterile or not.
• Abandoning sterility tests on a given number of samples taken from routine

batches.
• A reasonable number of sterility tests can detect only gross contamination or

serious failure of the sterilising process. But this was an old practice that gave a
sense of security, no matter how false it was.
• Releasing sterilisation batches on the base of dosimetry
• Discontinuing the use of biological indicators to control the efficacy of routine

sterilisation processes.
Before 2000, John Masefield began to promote the idea that not all medical products
needed a SAL of 10-6 and that SAL should consider how the product is used, but this
battle has not been won yet.
Two other great contributors to the science of radiation sterilisation must be mentioned:
Alan Tallentire and James Whitby.

Alan Tallentire (1929-2022)
IMRP Laureate 1999
Microbiologist, Emeritus Professor, University of Manchester,

School of Health Sciences, Division of Pharmacy & Optometry.
Alan Tallentire was a prominent figure of radiation sterilisation
from 1963 when he started as an advisor to the Food and
Medical Group at the UKAEA Wantage Research Laboratory.
He has held various positions at the UK Panel on Gamma and Electron Irradiation, the
UK Association for Radiation Research, and the International Association for Radiation
Research. He published many important papers and spoke at events around the world
for five decades.
The influence of the product bioburden - and the importance of controlling it – for the
efficiency of sterilisation was well understood early. It was obvious that a ‘one size fits
all dose’ was not satisfactory, no matter how well accepted this dose had been. There
was a need for a method, simple if possible, to determine the sterilisation dose on a
case-by-case approach. Such a method might sometimes lead to lower sterilisation doses
that would be less damaging for some materials, and as a result the range of radiation
sterilisable products might be broadened. It is Alan Tallentire who, in the 1970s, published
several articles [49, 50, 51] which proposed the basis of the dose setting methods that are
used today and that were first published by AAMI before being incorporated in the ISO
11137-2 standard.
James Whitby (1925-2016)

IMRP Laureate 2006
James Lyndall Whitby was professor of microbiology at the University of Western Ontario,
Canada. He was born in Hampstead, London, in 1925, and educated at Eton College,
King’s College, Cambridge and Middlesex Hospital Medical School, and qualified with
the MB BChir in 1948. After various posts in the UK, in 1971, James was appointed as a
professor of microbiology to the newly opened University Hospital on the campus of the
University of Western Ontario, in London, Ontario. He became Professor Emeritus in 1990
and retired from the position of chief of microbiology in 1993 [52]. In his later years, his
main interest was the radiation sterilisation of medical devices.
James Whitby carried out extensive studies on the radiation resistance of microorganisms
found on medical devices, which contributed to the development of standardised
protocols for dose setting methods. They were first extensively presented in 1981 during
a conference sponsored by Johnson & Johnson and later refined [53]. James and his wife
played chamber music and amassed a rich collection of antiquarian chamber music,
which they left to the libraries of Western Ontario University.

