CS 5100 Brochure

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Lighting the way

with diagnostics

Fully Automated Coagulation Analyser

CS-5100

Exceptional Productivity without


Compromise on Quality or Safety

www.sysmex-ap.com
EXCEPTIONAL PRODUCTIVITY

Highest Throughput

For both simple and complex assay panels.

Parameter Throughput (tests/hour)


PT 400
PT/APTT 400
PT/APTT/Fbg/AT/DD 270

Automation Connectivity

With the CS-5100 system there is an option to connect


to a laboratory automated transport system (LAS) using
direct sampling, without the need for robotic arms, for
greater reliability and efficiency.

Advanced cap-piercing technology

• Primary tube cap-piercing and sampling from a


sample rack or LAS* reduces operator exposure to
biohazardous materials.
• Both capped and open vial samples can be analysed
from the same sample rack, reducing the sample
processing time.
*Primary tube cap-piercing is available for GLP Systems.

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CS-5100

HIGH QUALITY RESULTS


The Power of Multi-wavelength Technology

The CS-5100 system is equipped with an optical fiber that supplies light
at five different wavelengths, and a detector capable of receiving light in
multiple wavelengths.

Having this multi-wavelength capability, the system takes care of, not just
the analytical results, but also pre-analytical problems.

Utilised optimal wavelength for each measurement parameter

• Clotting assays are measured at Chromogenic assay Lipids


the primary wavelength, 660nm, Clotting assay Haemoglobin
Chromogenic assay Bilirubin
where chromatic substances will Immunologic assay

have minimum effect, ensuring a Clotting assay


Absorbance

Immunologic assay
reliable result.
• Measurement is automatically Clotting assay
Immunologic assay
s w i tc h e d t o t h e s e co n d a r y Aggregation assay
wavelength, 800nm, when the
coagulation reaction shows
only a smal l change at the
primary wavelength, ensuring
an accurate result, such as in the
case of a severely lipemic or low Wavelength (nm)
fibrinogen sample.

Signal Signal
1,200 1,200

Secondary wavelength (800nm)


800 800

Primary wavelength Secondary wavelength


400 (660nm) 400 (800nm)

Switching
Primary wavelength (600nm)

turbidity level over threshold turbidity level over threshold

0 10 20 30 40 50 0 10 20 30 40 50
Seconds Seconds

Normal Reaction Curve Abnormal Reaction Curve

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EXTRA SAFETY
Haemolysis and inappropriate filling of tubes are two of the most
common pre-analytical problems in coagulation testing1. For peace of
mind, on-board, automated pre-analytic checks ensure the integrity
of the sample before analysis and flag the result if the sample is of
questionable quality, as well as further streamlining the sample handling
process on track systems.

Assay-specific HIL Check for Interfering Substances


The CS-5100 system measures the level of Haemolysis
(H), Icterus (I), and Lipemia (L) in the sample with an HIL
detector at three wavelengths, 405, 575, 660nm.

• The level of HIL is displayed as a flag, based on


user-defined criteria for each parameter, to ensure
appropriate interpretation of results.

Primary Sample Volume Check

The CS-5100 system detects the level of liquid in a


sample tube when aspirating the sample for the first
time. It determines whether or not it contains an
appropriate volume of blood according to the CLSI
guideline of 9:1 ratio.
Blood/
anticoagulant
ratio 9:1

• Sample tubes with volumes outside the acceptable


range are flagged, to avoid reporting of erroneous
results.

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CS-5100

A NEW STANDARD IN HAEMOSTASIS TESTING


Automated Platelet Aggregation Assays
Provide assessment of platelet-based ristocetin cofactor activity (vWF:RCo)
and platelet aggregation to ADP, epinephrine, collagen, arachidonic acid and Optical fiber
ristocetin2. Light
sensor

Stimer bar

Magnets

Analysis result with aggregation tracing and 8 channels for platelet


evaluation parameters aggregometry method

Automated FXIII Activity Assay


Measure FXIII activity using the unique wavelength, 340nm.

Multi-wavelength detection system

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A NEW STANDARD IN
HAEMOSTASIS TESTING

Inhibitor Testing with Cross-mixing Test

Simplify cumbersome procedures


• Automatic dilution
• Graph creation
• Index calculation
• Overlay of immediate and delayed type of graphs
Delayed type

Immediate
type

ICA (Rosner Index) = Index of circulating anticoagulant


ICA = (b-c) / a x 100
a = Coagulation time of 100% patient serum
b = Coagulation time of 50% patient serum
c = Coagulation time of normal serum

Cross-mixing analysis display

Clot waveform analysis (for research)

Potential clinical utility for evaluating coagulation


function in various bleeding disorders, especially
Haemophilia A, B, and monitoring bypass therapy4.

Clot curve

First derivative: coagulation velocity

Second derivative: coagulation acceleration

Wave analysis screen

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CS-5100

References

1. Lippi G, Salvagno GL, Montagnana M, Lima-Oliveira G, Guidi GC, Favaloro EJ. Quality standards for sample
collection in coagulation testing. Semin Thromb Hemost. 2012; 38:565–75.

2. Lawrie AS, Kobayashi K, Lane PJ, Mackie IJ, Machin SJ. The automation of routine light transmission platelet
aggregation. Int J Lab Hematol. 2014; 36(4):431-8.

3. Lawrie AS, Green L, Mackie IJ, Liesner R, Machin SJ, Peyvandi F. Factor XIII– an under diagnosed deficiency– are we
using the right assays? J Thromb Hemost. 2010; 8: 2478–82.

4. Shima M, Thachil J, Nair SC, Srivastava A.Towards standardization of clot waveform analysis and recommendations
for its clinical applications. J Thromb Hemost. 2013; 11:1417-20.

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Design and specifications may be subject to change due to further product development.

Sysmex Asia Pacific Pte Ltd Sysmex New Zealand Ltd Sysmex Vietnam Co., Ltd
Tel +65 6221-3629 Fax +65 6221-3687 Tel +64 (9) 630-3554 Tel +84 (8) 3997-9400 Fax +84 (8) 3997-9405
www.sysmex-ap.com www.sysmex.co.nz www.sysmex.com.vn

Sysmex India Pvt. Ltd Sysmex (Thailand) Co., Ltd Sysmex Vietnam Co., Ltd (Hanoi Branch)
Tel +91 (22) 6112-6666 Tel +66 (2) 032-2536 Fax +66 (2) 116-5396 Tel +84 (4) 3776-7020 Fax +84 (4) 3776-7022
www.sysmex.co.in www.sysmex.co.th www.sysmex.com.vn

PT Sysmex Indonesia Sysmex Philippines Inc. Sysmex Australia Pty Ltd


Tel +62 (21) 3002-6688 Fax +62 (21) 3002-6699 Tel +63 (2) 621-2460 Fax +63 (2) 621-2432 Tel +61 (2) 9016-3040
www.sysmex.co.id www.sysmex.com.ph www.sysmex.com.au

Sysmex (Malaysia) Sdn Bhd


Tel +60 (3) 5637-1788 Fax +60 (3) 5637-1688
www.sysmex.com.my
SAP/HAEMOSTASIS/CS-5100/16052019/V2.0

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