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    Pharma 10

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    hamza jassar
    This document discusses different types of adverse drug reactions and drug-drug interactions. It describes 5 types of adverse drug reactions: type A, type B, type C, type D, and type E. It also discusses 3 major causes of adverse drug reactions: patient factors, drug factors, and prescriber factors. The document then explains different types of drug-drug interactions, including interactions during gastrointestinal absorption, displacement, metabolism, renal elimination, and receptor interactions. Drug examples like penicillin, thiazides, chloroquine, chlorpromazine, digoxin, and warfarin are provided to illustrate these concepts.

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    Pharma 10

    Uploaded by

    hamza jassar
    62 views5 pages
    This document discusses different types of adverse drug reactions and drug-drug interactions. It describes 5 types of adverse drug reactions: type A, type B, type C, type D, and type E. It also discusses 3 major causes of adverse drug reactions: patient factors, drug factors, and prescriber factors. The document then explains different types of drug-drug interactions, including interactions during gastrointestinal absorption, displacement, metabolism, renal elimination, and receptor interactions. Drug examples like penicillin, thiazides, chloroquine, chlorpromazine, digoxin, and warfarin are provided to illustrate these concepts.

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    pharma 10

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    This document discusses different types of adverse drug reactions and drug-drug interactions. It describes 5 types of adverse drug reactions: type A, type B, type C, type D, and type E. It also discusses 3 major causes of adverse drug reactions: patient factors, drug factors, and prescriber factors. The document then explains different types of drug-drug interactions, including interactions during gastrointestinal absorption, displacement, metabolism, renal elimination, and receptor interactions. Drug examples like penicillin, thiazides, chloroquine, chlorpromazine, digoxin, and warfarin are provided to illustrate these concepts.

    Copyright:

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    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    62 views5 pages

    Pharma 10

    Uploaded by

    hamza jassar
    This document discusses different types of adverse drug reactions and drug-drug interactions. It describes 5 types of adverse drug reactions: type A, type B, type C, type D, and type E. It also discusses 3 major causes of adverse drug reactions: patient factors, drug factors, and prescriber factors. The document then explains different types of drug-drug interactions, including interactions during gastrointestinal absorption, displacement, metabolism, renal elimination, and receptor interactions. Drug examples like penicillin, thiazides, chloroquine, chlorpromazine, digoxin, and warfarin are provided to illustrate these concepts.

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    ON1VER£I1Y Of JORDA.

    N
    Faculty OF Medicine

    c: _',J\
    '\ j ,,-v

    LECTURE NO: 10
    • C<.>rnparing Type A and Type H

    "..}lam les TAT


    I, Penicillin Ene hII10 tb ~ c<.>Il"u15ion!;
    2 Tbiazides Goo
    3,ChIo muine Sedation
    4 Chloro enl<;ol Nausea, DiiU'l'hea

    • tonklng Qlthe tDble abon, if we gi"e a pati(fl( Thiazide$ lIIId he ~utfcred fi'om
    Guul, we can easily lower tho: dose and this side effeel "'ill probably disappear.
    Ho..'C'I"tl', if the patient 'IIITen:d from l1Jrombo(:)10lX'1,a, It wlillast in the patient.

    'TIle OIher minor types


    C) TJVC C

    L Continuous: use for a l<.>tij: Icon

    Ex: Aspirin (An.:tlgesic) ..1K'fI uocd 10 SlOp hea<.\ache, 11 mIght cause IlqIlJrotoxicily.

    0) T)-pe I)

    I O\:ht)'cd cff~slike

    - T eratogerw:$~' ITIiIlfomJatKJuvflh"'n'l, "de effects will be ~hO'1''Il after birth,

    · Carcinogenesis: lome c~10to"K: Jru~ (used to treal eancer) react Wilh lhe DNA.u'ICI

    c.au.~ n ~econdary cancer.

    17) Type [i'

    I Thi5 type 1lf'I"C~ "'hen the patient SlOps using the drug abruplly ",,[bullt decreaslO&

    the <lusc finl or ",en replacIOB II wah another drug ..'hich 'dll cause a rd,ound eITect

    • C.,,<c.<lIf Ad"crse Kuetlon,'


    We have thrtt ""'Jor cau..e.