Food Irradiation
Samuel Goldblith, the American food scientist who developed radiation sterilized food for
the NASA space program at the MIT, stated in 1970: “Never in the history of man has any
method of food processing invoked so much comment, induced so great a controversy,
nor required such an expenditure of funds before its use could be permitted even on a
limited basis as has the use of ionising energy”. Unfortunately, half a century later, this
statement remains valid.
In the 1950s, it was generally thought that the most significant application for ionising
radiations would relate to the preservation of food. Many research irradiators were built
whilst research programs were launched in numerous countries. The earliest and most
ambitious program was certainly the program of the US Army Quartermaster Corps, but
there were also significant research programs at the Low Temperature Research Station
in England, at the Federal Research Centre for Food Preservation in Karlsruhe, Germany,
at the Nuclear Research Centre of Cadarache in France, and elsewhere in Europe.
The German spice company Gewürzmüller was the first in the world to build its own
food irradiator, a Van de Graff machine installed in Stuttgart in 1958, just when Germany
banned irradiation of food. That same year the US Congress passed the Food, Drug and
Cosmetic Act. Ionising radiation would be treated as a food additive and the part of the
Act known as the Delaney clause would ensure that no food would be irradiated unless
this was specifically authorised. Many other countries felt that it was probably the right
thing to do, so the impact of the Act was devastating and is lasting to this day.
This did not totally dampen the faith in the future of food irradiation.
In the early 1960s, mobile irradiators were constructed to demonstrate the potential of
food and to gain practical experience by bringing the irradiators to the point of use. Fish
irradiators were also constructed on vessels: an AEG X-ray machine on a fisheries vessel
in Germany and a portable Co-60 irradiator on a vessel for Atlantic coastal fisheries in the
USA [34].
Several countries (Canada, France, Italy, Japan, Spain, USSR, Uruguay, USA, etc.) permitted
irradiation of potatoes, a low dose application, to inhibit sprouting during storage. In
Canada, a mobile demonstration Irradiator was built by AECL in 1961. Consisting of a
fully equipped and shielded 41 metric ton trailer which could travel by truck, train or
ship, the Mobile Demonstration Irradiator went into action in October 1961, on a farm
operated by Ottawa River Farms Limited, near Alfred, Ontario. The huge device could treat
approximately 1.15 tons of spuds per hour, each tuber being exposed for four minutes or
so [2]. Another irradiator on wheels using 175,000 curies of cesium-137 named Irma was
built in France at the initiative of Conservatome.
In 1964, Newfield Products, created by John Masefield in Canada, started to irradiate
potatoes on a commercial scale, with the objective of reducing potato imports from the
United States during the period between the two Canadian crops as they were 2 to 4
times more expensive than local ones. An unprecedented wet season ruined the 1965
potato crop, and the fledgling irradiation business [54].

Another potato irradiator would be
created in Japan in 1976 with very limited
commercial success. Little is known of the
accelerator that was used for the irradiation
of grain. It operated for a few years in
the port of Odessa. Around 1970, a grain
irradiator in Iskederun, Turkey, and a potato
irradiator at the Fuccino cooperative in Italy
were prevented from starting operation.
A remarkable project was the Pilot
Plant for Food Irradiation (Proefbedrijf
Voedselbestraling known as Provo) that
Figure: The source pass mechanism of the Newfield Products irradiator started in Wageningen, Netherlands in 1968.
With 100 kCi of cobalt-60, its main objective
was to bridge the gap between laboratory work and practical application. The existence of
this facility is the reason why the Netherlands would become a leader in food irradiation.
A host of food products could be test marketed thanks to Provo.
It is also where what later became known as the Radura logo
was created, initially intended as a mark of quality rather than a
distinctive sign.
Radura is the combination of RAD for radiation and DURA
meaning lasting in Latin. The dot and two leaves evoke a plant
in a closed package (the circle) penetrated by ionising radiation
(the breaks in the upper part of the circle). It might also be that
the central dot is the radiation source, the two leaves are the biological shield, and the
outer ring the transport system, the lower half of it being shielded from radiation [55].
The Provo facility was the anchor point for the International Facility for Food Irradiation
Technology (IFFIT), a joint research and training program of the Dutch Institute of Atomic
Research in Agriculture, the Food and Agriculture Organization of the United Nations
(FAO), the International Atomic Energy Agency (IAEA) and the Dutch Ministry of Agriculture
and Fisheries. Between 1978 and 1990, hundreds of engineers and scientists from about
fifty countries carried out research and were trained in all aspects of food irradiation:
technology, economics, or feasibility. During its 12 years of existence, IFFIT had two
directors: Ari Brynjolfsson, from Denmark, and Josef Farkas, from Hungary.
Proving that irradiated foods are safe would undoubtedly be a long and expensive
journey. The international scientific community joined efforts and cooperated within
the framework of the International Food Irradiation Project (IFIP) based in Karlsruhe,
Germany, who coordinated the research efforts. A Joint FAO/IAEA/WHO Expert Committee
on Food Irradiation (JECFI) formed in 1969, would periodically review the enormous
amount of data being generated. Other studies were carried out independently from
this project, for example in China with human volunteers. One study worth a special
mention is the Raltech study of the US Army Medical Department that lasted 7 years, used
230,000 chilled eviscerated broilers and cost 8 million dollars. Consisting of 20 separate

