Chapter 4 Act 8
Chapter 4 Act 8
Chapter 4 Act 8
Relation Between
Agonistic Antagonistic
If the drug facilitates, enhances, If the drug inhibits, prevents,
favors, prolongs, triggers, the hinders, obstructs, blocks, and stops
function of neurotransmitter. the functon of the neurotransmitter.
Drug 1: Curare
1
No recording at the
4- Injecting ACH in the synaptic
pre while post muscle
cleft
contracts.
5- Stimulate pre + injecting
Muscle relaxes.
curare
Radioactivity appears
6- Inject radioactive ACH
at the post neuron.
7- Inject radioactive curare then Radioactivity appears
ACH at same locations.
Explain the mode of action of Curare has approximately the same spatial configuration as Acetylcholine. Thus,
curare. curare occupies its receptors, leading to muscle relaxation (paralysis).
Drug 2: Morphine
The pain
sensation
or message
is
controlled
by the aid
of 3 types
of neurons:
2
1- Pick out the endogenous
factor (s):
2- Pick out the exogenous factor
(s):
Interpret
Analyze Significance Conclude
Variable Result Indicate that
P vesicles decrease
from 100 to 20
3- Stimulate presynaptic neuron
followed by EPSP at
the post neuron.
4- Release of P substance from 10 APs carrying the
presynaptic neuron. Pain message.
P vesicles decrease:
5- Stimulate pre synaptic and
100 to 80
modulatory neuron (release
2 APs carrying the
encephalin)
pain message.
6- Stimulating pre & injecting P vesicles remain 100
morphine No pain feeling
Morphine gas similar spatial configuration as encephalin. So, morphine occupies its
7- Explain the mode of action of
receptors leads to complete inhibition of P exocytosis causing total suppression of
morphine.
pain sensation.
8- Explain the long effect of
Since there is no specific enzyme to break it down.
morphine.
Drug 3: Cocaine
3
1- Pick out the endogenous
factor:
2- Pick out the exogenous
factor:
Interpret Conclude
Analyze Significance
Variable Result Indicate that
Feeling of pleasure
3- Stimulate dopamine neuron
and hyperactivity
Pleasure and
hyperactivity for
4- Same but with injecting
longer time.
cocaine.
Recapture pump
activity decreases
In normal cases, dopamine is released for few seconds giving the person the
5- Explain the mode of action of pleasure feeling for a short time then reabsorbed very quickly, on the other hand
cocaine. cocaine prevents its reabsorption which facilitates its prolonged fixation which in
turn prolongs its pleasure effect.
Drug 4: Amphetamines
4
Dopamine vesicles
3- Stimulate dopamine neuron
decrease
4- Same but with injecting Dopamine vesicles
amphetamines. decrease significantly
In normal cases, dopamine is released in few amounts leading to a pleasure and
5- Explain the mode of action of motricity feeling for a limited time. On the other hand, amphetamines facilitate the
amphetamines. exocytosis of dopamine causing an increase of pleasure, motricity and activity for
longer duration.