Biosensors For Early Disease Detection

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ELVIS ARIEMO

E021-01-1010/2020

BSC EEE

RESEARCH METHODOLOGY

Problem Statement

Traditional methods for tracking health often miss early signs of disease due to infrequent
measurements and invasive procedures. We need better biosensors to continuously and comfortably
monitor vital signs and detect diseases early through readily available bodily fluids or signals. This can
improve patient comfort, enable early intervention, and provide rich data for personalized healthcare.

Main Objectives

Main Objective: Develop Biosensors Real-Time Vital Sign Monitoring and Early Disease Detection

The main objective of this research is to design and develop next-generation biosensors that can
achieve:

 Continuous and non-invasive monitoring: Measure vital signs (e.g., heart rate, blood pressure,
respiration) and relevant biomarkers through readily accessible body fluids (e.g., sweat, tears,
saliva) or physiological signals (e.g., electrocardiogram).

 Early disease detection: Detect and track the onset or progression of diseases by monitoring
specific biomarkers associated with different pathologies.

 Real-time data transmission: Transmit collected data wirelessly in real-time for analysis and
feedback to healthcare providers and patients.

 High sensitivity and specificity: Accurately identify and quantify minute changes in vital signs
and biomarkers with minimal false positives or negatives.

 Biocompatibility and safety: Ensure user comfort and minimize potential health risks associated
with sensor implantation or long-term use.

Sub Objectives

1. Develop robust and biocompatible sensor materials: Design nanomaterials or other sensitive
elements that can interact with target biomarkers with high specificity and selectivity.

2. Optimize sensor integration and miniaturization: Design wearable or implantable devices that
are comfortable, unobtrusive, and offer long-term functionality.

3. Utilize advanced signal processing and machine learning: Develop algorithms to analyze sensor
data in real-time, identify early disease signatures, and generate actionable insights.

4. Establish secure and efficient data communication protocols: Ensure secure transmission of
sensitive health data while maintaining low power consumption for extended device lifespan.
References

E. B. Song, S. Lee, and Y. Kim, "Recent advances in electrochemical biosensors based on nanomaterials,"
Sensors (Basel), vol. 19, no. 5, p. 1040, 2019.

J. Li, Z. Li, M. Wu, Z. Guo, and R. Wang, "Wearable and implantable biosensors for personalized
medicine," Nature Reviews Materials, vol. 7, no. 3, pp. 292-320, 2022.

M. Zhang, S. Song, L. Zhang, S. Wang, and R. Xu, "Wearable biosensors for personalized healthcare,"
Chem. Commun. (Lond.), vol. 57, no. 57, pp. 7054-7071, 2021.

Y. Liu, M. Kim, D. Park, and R. P. Ram, "Recent advances in wearable biosensors for sweat analysis,"
Biosensors and Bioelectronics, vol. 226, p. 111098, 2021.

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