research projects, it examined the effect of consuming radiation sterilised chicken meat,
with respect to nutritional quality, teratogenicity, toxicity, carcinogenicity, reproductive
performance and genetic toxicity on dogs, rats, mice, hamsters, rabbits, and vinegar fruit
flies [56].
In September 1980, the JECFI concluded that irradiation of food at an overall average dose
up to 10 kGy presents no toxicological hazards and introduces no special nutritional or
microbiological problems. According to the Joint Expert Committee, toxicological testing
of foods irradiated up to 10 kGy was no longer required.
For many, this was a major achievement that would - finally - lead to the commercial take-
off of food irradiation.
The international cooperation that had been so successful was continued with a new
project: the International Consultative Group on Food Irradiation (ICGFI) created at the
initiative of FAO, IAEA and WHO. The Joint FAO/IAEA Division in Vienna provided the
secretariat, with Paisan Loaharanu, Head of the Food Preservation section, being the
linchpin. The project lasted from 1983 to 2003. ICGFI was addressing international trade,
legislation, applications, transfer of information, training, and generation of data.
Despite all the efforts that have been deployed, the use of irradiation for food has
remained marginal. Many service facilities initially created to irradiate food had to turn
to other products to survive. In-house food irradiation projects also failed. There were
two in France in the 1990s. In Normandy, the renowned dairy firm Isigny Cooperative in
Normandy could not make use of the gamma irradiator that they had built to guarantee
the microbiological safety of their raw milk soft cheese camembert. In Brittany,
SPI (Guyomarc’h Group) who installed an in-house accelerator to kill Salmonella in
mechanically deboned poultry meat for raviolis or frankfurters ceased operation when
their customers refused to write “irradiated” in the list of ingredients, as the new EU
Directive would require.
Unfortunately, like 50 years ago, discussions on irradiated food still get stuck with
questions on their safety, consumers acceptance, to mention the word irradiation on the
labels or not. The process is still considered as a food additive in most countries. Food
irradiation regulations were not harmonised, except in the EU where essentially herbs
and spices only are permitted. The volume of food being irradiated remains low, except
maybe in China.
So food irradiation is the most researched, the most discussed, and the least used food-
process. The huge potential of the technique to improve food safety and reduce losses
remains untapped. The recent good news however is the growing use of irradiation as a
phytosanitary measure.
In the second half of the 20th century, food irradiation had many talented and passionate
advocates beside Pierre Vidal, already mentioned.

Frank Ley
IMRP Laureate 1989
Born in Liverpool, England, Frank Ley was a member of the UK AEA

at Wantage in the 1950s. His background being in microbiology,
he had a passion for food irradiation, actively promoting its
use during the early years. In the 1960s, he became involved in
commercial irradiators projects in the UK. He was a founding
director of Irradiated Products Limited later Isotron plc. Frank encountered considerable
personal criticism from aggressive anti-irradiation lobby groups in the UK. Despite this, he
remains a passionate advocate of the technology.
Jan Leemhorst (1938-2015)

IMRP Laureate 1994
Jan Leemhorst left Philips in Eindhoven, the Netherlands,

to build and manage the irradiator of Gammaster in Ede.
This was a project of the Dutch Cooperative of Pharmacists,
OPG, who would sterilise their own products and offer spare
capacity to third parties. The tote box irradiator that started
in 1970 was soon insufficient. Since the demand for food
irradiation was growing, supported as it was by the nearby
Pilot Plant, a second irradiator was built. It was the first
world pallet irradiator, at first met with a lot of scepticism by
experts but adopted around the world a few years later. Before the new irradiator started
operation in 1982, a successful food irradiation symposium was organised in late 1981.
The book [60] became somewhat of a best-seller in the
food irradiation literature and was even translated into
Chinese a few years later. Its title Food Irradiation Now
reflected the optimism and the determination of the
symposium promoter:
Under the leadership of Jan Leemhorst, Gammaster
was the first truly international irradiation company
as it expanded in France and Germany in the 1980s,
then in South Africa, Sweden and Thailand in the 1990s.
Gammaster was later acquired by Isotron plc.
Jan Leemhorst is the person who propagated the Radura
logo internationally by suggesting its inclusion in the
Codex Alimentarius Standard for Irradiated Food as an
option to label irradiated food. He tirelessly advocated
food irradiation in multiple meetings around the world,
often frustrated by the slow regulatory progress.