    J. PaUrll(S
    AI Age
    Il) (ie"et" m.l~eup ,f ..'e ha\e apatieOl wilh a ml55inloll:mC, he nngh! nOt i:t'llhe
    lx,,,,,hl "lllle dlug
    () Alln~) >un.., Pl'OIJ"" ""gill he allertlc tn ,,'nit dnlp more Ih;m oth=

    Dj H'Slor" of lhe diK:lsC lh,,,', why IH' ,I~ 'tJ~! ,l$l, ')'< 1l<~ """,,,I ,he p;lIlcm', m~Jic J I

    hi<l,"'"

    1-) ( h Ii...- Ii~~ ,""' m"""~"I,'I ,llld ,~,~ ",,,Ie' r".l1\Jk,


    1. P'Ufr
    - AnticarK:er a.Gmlts lIS I have ment,oned some anticancer drugs might be m;ponsible
    for the fOllI\1tioD of some secondary ClllIctT!
    - Digoxin: one of the \le$t drugs used to tre,at I,Xl1II:t:Stivc hc~tt lilllure, howe"er it is
    ,~IOX;C wnh II.'~ MITOW m.:ll'gin of safet}', so if}'Qu dO\lble the lIoK' the palK'l1t
    1lllly 51Iffcr some ScriollS s'de effects
    - .'".ntimim>bial dru¥S many peopkl are allergic to IlIese dmp. that's why you ha''e to
    know the medical history of tile paticm s.., if ~ pallent" allerg,c to pemc,l1m)'Ou
    should oot give him any kind ofpmidllin or cephalQsp<JTin

    J. Pracribq:
    The physician should be careful wben prescribing a drug that is
    Used for a long period of time.
    Used In II. king critical pha.~c (ex. PrcgruulCY).

    " f)n'l:- f)m:: Inlencrion"


    •Th,s kioo of mtefaction ~ns when a palleD[ is taking more th3n one drug at a
    time
    - Thc numb<.T ",fintet1lCtions depends on the number ofl~ drup wen Dlthe same

    tim<:,

    - We ha"e to be so carTful "'hen giving ~ than one drug al a Ilmt: npl...,,~lly

    1 Wilen "'e ha'-c a narrow wmdo..'" narrow margm of safety"

    2 When lhey arc UlN for II. long time

    J In tile cue of chronic dise;tSn (cx- hyperu:ns;"'n, Diabc!es, cp,lq::>sy)

    • Types ofo."l:- n."g InlCtllCtIQl'


    A I'ha,'fT\3oOOlr.1Il(,11C 10lt1 ""'I jull.

    I. G3~lroinle<;tiIl31 Ah.~o ..rtion Interaction,

    Anlac,ds wlt.!t'ly lI.l'U fo.!l'I-'CI'l'l ukc.. a,lrll\)r """lralmng 'ugh ,,",dny.


    huw~'cr ~nta,"us rCJd "itll So.! ,,~,"y,j, "10> Fe" ~,a"'ple "htn g,,,en ",nh
    '(1r.xyclone lanl;biolicl. Itnlntrd~ d~t!e;\5e III ah;o;<J'l',ocm ";II~ Th<') "I", [",,<.1
    !" Tn'''l' sails Ioke (""~. " ~1~' " ,\!, ! t $~11l
    r,·I .. ,'c}'d",~ ,t ~I\('n "~,n~,, ,til IIL'n. the) ,,,II f,'rm "n lI11e,.-JCII....' " et.lmpln
    1,·I,,'I,I!I,,"1 "hlt.Io" ,II J.",,',",I' llll' " .. n ,tt--;"''f'l,,'n "nr
    I.' ,'n 'f ad'" ,n;<1 ered " "h "'dL I,'!r: n c10",· " ,II ,"",., '\ ,tlo " ,,'... ,I', I.., ,,,,,,',
    , "'I' n ,"
    -ChoIeStC1'amine: U.led to lower the cholesterolle,'cJ m lhe body It binds 10 bo1h:
    Digoxin (for conge~l;ve hean failure) and WlIrfllrin (lIII anticoogul;mt).
    . Antacids. Thc GJ tract PH i, very impon:mt for the ionizalioninonioniT.ation, 10
    If }"Ou ore lakin~ lilly Iilllaci<,\ iI will affecI the Ph of the G.I trael and theref"rc lh,
    I1tl:Dlioued mio, 50 you have to be cnreful with ""p;fllI, barblluTllla etc
    - MO'IiliIy: for example the anticllolinergic dnlgll slo"" the mulibty aDd therefore
    affect iu absorpfion.

    2. Interaction during displ:lCement:


    For cxalll'lc when we droj: A b4r>ds 10 albumin instead uftlrul;: B, the fr~ amount
    of drug B "ill increa!e and 50 'lJ absorpl1uD ""ill iD.:rc:;ue;u well.

    3, Tnteracting with certain drues durin2,


    metabolism.
    •UI1tl: drugs afTeeu the metabolism rate either by mduCllOD or inhibition and tllCTefore
    afTeclthe p;tlient h1msel(

    4. Interacting with certain drugs durin!! renal f.'.Iiminntion

    5, Interacting wilh the receptors' of sOllie drn!!s

    8Y:
    Tamara O:u"wish

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