Frank Fraser (1935-2004)
IMRP Laureate 1989
Born in Montreal in 1935, Frank Fraser was a multi-sport athlete.

His talents in football gave him a scholarship to Tennessee A&M
where he also excelled academically, graduating with a B.Sc. He
was a member of the Who’s Who Among Students in American
Universities and Colleges. Frank played in the Canadian Football
League for 8 years (1956-1964) with the Montreal Alouettes, the
Ottawa Rough Riders, Regina Roughriders, Edmonton Eskimos
and the 1962 Grey Cup winners, the Winnipeg Blue Bombers. He
joined AECL’s CPD (later to become Nordion) on a part-time basis while at the same time
juggling his football career and engineering studies. He became a permanent employee in
1964, started as Design Engineer and later became Vice-President Market Development.
Frank was in the forefront of the design, supply and installation of many of the Nordion’s
industrial irradiation plants around the world. A passionate champion of food irradiation,
Frank was Canada’s representative and Deputy Chairman of the ICGFI. He was pivotal in
establishing the Canadian Irradiation Centre in Laval, Quebec and the Food Technology
Services Inc. facility in Tampa, Florida (later acquired by Sterigenics). Frank retired from
MDS Nordion in 1998. Those who knew him appreciated his sharp mind, open spirit,
enthusiasm, and keen sense of humour [2, 59].
Josef Farkas (1933-2014)

IMRP Laureate 1992
József Farkas was Emeritus Professor of Food Science of

the Corvinus University of Budapest, Hungary, a part-time
scientific adviser of the Hungarian Central Food Research
Institute and a member of the Hungarian Academy of Science.
From 1957 to 1986, he worked at the Central Food Research
Institute in Budapest. From 1980 to 1985 he served as Project
Director of the International Facility for Food Irradiation
Technology in Wageningen, The Netherlands. József was
editor-in-chief of the international journal Acta Alimentaria
and the author or co-author of 12 books and several hundred scientific articles, many of
them on food irradiation, especially spices and dried ingredients [58].

Cultural Heritage Preservation
The use of irradiation to preserve and consolidate artefacts is now an established
application of irradiation. Recent IAEA projects and publications [61] have encouraged
its development. Romania, Croatia, Brazil, South Korea, Vietnam, and Tunisia are among
countries now using the method. The story started in the late 1960s at the Nuclear
Research Centre of Grenoble in France.
In 1969, the City of Grenoble, France wanted to renovate a badly deteriorated 18th century
parquet floor attributed to the highly regarded cabinetmaker Jean-François Hache and
located in the marriage hall of the former Grenoble Town Hall, which was to become the
Stendhal Museum. Louis de Nadaillac, an engineer of the Radiation Applications Section
of the French Atomic Energy Commission (CEA) proposed to the local Department of
Architecture and Buildings of France to adapt an industrial process for the manufacture
of “plastic wood” to treat this floor, by impregnating it with a resin hardened in situ by
gamma irradiation. The first industrial production of “wood-plastic flooring” had taken
place in the USA in the 1960s and the technique had been studied in laboratories at the
CEA in France and the University of West Virginia in the USA.
Louis de Nadaillac’s original idea was to use and adapt the process to rescue badly
deteriorated old wood, parts of which would otherwise have had to be replaced by a copy.
Convincing his colleagues of the relevance of this idea was difficult. On the one hand, he
had to persuade the rather conservative local
authority that this new method would make
it possible to preserve the authenticity of an
important element of local heritage. On the
other hand, he had to persuade a CEA
laboratory to take the risk of investing
in a pilot chemical treatment installation
at an irradiator. He eventually managed
to implement this treatment on an
almost industrial scale. His Radiation
Technology Group’s engineering skills
enabled Louis de Nadaillac to resolve
the initial technical difficulties. The
success of this large-scale treatment
served as a springboard for Nadaillac to
enthusiastically develop a larger project
and to lead a small team in what was still
an adventure in 1970.
The success of this first project
attracted the interest of other
heritage conservation authorities. At
the instigation of the Director of the
Louis de Nadaillac

International Council of Museums (ICOM), Hugues de Varine, experts met in June 1970 in
Grenoble to assess the possibilities of the new technique to conserve cultural property.
Four international working groups were formed: damaged wood, stone, immersed wood,
paper and fibres. Louis de Nadaillac involved major European heritage conservation
organisations such as the International Centre for Conservation (ICCROM) in Rome, and
the Institut Royal du Patrimoine Artistique (IRPA) in Brussels.
In 1971, a test program was carried out on samples of wood, stone, ethnographic materials,
waterlogged wood, and paper, supplied by the different participants, in collaboration with
the research laboratory of the Department of Historical Monuments. That same year, a
14th century Virgin and Child from Burgundy was treated with a new polyester resin. This
statue was presented at the “Atoms for Progress” exhibition during the World Conference
on the Peaceful Use of Atomic Energy in Geneva. For the first time, the use of gamma
rays for the conservation of a remarkable work of art from Burgundy was highlighted.
The event received a large coverage by the French and the foreign press, and the statue
became an emblem of the Nucléart program.
After initial enthusiasm, difficulties began. The long-awaited samples that were required
to start the impregnation program were slow to arrive. Attempts to automate the
extraction of water from waterlogged wood in the ternary phase were unsuccessful. The
critical tone of an editorial published by the authoritative magazine “Connaissance des
Arts” increased the difficulties associated with the development of the technology and
challenged the credibility of the program. This was nearly fatal for Nucléart.
Fortunately, a meeting of the ICOM Conservation Committee in Madrid provided an
opportunity to present the first convincing results to 300 conservation specialists. Louis de
Nadaillac was invited to join various specialised commissions, including the Commission
for “Stone Disease” of the Architecture Directorate. The Executive Committee of the
ICOM Conservation Committee created a working group on “Nuclear applications in
conservation” and entrusted him with its coordination.
A first agreement between CEA and Direction des Musées de France was signed in 1973.
That same year, Louis de Nadaillac was appointed Head of the “Nucléart project” created
by the CEA with financial autonomy and the required flexibility to develop new programs.
The first consolidation of cabinet wood was carried out in 1973 on a shelf element with
a decoration attributed to the Hache family of cabinetmakers. This consolidation was
complementary to the work of a cabinetmaker-restorer. Then treatment of altered works
began on a large scale.
The first results of the treatment of waterlogged wood were obtained in 1973 on objects
from daily life extracted from the Colletière site (11th century) in the Charavines Lake in
Savoy. A method of treating these woods was developed by successive baths of acetone
to replace the water, and styrene-polyester resin to replace the acetone.

The irradiation treatment that received the most publicity was undoubtedly the
disinfestation of Ramesses II’s mummy. In 1974, Egyptologists visiting his tomb noticed
that the mummy’s condition was rapidly deteriorating and flew it to Paris for examination.
Ramesses II was issued an Egyptian passport that listed his occupation as “King
(deceased)”. The mummy was received at Le Bourget airport, just outside Paris, with the
full military honours befitting a king.
The mummy was examined by the French National Museum of Natural History. Having
been damaged in the past by insect larvae, the mummy was also found to be infested by
a dense population of various types of fungi, though without any pathogenic bacteria. In
agreement with the Egyptian authorities, it was therefore decided to disinfect the mummy
by gamma irradiation at the Nucléart laboratory. No sampling of the actual mummy of
Ramses II was authorised, except for some fragments of hair and textile that were lying on
the linen or on the Plexiglas plate placed under it. More than four hundred samples were
taken from other lesser mummies to determine a dose effective enough to eradicate
more than sixty species of fungi without harming the components of the mummy such as
the hair, textiles, skin and teeth.
In 1973, Louis de Nadaillac prematurely died of leukaemia at the age of 36. Thanks to his
competence, his dynamism, and his sense of organisation, in just four years he succeeded
in establishing the foundations of Nucléart as the international reference [62, 63].

Annex 1: List of IMRP Laureates
Laureates IMRP # Place Year
Charles Artandi †
2 Miami, USA 1978
Paul Cooke †
William Baird †
3 Tokyo, Japan 1980
Arthur Charlesby †
Toshikazu Higashino † 4 Dubrovnik, Yugoslavia 1982
John Masefield †
5 San Diego, USA 1984
Vivian Stannett
Ken Morganstern V
6 Ottawa, Canada 1987
Joe Silverman †
Frank Fraser †
Frank Ley † 7 Noordwijkerhout, Netherlands 1989
Sam Nablo †
Marshall Cleland †
8 Beijing, China 1992
Joseph Farkas †
Jan Leemhorst †
William McLaughlin † 9 Istanbul, Turkey 1994
Pierre Vidal †
Sueo Machi †
10 Anaheim, USA 1997
Arne Miller
Masaaki Takehisa
11 Melbourne, Australia 1999
Alan Tallentire †
Joyce Hansen
12 Avignon, France 2001
Robert Morrissey †
Yves Jongen
13 Chicago, USA 2003
George West
John Corley
Theo Sadat 14 Kuala Lumpur, Malaysia 2006
James Whitby †
Dieter Ehlermann
15 London, UK 2008
Rocco Basson †
Olgun Güven
John Kowalski 16 Montreal, Canada 2011
Wang Chuanzhen †
Andrzej Chmielewski
17 Shanghai, PR China 2013
Paul Minbiole
Mohamad Al-Sheikhly
18 Vancouver, Canada 2016
Zhang Xianghua
Maria Helena Sampa
19 Strasbourg, France 2019
Yves Henon
† = Laureate is Deceased

Annex 2: The First International Meeting on
Radiation Processing (1976)
The International Atomic Energy Agency must be credited for having organized the first
three major international events in the field of radiation processing. These were:
• Large Radiation Sources in Industry

Conference on the Application of Large Radiation Sources in Industry and Especially
to Chemical Processes
Warsaw, Poland 8-12 September 1959
• Industrial uses of large radiation sources

Conference on the Application of Large Radiation Sources in Industry
Salzburg, Austria, 27-31 May 1963
• Large radiation sources for industrial processes

Symposium on the Utilization of Large Radiation Sources and Accelerators in
Industrial Processing
Munich, Federal Republic of Germany, 18-22 August 1969.
The first symposium dedicated to radiation sterilisation was organised on 7-8 December
1964 in Risø, Denmark, with the support of the UK Panel on gamma and electron. Ten
years later, Johnson & Johnson sponsored a first international conference on Technical
Developments and Prospects of Sterilization by Ionizing Radiation (Vienna, Austria, 1-4
April 1974), and held the First Kilmer Conference in East Windsor, New Jersey, on April,
30 - May 1, 1976.
The project to periodically hold a conference that would address all irradiation technologies
and applications was formed by several people, among which John Masefield. The First
International Meeting on Radiation Processing (IMRP 1) was held in Dorado, Puerto Rico
at the Cerromar Beach Hotel on 10-13 May 1976. In retrospect, the punchline selected for
the conference had something of a prophecy: Radiation’s Time Has Arrived.
The meeting was sponsored by the American Nuclear Society, the American Chemical
Society, and the Society of Plastics Engineers.
K.H. Morganstern (Radiation Dynamics) was Chairman of the conference and V.T.
Stannett was Chairman of the program committee composed of A. Chapiro, A. Charlesby,
W. McLaughlin, S. Okamura, J. Silverman, and Y. Tabata.
The table on the next page is a list of the presentations and speakers.

Basic concepts of radiation processing J. Silverman
Crosslinking and degradation of polymers A. Charlesby
Radiation initiated polymerization Y. Tabata
Radiation grafting A. Chapiro
Electron irradiation facilities M. Ramler
Gamma irradiation facilities R. Harrod
Radiation process control and equipment R. Derbyshire
Shielding and safety requirement for electron

C.R. Hoffman
accelerators systems
Radiation measurements and quality control W.L. McLaughlin
Successful and promising application of radiation

C. Artandi
processing – Sterilization
Preservation of food J.F. Diehl
Applications of radiation processing in biomedical engineering A.S. Hoffman
Sterility assurance of medical products W.C. Dierksheide
Applications in plastic film and sheet W.G. Baird
Applications in elastomers G.A. Böhm
Irradiation in the production of communication wires L.D. Loan
Applications in foam plastics D.A Tregeser
Applications in wood plastics A.E. Witt
Coatings applications C. Coppinger
Radiation processing for textiles W.K. Walsh
Ultraviolet applications for packaging R.B. Mesrobian
Low energy electron process application S.V. Nablo
Radiation treatment of sewage sludge –

A. Süss
Experience with an operating pilot plant
Radiation treatment of combustion gases S. Machi
Radiation treatment of solid waste W. Brenner
Laser fusion sources for radiation processing H. Gomberg

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[32] Varian
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[37] Silverman, Joseph
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Puerto Rico, 10-13 May, 1976. p. I1
accelerators in medicine and industry
7èmes Journées d’Etudes SATURNE,
[38] Harmer D.E.
Ramatuelle, France, 29 Janvier - 2 Fevrier
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Industrial Application of Radiation
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Salzburg, Austria, 27-31 May 1963.
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[34] Ehlermann, Dieter
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[39] Guven, Olgun [45] Chapiro, A.
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[40] Davidson and W.L. Geib, G.
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[41] Witt A.E.
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[42] University of Maryland
Professor Joseph Silverman remembered
[47] Darmandy E.M. et al.
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[63] de Tassigny., Christian

Personal communication, August 2021

The Business and Science
of Radiation Processing in 2022
November 2022

Radiation Processing Industry - The Early Year

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November 2022

1 Radiation Processing Industry: The Early Years

AAMI Association for the Advancement of Medical Instrumentation

Laurent Cortella, Nucleart, France Sophie Rouif, Ionisos, France

4 Radiation Processing Industry: The Early Years

5 Radiation Processing Industry: The Early Years

John Masefield, Chairman of the International

6 Radiation Processing Industry: The Early Years

7 Radiation Processing Industry: The Early Years

8 Radiation Processing Industry: The Early Years

Dr. Arthur Charlesby can be considered as the father

9 Radiation Processing Industry: The Early Years

10 Radiation Processing Industry: The Early Years

Paul Cook was born in Ridgewood, New Jersey, in 1924.

11 Radiation Processing Industry: The Early Years

Marshall R. Cleland was born in Vermillion, South Dakota

12 Radiation Processing Industry: The Early Years

Pierre Vidal devoted a major part of his long life to the

13 Radiation Processing Industry: The Early Years

An inventor and an entrepreneur, Samuel Nablo was born

14 Radiation Processing Industry: The Early Years

15 Radiation Processing Industry: The Early Years

16 Radiation Processing Industry: The Early Years

17 Radiation Processing Industry: The Early Years

The Ethicon Irradiator

18 Radiation Processing Industry: The Early Years

Picture: The irradiators hall at Wantage [24]

19 Radiation Processing Industry: The Early Years

The First Large Gamma Irradiators

Location Operator Designer Capacity (MCi) Since

Argentina – Ezeiza CNEA CNEA 1 1970

Australia – Dandenong Gamma Sterilization Pty AERE Harwell 2 1960

Denmark – Roskilde Nunc A/S AECL 1 1969

France - Dagneux Conservatome D1 CLAA 1 1960

France - Dagneux Conservatome D2 Conservatome 1 1968

France - Dagneux Conservatome D3 Conservatome 1 1973

Germany – Hamburg Ethicon GmbH Marsh 0.75 1966

Germany – Melsungen B.Braun Co. Sulzer Brothers 0.6 1966

Germany - Rommelshausen Firma Willy Rüsch AECL 1.5 1968

Italy - Bologna ICO SpA Marsh 0.5 1967

Japan – Tochigi Japan RI Irradiation Service 0.5 1970

Table extracted from Table II in [25]

20 Radiation Processing Industry: The Early Years

21 Radiation Processing Industry: The Early Years

The First In-House Industrial Accelerators

22 Radiation Processing Industry: The Early Years

The first contract service accelerators

23 Radiation Processing Industry: The Early Years

24 Radiation Processing Industry: The Early Years

25 Radiation Processing Industry: The Early Years

26 Radiation Processing Industry: The Early Years

Joseph Silverman was one of the creators of radiation chemistry

Vivian Stannett (1917-2002)

Vivian Stannett was a prominent polymer scientist and engineer

27 Radiation Processing Industry: The Early Years

28 Radiation Processing Industry: The Early Years

29 Radiation Processing Industry: The Early Years

• Transiting from the concept of absolute sterility to sterility assurance level. It is in

• Abandoning sterility tests on a given number of samples taken from routine

• A reasonable number of sterility tests can detect only gross contamination or